@lykos Implement stratetgic PUFA. My metabolism gets too fast and I don't have the means to eat more only "peaty" food. Therefore Peating only sort of works for me and I rather be full then always on hyper drive and hungry within 30 minutes. I recommend purposely slowing down your metabloism a bit. Dont do it with grainsludge. But Salty Salmon locs and bacon are prob my go to PUFA. If u are young like me so under 20 I think eating strictly peaty might be overrated. You cant live life to your fullest on a empty stomach.

lowers endotoxin tho right? May have to go the ajoonus route. Only thing I think coffee / caffeine is good for is liver...... But I really cant handle it

@lykos Murdoch Murdoch style peat :0

@Mossy I used to get sedated taking it on my own and in tablespoon quantities, but I now only consume it alongside food/(or milk or some other caloric drink) and only a tsp at a time. It doesn’t sedate me this way. With food, I literally just sprinkle it on top, (adds a little sweetness and not much flavor really). There’s also the possibility that it lowers stress hormones and perhaps over time I’ve lowered my stress and increased my energy such that it no longer has such an effect. Either way, try tsp vs tblspn and with food vs simply water if you haven’t already.

@CrumblingCookie Retinol deficiency is very possible, but wouldn't that implicate low ceruloplasmin? Mine is right in the middle of reference range (0,22 g/l)

@cedric said in Refined beet sugar: Sugar beet and MS- azetidine/proline analogy A Classic Misincorporation Risk The "Geographical Correlation" Trap (Vitamin D Factor and "Lobbying" Angle" for glyphosate) a primary driver for MS is a massive interpretation playing on Fear: Sugar beets in the US are largely GMO and heavily treated with glyphosate, whereas cane sugar (historically) had different treatment profiles. lobbying theory: the "villain" is likely Glyphosate rather than the beet itself. Edit: Or how to get people considering a study by incorporating glyphosate into a common product. Well-targeted.

Dr. Bertalan Mesko, PhD, known as The Medical Futurist, is the Director of The Medical Futurist Institute. He specializes in analyzing the impact of science fiction technologies on global medicine and healthcare. As a geek physician with a PhD in genomics, he is also an Amazon Top 100 author and serves as a Private Professor at Semmelweis Medical School in Budapest, Hungary. https://medicalfuturist.com/

@DavidPS Thanks, there is also complementary story https://www.mdpi.com/1422-0067/26/17/8655 Ivermectin Binds to the Allosteric Site (Site 2) and Inhibits Allosteric Integrin Activation by TNF and Other Pro-Inflammatory Cytokines by Yoko K. Takada 1 andYoshikazu Takada 1,2,3,*ORCID 1 Department of Dermatology, University of California School of Medicine, Research III Suite 3300, 4645 Second Ave., Sacramento, CA 95817, USA 2 Department of Biochemistry and Molecular Medicine, University of California School of Medicine, Research III Suite 3300, 4645 Second Ave., Sacramento, CA 95817, USA 3 VA Northern California Health Care System, 150 Muir Road, Martinez, CA 94553, USA * Author to whom correspondence should be addressed. Int. J. Mol. Sci. 2025, 26(17), 8655; https://doi.org/10.3390/ijms26178655 Submission received: 1 August 2025 / Revised: 28 August 2025 / Accepted: 1 September 2025 / Published: 5 September 2025 (This article belongs to the Section Molecular Immunology) Abstract Ivermectin (IVM), a broad-spectrum anthelmintic agent, has anti-inflammatory properties, and affects cellular and humoral immune responses. We recently showed that multiple pro-inflammatory cytokines (e.g., FGF2, CCL5, CD40L) bind to the allosteric site (site 2) of integrins and activate them. 25-Hydroxycholesterol, a pro-inflammatory lipid mediator, is known to bind to site 2 and induce integrin activation and inflammatory signals (e.g., IL-6 and TNF secretion), suggesting that site 2 is critically involved in inflammation. We showed that two anti-inflammatory cytokines (FGF1 and NRG1) bind to site 2 and inhibit integrin activation by inflammatory cytokines. We hypothesized that ivermectin binds to site 2 and inhibits inflammatory signaling by pro-inflammatory cytokines. A docking simulation predicts that ivermectin binds to site 2. Ivermectin inhibits the integrin activation induced by inflammatory cytokines, suggesting that ivermectin is a site 2 antagonist. We showed that TNF, a major pro-inflammatory cytokine, binds to integrin site 2 and induces allosteric integrin activation like other pro-inflammatory cytokines, suggesting that site 2 binding and integrin activation is a potential mechanism of the pro-inflammatory action of these cytokines. Ivermectin suppressed the activation of soluble β3 integrins by TNF and other pro-inflammatory cytokines in a dose-dependent manner in cell-free conditions. Binding to site 2 and the inhibition of binding of inflammatory cytokines may be a potential mechanism of anti-inflammatory action of ivermectin.

