https://www.youtube.com/watch?v=2cZ_EFAmj08

@LucH said in Toward a Better Understanding of Reactive Oxygen Species: @Amazoniac said in Toward a Better Understanding of Reactive Oxygen Species: The ROS linked to fat metabolism can arise partly from parallel effects, such as structural or functional perturbations and up-regulation of alternative ROS-producing enzymes (NOX, XO, COX, LOX, CYP2, etc.). I suppose that here we're mainly talking about excess PUFA loaded in adipocytes (AA cascade). When we stress or have a diet (fat loss). If we remain under 10 g PUFA/day, preferably 5-6 g, it would be OK. Edit: fine, the picture on ROS effects. (downloaded) ROS concentration & deleterious effects on cells. The next question is: What about when corn / soy food (from real food) is eaten, with LPS by-side load. Otherwise, it remains a theory. 1° In presence of ALA (thiol antioxidant) or a lipoprotection (A D3 K2 + vit E). 2° The same with aspirin or WWB. Parallel effects can also come from saturated fatty acids. Yet another example: Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance (Cyt c received fewer electrons overall, and pyruvate (oxaloacetate precursor) didn't normalize.) Impairing ATP synthesis limits electron consumption, which favors leakage from affected sites. On a related note, whether an imported fatty acid is saturated or not, the first stage of each β-oxidation cycle involves creating or dealing with an unsaturated intermediate (enoyl-CoA), and it's the hydrating reaction by enoyl-CoA hydratase* (ECH) that resolves the double bond by adding water, which also introduces the oxygen atoms that lack in fatty acids. *Synonym: unsaturated acyl-CoA hydratase This temporary double bond adds to any existing fatty acid double bonds outside of the segment being oxidized. After hydration, the NAD-dependent dehydrogenase (HADH) and the CoA-dependent thiolase (KAT) conclude a β-oxidation cycle. [image: 1770837140988-3a06059b-f0ac-452e-943e-35dceaf24dae-image.png] ⠀(10.1016/B978-0-12-382163-8.00022-0) Proper ECH activity relies on functional HADH and KAT, especially when the three enzymes form a supercomplex (the mitochondrial trifunctional protein, MTP) and work together to metabolize longer-chain fatty acids. Control of mitochondrial β-oxidation: sensitivity of the trifunctional protein to [NAD+]/[NADH] and [acetyl-CoA]/[CoA] Inhibitory effect of 3‐hydroxyacyl‐CoAs and other long‐chain fatty acid β‐oxidation intermediates on mitochondrial oxidative phosphorylation Pathophysiology of fatty acid oxidation disorders and resultant phenotypic variability Despite the experiment suggesting that inhibition is unlikely at healthy NADH/NAD⁺ and acetyl-CoA/CoA ratios, any factor that compromises one enzyme can affect the others. Local ratio perturbations or failure of backup systems may still lead intermediates to accumulate, including enoyl-CoA (the supercomplex's primary substrate). Given that some enzymes related to β-oxidation generate ROS, enoyl-CoA accumulation might place this unsaturated intermediate near ROS sources and start lipid peroxidation that then spreads to other lipids, such as cardiolipin. But it's a speculation.

Thank you, @Mossy. Most of what I post making are my dad’s meals. My own meals are rather basic, since finding Dr. Vickor’s work on trauma and doing the local food challenge. As much as I’m a foodie, I enjoy the simplicity. It takes me only an hour to prep my meals for the week, which consists of chopping veggies, pan-searing 1.5 lb of sea scallops, soft-boiling and peeling 2 dozen eggs, boiling 2 lb of mushrooms for broth, roasting 3 sheet pans of potatoes and squash, simmering a large pot of corn chowder and berries for compôte, and transferring yogurt to a 2 liter jar fitted with a nut milk bag so it can strain in the fridge until it’s as thick as quark. The rest of my diet is locally and regionally produced skyr, honey, herbal teas and apple cider. My meals throughout the week take no more than 5 minutes to heat up, giving me time regularly for morning hikes and come spring, lunches at the lake near my house. I can understand the inconvenience, sure, and yard work is still a good way to connect with nature. There are mountains 5 minutes from my house, but I’ve been mainly going on the trail on my family’s property that leads right to the town lake and on the rail trail a minute away because it’s well-maintained for my dad to accompany me to decompress, especially while going through his cancer treatments. Regarding your compost—there are elevated compost tumblers that should keep the cats out? Or…if you do decide to start a garden, there’s always a keyhole garden where a simple cage for compost is placed in the center of a notched garden bed to feed the garden, and that should prevent contamination? Combine it with the German horticultural technique (hügelkultur) of using decaying logs, branches and trimmings for a mounded garden bed, and your garden should be quite productive. Both work well for container gardens, too. Haha…well, it is nice to receive packages. Just think how nice it would be for him to receive a surprise package containing steel wire mesh, wire cutters, pliers, work gloves and instructions on how to build a compost cage. He overcomes his boredom and you overcome your cat contamination problem.

