https://www.youtube.com/watch?v=8mDWI84FlEg

@sunsunsun said in anyone using LGS NDT?: is it good? It’s probably fine if that’s all you have access to, but it’s not standardized so you don’t know what you’re getting for hormones from batch to batch, which makes dosing nearly impossible. If you have access to fish heads or chicken necks with intact thyroid glands, you may find that more cost-effective.

In case anyone is interested, here is a no-bake cheesecake recipe made with strained yogurt: https://hungryandchill.com/icelandic-delight-skyr-cake/

@hwisdom did you actually try this?

Thanks for posting. Excerpt from the study: In the U-13C-Glu + Lys + AA model, AA produced glyoxal (GO), methylglyoxal (MGO), CML and CEL, which was significantly higher than with Glu alone. This study provides a theoretical basis for the formation mechanism of AGEs in the Maillard reaction involving AA. Comment: Among Amadori rearrangements (becoming a Maillard reaction), methylglyoxal (MGO) is a frequent and strong one. But the body is able to manage these AGEs from food if we get glutathione enough (and cofactors to recycle or spare oxidized GSH). However the problem comes from other agressions ... Useful info (in French but with links in English) Glucosepane glycation et agents protecteurs https://mirzoune-ciboulette.forumactif.org/t2184-glucosepane-glycation-et-agents-protecteurs#30714 In anyone aging or subjected to prolonged metabolic stress (persistent inflammation, toxins, processed foods), the body's metabolism becomes disrupted and the entire redox system weakens. Glutathione levels decrease, other cofactors become deficient, and defenses against dicarbonyls are compromised. This overall shift in redox metabolism creates a favorable environment for the increased formation of glucose, a major AGE (Advanced Glycation End Product). Most of the AGEs formed in the body do not come directly from ingested foods (sugar and meat), but from two highly reactive dicarbonyls: 3-deoxyglucosone (3-DG) and methylglyoxal. Our natural defenses—zinc, insulin, glutathione, among others—serve precisely to neutralize these compounds before they can attack proteins. When these defenses are depleted, due to age or metabolic stress, AGE formation accelerates. Protective agents against 3-DG and MGO (two highly reactive dicarbonyls) B6 PLP Benfotiamine Optimize and recycle glutathione Anti-glycation formula (L-carnosine, aminoguanidine, sodium R-lipoate, benfotiamine, L-histidine, guava/banaba leaf extract (1% corosolic acid)). Details on the link.

@Maximalus no

@engineer I added in 600+g carbs, so I am probably holding in more glycogen / water weight. Last tuesday, I weighed 81.6kg. But that could be water weight cope, so let's see how week 2 goes.

@sunsunsun Wax moths? They don't even have neutrophils and I won't deep-dive into finding out how their hemolymphs specifically compare to human or mammalian neutrophils. I really do harbor strong apprehensions against the potential (mis)use of doxy on fungal infections. What I would much rather do is oral terbinafin + fluconazole. The terbinafin by itself is useless against many fungi species but allegedly it strongly inhibits expression of the fungal efflux pumps responsible for azole resistance! This still won't tackle activitiy in the biliary tract, though. I've done some more reading of publications on biliary / gallbladder candida / fungi. Fungi can be causes of calculous (lithiasic) or also acalculous cholecystitis with or without mixed bacterial infections (Escherichia coli, Enterococcus, Klebsiella, Enterobacter, Clostridia). Even in such rare and often fatal cases that happened to be documented, candidemia was rare despite frequent (almost always) fungal infection of other organs. https://pubmed.ncbi.nlm.nih.gov/8862389/ https://pubmed.ncbi.nlm.nih.gov/28703118/ https://pmc.ncbi.nlm.nih.gov/articles/PMC8764969/ https://pmc.ncbi.nlm.nih.gov/articles/PMC12338181/ https://pubmed.ncbi.nlm.nih.gov/24474028/ https://pubmed.ncbi.nlm.nih.gov/8207288/ I don't have visible gallbladder wall thickening or distention or an obviously, universally accepted liver disease (except for hepatomegaly) but if I had I sure as hell would want to insist on flucytosine, or flucytosine + i.v amphotericin B along with any broad-spectrum antibiotics and before mutilating surgeries they'd offer. Have looked more into berberine again, too. It's impossible to achieve its antimicrobial concentrations (at least 0.1mg/mL) systemically. Serum concentrations are about 0.5 - 16 ng/mL. I.e. 0.000005 mg/mL. Ridiculous! The berberine in practical doses of 500-1500mg will thus be acting mainly within the GI lumen in support of oral Ampho-B. Berberine has low absorption but some will spill over to reach the liver for extensive first-pass metabolism, yet probably not into biliary ducts.

