Update: I've ordered the microscope and a special F to X mount adapter for my Fujifilm camera to get "awesome" photos with.

@AlphaZance Very nicely presented. Viewing the same data but interpreting from different lenses. First, mainstream short term vs. Ray Peat long term. Secondly, mainstream blood level vs. Ray Peat tissue level. I have this kind of experience using my Ray Peat perspective when I use Deepseek AI. I ask a normal health related question like a newbie would. I would get a typical run-of-the-mill mainstream medical response. Then I push back explaining why I differ using my RP hat. Deepseek would reconsider and reframe after I reason out. And I would get a more Peaty response. I can share one session I had with Deepseek to givevan example. Just let me know if you or anyone here is interested.

@sunsunsun do you know a phosphurus supplement? I couldn't find any apart from calcium phosphate. International shipping is fine.

Improving blood flow to the extremities (hands and feet) involves more than just "moving more." It requires a balance between the mechanical pumping of the heart and the biochemical signals that tell your blood vessels to open up (vasodilation). For someone focused on metabolic efficiency, the goal is to improve circulation without triggering excessive stress responses that can actually lead to peripheral vasoconstriction. 1. The Biochemical Trigger: The Role of CO2 Effective circulation depends on the Bohr Effect. For oxygen to leave your blood and enter your tissues (especially in the small capillaries of your fingers and toes), carbon dioxide (CO2) must be present. Vasodilation: CO2 is a powerful natural vasodilator. When your metabolic rate is high and you are producing CO2 efficiently, your blood vessels relax, allowing blood to reach the extremities. The Trap: Over-exercising to the point of "gasping for air" or hyperventilating actually flushes CO2 out of the system. This can cause the peripheral vessels to constrict, leading to cold hands and feet even while your heart rate is high. 2. Strategic Exercise Selection To optimize blood flow to the extremities, the type of movement matters. Resistance Training (Concentric Focus): Lifting weights or bodyweight movements (like squats or push-ups) creates a mechanical "pump" effect. Focus on the concentric (the lifting phase) to stimulate blood flow and metabolic demand without creating excessive tissue damage or systemic inflammation. Low-Impact Steady State (LISS): Walking at a brisk pace where you can still breathe through your nose helps maintain a high CO2 tension. This keeps the peripheral "gates" open longer than high-intensity sprinting might. Micro-Movements: If you spend long periods at a desk, simple calf raises or grip strengtheners are highly effective. The calves are often called the "second heart" because their contraction is essential for pumping venous blood back up from the feet. 3. Thermoregulation and the "Core-to-Extremity" Link Your body prioritizes keeping your internal organs warm. If your core temperature drops even slightly, the body will pull blood away from your skin and extremities to protect the center. Warmth as a Catalyst: Exercising in a warm environment or wearing adequate layers helps signal to the nervous system that it is "safe" to send blood to the periphery. Metabolic Rate: A robust oxidative metabolism keeps your internal "furnace" running. If your resting metabolic rate is low, your body will naturally be more stingy with blood flow to the fingers and toes. 4. Nutritional and Biochemical Support Circulation is also a matter of fluid dynamics and mineral balance. Magnesium and Calcium: Magnesium helps the smooth muscles of the blood vessels relax (vasodilation), while calcium helps them contract. Ensuring adequate magnesium intake can prevent the "clamping" of peripheral vessels. Sodium Balance: Adequate salt intake is necessary to maintain blood volume. Low blood volume makes it much harder for the heart to push blood all the way to the ends of the limbs. Short-Chain Fatty Acids (SCFAs): Compounds like butyrate can support mitochondrial health and gut integrity, which indirectly supports systemic blood flow by reducing the low-grade inflammation that can make vessels "stiff." Summary of Strategies Strategy Action Mechanism Nasal Breathing Breathe only through the nose during light exercise. Increases CO2 retention and vasodilation. Calf Raises Perform 20 reps every hour while sitting. Engages the "venous pump" in the lower legs. Temperature Check Keep the torso and neck warm. Prevents the "survival" vasoconstriction reflex. Mineral Balance Ensure sufficient Magnesium and Salt. Maintains blood volume and vessel flexibility.

@awawat there’s more where that came from ( ͡° ͜ʖ ͡°) Also, I would consider your rT3 levels if you’ve taken only T4 with no results for a while. Peat talked about success with low doses over a course of 6-24 months. Maybe you could play with higher ratios of t3 to t4 in your lunch and dinner doses. Danny Roddy probably has the most complied info on practical thyroid use, between convos with Peat, and feedback with health coaching. I think he might have a concise vid on using thyroid on YouTube

