@alfredoolivas said in Fenclonine: Watch engineer smash all the tortas in Miami now Speak of the devil except not in Miami

Update: I have received an email from Georgi about why it increases serotonin: Pramipexole is actually known to the Peat community and Peat was asked about pramipexole several times, and he cautioned against using it. It seems that this drug desensitizes the 5-HT1A receptor, which is a so-called "autoreceptor" and its activation decreases firing of 5-HT neurons and overall 5-HT tone in the brain. So, a desensitized 5-HT1A would mean increased serotonin tone/release and thus firing of the 5-HT neurons. This may be one reason Peat cautioned against using it. It also has several unpleasant side effects such as increased compulsive sexual behavior, which medicine claims is due to dopamine overload, but recent studies have shown that the culprit is serotonin. So, pramipexole seems to have a strong serotonergic effect in addition to its dopamine agonism, which seems to be missing in other dopamine agonists such as bromocriptine and the rest of the ergot derivatives. https://haidut.me/?p=2895 https://pmc.ncbi.nlm.nih.gov/articles/PMC3297071/ "...The hippocampus and prefrontal cortex (PFC), structures manifesting volume decreases in depressed individuals, are also affected in rodents with chronic stress.20–24 It is not surprising that one of the common pathways for antidepressant response is an increase in the gene expression of neurotrophic/neuroprotective factors in the PFC and hippocampus.25,26 Previous work documented that prolonged administration of PPX in rats induced a desensitization of somatodendritic D2 autoreceptors in the ventral tegmental area (VTA), allowing the firing of DA neurons to normalize, and of 5-HT1A receptors in the dorsal raphe (DR) that enabled the spontaneous firing rate of 5-HT neurons to increase above control levels.27 Considering the effectiveness of PPX in the treatment of MDD, the importance of both DA and 5-HT systems in the pathophysiology of depression, and the DA innervation of the PFC and the 5-HT innervation of the hippocampus, the assessment of the net effect of chronic PPX administration on DA and 5-HT neuronal tone in the PFC and hippocampus, respectively, was deemed relevant to understand its antidepressant action." "...Similarly to PPX, the increase in the spontaneous discharge of DR 5-HT neurons produced by subchronic administration of the atypical antipsychotic aripiprazole has been found to be due to activation of the D2-like receptors and desensitization of 5-HT1A autoreceptors.62 " Let's see what happens with a microdose.

@engineer got a hooter in my pants and it aint coming down, and im sure you are not gonna take accountability for it

@Ecstatic_Hamster I would have said a pacifier and then i saw your name. try some agmantine sulfate it agonises a1 lower NO agonise 5ht1b/a receptor antagonise nmda . and is the most potent anti addiction substance you can get.

Days 1-now: Every day, I have taken at least 5-6mg (4 drops) and the blood flow aspect is subtle, but there. When I worked out I tried taking 4 drops more and it did help more there. Looks like tadalafil works!

i don't think it's good. But perhaps micro dosing has some benefit.

@sunsunsun Hitler?

@Meeka I stopped taking it early and felt better within a couple of days. I was prescribed it again after that and only made it through one dose. I won’t be taking that antibiotic again.

@hawk1 Yeah I don't think you understood the article, if you are looking at these sources.

@Mossy said in Bile can serve as a reservoir for funghi, making them harder to treat: you obviously don't think the vitamin A from liver is enough or effective in the same manner as supplementing vitamin A? No. Whenever I can eat 2 chicken livers (broth) it's fine. Not always available. No need to supplement if I eat liver. Apart case: Infection, higher ratio and more D3.

@wester130 I have two versions. One came diluted, at 25%. The other is 100%, not diluted. And, to qualify me even further for a Darwin award, I didn't even mean to grab oregano oil, but a different oil. I put the 100% on my skin.

@Jennifer Good news that you're getting away from the computer.  I've been doing the same. I don't believe I can change the title, but if I could, I promise I would, to put the burden, so to speak, on me, rather than you.  Though, I think the evidence will show your inclination to cooking is more natural than mine. Ok, so your brother likes attention to detail as well.  I think that makes sense.  Guys can have a more analytical approach, and girls more intuitive.  Though, that can vary, I think, depending on the task.  For me, cooking these days is more work than fun.  So, I think my desire to be precise is so I can be efficient with my time and move on to another task, or even better, free time.  Though, with my precision, I do want to get it right, so the finished dish tastes as it should. Indeed, that is trying, to say the least — serious trauma.  I'm glad you're able to move forward and that you've gotten thyroid to work for you.  It was an eye opener for me, to learn that supporting the physiological can help deal with the psychological.  I tended to approach everything as mind over matter.  Where sometimes supporting the matter can help the mind.  If thyroid works for you, I see that as a win. I must say, I would've coveted your red floaties over the blue.  At least as a younger child.  My story is very similar, coincidentally, where I was crying to have the red cup my brother had, and I had the blue.  Ok, now that I can relate to...floating in the water and relaxing, versus trying to conquer the wave. I think if there is one activity that is anti-internet age, it is floating.  The saying these days is to "touch grass", to all of us who are online too much...maybe we can add to that, "go float", "touch water", etc. That is tough, new meals on demand.  I've trained my dad to know he won't get that every night.  Most nights are a mix of premade and new ingredients.  Like I may have premade seasoned beef and rice, which I'll use in a just-made burrito or taco.  So, your dad's appetite is low to the point that only fresh food appeals to him?  Or, is he purposely being ornery? I think you'd have a good chance if The Peat is Right or Wheel of Alternative Medicine ever becomes a game show. Interesting about sprouted grains being sweeter.  Maybe there is something to that.  Where a riper version of something is usually sweeter...maybe the same for sprouted grains.  You had me at Wonka .  Wonka anything has got to be better.

