https://www.youtube.com/watch?v=LG2ocgQKzuQ

@lobotomize There are countless studies showing the benefits of vitamin D3, IMO, you are focussing way to much on genetically modified knock-out animal models and in vitro studies, both of which do not replicate normal, in vivo circumstances. BTW, vitamin d3 can DECREASE conversion to 1-25 hydroxyvitamin D and realistically, the ratio between the two matters probably as well. https://dannyroddy.substack.com/p/vitamin-d-bioenergetic-wunderkind

@samson yes and I did that type of diet last year and it worked but it wasn't as effective

Acute aid treatment after brain injury Case Report: Buccal administration of hydrogen-producing blend after a mild traumatic brain injury in a professional athlete https://pubmed.ncbi.nlm.nih.gov/32595937/

@sphagnum I wouldn't worry about the ratio, just consume enough Calcium and Magnesium foods/supplements to your well-being and tolerance. Also in the cited study above, the ratio is 2.3, not 2:3, so it's more than two times more elemental calcium than magnesium. 2:1 seems to be the recommended ratio in health institutions. Calcium to Magnesium Ratio Higher Than Optimal Across Age Groups Objectives The ratio of calcium to magnesium (Ca: Mg) intake has gained immense attention in recent years, since a ratio above 2:1 has been associated with increased risk of metabolic, inflammatory and cardiovascular disorders. The objective of this study was to assess Ca: Mg ratios across age groups and to determine the relationship between Ca: Mg ratios and markers of inflammation. https://pmc.ncbi.nlm.nih.gov/articles/PMC6574898 Calcium: magnesium intake ratio and colorectal carcinogenesis, results from the prostate, lung, colorectal, and ovarian cancer screening trial Conclusion Higher calcium intake may be related to reduced risks of incident advanced and/or synchronous adenoma and incident distal CRC among subjects with Ca:Mg intake ratios between 1.7 and 2.5. https://pmc.ncbi.nlm.nih.gov/articles/PMC6889387 Dietary calcium and magnesium intake and risk for incident dementia: The Shanghai Aging Study Our findings suggest that high dietary intake of Mg is associated with an increased risk of dementia mainly among older adults with low Ca:Mg intake ratios. Proper balance of Ca to Mg in the diet may be critical to the relationship between Mg intake and risk of dementia. https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.12362

UA promotes bile secretion. https://www.researchgate.net/publication/8982378_Effects_of_ursolic_acid_on_liver_protection_and_bile_secretion

I noticed the reprint of Nutrition for Women says "100 short articles by Ray Peat, PHD," where the old one said "92...". What did they add to it? Also, note that From PMS to Menopause is for sale on Peat's website but not Amazon, and Peat's website doesn't have Generative Energy. Weird. I wonder if Katherine gets more of the money if you order from Peat's site. I'd imagine so.

@cs3000 can u give a tl;dr

I have posted about the hypermetabolic übermice before. I'm trying to understand the mechanism. From what I can tell increasing PEPCK-C in the muscle, mainly inhibits anaerobic glycolisis (fermentation metabolism) and increases OxPhos. I think that is the fundamental mechanism. The fact that tjsr doubles life span and increases reproductive health so much, corroborates what Peat said for decades. "...we identified a progressive decrease in cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C), a longevity-associated metabolic enzyme, and a reciprocal increase in glycolytic pyruvate kinase (PK) that were necessary and sufficient to limit lifespan. Decline in PEPCK-C with age also led to loss of cellular function and integrity including muscle activity, and cellular senescence. Genetic and pharmacologic interventions of PEPCK-C, muscle activity, and AMPK signaling demonstrate that declines in PEPCK-C and muscle function with age interacted to limit reproductive life and lifespan via disrupted energy homeostasis. Quantifications of metabolic flux show that reciprocal changes in PEPCK-C and PK with age shunted energy metabolism toward glycolysis, reducing mitochondrial bioenergetics. Last, calorie restriction countered changes in PEPCK-C and PK with age to elicit anti-aging effects via TOR inhibition. Thus, a programmed metabolic event involving PEPCK-C and PK is a determinant of aging that can be modified to modulate aging." https://pubmed.ncbi.nlm.nih.gov/26631730/ "...overexpression of the central gluconeogenic gene pck-2 (encoding PEPCK) increases health measures via a mechanism that requires DAF-16 to promote pck-2 expression in specific intestinal cells. Dietary restriction also features DAF-16-dependent pck-2 expression in the intestine, and the healthspan benefits conferred by dietary restriction require pck-2. Together, our results a new paradigm in which nutritional signals engage gluconeogenesis to influence aging quality via DAF-16." https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008982 "Finally, a synergistic induction of PEPCK gene transcription by T3 and cAMP is described. " https://pubmed.ncbi.nlm.nih.gov/1657985/

@CrumblingCookie said in Boron supplements: Best decision in years! Yet still far from the overall condition being resolved. That's a hardcore protocol. What symptoms did you see improvement with ?

@cs3000 any update on your electrical symptoms from sunlight and vitamin D?

@LunaticRed said in Fatty acid oxidation drives senescence: I recommend you to use Claude-opus-4-6-search instead of Gemini3, it's more powerful and better at searching information Thanks for the info. I appreciate. Here is a link for my first try / search on Vit k2 MK4 (in French): AI Conversation No. 3: HD Vit. K2 MK4 to target vascular, cerebral and hormonal aspects. https://mirzoune-ciboulette.forumactif.org/t2185-conversation-avec-lia-n3-hd-vit-k2-mk4-pour-cibler-les-aspects-vasculaire-cerebral-et-hormonal#30719 Need [image: 1775046783689-aa.emoticon-coffee.gif]

@user73636 what AI did you use for this? Grok 4.20 Expert is not suggesting that this is happening.

@lobotomize said in WARNING Alkaline environments hyper-accelerate the Maillard: aspirin also does the blocky thing Yes, very useful but we have to manage the impact on platelet renewal, whatever the dose is. 10-12 days to recover a functional system. I can give a link if interested.

Not sure about this type of cancer, but there are good case studies for cyproheptadine. There was a thread on the old forum that cyproheptadine completely cured liver cancer in one case. All I could find on leukemia is this: https://pubmed.ncbi.nlm.nih.gov/18502826/. Keep in mind that it makes people groggy and tired a lot. So if the goal is to make your uncle feel better, it might not be the best option, even if it helps a bit. Good luck!

Fat loss has absolutely nothing to do with metabolic efficiency. When the body has enough nutrients it will spend some of that nutrients on building new fat cells. This can only be stopped by inhibiting mTOR activation, usually through APMK, which naturally happens during fasting and during heavy exercise. The threshold is high, passively burning more energy will not suddenly spike APMK.

@maplesyrupbro Good to know. Did you use idealab's DHT? Tell us the important details. @bio3nergetic @gg12 I'm not cut, and this is not purely about size. The increase in size would come from better vascularization, also increasing sensitivity which I lack.

@gg12 said in Oat bran really helping sibo: 2/3 cup oat bran OK but don't forget potassium since oat is very high in oxalates (lithiasis). Take a fruit before. Not always blueberries. Alternate. If you take it with milk, it could do the job (chelation), provided you get 4x more Ca tan Ox.