https://www.youtube.com/watch?v=MZIvg4GbJUs [image: 1771462772188-it_never_did.png]

@Kilgore said in Is there anyone who has improved their autism by following Peaty principles?: vaccine induced asperger There's no recipient on earth free of an alteration. Nor an alteration that's separable. @Kilgore said in Is there anyone who has improved their autism by following Peaty principles?: not depressed Don't dwell on that.

@haidut There are many ways to deplete GSH in cancer cells e.g. arsenic AI Arsenic exposure causes significant glutathione (GSH) depletion by increasing reactive oxygen species (ROS) and directly binding to sulfhydryl groups, leading to oxidative stress and reduced antioxidant capacity in blood and tissues. Depletion of GSH sensitizes cells to arsenic-induced apoptosis, frequently utilized in cancer therapies (e.g., leukemia) to enhance the efficacy of arsenic trioxide. Mechanisms of Arsenic-Induced Glutathione Depletion Oxidative Stress: Arsenic exposure increases ROS, which consumes GSH, a crucial cellular antioxidant. Direct Binding: Arsenic binds directly to glutathione and other thiol-containing proteins. Inhibition of Synthesis: Exposure can reduce essential raw materials for GSH synthesis, such as cysteine and glutamate. Enzyme Activity: While glutathione-S-transferase (GST) activity might increase in response to stress, it often results in a net decline of the GSH pool. Significance of GSH Depletion Increased Toxicity: Lowered GSH levels render cells more vulnerable to arsenic toxicity. Cancer Therapy: GSH depletion (e.g., via Buthionine sulfoximine, BSO) enhances arsenic trioxide's ability to kill cancer cells, as shown in leukemia studies. Reduced Detoxification: Impaired GSH levels impair the body's ability to methylate and excrete arsenic. Consequences and Mitigation Oxidative Damage: Depletion causes significant decreases in brain and blood protective enzymes like superoxide dismutase (SOD) and glutathione peroxidase (GPx). Therapeutic Approaches: Antioxidants or chelators, such as MiADMSA, have been shown to be effective in restoring GSH levels and reducing ROS induced by arsenic. gold nano-particles https://www.sciencedirect.com/science/article/abs/pii/S138589472501232X auranofin -indirectly https://pmc.ncbi.nlm.nih.gov/articles/PMC8777575/ silver nano-particles https://www.sciencedirect.com/science/article/abs/pii/S0378427410017984 https://thesilveredge.com/clinicalstudies/ selenite and selenate https://pubmed.ncbi.nlm.nih.gov/10406889/

@cedric good info

Anything with Robert Duvall in it. RIP https://www.youtube.com/watch?v=1xp6UDFY5Jg

https://www.youtube.com/watch?v=VTchFM3wb68

@bio3nergetic We must remember that vit.A , retina/brain/LRAT require phospholipids/lecithin Lecithin forms cell mambranes and we lose it while aging Perhaps some forms of vit.A "toxicity" could be a lecithin deficiency AI Lecithin supplementation has shown potential in supporting retinal function, primarily through its role in enhancing the bioavailability of nutrients essential for eye health and as a component of specialized medical treatments. Lecithin, particularly in the form of lecithin-bound iodine (LBI) or phosphatidylcholine, is associated with improvements in retinal pigment epithelium (RPE) health, tear film stability, and the reduction of oxidative damage in the retina. Key Findings on Lecithin and Retinal Function: Retinal Pigment Epithelium (RPE) Protection: Lecithin-bound iodine (LBI) has been used in Japan to treat retinal diseases, including central serous chorioretinopathy. In studies, LBI was shown to prevent hypoxic damage to RPE cells and suppress inflammatory responses (such as CCL2 secretion), suggesting a protective effect on the retinal structure. Retinal Degeneration and Function: In animal models of retinal degeneration, a lecithin-containing diet improved retinal function, as evidenced by higher b-wave amplitude in electroretinography (ERG) tests compared to control groups. It was found to reduce the invasion of macrophages into the retina and decrease inflammatory markers. Enhancing Nutrient Absorption: Lecithin acts as an emulsifier that helps the body absorb and utilize fat-soluble vitamins, including Vitamin A, which is crucial for producing visual pigments in the retina and maintaining photoreceptor function. Exudative Age-Related Macular Degeneration (AMD): Research into the use of iodized lecithin tablets for exudative AMD indicated a potential positive impact, with studies reporting improved visual acuity and reduced retinal thickness in treated groups compared to control groups. Tear Film Stability (Dry Eye Disease): Sunflower lecithin supplementation has been shown to improve dry eye disease (DED) symptoms. As a rich source of phosphatidylcholine, it may enhance the lipid secretions from the meibomian glands, stabilizing the tear film. Retina Protection against Toxicity: Studies on rat retinas indicate that lecithin can help maintain the structural integrity of retinal proteins (specifically α-helix and β-sheet ratios) when exposed to oxidative stress, potentially reducing damage from, for example, chemotherapeutic agents like ifosfamide. Important Context: Lecithin-Retinol Acyltransferase (LRAT): Lecithin:retinol acyltransferase is an enzyme crucial for the metabolism of Vitamin A in the retina. It helps convert all-trans retinol to all-trans retinyl ester, a key step in the visual cycle. Limitations: While promising, some uses of lecithin, specifically lecithin-bound iodine, have limited clinical trials outside of Japan, and many findings are based on preclinical or older studies. In summary, lecithin supplementation, particularly when containing iodine or as a source of phosphatidylcholine, may support retinal function by improving structural integrity, reducing inflammation, and increasing the absorption of necessary nutrients, according to research.