@LetTheRedeemed https://www.diningandcooking.com/2025190/new-study-suggests-link-between-cheese-and-long-life/ " The study, published in the Journal of Agricultural and Food Chemistry, suggested that fermented dairy products such as cheese could contribute to longevity and health." https://www.guentensperger-kaese.ch/en/post/news-cheese-and-life-expectancy

I have ordered a-pinene and phytol from the above website. We'll see if it arrives since the whole process was kind of weird. @cs3000 have you tried supplementing a/b-pinene? It seems to have some interesting properties. Maybe could be used as a cancer prevention. Another possibility: use pinus cembra essential oil. It's ~40% a-pinene and ~10% b-pinene, with other terpenes like limonene making up the rest. Theoretically it should be safe to ingest a drop of the essential oil, if diluted and organic. I haven't tried it yet, but can attest to its calming effects just from inhaling it. In this study it increases life span just from inhaling it in flies under certain conditions. https://www.nature.com/articles/srep28540

@LucH I understand, there is no way for you to assess the unique situation of my father; I was just curious if you cycled this like the others. I appreciate the additional information.

@alfredoolivas I know that small amount are good but I do not pay attention so much to the "dosage of food." May that list is more handy https://www.nejm.org/doi/pdf/10.1056/NEJM199308053290619?articleTools=true

@Luke

@evan.hinkle removing the old collagen can be helpful, yes, by forcing fresher collagen to be produced

[image: 1770205907556-7620887b-00fd-4268-ae17-1d85db93dcce-image.png]

@Mauritio - Thanks From AI Effects of Lactobacillus reuteri Lactobacillus reuteri (L. reuteri) is a well-studied probiotic known for its beneficial effects on gut health and immune function. Research indicates that L. reuteri can influence the production of IL-10 in several ways: Immune Modulation: L. reuteri has been shown to enhance the production of IL-10, which helps to reduce inflammation and promote a balanced immune response. Gut Microbiota Interaction: By modulating gut microbiota composition, L. reuteri can create an environment that favors the production of IL-10, contributing to improved gut health and reduced inflammatory conditions. Clinical Studies: Some studies have reported that supplementation with L. reuteri leads to increased levels of IL-10, suggesting its potential role in managing inflammatory diseases. How does Lactobacillus reuteri affect immune function beyond IL-10 production? Lactobacillus reuteri enhances immune function by increasing phagocytic activity in macrophages and boosting the secretion of nitric oxide and prostaglandin E2, which are crucial for immune responses. It also produces antimicrobial molecules like reuterin, which helps inhibit pathogenic microorganisms, contributing to overall immune health.

