@jamezb46 it isnt orally bioav

@disfrutarlo. I happen to hear just now Ray saying that serotonin levels (stress) may raise TSH https://youtu.be/_NeCwCZYdWQ?t=1884 . In general, TSH better reflects the thyroid hormone concentration in the pituitary than in cellular tissue. The following reference is illuminating about this and is replete with quotes on why TSH is a poor predictor of thyroid health: Thyroid Hormone Transport into Cellular Tissue. To solve your friend's puzzle, I'd check his rT3, rT3/T3, and see whether he might have other comorbidities that may affect the pituitary health.

https://youtube.com/watch?v=x_JYarlZYMY [image: images?q=tbn:ANd9GcS8z06F3BsuPmoNPqQye8dLWxBrUG3fs2OQzUNCTKXihA&s=10]

@Mauritio pharma grade is 99.5% +

Week 20: 81.1kg to 66.5kg I was really sick from estradriol btw. Not DHEA.

@zaaku, what helps me during these "bad energy" encounters is making sure I breathe through the nose only and only with the frequency of 12-24 breaths per minute. This is to activate the hippocampus rather than the amygdala, which evokes the fight-or-flight response and which is activated when we breathe fast. Humming (for about 5 seconds at a time) calms me down too.

@16characterstwas I absolutely was. I still remember the exact date this started, because very significant and stressful event happened on that day. It was more than 20 years ago. And every time I experience another big stressful event, my health gets a little worse, never to return to its previous state.

Progesterone can only do good, especially after taking hellacious finasteride, I would be grateful my body can produce any amount and leave it alone. For men, in the short term progesterone's benefits might not be obvious, but in the medium and long term it is spectacular. What to definitely avoid and keep low is estrogen, which progesterone is good at doing.

@sunsunsun gracias

@Mossy said: I would say similar, at least 145 bpm, sometimes considerably higher. When my heart went to that rate, it requires my full attention. It feels like an emergency situation. My point being, it's an acute attack, not something where I can just go on as normal. I would place the cayenne pepper in my mouth and let it sit there until I can feel my rate coming down. Maybe 10 minutes or so. I don't recall exactly. Should it ever happen again, which I hope it never does, I'll time it. I haven't had an episode in a long time. Wow. Just from standing? The most acute episodes I had were in the first 10-15 days. The worst was one morning while I was standing in the bathroom peeing and I was at 130-135. Felt absolutely horrible, like I was dying. I would normally have to do some sprints to get to 130. I continue to improve in all health metrics though. The whole body "ill"/"dying"/"impending doom" feeling has been gone for about a month, resting and active heart rates continue to come down and I make new PRs every other day. The pain in my side/back/muscles has been mostly gone for a bit now, though I did have a little sore/pain feel in my side today, very faintly. So, the cayenne trick is becoming less and less necessary. I will keep it in my back pocket if I have a high BPM attack. For now the only thing I'm continuing is the Zyrtec and Pepcid AC, and I've been hydrating way more than usual, keeping my blood volume up. Those Liquid IV packets are a godsend. One of the best Costco purchases one could make. Great to have on hand for emergency illnesses. Also continuing to improve my diet, been eating healthier, improved my sleep habits. Working hard and doing lots of cardio the past week. Stuff I would not have been able to do a little over a month ago. The thing I'm most thankful for is that the terrible insomnia is gone, I couldn't have taken much more of that. Absolutely horrendous experience that was. Body feeling like I was running from a horror villain all night. I'm back to my normal self of being able to drift into sleep within minutes.

@sunsunsun said: do u have link for 2g out of 10g absorption of glycine I suppose you wanted the justification. Why so little... Full answer here: How much glycine absorbed with powder https://bioenergetic.forum/topic/9482/how-much-glycine-absorbed-with-powder In short: The transporters are quickly saturated with 2 tsp glycine powder.

@pondfountain chronic caffeine consumption negates the Ach-increasing effects of caffeine. Chronic caffeine treatment reduces caffeine but not adenosine effects on cortical acetylcholine release The results indicate that prolonged consumption of high doses of caffeine causes changes in the responsiveness of cholinergic neurons to caffeine. The change is not shared by adenosine, through whose recognition sites caffeine is believed to act. It is therefore possible that the adaptive changes following repeated caffeine administration involve either only the coupler-transducer mechanism activated by the antagonist, or effects unrelated to receptors.

You’ll see that, in addition to any androgen binding to GR, you’ll have two potent anti-catabolic factors: mTOR and PGC-1α; GR negatively regulates both To put it very simply, REDD1 negatively regulates mTOR, and FOXO1 is largely regulated by PGC-1α. Although they function “separately,” they can converge since REDD1 not only inhibits mTOR but also increases FOXO1. You can make them resistant to catabolism by inhibiting FOXO1, and abolish the effects of GCs by inhibiting REDD1. Not surprisingly, type 1 fibers—rich in mitochondria and OXPHOS—are resistant to stress-induced atrophy (glucocorticoids, energy deprivation, etc.) but are also resistant to hypertrophy. Glycolytic fibers, on the other hand, which are prone to energy deficits because they have few mitochondria and rely on glycolysis, are sensitive to stress but are also sensitive to hypertrophy due to greater GR and AR density. [image: 1786057988696-d19493b6-4e2d-43de-ad03-f365e0eb848c-image.jpeg]

@Jennifer thanks, i appreciate your contributions

@sunsunsun Indeed! Hence my need to call out my generalizing.

@Ena Re: antifungal/antimicrobial effect of lovastatin. It looks like lovastatin (LOV) potentiates other antifungals rather than having that effect by itself. "LOV single treatment was unable to inhibit C. albicans strains except the ERG3 and ERG11 double mutant. LOV and itraconazole (ITZ) combination was capable of inhibiting the C. albicans planktonic cells and biofilms synergistically including the ITZ resistant mutants." --- From the abstract to Lovastatin synergizes with itraconazole against planktonic cells and biofilms of Candida albicans through the regulation on ergosterol biosynthesis pathway.

@Peater0921 I for one have had a great experience with Deus, I tried a few UGL ones and they have been the most reliable.

@TexugoDoMel excellent response! Thank you