@wester130 said: @jamezb46 i am going to try Black Seed Essential Oil is that an acceptable substitute Hands down this is much much better. Just coming in isolated without being in a form reeking of PUFA makes it very potent with all its anti-inflammatory and anti-microbial benefits. It is a quinone, but it is much more if I just consider it being possibly a solution to my recurring high blood pressure arising from my system having a deep reservoir of deeply rooted synergistic pathogens ranging from bacteria and cell-wall deficient forms to fungal forms. In killing these microbes, I also have to deal with endotoxins and its highly inflammatory as well as highly oxidative effects. I plan on using it as part of a stack which I have been using and my blood pressure has lowered but has reached a wall of resistance. Will likely use it as a suppository in an VCO carrier oil or an EVOO carrier oil, just to bypass the liver first pass. Because I don't see myself using 50mg of it each day as I would in taking a 1000mg capsule of 5% TQ (in Sabel's Ethiopian souced product), because that much is needed to compensate for the PUFA load in Sabel's product, I consider the price of $60 per bottle of 360 drops at 4mg TQ per drop being cost effective with a daily dose of 24mg, which amounts to 6 drops a day. This would make a bottle last for 60 days. I am assuming 24mg unPUFA'ed TQ would be as potent as 50mg PUFA'ed TQ in Sabel's capsule. Guys, I am doggedly in pursuit of my goal of lowering my bp to normal levels. It has only begun to bear encouraging results the past year. The end is near. Thanks to the conceptual framework of Ray, the superhuman scribe in AI, and the enabling availability of very useful substances courtesy of haidut.

@lobotomize You are healing your body, thinking, reflecting. The first part was BS XD. But you are thinking, reflecting, and helping your health XD. Sunbathing is not doing nothing lol. I do it for 30 minutes to an hour a day. Even when it's just sunny. Not a heatwave. Europoors have to.

@GRay I would not worry about this. You can always take glycine/gelatin/lysine/BCAAs with it if you're really concerned it could contain or be converted to arginine.

@Mauritio Another piece of this puzzle I'm putting together is that 17a-HSD seems to be mainly concentrated in the testes with very little peripheral activity relative to 17b. And it seems to be stimulated by gonadotropins. So supplemental androstenedione and DHEA are pretty unlikely to form meaningful amounts of epiTest. Frustratingly, it does look like supplementing epiTest directly is probably the only real way to accomplish our goals. Another roadblock is that 17a steroids have a steric hindrance which prevents cleavage of most esters. This means that the steroid ester floats around with the ester still attached, and the unchanged steroid ester can have a meaningfully different pharmacological profile than a base steroid. For example, 17a-hydroxyprogesterone acetate doesn't convert to 17ahp base very much, and this changes its receptor binding. (Positively in this case) For a 17a androgen, the uncleaved ester would probably make it unable to bind to the androgen receptor at all. So while it could potentially form estered 17a neurosteroids with long half lives (which could certainly be interesting) it probably will not be useful in the same way that natural EpiTest would. It's quite a condundrum. That all being the case, it's pretty clear IMO that doing a group buy or convincing said source that there's a market for this molecule is probably our best bet.

@hawk1 @hawk1 I'd be careful with stacking a bunch of bioregulators at once. If you decide to try them I'd start with one and see how you respond before adding anything else. From what I've seen epitalon and pinealon are probably the most commonly discussed for sleep and recovery, while cartalax gets mentioned a lot for joint support. The biggest challenge is that there's not a ton of high- quality human data on many of these, so it can be hard to separate real effects from placebo. If sleep and recovery are your main goals I'd focus there first before experimenting with performance related peptides.

