does the free acetyl also have this interactions with CAII?

I think the mTOR-always-on is a general problem with any low-stress targeted approach, not limited to milk. Some stress is required for normal metabolic functioning. Fasting during the night and exercising is a good way of "micro dosing" stress in a way that is actually beneficial. The rest I wouldn't read too much into. AIs are dumb as fuck.

I have been taking 10mg boron for a couple months and I'm wondering if it's triggering aromatase due to low SHBG and high total T. Any thoughts on if this could actually be the case?

https://youtube.com/watch?v=2KPTiSYuzwg

@sunsunsun Great find sushi I think it was reffering to this study It used a HED of 70mg a week for an 80kg man, which is a very low dose. They measured protein synthesis by measuring the concentration of RNA in muscle, which usually increases during AAS administration, but fell during trenbolone treatment. The tren rats had less amino acids in their muscle, indicating less muscle breakdown and more nitrogen per kg of bodyweights and normal organ sizes (actually less as a percent of bodyweight) it's interesting. to see its' unique effects

@mauritio i was looking into oleanolic acid before but didn't see a good way to get enough, turns out its almost Ursolic acid (isomers of each other) [image: 1775198950057-148baac5-6452-4b03-be2f-ccad05ff4b00-image.png] lowered morphine withdrawals (taken orally) 7mg/kg rats, lowered serotonin and NE in cortex. and effects lower also https://pmc.ncbi.nlm.nih.gov/articles/PMC8402955/ light box open arms test seems like a good model for emotional state stuff maybe better than forced swim, (i dont think FST translates well, open arms is measuring general activity instead of specific stress & muscle endurance situation). https://pubmed.ncbi.nlm.nih.gov/24920136/ mg/kg orally mice [image: 1775202811922-bbc3e18a-5164-424f-94ab-37a4da8b6ad5-image.png] 40mg/kg lost effect in their other model they said it tilted over to sedation check out the bdnf effect in hippocampus (i think might work as a 5ht1a agonist) [image: 1775198747368-7068b6c5-b0d9-466d-94a1-446e4c254af5-image.png] might be effective lower than 10mg/kg even when used for a longer day to day timeframe (which might lower dht going by the ursolic one) Oleanolic acid alleviates the extrapyramidal symptoms and cognitive impairment induced by haloperidol through the striatal PKA signaling pathway in mice https://www.sciencedirect.com/science/article/pii/S0753332223014373?via%3Dihub and Oleanolic acid attenuates MK-801-induced schizophrenia-like behaviors in mice. https://www.semanticscholar.org/paper/Oleanolic-acid-attenuates-MK-801-induced-behaviors-Park-Lee/ab04e36ca7231ee46adcf984f0afa18f43dd38d1 @mauritio said UA promotes bile secretion. www.researchgate.net/publication/8982378_Effects_of_ursolic_acid_on_liver_protection_and_bile_secretion also lipophilic so maybe with some fat for absorption if someone doesnt notice effects (very low oral bioavailability %)

Probably because the cells utilize more sugar as a concerted effort to recover from infection. If we picture a U curve, with the state of infection being one extreme side, more sugar would perhaps satiate the need to recover from infection with the surplus leveling out for glycogen formation.

Acute first aid treatment after brain injury Case Report: Buccal administration of hydrogen-producing blend after a mild traumatic brain injury in a professional athlete https://pubmed.ncbi.nlm.nih.gov/32595937/

@sphagnum I wouldn't worry about the ratio, just consume enough Calcium and Magnesium foods/supplements to your well-being and tolerance. Also in the cited study above, the ratio is 2.3, not 2:3, so it's more than two times more elemental calcium than magnesium. 2:1 seems to be the recommended ratio in health institutions. Calcium to Magnesium Ratio Higher Than Optimal Across Age Groups Objectives The ratio of calcium to magnesium (Ca: Mg) intake has gained immense attention in recent years, since a ratio above 2:1 has been associated with increased risk of metabolic, inflammatory and cardiovascular disorders. The objective of this study was to assess Ca: Mg ratios across age groups and to determine the relationship between Ca: Mg ratios and markers of inflammation. https://pmc.ncbi.nlm.nih.gov/articles/PMC6574898 Calcium: magnesium intake ratio and colorectal carcinogenesis, results from the prostate, lung, colorectal, and ovarian cancer screening trial Conclusion Higher calcium intake may be related to reduced risks of incident advanced and/or synchronous adenoma and incident distal CRC among subjects with Ca:Mg intake ratios between 1.7 and 2.5. https://pmc.ncbi.nlm.nih.gov/articles/PMC6889387 Dietary calcium and magnesium intake and risk for incident dementia: The Shanghai Aging Study Our findings suggest that high dietary intake of Mg is associated with an increased risk of dementia mainly among older adults with low Ca:Mg intake ratios. Proper balance of Ca to Mg in the diet may be critical to the relationship between Mg intake and risk of dementia. https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.12362