@sunsunsun said: any opinion on pH and yeasts? Which pH where are you thinking of? I'd confidently say that high stomach pH is a very significant risk factor. Especially over time. Not only is there a higher quantity of yeasts passing the stomach but also the less acidic chymus will be met by less alkalic bile (or lesser quantities thereof). Unless there's some metabolic bicarbonate depletion (on top) which puts the less alkalic bile into first place of such chicken-egg interdependencies. Any way, there'll be more exogenous microorganisms than there ought to be and along with the incomplete digestion and shifts in microbiome more mucosal disturbances and pathogenic colonization and translocation. I've come across this publications from 1965 on moniliasis (=candidiasis) Moniliasis, Steatorrhea, Diabetes Mellitus, Cirrhosis, Gallstones, and Hypoparathyroidism in a 10-Year-Old Boy and found it interesting how they (unsuccesfully) discussed the very confusing and complex relations. They had probably stumbled upon the back then still unestablished "Autoimmune Polyglandular Syndrome Type 1 (APS-1) / Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED)". Yet I don't know whether such a term and associated genetic variance has resolved any underlying mechanisms. They were really confused as to what's causing what. What they observed were strongly reduced magnesium uptakes (probably because of fungal infection), which is necessary for parathyroid hormone synthesis, followed by accordingly diminshed calcium uptake. D3 was of no assistance. There was also lots of steatorrhea which preceded many of the other symptoms by years and is somehow reciprocally dependent on calcium. And autoimmunity (intracellular fungal vacuoles? antibody or T-cell cross-reactivity? antigenic mimickry?) against the (para)thyroid gland, as well as hepatic changes. A real mess! -> I'm suspecting that any mess with having both decreased magnesium yet also decreased/intolerable Mg uptake and a chronically fluctuating/insufficent calcium metabolism should point oneself to consider fungal infections! It surely won't be as extreme as in those genetic cases but how would you ever know whether PTH levels are as high as they need to be? Disturbances of these essential alkaline electrolytes sort of lead back, over a long stretch, to your general pH question. Pertinent to the discussion may be work presented by Louria and Brayton in Nature (Jan. 18, 1964, p. 309), who found a substance in blood lethal to Candida albicans in normal persons. A moderate to marked reduction to this substance was found among patients with cirrhosis, hepatitis, diabetic azotemia, and in patients with mucocutaneous and systemic moniliasis. The percentage of persons possessing the factor is slightly reduced among groups of patients with diabetes (without azotaemia) and with disseminated carcinoma. This is about transferrin again @sunsunsun . Specifically, back then they had narrowed it down to a molecule between 10-20kDa - which surprisingly doesn't match up with transferrin but suggests an even more potent polypeptide that has been split off the complete transferrin molecule. Unless their filter meshes back then were somehow wrong. Anyway the results of the other studies suggest that transferrin is a direct source of this active polypeptide. The substance appears to have impressive specificity. It is active against Candida albicans and Candida stellatoidea but not against other Candida species [glabrata, krusei] or other yeasts such as Cryptococcus neoformans or Saccharomyces cerevisae. ! The iron-chelating property of this likely transferrin peptide does not harm C. glabrata or C. krusei or other non-albicans fungi! This is highly relevant. Puts the approaches directed at iron-chelation also in a highly species-specific context to consider. Tannic acids are highly anti-fungal. Among other mechanisms, they inhibit hyphal growth of C. albicans and hinder their adhesion to mucosal cells. In animal experiments, sufficient dietary tannic acids directly increased Candida excretion (i.e. fungi which failed to colonize or invade). This may be an important mechanism behind the acutely anti-diarrheal and anti-microbial activities of oral tannin-albuminate or tannin-gelatinate. Sort of shifts the dietary focus away from those merry-go-round prebiotic and soluble or insoluble fiber discusstion and puts weight onto dietary tannic acid content. Which also lead to fruit (berries!) and vegetables and rather more traditional, more natural, tarter or more bitter varieties than today's varieties aimed at maximizing sweetness and yield. One of the most widespread and available tannins which also offers large mucosal absorption is EGCG. EGCG of course strongly chelates iron. Surprisingly, though, it provides a more complex mechanism of action. EGCG is indeed most antifungal against C. glabrata! EGCG sort of also targets liver tissues so this is good news. Have ordered EGCG (decoffeinated) to augment the FCy/5-FC and horseradish. Some flavonoids markedly downregulate Candida CDR1 (which regulates the efflux pumps and resistances against azoles!): Flavones, Flavonols, and Glycosylated Derivatives-Impact on Candida albicans Growth and Virulence, Expression of CDR1 and ERG11, Cytotoxicity The reduction of both fungal virulence and expression of antifungal resistance-linked genes was the most pronounced for apigenin and apigetrin; these results indicate flavonoids' indispensable capacity for further development as part of an anticandidal therapy or prevention strategy. Here, however, kaempferol's antifungal properties beat apigenin, which exhibits some ambiguous and controversial effects (like upregulating ERG11, inhibition of which is the target for azoles) by miles. Kaempferol seems worth noting down. Inhibition of Candida albicans extracellular enzyme activity by selected natural substances and their application in Candida infection, 2008

@sunsunsun thx sushi

@uncover do I correctly remember that you had logged your aspirin+workout experiences, on the rpf?

I actually just realized Yucca also has a 3:1 4:1 ratio just like the carrot salad and bok choy

@LucH thanks. I prefer taking MK4. I have seen often people have side effects from the MK7

@Milk-Destroyer not really, just as a convenience to add to oatmeal if i dont have eggs for some reason. there’s no point when i can just drink 1L of milk for a protein drink giving 36g protein.

@Mauritio Yeah I was thinking of your post and looked into it a but

@alfredoolivas Looks like 10mg or 20mg for "as needed" and 5-10mg for once daily I don't know about pumps yet because I haven't worked out yet but will tell you as soon as I do. Update: After doing some exercises I can get a pump a lot easier. I'm also feeling like there's more blood flow but that could be a placebo.

here is what i am doing now centella extract 50ml separely mix polysorbate 20 drops thyme oil 4 drops lemon myrtle 4 drops patchouli 4 drops rose geranium 4 drops cinnamon bark 2 drops mix this into the centella extract liquid. mixes perfectly, not oily at all. basically a water solution so I get the benefit of centella and essential oils

https://www.youtube.com/watch?v=H7Nmz7puMog

Thank you, @kilgore and @LetTheRedeemed ️.

low dose doxycycline or minocycline is basically a quinone supplement. amoxicillin should be taken as amoxicillin clauvinate for wider range of bacteria targeted

@jamezb46 literally something like what you've posted in the next paragraph as counter evidence you cultured swine

@Mallard6146 What did you end up deciding to do? I recently took a 7 day course of clarithromycin 500 mg 2x a day. I had some of the worst gas and bloating in my life. I also had really bad insomnia and felt asexual.