I'm going to end up with useful nutrients to protect lipid directly 1. Antioxidants That Protect Lipids Directly Vitamin E (tocopherols + tocotrienols) • Acts as the primary lipid-phase antioxidant, protecting membrane phospholipids from peroxidation. • Gamma-tocotrienols add stronger chain-breaking antioxidant activity in membranes. Dose: 400 IU mixed tocopherols (with gamma tocotrienols) 2–3×/week, or 20–25 mg/day. Note: More is not better; excess can disrupt redox balance. Beta-carotene (from food) • Quenches singlet oxygen and supports antioxidant recycling. • Best obtained from diet (carrots, sweet potatoes, leafy greens). Astaxanthin • A potent carotenoid that embeds across the lipid bilayer and protects both sides of the membrane from ROS. • Particularly effective in mitochondrial membranes. 2. Water-Soluble Antioxidants and Cofactors Vitamin C • Regenerates oxidized vitamin E. • Supports collagen, immune function, and general redox balance. Magnesium • Key mechanism: Magnesium inhibits PLA₂, the enzyme that releases arachidonic acid (AA) from membrane phospholipids. • Mg²⁺ stabilizes phospholipid bilayers, reduces Ca²⁺-dependent PLA₂ activation, and lowers eicosanoid production. Dose: 350–420 mg/day elemental magnesium. Form: Magnesium bisglycinate (≈2.5 g/day split into 2–3 doses to reach ~450 mg). Note: Higher needs after stress; do not “preload” before stress. Zinc • Protects thiol groups and stabilizes membrane proteins. • Inhibits NADPH oxidase–induced lipid peroxidation, reducing the arachidonic acid cascade. Dose: 10–15 mg/day. Mechanism: o ↓ membrane peroxidation o ↓ PLA₂ activation o ↓ free AA release o ↓ PGE₂ formation (independent of COX inhibition) Key references: • Prasad, Am J Clin Nutr, 2009 • Ho et al., Free Radic Biol Med, 2008 Selenium • Required for GPx4, the enzyme that repairs lipid hydroperoxides directly in membranes. • GPx4 is the only enzyme that can detoxify oxidized phospholipids inside the bilayer. Dose: 100 mcg 2–3×/week; more if inflammation is present. Note: Excess selenium causes fatigue and organ stress — more is not better. 3. Structural Lipid Support Phosphatidylcholine (PC) • The primary phospholipid of cell membranes. • Essential for maintaining bilayer structure, fluidity, and repair. • Supports ER–mitochondria lipid exchange, which is required for cardiolipin remodeling. Stearic Acid • A saturated fatty acid that “solidifies” and stabilizes membranes without promoting peroxidation. • Helps maintain the optimal balance between membrane fluidity and rigidity. Sources: Cocoa butter, dark chocolate, beef tallow. Why This Matters for Mitochondria • PC stabilizes the outer mitochondrial membrane and supports lipid trafficking. • PE (phosphatidylethanolamine) shapes the inner membrane and allows cardiolipin to organize respiratory complexes. • Cardiolipin anchors the electron transport chain and is extremely sensitive to oxidation. • GPx4, vitamin E, astaxanthin, zinc, and magnesium protect cardiolipin and PC from peroxidation and enzymatic degradation. • Stearic acid and low-PUFA intake prevent fragile, oxidation-prone lipids from entering mitochondrial membranes. Together, these nutrients maintain membrane integrity, mitochondrial efficiency, and resistance to oxidative stress.

Or just boycott YouTube. https://old.reddit.com/r/youtube/comments/1qw91b9/spcai253d_is_dead/?sort=new https://old.reddit.com/r/youtube/comments/1qjhto5/didnt_there_used_to_be_a_sort_by_recent_option_wtf/?sort=new https://old.reddit.com/r/youtube/comments/1qhib0p/youtube_removed_the_most_recent_search_filter_and/?sort=new

@cyberpeater22 hi just to clarify you don’t like the taste of coffee… coffee is grown all over the world making different flavors, it’s handled in different ways and can make some rancid and taste terrible. If fresh it can be roasted in tons of different ways bringing out tons of different flavors, your water hard or sort can really change the flavor. How you brew it can really change the flavor, drip, French press, pour over, espresso, and a few others, there’s even some good instant coffees not that those are very Peaty, then of coarse there are things to add to the coffee once it’s brewed… milk cream heavy cream whipped cream sugar brown sugar maple syrup honey cinnamon clove etc… Some of these things I’ve mentioned above I loathe and some of them I can’t live without. I don’t like coffee and I love coffee could both come out of my mouth depending on these variables. Pu-erh tea is great too!