Magnesium ratio for Ca:Mg is a nonsense as long you target the RDA for Ca 1000-1200 mg Ca. We’d better target the minimum amount, which is makes more sense. Why? The body is able to optimize the assimilation. As far as I’m concerned, I target: Ca: 800-850 mg. minimum 600 mg if other acid-base elements are correct. Mg: 300 mg. Not higher than 450 mg (Vit D). K: 3000 mg. Comment: Yes, Mg is useful. And so are MCTs from coconut. But before targeting ketosis for changing the microbiote, you’d better think twice and enlarge the view / the approach. You’ll probably get the same result with a 3-4 day fast and 600 K/cal diet, combined with a 16.8 diet. Useful info: https://mirzoune-ciboulette.forumactif.org/t2182-conversation-ia-n1-relation-calcium-mg-et-k-ajr-revisite-et-prevention-lithiase#30697 AI Conversation N° 1: Calcium, Mg, and K Relationship. Revised RDA and Kidney Stone Prevention. Context: Kidney stones. Excerpt (translated from French) Potassium intake (fine for getting oxalate crystals very brittle) and fiber (25-35 g/day). This is a key element. Personally, I aim for 3000 IU of K, 300 IU of Mg, and 800-850 IU of Ca (never below 600 mg for Ca). And don't bother me with the Mg/Ca ratio and aiming for 1200 mg of Ca. That's unrealistic… Acid-base balance is the determining factor. As long as PTH (0.5-3) isn't stimulated, things should be fine. This needs to be verified and nuanced (done on the given link with the “help” of AI). Potassium intake (very fragile oxalate crystals) and fiber (25-35 g/day). This is a key element. And if you're wondering how I use AI to avoid dodging the issue and thus influencing other readers, here's an explanatory link on my forum: https://mirzoune-ciboulette.forumactif.org/t8-presentation-de-luc-alias-nestor345#9 Excerpt: I use digital tools to confront my own statements and ensure the coherence of my summaries, but the 'spirit' of the advice comes from the literature I study and the feedback from my own community at Mirzoune et Ciboulette forum. I see my role as a translator or an analyst who reviews an interesting book or document. Having been a language teacher, my focus is on taking complex, dense information and making it structured and accessible for someone who’s lost or overwhelmed, who currently lacks the energy to digest a 200-page book. PS: I Know: We shouldn’t trust IA (…).

Histamine is a stress signal Iirc it also turns on NO You are under metabolic stress You need to energize cell function I am simplifying this a lot…. 1- blood sugar. 2- endotoxin. Start there If you raise your metabolic rate Naturally- not with exogenous t4 But sugar Sugar supplies your liver and thyroid essential metabolic support It’s a pillar of Peats teachings Addendum: not glucose supplements

@lobotomize right but this is a mycelium product not a mushroom (fruiting of mycelium) product. I know Reishi mushroom blocks 5 ar but I don’t see that shiitake does. Thanks, I’ll keep looking!

@sunsunsun both are good, but you are 100% correct.

@CrumblingCookie https://pmc.ncbi.nlm.nih.gov/articles/PMC3393430/

@Gardner i ate four pita wraps last night after already eating a peaty meal of greek yogurt and cooked fruit , i noticed zero downside to the wheat flour meal vs the peaty dairy + fruit meal all of this is possible due to mogging timeline once u begin to mog it doesnt matter , i suspect even some pufa deep fried food is ok, but it grosses me out to think of eating deep fried pufa oil tbh so i havent tried

@DavidPS said in The Top 5 Can’t-Miss Sport Supplements: Nitrates, found in beetroot juice Nitrates, found in beetroot juice. they interfere with cytochrome c oxidase no?

@lobotomize I was being sarcastic but, so, what I meant was, you are smarter meaning the brain is in like an excited lots of blood glucose from the cortisol adrenal realize. I’m not saying that’s a good thing or healthy but it does happen.

@alfredoolivas I don't think so because it's entirely possible to have a state of high dopamine and low prolactin. It might just act as a secondary mechanism apart from some other dopamine pathway solely to prevent a prolactin overload. The fact that it uses dopamine to prevent such an overload is an irrelevant implementation detail because it's not common you see people in a high dopamine but high prolactin state.

@engineer I can't use the entire weight because I somehow lost some of the sand bags (probably while I was moving, a former colleague once said "Moving three times is like being burglarized once"). The max weight is about 20kg now, That weight is good for exercises like pushups or body rows where you make quick progress and can carry more added weight. The vest I have is also pretty tight, so it doesn't bother me much with pushups. It's also good for weighted jump squats. I don't have a pullup bar right now, but I don't think I could ever reach multiple pullups with 20/25kg added weight. I could hardly do eight pullups without vest even when I was still young and in good shape. It's definitely a great addition.