@sunsunsun lets see...

https://youtu.be/cXHyf-di6C0

@ThinPicking in the article where he calls avocados toxic due to the pufa content, references a study that shows they are toxic in the study specifically due to the non-oil component because the study tests avocado oil vs. avocado oil with the avocado polyphenols (or whatever they are) removed and only the avocado oil without the stuff removed causes the issue. so the study itself says the pufa does nothing bad as tested

@heyman DHT is just a metabolite of T, and there are many differences between the two: DHT is way more androgenic T is a cortisol antagonist, while DHT is less so DHT depends on the 5ar enzyme which is the target of so-called "hair loss" medicines like finasteride and dutasteride

ooh yea aspirin blocks further production

@CrumblingCookie said in Peaty uncoupler vs. Ozempic who wins ? New study.: If it enhances autophagy through AMPK it should not be limited to mitophagy but also cover xeno-autophagy Good point. That might make it helpful for fighting infections. @CrumblingCookie said in Peaty uncoupler vs. Ozempic who wins ? New study.: So a shift away from carbohydrates to FAO People often paint uncouplers as FAO-increasers. But they increase FAO and carb oxidation. The above article mentions it increasing TCA cycle, which can be fed by carbs and fat. It probably also depends on which tissues we are talking about. If you want to lean out your liver increasing FAO there is probably a good thing. @CrumblingCookie said in Peaty uncoupler vs. Ozempic who wins ? New study.: The MOA of BAM15 would then be a combination of inducing UCP and something along the line of metformin or berberine or spermidine (but lacking the Beclin-1 upregulation). (A comparison with resveratrol is less suitable since, although it lowers intracellular ATP through AMPK, I dare say its most important effect is through Sirt1) AMPK increases SIRT1. So BAM15 should do that, too.

@lobotomize yes but i think you'd have to be in somewhat decent shape to reap the benefits of cold showers. There is such a thing is cold resistance when it comes to thermogenesis and uncoupling. IIRC there was a study showing that grains of paradise were able to reverse that state in humans.

@lobotomize my skin looked completely smooth and glowing for like a day when I got really sick once. Maybe your body has some emergency mechanism that temporarily boosts your metabolism when you're sick

@Peatful my dog actually grew a lipoma of some sort when I added bluebonnet brewer's yeast powder to her diet.

@hawk1 I have similar concerns to you regarding suppression. So, despite that, I have also gone the nuclear route with 500mg a week of T isocaproate. Surprisingly, I haven't detected much suppression if any because vitamin E, pregnenolone/DHEA, and progesterone all work to oppose estrogen and prolactin which are the main underlying mechanisms behind endogenous shutdown. This is all because regular T aromatizes, unlike 11KT, which shockingly does NOT! So even if you're not already doing other Peaty things you are already in a low risk position.

@engineer You can find a chemical for everything, but often creating or buying it costs too much compared to its value

@16characterstwas put some fish oil on the phone it will oxidise the evil blue light

Maybe the problem's above your complaint @gg12 . Hydrochloric acid.

@16characterstwas why would reduce endotoxin increase weight gain?

@sphagnum Orally with water. https://www.amazon.de/-/en/Singulares-Shell-Powder-Extra-Fine/dp/B07TD46XG5?th=1

@Gardner that post was after potato as starch meal so yor assumption is incorrect and secondly i take increased appetite as easy marker of increased vitality

@gg12 Does coffee deplete calcium ? Don’t think so Why is my sleep worse on days I drink coffee / it’s hard to fall asleep even if I drink it at 9am. I almost feel like the effects last for a day or two. Try less strong coffee or decaf (with cream and sugar.) And in small amounts. Then work your way up. I feel like it makes my metabolism too fast so I franticly eat starch slop to calm down the starvation. But this just makes issues worse in the long term. Have it with cream and sugar. makes all the difference in the world. Should I force a cup of coffee everyday and hope I adapt? I have SIBO , lactose intolerance, poor liver, bad liver glycogen etc just looking to get things up to speed again. No, forcing doesn’t work. But it does help with those and alot of things, not just because of the caffeine but also because of the nutrients, chlorogenic acid, etc. So start with decaf (still has some beneficial caffeine ) and in smaller amounts, then work your way up. Add some cream and sugar to balance out the caffeine and other components.

@Mossy said in The processing of MILK and unsaturation: Strangely, the Alexandre brand milk, the one with the true full milk fat (6%), A2, and 100% grass-fed, uses a plastic bottle. Too bad. They were so close to seemingly having the crème de la crème of milk (pun maybe intended, subconsciously...haha). Not that I could buy this on a regular basis, but if opportunity allowed, it would be nice to get this with glass. Yes, indeed. I think so too. Milk has a shorter shelf-life than water. Water in plastic bottles are often 6 months old. So more time for nano particles to migrate. We speak here about nano, not micro-particles, enable to pass through the BBB. If you mix tap water for usual drink, mineral water for coffee machine (less calcium) and flashed-pasteurized milk 250 ml (1/2 gallon) (whatever the source is, glass or plastic), it should be OK. OK if you get some kinds of polyphenols (EGCG, resveratrol, and Theracurcumin to moderate glial plaque. The Taurine / Vitamin B6 (PLP) / Magnesium Trio. NB: I fill a jar the day before (+/ 20 H) with tap water (chlorine evaporated and less Ca left) and afterwards in a magnetic thermos bottle (inox) for the the following daily use. Useful info for other readers: https://bioenergetic.forum/topic/9017/neuro-degeneration-a-multi-factorial-approach => Useful nutrients for the brain. Modulation of the nervous system.