I noticed the reprint of Nutrition for Women says "100 short articles by Ray Peat, PHD," where the old one said "92...". What did they add to it? Also, note that From PMS to Menopause is for sale on Peat's website but not Amazon, and Peat's website doesn't have Generative Energy. Weird. I wonder if Katherine gets more of the money if you order from Peat's site. I'd imagine so.

I have posted about the hypermetabolic übermice before. I'm trying to understand the mechanism. From what I can tell increasing PEPCK-C in the muscle, mainly inhibits anaerobic glycolisis (fermentation metabolism) and increases OxPhos. I think that is the fundamental mechanism. The fact that tjsr doubles life span and increases reproductive health so much, corroborates what Peat said for decades. "...we identified a progressive decrease in cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C), a longevity-associated metabolic enzyme, and a reciprocal increase in glycolytic pyruvate kinase (PK) that were necessary and sufficient to limit lifespan. Decline in PEPCK-C with age also led to loss of cellular function and integrity including muscle activity, and cellular senescence. Genetic and pharmacologic interventions of PEPCK-C, muscle activity, and AMPK signaling demonstrate that declines in PEPCK-C and muscle function with age interacted to limit reproductive life and lifespan via disrupted energy homeostasis. Quantifications of metabolic flux show that reciprocal changes in PEPCK-C and PK with age shunted energy metabolism toward glycolysis, reducing mitochondrial bioenergetics. Last, calorie restriction countered changes in PEPCK-C and PK with age to elicit anti-aging effects via TOR inhibition. Thus, a programmed metabolic event involving PEPCK-C and PK is a determinant of aging that can be modified to modulate aging." https://pubmed.ncbi.nlm.nih.gov/26631730/ "...overexpression of the central gluconeogenic gene pck-2 (encoding PEPCK) increases health measures via a mechanism that requires DAF-16 to promote pck-2 expression in specific intestinal cells. Dietary restriction also features DAF-16-dependent pck-2 expression in the intestine, and the healthspan benefits conferred by dietary restriction require pck-2. Together, our results a new paradigm in which nutritional signals engage gluconeogenesis to influence aging quality via DAF-16." https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008982 "Finally, a synergistic induction of PEPCK gene transcription by T3 and cAMP is described. " https://pubmed.ncbi.nlm.nih.gov/1657985/

@cs3000 any update on your electrical symptoms from sunlight and vitamin D?

@LunaticRed said in Fatty acid oxidation drives senescence: I recommend you to use Claude-opus-4-6-search instead of Gemini3, it's more powerful and better at searching information Thanks for the info. I appreciate. Here is a link for my first try / search on Vit k2 MK4 (in French): AI Conversation No. 3: HD Vit. K2 MK4 to target vascular, cerebral and hormonal aspects. https://mirzoune-ciboulette.forumactif.org/t2185-conversation-avec-lia-n3-hd-vit-k2-mk4-pour-cibler-les-aspects-vasculaire-cerebral-et-hormonal#30719 Need [image: 1775046783689-aa.emoticon-coffee.gif]

@user73636 what AI did you use for this? Grok 4.20 Expert is not suggesting that this is happening.

@lobotomize said in WARNING Alkaline environments hyper-accelerate the Maillard: aspirin also does the blocky thing Yes, very useful but we have to manage the impact on platelet renewal, whatever the dose is. 10-12 days to recover a functional system. I can give a link if interested.

Not sure about this type of cancer, but there are good case studies for cyproheptadine. There was a thread on the old forum that cyproheptadine completely cured liver cancer in one case. All I could find on leukemia is this: https://pubmed.ncbi.nlm.nih.gov/18502826/. Keep in mind that it makes people groggy and tired a lot. So if the goal is to make your uncle feel better, it might not be the best option, even if it helps a bit. Good luck!

Fat loss has absolutely nothing to do with metabolic efficiency. When the body has enough nutrients it will spend some of that nutrients on building new fat cells. This can only be stopped by inhibiting mTOR activation, usually through APMK, which naturally happens during fasting and during heavy exercise. The threshold is high, passively burning more energy will not suddenly spike APMK.