@alfredoolivas the purpose of PT-141 is specifically to increase NO similarly to the PDE5 inhibitors like sildenafil/tadalafil, and it seems to be great at doing that. The benefit of melanotan II would be the added tanning which would be good if that's what you're looking for with the androgenicity/GR antagonism as a bonus. I personally have no need for that extra NO but in small quantities I think it wouldn't be a problem unless there's evidence otherwise. For the "symptom free cushing" thing it appears that if there are truly no symptoms, then the actual cause could be a faulty test where it's getting triggered by something else or had some manufacturing defect. Actually, the fact that the result was off the charts with no symptoms and that this was one case drastically increases the probability of a testing error. I am so curious about MT II's tanning and androgenicity that I'm thinking of grabbing some vials and trying something like 50ug/d. Anybody else thinking the same?

@bio3nergetic It doesn't matter. Your body will break down the PC into lysophosphatidylcholine + free fatty acids. Back in the body, your body will a join the lysophosphatidylcholine with circulating fatty acids. When the enter the cell, it breakds down back into lysophosphatidylcholine, and rejoins with fatty acids in the cell back into PC.So as long, as you eat saturated fat with the PC, then basically, you will be receiving saturated PC. It's not a scam by Haidut, because he is selling what it says on the label, but it's useless when compared to alternetive forms of PC, which are sold for much much cheaper.

@revenant Mine isn't yet. Some people have tested alphagels and it turned out to be testosterone, but in others it was actually DHT. Not throwing shade but I would be a little cautious. In general it is a good idea to test if you can afford it even for reputable vendors, like alphagels to be 100% sure.

@Mauritio @mossy i had a cup of lemon balm tea after lunch yesterday and it was very calming, similar to chamomile but not sleepy-calm. My guess is that lemon balm is better for day time stress, and chamomile better for after dinner nighty night time! 🫖

@risingfire That's just the brain of the average Bronze Age Pervert follower, praising Hitler and then justifying anything Israel/Mossad does right after that. He previously denied being a BAP fan but i think it's very obvious that he is, the style of trolling and the language he uses just gives it away too easily.

@engineer I've ordered phytol, which also has androgenic properties. And maybe vitex Agnus castus and tetrahydrocurcumin.

@AL said in Vitamin E Source in Europe: You also have this one , mixed tocopherols. I tried this one. Had a pretty rancid taste. Didn't like it at all.

3 meals each with 100g of carb and 36g lean protein and 15g of fat give 2000calories a day and thats not even counting vegetable side dishes. so you're exaggerating on how low the calorie count of 500 if you eat clean. I would do 3 meals with 200-250g of veg per meal and some pineapple and eggshell. some c8/c10 mct oil might clean out the gut. your comment about how "all" the food around you has fuing st in it is hitting that you have some sort of neuroticism and thats probably causing more issues than a SIBO which will probably resolve after digestion speeds up.

@DavidPS said in Using AI to summarize a YouTube video: The issue with some Youtube videos is that they are lengthy and they do not contain timestamps. It is difficult to determine in advance if the time commitment will be worth it. Is the 'juice is worth the squeeze'? I thought it was mandatory bioenergetic protocol to discard 99% of all allegedly informative content, consume the remainder at 2x speed, mentally data label the contradictions and grade the shifty vibes of the subject.

@Milk-Destroyer it's been sold in the US long before Mexico

@Corngold said in Unbelievable Reddit thread: I think male hair has been sexualized by the non-committing hypergamous modern female and baldness was always the norm for at least 50% of dudes after like 25-30. "Unconsciously" they probably know what actually causes it. I don't, so I can't say anything more about this. They're all adorable. Also the shape of a Hamilton-Norwood is not suspicious at all.

@evan.hinkle I will try that — thanks. I have been meaning to use it with coffee as a sweetener as well. And maybe I'll try it in jello instead of sugar: adding even more glycine to the gelatin.

@engineer How's your experience with this setup going so far? I just moved into a house that receives very little natural light coming in through the windows, as it's squeezed tightly in between two other shotgun-style houses, and I'm looking into my various options for tackling the problem. I've got plenty of chicken clamp-lamps, and a red light panel that I use for spot treatment directly on my body, but I need a broader solution that'll cover an entire room and make working from home without adequate natural sunlight tolerable.

using Mg topically is the only way it really works for me. I hate the feeling so I spray it on and rinse it off about 15-20 minutes later. I use it at nigh and mostly on my legs. If I'm lazy I just wipe it off with a wet cloth. If I don't do it I also get a nasty rash. I don't get a rash on my legs either but I do on my stomach and arms, even for a shorter time. Just my experience.

Get some trees in your home! Shefflera are easy, ficus do well and ponytail palms!