Dandruff or scalp irritation? Try BLOO.

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    DavidPSD
    @ThinPicking - Agrred, but the medium is not the message. If the shoe fits, then consider wearing it.
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    has anyone ever considered scar gels for hair loss? there is a lot of overlap with healing the skin and TGFb-1 many of them contain interesting ingredients that would stop inflammation in the scalp
  • Bioenergetic Films

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    LukeL
    Why Do You Hurt Me, @ThinPicking ? I've Always Been Loyal To You.
  • Humorous musings

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    DavidPSD
    [image: 1771502249676-e02b7abf-fb53-4307-a6cc-da2c737c2b14-image.png]
  • Healthy alternative to chips

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    LucHL
    How to manage: Asparagin gives acrylamide Be careful if you use almond flour/powder, and eat chips, and to a lesser extent almond cake, because almonds and potatoes are foods rich in asparagine. Heated above 120 and especially 130° C, asparagine transforms itself into acrylamide, toxic: It is a carcinogenic glycotoxin (120–130° C = 248–266° F). Acrylamide is formed when asparagine, a natural amino acid, reacts with sugars, such as fructose or glucose. This reaction, however, only occurs if the cooking temperature reaches a certain degree, which varies depending on the properties of the product and the cooking method. This will not be the case if the potato is cooked in water or steamed (not by pressure), but if it is fried or roasted. Remember that only the dose and frequency make a product become poison! NB: When you put lemon juice or cider vinegar in a cake or bread, less acrylamide is formed (Maillard reaction is dampened).
  • Bioenergetic Music/Music Theraphy.

    The Noosphere
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    ThinPickingT
    https://www.youtube.com/watch?v=MZIvg4GbJUs [image: 1771462772188-it_never_did.png]
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    ThinPickingT
    @Kilgore said in Is there anyone who has improved their autism by following Peaty principles?: vaccine induced asperger There's no recipient on earth free of an alteration. Nor an alteration that's separable. @Kilgore said in Is there anyone who has improved their autism by following Peaty principles?: not depressed Don't dwell on that.
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    @haidut There are many ways to deplete GSH in cancer cells e.g. arsenic AI Arsenic exposure causes significant glutathione (GSH) depletion by increasing reactive oxygen species (ROS) and directly binding to sulfhydryl groups, leading to oxidative stress and reduced antioxidant capacity in blood and tissues. Depletion of GSH sensitizes cells to arsenic-induced apoptosis, frequently utilized in cancer therapies (e.g., leukemia) to enhance the efficacy of arsenic trioxide. Mechanisms of Arsenic-Induced Glutathione Depletion Oxidative Stress: Arsenic exposure increases ROS, which consumes GSH, a crucial cellular antioxidant. Direct Binding: Arsenic binds directly to glutathione and other thiol-containing proteins. Inhibition of Synthesis: Exposure can reduce essential raw materials for GSH synthesis, such as cysteine and glutamate. Enzyme Activity: While glutathione-S-transferase (GST) activity might increase in response to stress, it often results in a net decline of the GSH pool. Significance of GSH Depletion Increased Toxicity: Lowered GSH levels render cells more vulnerable to arsenic toxicity. Cancer Therapy: GSH depletion (e.g., via Buthionine sulfoximine, BSO) enhances arsenic trioxide's ability to kill cancer cells, as shown in leukemia studies. Reduced Detoxification: Impaired GSH levels impair the body's ability to methylate and excrete arsenic. Consequences and Mitigation Oxidative Damage: Depletion causes significant decreases in brain and blood protective enzymes like superoxide dismutase (SOD) and glutathione peroxidase (GPx). Therapeutic Approaches: Antioxidants or chelators, such as MiADMSA, have been shown to be effective in restoring GSH levels and reducing ROS induced by arsenic. gold nano-particles https://www.sciencedirect.com/science/article/abs/pii/S138589472501232X auranofin -indirectly https://pmc.ncbi.nlm.nih.gov/articles/PMC8777575/ silver nano-particles https://www.sciencedirect.com/science/article/abs/pii/S0378427410017984 https://thesilveredge.com/clinicalstudies/ selenite and selenate https://pubmed.ncbi.nlm.nih.gov/10406889/
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    @cedric good info
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    ThinPickingT
    https://www.youtube.com/watch?v=VTchFM3wb68
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    @bio3nergetic We must remember that vit.A , retina/brain/LRAT require phospholipids/lecithin Lecithin forms cell mambranes and we lose it while aging Perhaps some forms of vit.A "toxicity" could be a lecithin deficiency AI Lecithin supplementation has shown potential in supporting retinal function, primarily through its role in enhancing the bioavailability of nutrients essential for eye health and as a component of specialized medical treatments. Lecithin, particularly in the form of lecithin-bound iodine (LBI) or phosphatidylcholine, is associated with improvements in retinal pigment epithelium (RPE) health, tear film stability, and the reduction of oxidative damage in the retina. Key Findings on Lecithin and Retinal Function: Retinal Pigment Epithelium (RPE) Protection: Lecithin-bound iodine (LBI) has been used in Japan to treat retinal diseases, including central serous chorioretinopathy. In studies, LBI was shown to prevent hypoxic damage to RPE cells and suppress inflammatory responses (such as CCL2 secretion), suggesting a protective effect on the retinal structure. Retinal Degeneration and Function: In animal models of retinal degeneration, a lecithin-containing diet improved retinal function, as evidenced by higher b-wave amplitude in electroretinography (ERG) tests compared to control groups. It was found to reduce the invasion of macrophages into the retina and decrease inflammatory markers. Enhancing Nutrient Absorption: Lecithin acts as an emulsifier that helps the body absorb and utilize fat-soluble vitamins, including Vitamin A, which is crucial for producing visual pigments in the retina and maintaining photoreceptor function. Exudative Age-Related Macular Degeneration (AMD): Research into the use of iodized lecithin tablets for exudative AMD indicated a potential positive impact, with studies reporting improved visual acuity and reduced retinal thickness in treated groups compared to control groups. Tear Film Stability (Dry Eye Disease): Sunflower lecithin supplementation has been shown to improve dry eye disease (DED) symptoms. As a rich source of phosphatidylcholine, it may enhance the lipid secretions from the meibomian glands, stabilizing the tear film. Retina Protection against Toxicity: Studies on rat retinas indicate that lecithin can help maintain the structural integrity of retinal proteins (specifically α-helix and β-sheet ratios) when exposed to oxidative stress, potentially reducing damage from, for example, chemotherapeutic agents like ifosfamide. Important Context: Lecithin-Retinol Acyltransferase (LRAT): Lecithin:retinol acyltransferase is an enzyme crucial for the metabolism of Vitamin A in the retina. It helps convert all-trans retinol to all-trans retinyl ester, a key step in the visual cycle. Limitations: While promising, some uses of lecithin, specifically lecithin-bound iodine, have limited clinical trials outside of Japan, and many findings are based on preclinical or older studies. In summary, lecithin supplementation, particularly when containing iodine or as a source of phosphatidylcholine, may support retinal function by improving structural integrity, reducing inflammation, and increasing the absorption of necessary nutrients, according to research.
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    @user73636 Vit. K3 and C can bypass Q10 to cyt.c Vit .K3 is intermediate to K2 https://pmc.ncbi.nlm.nih.gov/articles/PMC5953218/
  • Thoughts on magnesium malate