More info on the way how coco acts... How does coconut oil can stabilize or protect ingested PUFA from oxidation? Key ideas Coconut oil is not just resistant to oxidation but it can stabilize membranes. Coconut oil protects against the inflammation caused by endotoxins (but don’t use coco in case of a detox at the beginning of the process because it could amplify the immune reaction). SFA has an impact on enzyme expression when use in high amount (far from the ratio 2:2:1 for SFA/MUFA/PUFA). If you have a high intake of LA (omega-6), it can compete with ALA (omega-3) for the enzymes that are responsible for converting ALA into anti-inflammatory eicosanoids. SFAs like lauric acid (from coconut oil) don’t require desaturases. Thus, adding coconut oil won’t inhibit PUFA processing by competing for those enzymes, because SFAs don’t undergo desaturation. Coconut oil is 90 % SFA with 2/3 MCT oil. Adding coconut oil may help protect membranes by giving a spatial and stabilizing protection, improving membrane packing. ! Caveat: Balance is Key: Too much of a good thing is bad. How does coconut oil can stabilize or protect ingested PUFA from oxidation? Coconut’s structure, primarily consisting of saturated fats, is less susceptible to the chemical reactions that cause oxidation. Not just opposing resistance or fragility to oxidation (rancidity) but the way SFA can stabilize membranes. Coconut oil can indirectly protect PUFAs from oxidation by stabilizing the overall lipid environment and potentially influencing PUFA metabolism. (1) Saturated fat content, particularly medium-chain fatty acids (MCFAs) like lauric acid, can help to pack and stabilize cell membranes, making them less susceptible to the damaging effects of oxidation. Additionally, coconut oil's unique fatty acid profile and natural antioxidants may further contribute to its resistance to oxidative damage. When adding SCFA in a meal having some PUFA, it forms a tighter packing; when incorporated to tissues, it reduces the space available for PUFA chains to move and react with free radicals, thus stabilizing the membrane and protecting PUFAs from oxidation. Ray Peat, making a extrapolation in “Unsaturated fatty acids: Nutritionally essential, or toxic?” Question to AI How can SFA from coconut oil stabilize and thus protect incorporated fat in membrane? A clue: When incorporated to tissues, it reduces the space available for PUFA chains to move and react with free radicals, thus stabilizing the membrane and protecting PUFAs from amplifying ROS. Detailed answer on the link. https://mirzoune-ciboulette.forumactif.org/t2109-english-corner-coconut-oil-stabilizes-or-protects-ingested-pufa-from-oxidation#30204

@sunsunsun said in Height Growth That Makes Sense: sports female player and take her home. Obviously a joke @sunsunsun said in Height Growth That Makes Sense: you not the guy who bragged about abusing a muslim woman in public? thats definitely not me probably the Hitler guy @epstein who I have banned btw

[image: 1776786468717-a4097f4b-73f2-4c4b-a340-db6378d8681d-image.png] JP is doing everything to not go back to this.

@engineer I heard some QUACK pot on twitter claim 17 epi Oxandrolone and androstane come up as Oxandrolone on lab tests.

@Mauritio said in Random, interesting studies: anything that has alot of polyphenols with the aspirin should work. Yes, to counteract excess oxidation and then inflammation. But we need to optimize mucin thickness with glutamine (and taurine to counteract the excitotoxcity in the brain). I take half a teaspoon of taurine and the same with glutamine powder, one hour before bedtime, when I feel a stomach acidity. No glutamine if you suffer from dysbiosis (suspicion of candidiasis: it feeds the bacteria). When it's nervous, L-theanine 225 mg and 1 tsp collagen do the job (cramp). Never take SSRS as a usual med...

I call this Illuminatione, not dropspirenone [image: 1776734580390-96ac4c93-20b6-4a3c-b8a1-542411766669-image.png]

@engineer yeah you are shooting ROPES

@CrumblingCookie interdasting thanks