I don't have an answer but i share your doubt, it doesn't seem like reducing inflammation would reduce muscle growth. Am pretty sure there's someone with an answer for that but ... i'd love to hear it too. As for myself, i always have three water bottles handy which i take a gulp from before and after a workout. My mixed Vitamin-B water, my buffered Aspirin and Quali-C water, and my Mag+Calcium bicarbonate mineral water. I do not get sore unless i really push it with extra negative reps, and even then the soreness is mild and disappears fast. Almost forgot, i always have my fortifield collagen powder after workouts too, am sure it's helping. As for bliss with coffee i recommend everyone try the following, put a small pinch of Mag-Sulfate (USP epsom salt) in every cup. Just as sugar can help blunt the cortisol response that small amount of Magnesium is noticeable, it actually caught on at my workplace. Collagen in coffee is icing on the cake at this point.

https://youtu.be/L8tb7ffIsyg?si=Fo31Gd75WDqLa3o_

@wester130 citrulline boosts all NO (including the inflammatory kind) not just eNOS and nNOS

@sunsunsun not everybody wants anabolism, maybe you just want to look manlier but don't want/need to be bigger, also you can use topical dht to regrow hair

This study has an interesting hint: we need small and hydrophilic molecules for an anti-fungal effects that isn't reduced by bile. "In contrast, small and hydrophilic molecules, such as cycloheximide, flucytosine, or sodium azide kept their antifungal properties. " It's difficult to not despair in the face of things continueingly worsening since the stop of fluconazole 300mg pd in spite of having commenced flucytosin treatment (100mg/kg BW /day) already 5 days ago. Flucytosine's mechanism of action is a slow, gradual, delayed intracellular conversion and poisoning in contrast to the rather immediate mechanism of action of fluconazole. Whilst Flu especially accumulates in mucosal tissues, it principally seems true that FCy doesn't even start to work within a couple of days but requires about 2 weeks to get going: Fluconazole vs. flucytosine in the treatment of esophageal candidiasis in AIDS patients: a double-blind, placebo-controlled study, 1995 I've read in some paper that the fear of developing resistancy to FCy monotherapy is much exaggerated as there have been very few reported cases of it happening in-vivo. The urgent recommendation of pairing FCy with i.v. AmB for at the very least 2 weeks of treatment induction must be, to a great extent, down to bridging the temporal gap until onset of FCy efficacy. Serologically, my C. albicans antibodies are nil and serum CAGTA antigen is also nil (that's the Candida spp. hyphal protein). Thus, unless there's a specific humoral defect, C. albicans has no involvement at all in my case. C. glabrata, however, generally doesn't do hyphae but is able to be sufficiently nasty and virulent in its yeast form. Circulating serum 1,3-beta-D-Glucan levels (as a systemic marker for most fungal species) also aren't elevated but at half of the lab's threshold. There are therefore really no lab markers at all to support any physician in joining speculations on a hepatic/biliary fungal infection. It's difficult to not despair. Have stopped the borax drinking water. Have started 500-1000mg of UDCA per day to enhance bile solubility and hydrophilicity. Also trialled alpha-GPC for two days in this context. However, that turned super awful. Choline and in particular alpha-GPC is a superfood to fungi which they gobble up for its choline and phosphate. Kind of disadvantageous when you know that the liver needs substantial amounts of choline for itself. Have pinned 100mg Thiamin-HCl i.m. @mossy I wouldn't know! I dislike and distrust liver so have gone for the isolated substances and followed them up with testing of serum (free) copper, ceruloplasmin and retinol. IIRC there was one guy writing on the old RPF that he had eaten lots of liver regularly and his lack of copper was surprisingly unaffected until he started supplements.

@Mossy dont you dilute it yourself?? for example one drop per 50ml liquid? i don't understand - you used the oil straight?

@Jennifer Thank you, but please don't worry about being late or not replying.  I think this forum should be a no-stress, take it as it comes, endeavor.  It's one of the freedoms — and I don't know yet if it's a positive or negative — of the modern life, among the many inherent burdens, the ability to dive in and out of topics and conversations, on a whim.  As soon as it becomes an obligation, it kind of takes the fun and benefit away.  And with this information age, we can easily take on obligations far beyond our capacity to handle all of them.  The local town or city has now become the world, to some degree! Ok, that is good to know about yogurt and pancakes. I have actually been thinking of making pancakes.  In my flour research, I see that I would purposely want a lower protein flour.  I was kind of hoping to be able to use bread flour for everything .  Maybe I still can, but it seems normally you wouldn't want to. I appreciate the kind words.  I have slowly made strides in my over all health, as compared to when I first started Peating.  Your success story with thyroid is intriguing, and has me not totally throwing the idea out, though it is down on the list.  It will be interesting to know if your thyroid maintains after you stop supplementing with it...if. Indeed.  I think that is where my natural inclinations to be wary of water prove themselves...when a giant wave pummels me!  I don't know if you've ever been caught under a wave and it pins you to the ocean floor momentarily, but not fun!  Those who are meant for water don't think too much of it.  I'm not one of them, for better or worse. For sure.  Peakcock = rockstar, from any measurement.  (Just don't tell the other male birds that.) One dad is enough...haha.  And the way I approach things, with attention to detail, is to a fault.  It's the error of perfectionism, which ironically, is not perfect. ; )  So, to have two dads waiting and tapping their fingers would not be a good scenario. Ok, that is interesting about Brix, being more important than organic over conventional.  I've always had a hunch about that, and you'd think with all my years on the forums I would've gleaned a more concrete understanding than I have.  See, that's why I ask Jennifer .  You had mentioned Brix before...I'll look into that as time allows.  I am definitely interested in those sprouted grains, but I've had to cut back on the good stuff, due to budget.  When I go back to it, these sprouted grains are where I'll start.