Nice work 87. @MateLover87 said: 3 weeks ago I started measuring my body temperature, and it's always below 36.4°C (on average 36°C). While I no longer get migraines, I’m trying to reintroduce milk, but it still caused me discomfort. Yesterday, for the first time, I didn’t have any discomfort with milk. I’m also eating lots of honey and Rapadura (brown sugar), a daily carrot, and I also tried 4mg of Cypro once per week (good results, but will try a smaller dosage like 2mg). I am now avoiding not only seed oils but also nuts or anything else with PUFAs. I feel like I'm improving, haven’t had a migraine since I started peating, and I feel warmer and with more energy, but my temperature when waking up is still below 36.4°C—maybe it will take more time. I am supplementing Selenium and thinking of adding myo-inositol to support the thyroid. Also slowly consider the time of day relative to your rhythm. And anything you may or may not be doing with salt. https://bioenergetic.forum/topic/6546/aspirin-in-the-morning-vs-aspirin-at-night [image: 1743599464071-img_20250331_155356.jpg]

@Jennifer Good point. I generally like meat for protein but yeah, you're right about seafood or dairy also being good sources. I must have had similar effects from vitamin and nutrient deficiencies because I had signs of hypothyroidism (overweight, thinning hair, low energy, slow digestion, etc) for several years. Also a lot of sugar cravings while eating crappy food. I think red meat and reducing pufa helped me initially. Now I worry more about getting variety and not skipping things like gelatin, greens, etc., and have been much better in the last 4 years. Maybe you know why - but it's hard to find high protein sources that are also low in fat. Beans and seafood, for example, are always touted as good protein sources. Chicken breast I suppose is low fat. Low or nonfat dairy is good as well. My issue is that I'm never satiated with low fat protein sources. It will lead to me adding butter, olive oil, or something else with fat, naturally. It really is the predicament for trying to consume less fat daily and still get protein needs. But, this is why I question the supposed protein requirements. Sugar IIRC doesn't have any recommended daily requirement, which is really interesting. I've never felt worse eating more fruit, but I wonder if eating more fruit can reduce the craving for protein??

@evan.hinkle yes i agree it isn't conclusive, all theory

https://youtu.be/-6WmSZyDysA [image: 9ab24f2c269203afc2e64b0f09ab4c3e.jpg]

@LetTheRedeemed anorexic chicken log soon

@Jennifer [image: 1782139867350-sad-hopeful-wojak.png]

@CrumblingCookie Hesperedin/ Hesperitin are interesting substances. IIRC @cs3000 posted some good studies on them on the RPF. And not only is it anti-fungal, but in accordance with the topic of this thread, it could help with fungal issues via alleviating cholestasis / helping with bile flow. It is an FXR agonist: "HP prevented bile acid toxicity in HepaRG cells, and this effect was blocked by FXR silencing. HP appears to activate FXR to prevent cholestatic liver injury." And a Cholagogue: "...HP promoted bile acid excretion into feces..." https://pubmed.ncbi.nlm.nih.gov/32841642/ Also seems to be anti-estrogenic and activates 5HT1a https://pubmed.ncbi.nlm.nih.gov/23238426/ https://pubmed.ncbi.nlm.nih.gov/22996046/

I think it has to do with bile flow issues /cholestasis. IIRC a progesterone metabolite is implicated in pregnancy induced cholestasis. "Significantly less hepatic bile partitioned into the gallbladder in progesterone-treated than in control animals." https://pmc.ncbi.nlm.nih.gov/articles/PMC1191632/ Ive had similar issues in the past when taking pregnenolone and progesterone. Id try some things that help with cholestasis like TUDCA, gentian or cascara.

@engineer update

@Atman cool thanks i also agree my original post is more a critique of bad local city council development practices, like doing stuff that makes built environment worse for another generation because economic will to tear down something just built even when it is bad is low

@gg12 In natural form and size, it already works. Nano is not only superfluous, but isn't proven safe.

@springsnow check DMs

Fresh berries and sliced bananas are always good upgrade. You can also do warm cinnamon apples, stewed cherries or a little vanilla Greek yogurt with fruit.

@CrumblingCookie megadosing ghkcu is literally proven suboptimal by the studies , and ghk base and ghkcu are interchangeable. the former will just pick up cu in serum. thats all.

@alfredoolivas fuck