@sunsunsun Merci! Below is a summary in case someone in need will be reading this in the future: Introduction Combination of vitamins E+D about as effective as antibiotic for treating bacterial sepsis/infection daily 1-2k IU D3 + 8.75mg/kg (700-800mg) Vit E (d-alpha-tocopherol or mixed unesterified d-isomers of all 4 tocopherols) The tetracyclines protect against sepsis independently of their antibiotics effects Tetracyclines might be the preferred antibiotic treatment (i.e. doxycycline in a HED of 0.25 mg/kg (intraperitoneal route, so orally one would need ~0.4 mg/kg to achieve the same effects) Endotoxin/LPS is a major driver of blood clotting, sepsis, heart attacks and strokes Aspirin (although only acts downstream of the endotoxin/LPS cascade) Substances that can limit the amount of endotoxin/LPS produced and entering the blood: easily digestible food; avoiding “resistant” starches carrot salad, charcoal (*not really applicable after appendectomy) Niacinamide and vitamin E to help restore the gut barrier pregnane steroids (and especially bioidentical progesterone) to directly bind endotoxin in the bloodstream Inhibiting fatty acid synthesis (FAS) dramatically improves sepsis survival rate least risky of FAS-Inhibitors is probably orlistat (Still severe side effects) aspirin might be good alternative; adding niacinamide + thiamine might improve its effectiveness against sepsis by improving glucose oxidation and reducing lipolysis respectively Inhibiting fatty acid synthesis reverses bacterial antibiotic resistance Aspirin (80mg-100mg daily) inhibited FAS by +50% Aspirin As A Cure For Sepsis excellent thread https://lowtoxinforum.com/threads/aspirin-as-a-cure-for-sepsis.15753/post-215210 Baking Soda Dramatically Increases Antibiotic Effectiveness, Could Help In Sepsis (!) Note: research involved in vitro work only + oral route probably not applicable after appendectomy see Haidut comment Caffene restores lowered cytochrome C oxidase activity + Caffeine restores cytochrome C damaged by sepsis one cup of coffee or about 80mg-100mg of caffeine probably better to do in recovery, not with acute sepsis DHEA Protects From Endotoxin Effects And Lethality single HED dose of as little as 5mg - 7mg DHEA daramatically increased survival of lethal endotoxins DHEA protects from endotoxin (even lethal doses) IV B1+Vit. C+ Cortisone Prevents Septic Induced Death Full interview with Dr. Paul Marik his 2017 paper in question for early treatment protocol Vit C (1.5 g every 6 h for 4 days or until ICU discharge) Thiamine (200 mg every 12 h for 4 days or until ICU discharge) Hydrocortisone (50 mg every 6h for 7 days or until ICU discharge followed by a taper over 3 days) read on the other forum this one failed to replicate, although some studies exist that show somewhat sig improvement https://www.amjmed.com/article/S0002-9343(19)30699-0/fulltext s/o @mauritio T3 levels are a predictor of mortality from sepsis This study (and this one) shows that lactic acid is an independent risk factor for death due to sepsis. CO2 lowers lactic acid, T3 increases CO2. So it makes sense that T3 was so strongly correlated with survival in sepsis patients. -> improve CO2 / lower lactate (thiamin, niacinamide) This study shows a significant increase in survival time of people who take aspirin before hospitalization (by 1.3 days) Vitamin B2 Remarkably Effective Against Endotoxin, Sepsis, And Other Bacterial Infections especially its activated form riboflavin '5 phosphate (R5P) minimum effective human equivalent oral doses for the combination of R5P and valine were approximately 0.2mg/kg and 25mg/kg respectively. This assumes bioavailability of 90% and 70% for R5P and valine. The Pyruvate Dehydrogenase Complex in Sepsis: Metabolic Regulation and Targeted Therapy "A group of drugs that target PDHC activation, including dichloroacetate (DCA), thiamine, amrinone, ciprofloxacin, and TNF-binding protein (TNFbp), have been shown to ameliorate the symptoms of sepsis" Septic Shock: Serotonin Is The Likely Cause Of Septic And Anaphylactic Shock Anti-Serotonin (Cyproheptadine) + Aspirin Famotidine & Anti-histamines Protect Organs In (septic) Shock Both an H2 blocker (Famotidine, Cyproheptadine) and an H1 blocker (Chlorphenamine) were each offered protection Inosine Increases NAD/NADH Ratio And Reduces Systemic Inflammation s/o Koveras Anti-Serotonin, Cypro, Tryptophan Metabolism, Vitamin C, Hydrocortisone, Thiamin https://lowtoxinforum.com/threads/do-not-forget-to-give-thiamine-to-your-septic-shock-patient.12006/ See also: Haidut on radiation exposure due to x-ray https://bioenergetic.forum/topic/3037/advice-on-lowering-endotoxin/18 https://bioenergetic.forum/topic/2140/any-info-on-sepsis-bacteremia-antibiotics-used/16 Citrulline to restore immune function after sepsis L-Citrulline restores immunity & T Cell mitochondria function acutely highest food sources: 1 cup of red flesh watermelon might have ~150mg per cup. or ~400mg for yellow flesh watermelon https://bioenergetic.forum/post/42939 Anti-inflammatory Effect of Low-Intensity Ultrasound in Septic Rats https://bioenergetic.forum/post/60444 (!) avoid mitophagy enhancers like menaquinone (K2), urolithin-A or mitochondrial uncouplers like DNP, BAM15, methylene blue, theobromine etc. (especially in the initial stage of sepsis) https://lowtoxinforum.com/threads/aspirin-in-the-context-of-endotoxin-tolerance.49865/

@Mike_Fave Glad to see u on this forum ur a good youtuber