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  • shuz the website down

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    lobotomizeL
    @alfredoolivas just bribe you doctor if you rich enough to import t3
  • Not all sirtuins are bad? (SIRT3)

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    alfredoolivasA
    @user73636 SIRT 1 binds to NAMPT and deactylates it, reactivating it https://bioenergetic.forum/topic/9084/microgram-doses-of-nicotine-improve-the-nad-nadh-ratio-independent-of-the-acetylcholine-receptor.-....big-increase-in-neurogenisis-improves-inflamation-cognition-blood-sugar-and-anxiety.-triples-bdnf-and-causes-a-30-fold-increase-in-doublecortin?_=1771443781283
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    MauritioM
    Addendum: Phytol's major metabolite phytanic acid has a half life of 15-20 days! I couldn't really figure out my dosage and felt like effects lasted relatively long. I thought it had to do with a biphasic effect on GABA-A, which also makes things confusing sometimes . But I think it's probably the long half life. Not necessarily a deal breaker, just something to keep in mind.
  • Random, interesting studies

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    MauritioM
    List of (peaty) AMPK activators: Biotin Aspirin Frankincense Methylene blue thyroid hromone, fisetin trehalose lactoferrin papain, ecdysterone phytol vitamin D apple polyphenols Far infrared light
  • 11KT - 11-keto-Testosterone

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    MauritioM
    @wester130 I thought it was interesting. Because if it was just some "adrenal stress hormone" as some will surely dismiss it as, it probably wouldn't peak during the time where people generally are the most healthy.
  • Cynoplus sources in US

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    @Chud said in Cynoplus sources in US: @Ecstatic_Hamster did you recieve it? I did. All good.