Just FYI I haven't gotten the flu since atleast I was 10! So 14 years. Only type of sickness I would get is a cold after I went outside with wet hair.

why are you eating a not-varied diet in the first place

@Thyrotic Hey, did you survive?

As a counterpoint, I think I've crashed my estrogen with both androsterone and 11kDHT in the past but never noticed anything with my joints because I was taking boron at the same time.

thank you all for this incredibly valuable thread. @alfredoolivas thanks for starting it. I suppose like estrogen, prolactin has its good sides. This has helped me see some more research material I would have missed that I can study.

@alfredoolivas something that could help is HUGE amounts of milk, or something else with a lot of bulk and liquid

Talk with AI (Claude) How efficient is the intake of a MK4 supplement, (with enough fat, hereby 25 g fat with some MUFAs), when taking 1 mg (1 000 mcg) K2 MK4? Question of vehicle only? No intermediate change into menadione, I suppose, since there is no digest process. Need a confirmation, whenever there is a target amount limited to 2-3 mg K2 supplement. Note: 2 takes of 1 mg MK4 at breakfast and midday meal, with 1 000 UI D3 (both at the same time, AKA 2 x 1 000 UI D3). Brain target. AI says (Claude): Summary: A moderate amount of D3 and K2 are co-absorbed in the same chylomicron pathway; so simultaneous intake is fine. Brain target and dose adequacy: 2 mg/day total is a reasonable range for a brain-focused protocol. Step 1 — Chylomicrons (intestinal phase, 0–4h postprandial) Step 2 — Chylomicron remnants → liver (4–6h) Step 3 — VLDL → IDL → LDL (hepatic re-export, hours to days) A possible route for extra-hepatic tissue supply is that part of the K-vitamins are re-packed into LDL, which forms a major transport system from the liver to peripheral tissues. ScienceDirect This is the key insight for your brain target — the liver processes the chylomicron-delivered MK4 and re-exports it via VLDL, which is then progressively remodeled into IDL and LDL for peripheral tissue delivery. Agarose gel electrophoresis of lipoprotein fractions after K2 supplementation revealed distinct chylomicron bands and variations in VLDL and HDL mobility, influenced by dietary lipids and VK2 supplementation. Wiley Online Library

COX-2 is overexpressed in advanced stages of tumors. Aspirin starts inhibiting COX-2 meaningfully after dosages of about 500mg (better would be >1g). Aspirin vindicated as an anti cancer drug. "Most solid tumors express the cyclooxygenase-2 (COX-2) protein, a target of NSAIDs. COX-2 overexpression in tumorsis considered a predictor of more advanced stage disease and of worse prognosis in a number of studies investigating solid malignancies. Therefore, NSAIDs are evaluated as anti-cancer drugs." Artificially overexpressing COX-2 makes mice more prone to developing tumors and knocking it out makes them less likely to develop tumors. "Both COX-1 and COX-2 are involved in tumor vascularization. COX inhibitors can directly affect angiogenesis [47]. " "Thus, COX-2 may be the cause of progression of estrogen-dependent breast cancer either directly by stimulating tumor cell proliferation, or indirectly by upregulating aromatase activity [60]. " "Part of the rationale for combining NSAIDs with chemotherapy involves circumvention of chemotherapy resistance mechanisms." https://pubmed.ncbi.nlm.nih.gov/16945549/ COX-2 inhibition makes chemotherapy (5-fluorouracil) more effective in vitro. https://pubmed.ncbi.nlm.nih.gov/21163769/

"Platelet COX inhibition was nearly complete already at 37.5 mg aspirin daily, as evidenced by >98% suppression of serum thromboxane B2 ..." https://pubmed.ncbi.nlm.nih.gov/16601836/

@alfredoolivas yeah im aware. Me and my son use this account. We are not on here though mainly the raypeat forum. And the reason i give him t3 is because his ATP production is bad.

skin surface way is capacitive coupling https://pubmed.ncbi.nlm.nih.gov/8200888/ this showed effect i dont have the info on their approach rn. non fusing fractures for 11+ months 6/10 fused vs 0 The non-union healed in six of the ten patients who had been managed actively but in none of the patients who had been managed with the placebo unit. https://www.semanticscholar.org/paper/Capacitively-coupled-electrical-stimulation-results-Abeed-Naseer/bc78f0db97ce86d9fc64d5487b91cee839744c8d 11 of non unions unified by 15 weeks applied through steel plates on the skin - healed if the plates were within 8cm of each other The only significant factor determining the success of healing was the distance between the plates; a distance of eighty millimeters or less resulted in healing in all cases https://pubmed.ncbi.nlm.nih.gov/8458140/ partial limb regeneration https://pmc.ncbi.nlm.nih.gov/articles/PMC4683620/ https://pmc.ncbi.nlm.nih.gov/articles/PMC3495370/

@Ray-Peat-Fanboy no politics allowed in my Christian ray peat forum

@engineer nop sadly not