@alfredoolivas added sugar is slop, even more so if you dont intend to eat meat, optimal amount is 0 if you have the possibility to eat good fruits

https://bioenergetic.forum/post/53285 https://bioenergetic.forum/post/53271 I had fun reading these again, thank you sneedster. And no one can argue with you, they may as well argue with a bathroom mirror. @sunsunsun said in Avocado: Toxic but how much?: Even the authors of the liver collagen solubility study showing avocado tended to promote fibrosis say they are surprised at their result because their previous study in skin showed the opposite effect. Something's wrong with the controls in almost all of the literature and we all know it. There were at least 2 whole threads about this on rpf. This was also highly amusing btw. 9/9 spirited character. https://bioenergetic.forum/post/63157 @sunsunsun said in Avocado: Toxic but how much?: Danny Roddy who apparently is le Ray Peat expert never caught this or called him out on it. This is a guy who charges people money for his 'expertise' on bioenergetics. The hasty pursuit of practical application for chicken farming.

@alfredoolivas said in Are microdoses of mifeprestone the ultimate receptor level anti-glucorticoid?: it would likely occupy all progesteorone receptors, it's birth control, you can get it through online pharmacies I think. Then I don't think it's really worth the hassle. Id still be curious to hear how something like this feels and affects a person...

https://youtu.be/cXHyf-di6C0

@heyman DHT is just a metabolite of T, and there are many differences between the two: DHT is way more androgenic T is a cortisol antagonist, while DHT is less so DHT depends on the 5ar enzyme which is the target of so-called "hair loss" medicines like finasteride and dutasteride

ooh yea aspirin blocks further production

@CrumblingCookie said in Peaty uncoupler vs. Ozempic who wins ? New study.: If it enhances autophagy through AMPK it should not be limited to mitophagy but also cover xeno-autophagy Good point. That might make it helpful for fighting infections. @CrumblingCookie said in Peaty uncoupler vs. Ozempic who wins ? New study.: So a shift away from carbohydrates to FAO People often paint uncouplers as FAO-increasers. But they increase FAO and carb oxidation. The above article mentions it increasing TCA cycle, which can be fed by carbs and fat. It probably also depends on which tissues we are talking about. If you want to lean out your liver increasing FAO there is probably a good thing. @CrumblingCookie said in Peaty uncoupler vs. Ozempic who wins ? New study.: The MOA of BAM15 would then be a combination of inducing UCP and something along the line of metformin or berberine or spermidine (but lacking the Beclin-1 upregulation). (A comparison with resveratrol is less suitable since, although it lowers intracellular ATP through AMPK, I dare say its most important effect is through Sirt1) AMPK increases SIRT1. So BAM15 should do that, too.

@lobotomize yes but i think you'd have to be in somewhat decent shape to reap the benefits of cold showers. There is such a thing is cold resistance when it comes to thermogenesis and uncoupling. IIRC there was a study showing that grains of paradise were able to reverse that state in humans.

@lobotomize my skin looked completely smooth and glowing for like a day when I got really sick once. Maybe your body has some emergency mechanism that temporarily boosts your metabolism when you're sick

@Peatful my dog actually grew a lipoma of some sort when I added bluebonnet brewer's yeast powder to her diet.

@hawk1 I have similar concerns to you regarding suppression. So, despite that, I have also gone the nuclear route with 500mg a week of T isocaproate. Surprisingly, I haven't detected much suppression if any because vitamin E, pregnenolone/DHEA, and progesterone all work to oppose estrogen and prolactin which are the main underlying mechanisms behind endogenous shutdown. This is all because regular T aromatizes, unlike 11KT, which shockingly does NOT! So even if you're not already doing other Peaty things you are already in a low risk position.

@engineer You can find a chemical for everything, but often creating or buying it costs too much compared to its value

@16characterstwas put some fish oil on the phone it will oxidise the evil blue light

Maybe the problem's above your complaint @gg12 . Hydrochloric acid.

@16characterstwas why would reduce endotoxin increase weight gain?

@sphagnum Orally with water. https://www.amazon.de/-/en/Singulares-Shell-Powder-Extra-Fine/dp/B07TD46XG5?th=1

@Gardner that post was after potato as starch meal so yor assumption is incorrect and secondly i take increased appetite as easy marker of increased vitality