To lose fat you need to reduce mTOR activation, e.g. the body's growth signal. Else it will always reserve some of the calories you eat to build even more fat reserves and it becomes a endless cycle of e.g. not losing weight. Reducing mTOR is primarily achieved through AMPK. The three main ways to increase AMPK are: Intermittent Fasting Exercise (particularly HIIT, you need to be out of breath afterwards, weightlifting doesn't increase AMPK unless you go very high volume, neither does walking or light exercise) Exogenous AMPK like Berberine

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@happyhanneke said in Sudden dental issues/lack of saliva: Therefore, I am going to the doctor to have a blood test done. If you have suggestions on what to specifically have tested I would like to know. I will ask her for sure to do thyroid panels. Calcium in serum, parathyroid hormone (PTH) in serum, total serum protein, free copper in serum. Calcium and citrate in 24h urine to see more on calcium balance and acid neutralizing capacity.

@engineer W engineer

Here's a concrete example of where the information came from and how I used AI, in relation to microglia and inflammation. I don't master everything https://mirzoune-ciboulette.forumactif.org/t2174-neuropathologie-comment-attenuer-la-fibrose-en-cas-d-algodystrophie-et-de-fibromyalgie#30632 Excerpt Neuropathology & how to mitigate fibrosis in complex regional pain syndrome (CRPS) and fibromyalgia. Key ideas • Improve nerve conduction and limit hyperalgesia. • Limit fibrosis (dermal sclerosis) by modulating TGF-β1 stimulation. • Combined approach to fibrogenesis, the extracellular matrix (ECM), and inflammation. • Tactics to counteract fibrosis & optimize conduction – Practical aspects. Antifibrotic action of curcumin & dexamethasone. Anti-excitotoxic action of magnesium bisglycinate Neurotropic mechanism of action of thiamine (B1), pyridoxine (B6), and vitamin B12 in cases of heightened neurosensitivity and as modulators of inflammation PEA to stabilize mast cells and limit microglial activation. By stabilizing mast cells, PEA reduces the sensitization of peripheral and central nerves.

No proof with iodine on warf but ... I don't need a study to confirm the efficacity on every virus when it helps the immune system How effective is iodine as virucidal? (And by microbes, viruses, fungi and parasites) DOI: 10.1530/ERC-17-0515 Role of iodine metabolism in physiology and cancer. Endocr. Relat. Cancer. 2018 New research supports the exciting idea that I- participates as a protective antioxidant and can be oxidized to hypoiodite, a potent oxidant involved in the host defense against microorganisms. This was possibly the original role of I- in biological systems, before the appearance of TH in evolution. I- per se participates in its own regulation, and new evidence indicates that it may be antineoplastic, anti-proliferative and cytotoxic in human cancer. Alterations in the expression of I- transporters are associated with tumor development in a cancer-type-dependent manner. SARS-Cov-2 doi: 10.1371/journal.pone.0254341 The in vitro virucidal activity of intranasal Povidone-Iodine (PVP-I) has been demonstrated recently to reduce SARS-CoV-2 viral titers. EID (200 μg iodine/ml) after exposure for 60 and 90 seconds was compared to controls. In both cases, the viral titer was reduced by 99%. EID = Essential Iodine Drops. Influenza viruses Iodine, particularly in the form of povidone-iodine, is effective against influenza viruses by disrupting their structure and blocking their ability to attach to and enter host cells. How it works • Disrupts viral structure: Iodine makes structural changes to the viral coat by attacking key viral proteins • Blocks attachment: Iodine interferes with the hemagglutinin protein, preventing the virus from attaching to receptors on human cells. • Inhibits viral release: It also inhibits neuraminidase, a viral enzyme essential for releasing new virus particles from infected cells.

@LetTheRedeemed You get a pass for Northern English accent. Scottish accent will lead to a permanent ban.

Ray also said this about potatoes: “Two pounds of well-cooked mashed potato has the protein value similar to a liter of milk, about 33 grams of protein.” In case anyone is interested, below are some potato recipes I make. For the first recipe I use a jumbo 6 cup muffin pan and with the second recipe, I also use the crust for tourtière (meat pie) and quiche. https://www.youtube.com/watch?v=gPBwC3IgP6c https://www.youtube.com/watch?v=OQ-D89GHxjE https://www.youtube.com/watch?v=argKpeiKFfo

I think the most powerful tool for both SIBO and SIFO is MSM sulfur. This podcast by Dr Janel explains how well it has worked for antibiotic resistant sibo. Its cheap, safe and works. https://gijanel.com/gi-janel-one-video/

The thing I don't get is why the antisemite picks "Epstein" as a username

@user1 yea for the sleep paralysis, also yea I would be lying if I said I didnt get sleep paralysis a lil recently

Get your eggs in! Spinach also is rich in lutein. Interestingly, cooking it doesn't degrade the lutein content. And having calcium with the spinach is two-fold beneficial: block oxalate absorption enhance lutein absorption by 30 to 40%

@Ecstatic_Hamster said in Does low TSH correlate with longevity and health: What do you think about this and why? I think that a low TSH is associated with health, especially when it occurs naturally without pharmaceuticals or exogenous hormones. I do not think that a low TSH is associated with longevity; but I think that a high TSH is associated with increased mortality (a shorter duration in lifespan). So there is an incentive to keep TSH low or at least on the low side of the normal range. As to the 'why", I have not read the literature but I have a general analogy. First, there has been an explosion in the number of people with Type II diabetes and the term adult onset diabetes is no longer appropiate since children also develop Type II diabetes. The general cause for this explosion is our modern lifestyle (with many non-ancestral components) which has over stimulated our hormonal insulin secretion. And for the analogy, lifestyle promotes high ISH (insulin secreting hormone). It takes years of high ISH before diabetes is diagnosed. [image: 1771780870851-e3378664-92f2-4d65-a6f7-8b80cc3897c1-image.png] I am wondering if high TSH will eventually result in thyroid problems, that is thyroid resistance and the lucrative medical manangement thereof. There are hotlinked references about thyroid resistance at the end of this article. Thyroid hormone resistance and its management (2016)

@CrumblingCookie nice

@engineer Yes citrulline and arginine are the popular ones and are indiscriminate when there is inflammation and iNos present. As Peat advised, not wise to mess around with. MT2 indeed is not related to the inflammatory NO pathways which is good. But always good to be cautious still.

i am now re thinking this idea after finding another patent using losartan for hair US20160081901A1 - "Compositions and methods for hair growth"

Sometimes you can search the transcript.