@wester130 retinol also supposedly has a role in thyroid transport (I think t3)

Cysteine Sulfoxides(from onions) ehance progesterone production in vitro. https://pubmed.ncbi.nlm.nih.gov/33066465/

@user73636 said in A Thereotical combination for inhibition of warburg effect: Pyrroloquinoline quinone I quite like Pyrroloquinoline quinone, and it does make me ravenous.

@Raymoud-al-Peet it's not even good trolling. It's lower level even for a retard like himself

Walking continuously for 15 minutes is actually a minimum amout of activity. According Dr, Mercola there are additonal benefits for liver fat reduction. this begins at about 20 to 25 minutes of moderate activity five days weekly, with the strongest efficiency gains occurring around 150 to 160 minutes per week. https://articles.mercola.com/sites/articles/archive/2026/02/12/optimal-exercise-dose-reducing-fatty-liver.aspx?ui=f75a5a937074cc5b2fe8c56ad7c8da4175c90f9af39afe799ad679ff096c9372&sd=20050420&cid_source=dnl&cid_medium=email&cid_content=art1HL&cid=20260212&foDate=false&mid=DM1883713&rid=500975687

[image: 1770899753974-18c4e27b-44c0-45b6-ad02-22dce0db8e71-image.png]

https://www.youtube.com/watch?v=1k8craCGpgs

@LucH said in Toward a Better Understanding of Reactive Oxygen Species: @Amazoniac said in Toward a Better Understanding of Reactive Oxygen Species: The ROS linked to fat metabolism can arise partly from parallel effects, such as structural or functional perturbations and up-regulation of alternative ROS-producing enzymes (NOX, XO, COX, LOX, CYP2, etc.). I suppose that here we're mainly talking about excess PUFA loaded in adipocytes (AA cascade). When we stress or have a diet (fat loss). If we remain under 10 g PUFA/day, preferably 5-6 g, it would be OK. Edit: fine, the picture on ROS effects. (downloaded) ROS concentration & deleterious effects on cells. The next question is: What about when corn / soy food (from real food) is eaten, with LPS by-side load. Otherwise, it remains a theory. 1° In presence of ALA (thiol antioxidant) or a lipoprotection (A D3 K2 + vit E). 2° The same with aspirin or WWB. Parallel effects can also come from saturated fatty acids. Yet another example: Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance (Cyt c received fewer electrons overall, and pyruvate (oxaloacetate precursor) didn't normalize.) Impairing ATP synthesis limits electron consumption, which favors leakage from affected sites. On a related note, whether an imported fatty acid is saturated or not, the first stage of each β-oxidation cycle involves creating or dealing with an unsaturated intermediate (enoyl-CoA), and it's the hydrating reaction by enoyl-CoA hydratase* (ECH) that resolves the double bond by adding water, which also introduces the oxygen atoms that lack in fatty acids. *Synonym: unsaturated acyl-CoA hydratase This temporary double bond adds to any existing fatty acid double bonds outside of the segment being oxidized. After hydration, the NAD-dependent dehydrogenase (HADH) and the CoA-dependent thiolase (KAT) conclude a β-oxidation cycle. [image: 1770837140988-3a06059b-f0ac-452e-943e-35dceaf24dae-image.png] ⠀(10.1016/B978-0-12-382163-8.00022-0) Proper ECH activity relies on functional HADH and KAT, especially when the three enzymes form a supercomplex (the mitochondrial trifunctional protein, MTP) and work together to metabolize longer-chain fatty acids. Control of mitochondrial β-oxidation: sensitivity of the trifunctional protein to [NAD+]/[NADH] and [acetyl-CoA]/[CoA] Inhibitory effect of 3‐hydroxyacyl‐CoAs and other long‐chain fatty acid β‐oxidation intermediates on mitochondrial oxidative phosphorylation Pathophysiology of fatty acid oxidation disorders and resultant phenotypic variability Despite the experiment suggesting that inhibition is unlikely at healthy NADH/NAD⁺ and acetyl-CoA/CoA ratios, any factor that compromises one enzyme can affect the others. Local ratio perturbations or failure of backup systems may still lead intermediates to accumulate, including enoyl-CoA (the supercomplex's primary substrate). Given that some enzymes related to β-oxidation generate ROS, enoyl-CoA accumulation might place this unsaturated intermediate near ROS sources and start lipid peroxidation that then spreads to other lipids, such as cardiolipin. But it's a speculation.