@user73636 Vit. K3 and C can bypass Q10 to cyt.c Vit .K3 is intermediate to K2 https://pmc.ncbi.nlm.nih.gov/articles/PMC5953218/

@alfredoolivas just bribe you doctor if you rich enough to import t3

@user73636 SIRT 1 binds to NAMPT and deactylates it, reactivating it https://bioenergetic.forum/topic/9084/microgram-doses-of-nicotine-improve-the-nad-nadh-ratio-independent-of-the-acetylcholine-receptor.-....big-increase-in-neurogenisis-improves-inflamation-cognition-blood-sugar-and-anxiety.-triples-bdnf-and-causes-a-30-fold-increase-in-doublecortin?_=1771443781283

Addendum: Phytol's major metabolite phytanic acid has a half life of 15-20 days! I couldn't really figure out my dosage and felt like effects lasted relatively long. I thought it had to do with a biphasic effect on GABA-A, which also makes things confusing sometimes . But I think it's probably the long half life. Not necessarily a deal breaker, just something to keep in mind.

List of (peaty) AMPK activators: Biotin Aspirin Frankincense Methylene blue thyroid hromone, fisetin trehalose lactoferrin papain, ecdysterone phytol vitamin D apple polyphenols Far infrared light

@gg12 1.) you made an assertion with "you" which means you are telling "me" something without knowing anything about me, it is rude tbh 2.) you think "based" content is any more less cringe than "zog" content

[image: 1771417636030-c9af89fb-ce9d-4abd-858c-73382b3c71a6-image.png]

@wester130 I thought it was interesting. Because if it was just some "adrenal stress hormone" as some will surely dismiss it as, it probably wouldn't peak during the time where people generally are the most healthy.

@Chud said in Cynoplus sources in US: @Ecstatic_Hamster did you recieve it? I did. All good.

I’ve been enjoying getrecall.ai. Worth the money.

@happyhanneke, I searched through Ray’s radio interviews addressing cavities and all I’m finding for potential causes are low thyroid, excess estrogen, stress, poor digestion and poor saliva production. Some examples: Question: We've got another question here on dental health. Question about there's a lot of people who recommend eliminating sucrose, fructose, and most fruits when people have dental ailments. And on the other side of it, you know, you talk about increasing, you know, carbohydrates, you know, for cell metabolism, et cetera. Can you elaborate a little bit on that, why there's so much conflicting information on that, and what contributes to dental issues? Ray Peat: I saw a recent article on dental health in Sweden, and they saw that during the time that cavities have decreased radically, sugar, candy, and soft drink consumption had actually increased, and they couldn't account for why the teeth were healthier while they were -- the basic diet hadn't changed so much, but had increased in the supposedly cavity-causing snack foods. And in my sugar article, I mention some of the old studies in which they modified the thyroid or estrogen and found that increased estrogen increased the dental decay, increased thyroid reduced the dental decay. And one whole line of dental research has shown that stress will very quickly cause an outbreak of cavities. And mainline dentistry just thinks in terms of germ growth in the mouth and completely neglects the chemical and immunological function of the saliva. I think the saliva is the mediator of stress. https://bioenergetic.life/transcripts/88db6?t=4785&c=109 Question: Now, do you think that a lot of our digestive distress is from a kind of a society of sitting? Ray Peat: Yeah, definitely. Everyone who takes up the habit of walking for an hour or so a day notices improved digestion. The general sense of well-being is largely because of the improved movement of the intestinal muscles but also improved secretions. Feeling good and relaxing and moving around reduces the nervous tension and that increases the secretions. You can see it even in saliva. When you're very anxious, your mouth tends to go dry because of the shift from one part of the nervous system to the other shuts off secretions starting in the mouth but affecting all the way down. Question: Yeah, so there is kind of a north to south process, right? So, would you say that the saliva is just as important as the stomach acid? I mean, as it starts there and it works down to the stomach acid and then the CCK and all the different secretions that happen from the pancreas and the liver. Is it pretty important to start with the fundamentals like keeping a good cephalic head phase of digestion going as well as good adequate stomach acid? Ray Peat: Oh yeah, anyone who has taken a drug that shuts down saliva production has generally had an outbreak of cavities. The anti-cholinergic drugs and some of the anti-histamines reduce the production of saliva so much that it's not just the drying of the lower quantity of saliva but the composition changes chemically. Instead of washing away and inactivating bacteria and their products, it tends to favor their growth. So, you can see it as increased deposits on the teeth but especially in the extremely fast development of cavities when the mouth is dry. https://bioenergetic.life/transcripts/13b78?t=382&c=8