Thank you, @Mossy. Most of what I post making are my dad’s meals. My own meals are rather basic, since finding Dr. Vickor’s work on trauma and doing the local food challenge. As much as I’m a foodie, I enjoy the simplicity. It takes me only an hour to prep my meals for the week, which consists of chopping veggies, pan-searing 1.5 lb of sea scallops, soft-boiling and peeling 2 dozen eggs, boiling 2 lb of mushrooms for broth, roasting 3 sheet pans of potatoes and squash, simmering a large pot of corn chowder and berries for compôte, and transferring yogurt to a 2 liter jar fitted with a nut milk bag so it can strain in the fridge until it’s as thick as quark. The rest of my diet is locally and regionally produced skyr, honey, herbal teas and apple cider. My meals throughout the week take no more than 5 minutes to heat up, giving me time regularly for morning hikes and come spring, lunches at the lake near my house. I can understand the inconvenience, sure, and yard work is still a good way to connect with nature. There are mountains 5 minutes from my house, but I’ve been mainly going on the trail on my family’s property that leads right to the town lake and on the rail trail a minute away because it’s well-maintained for my dad to accompany me to decompress, especially while going through his cancer treatments. Regarding your compost—there are elevated compost tumblers that should keep the cats out? Or…if you do decide to start a garden, there’s always a keyhole garden where a simple cage for compost is placed in the center of a notched garden bed to feed the garden, and that should prevent contamination? Combine it with the German horticultural technique (hügelkultur) of using decaying logs, branches and trimmings for a mounded garden bed, and your garden should be quite productive. Both work well for container gardens, too. Haha…well, it is nice to receive packages. Just think how nice it would be for him to receive a surprise package containing steel wire mesh, wire cutters, pliers, work gloves and instructions on how to build a compost cage. He overcomes his boredom and you overcome your cat contamination problem.

@alfredoolivas the purpose of PT-141 is specifically to increase NO similarly to the PDE5 inhibitors like sildenafil/tadalafil, and it seems to be great at doing that. The benefit of melanotan II would be the added tanning which would be good if that's what you're looking for with the androgenicity/GR antagonism as a bonus. I personally have no need for that extra NO but in small quantities I think it wouldn't be a problem unless there's evidence otherwise. For the "symptom free cushing" thing it appears that if there are truly no symptoms, then the actual cause could be a faulty test where it's getting triggered by something else or had some manufacturing defect. Actually, the fact that the result was off the charts with no symptoms and that this was one case drastically increases the probability of a testing error. I am so curious about MT II's tanning and androgenicity that I'm thinking of grabbing some vials and trying something like 50ug/d. Anybody else thinking the same?

@revenant Mine isn't yet. Some people have tested alphagels and it turned out to be testosterone, but in others it was actually DHT. Not throwing shade but I would be a little cautious. In general it is a good idea to test if you can afford it even for reputable vendors, like alphagels to be 100% sure.

@engineer I've ordered phytol, which also has androgenic properties. And maybe vitex Agnus castus and tetrahydrocurcumin.

@AL said in Vitamin E Source in Europe: You also have this one , mixed tocopherols. I tried this one. Had a pretty rancid taste. Didn't like it at all.

3 meals each with 100g of carb and 36g lean protein and 15g of fat give 2000calories a day and thats not even counting vegetable side dishes. so you're exaggerating on how low the calorie count of 500 if you eat clean. I would do 3 meals with 200-250g of veg per meal and some pineapple and eggshell. some c8/c10 mct oil might clean out the gut. your comment about how "all" the food around you has fuing st in it is hitting that you have some sort of neuroticism and thats probably causing more issues than a SIBO which will probably resolve after digestion speeds up.

@Milk-Destroyer it's been sold in the US long before Mexico

@Corngold said in Unbelievable Reddit thread: I think male hair has been sexualized by the non-committing hypergamous modern female and baldness was always the norm for at least 50% of dudes after like 25-30. "Unconsciously" they probably know what actually causes it. I don't, so I can't say anything more about this. They're all adorable. Also the shape of a Hamilton-Norwood is not suspicious at all.

@evan.hinkle I will try that — thanks. I have been meaning to use it with coffee as a sweetener as well. And maybe I'll try it in jello instead of sugar: adding even more glycine to the gelatin.