@BearWithMe Can it be lack of retinols as cofactor for ceruloplasmin synthesis, or general liver damage?

@sunsunsun Merci! Below is a summary in case someone in need will be reading this in the future: Introduction Combination of vitamins E+D about as effective as antibiotic for treating bacterial sepsis/infection daily 1-2k IU D3 + 8.75mg/kg (700-800mg) Vit E (d-alpha-tocopherol or mixed unesterified d-isomers of all 4 tocopherols) The tetracyclines protect against sepsis independently of their antibiotics effects Tetracyclines might be the preferred antibiotic treatment (i.e. doxycycline in a HED of 0.25 mg/kg (intraperitoneal route, so orally one would need ~0.4 mg/kg to achieve the same effects) Endotoxin/LPS is a major driver of blood clotting, sepsis, heart attacks and strokes Aspirin (although only acts downstream of the endotoxin/LPS cascade) Substances that can limit the amount of endotoxin/LPS produced and entering the blood: easily digestible food; avoiding “resistant” starches carrot salad, charcoal (*not really applicable after appendectomy) Niacinamide and vitamin E to help restore the gut barrier pregnane steroids (and especially bioidentical progesterone) to directly bind endotoxin in the bloodstream Inhibiting fatty acid synthesis (FAS) dramatically improves sepsis survival rate least risky of FAS-Inhibitors is probably orlistat (Still severe side effects) aspirin might be good alternative; adding niacinamide + thiamine might improve its effectiveness against sepsis by improving glucose oxidation and reducing lipolysis respectively Inhibiting fatty acid synthesis reverses bacterial antibiotic resistance Aspirin (80mg-100mg daily) inhibited FAS by +50% Aspirin As A Cure For Sepsis excellent thread https://lowtoxinforum.com/threads/aspirin-as-a-cure-for-sepsis.15753/post-215210 Baking Soda Dramatically Increases Antibiotic Effectiveness, Could Help In Sepsis (!) Note: research involved in vitro work only + oral route probably not applicable after appendectomy see Haidut comment Caffene restores lowered cytochrome C oxidase activity + Caffeine restores cytochrome C damaged by sepsis one cup of coffee or about 80mg-100mg of caffeine probably better to do in recovery, not with acute sepsis DHEA Protects From Endotoxin Effects And Lethality single HED dose of as little as 5mg - 7mg DHEA daramatically increased survival of lethal endotoxins DHEA protects from endotoxin (even lethal doses) IV B1+Vit. C+ Cortisone Prevents Septic Induced Death Full interview with Dr. Paul Marik his 2017 paper in question for early treatment protocol Vit C (1.5 g every 6 h for 4 days or until ICU discharge) Thiamine (200 mg every 12 h for 4 days or until ICU discharge) Hydrocortisone (50 mg every 6h for 7 days or until ICU discharge followed by a taper over 3 days) read on the other forum this one failed to replicate, although some studies exist that show somewhat sig improvement https://www.amjmed.com/article/S0002-9343(19)30699-0/fulltext s/o @mauritio T3 levels are a predictor of mortality from sepsis This study (and this one) shows that lactic acid is an independent risk factor for death due to sepsis. CO2 lowers lactic acid, T3 increases CO2. So it makes sense that T3 was so strongly correlated with survival in sepsis patients. -> improve CO2 / lower lactate (thiamin, niacinamide) This study shows a significant increase in survival time of people who take aspirin before hospitalization (by 1.3 days) Vitamin B2 Remarkably Effective Against Endotoxin, Sepsis, And Other Bacterial Infections especially its activated form riboflavin '5 phosphate (R5P) minimum effective human equivalent oral doses for the combination of R5P and valine were approximately 0.2mg/kg and 25mg/kg respectively. This assumes bioavailability of 90% and 70% for R5P and valine. The Pyruvate Dehydrogenase Complex in Sepsis: Metabolic Regulation and Targeted Therapy "A group of drugs that target PDHC activation, including dichloroacetate (DCA), thiamine, amrinone, ciprofloxacin, and TNF-binding protein (TNFbp), have been shown to ameliorate the symptoms of sepsis" Septic Shock: Serotonin Is The Likely Cause Of Septic And Anaphylactic Shock Anti-Serotonin (Cyproheptadine) + Aspirin Famotidine & Anti-histamines Protect Organs In (septic) Shock Both an H2 blocker (Famotidine, Cyproheptadine) and an H1 blocker (Chlorphenamine) were each offered protection Inosine Increases NAD/NADH Ratio And Reduces Systemic Inflammation s/o Koveras Anti-Serotonin, Cypro, Tryptophan Metabolism, Vitamin C, Hydrocortisone, Thiamin https://lowtoxinforum.com/threads/do-not-forget-to-give-thiamine-to-your-septic-shock-patient.12006/ See also: Haidut on radiation exposure due to x-ray https://bioenergetic.forum/topic/3037/advice-on-lowering-endotoxin/18 https://bioenergetic.forum/topic/2140/any-info-on-sepsis-bacteremia-antibiotics-used/16 Citrulline to restore immune function after sepsis L-Citrulline restores immunity & T Cell mitochondria function acutely highest food sources: 1 cup of red flesh watermelon might have ~150mg per cup. or ~400mg for yellow flesh watermelon https://bioenergetic.forum/post/42939 Anti-inflammatory Effect of Low-Intensity Ultrasound in Septic Rats https://bioenergetic.forum/post/60444 (!) avoid mitophagy enhancers like menaquinone (K2), urolithin-A or mitochondrial uncouplers like DNP, BAM15, methylene blue, theobromine etc. (especially in the initial stage of sepsis) https://lowtoxinforum.com/threads/aspirin-in-the-context-of-endotoxin-tolerance.49865/

@wester130 that was interesting, and something that always rings an alarm for me is when it aligns with something Peat had mentioned. In this case I couldn’t help but think of the story of the man who regrew his hair when he fell in the fireplace and burned his scalp. I mean all he did was essentially give himself a very painful peel right?

@lykos Estrogen masculines. Not everything is one absolute forever. Estrogen is not inherently bad. It is necessary. Milk is the most accessible form of calcium which many of us have been deprived of.

@Mike_Fave Glad to see u on this forum ur a good youtuber

Androgenic and aphrodesiac action of the medicinal plant Lithospermum Arvense (bird millet) https://pubmed.ncbi.nlm.nih.gov/2743927/

@engineer no i have not maybe I have a theory All my back hair and neck hair was driven by estrogen, and the DHT reduced all the estrogen and they fell out I don't know though

@DavidPS Interesting IIRC L. Reuteri increases it and the testosterone increase was reliant on IL10 increase.

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@Amazoniac said in Toward a Better Understanding of Reactive Oxygen Species: The ROS linked to fat metabolism can arise partly from parallel effects, such as structural or functional perturbations and up-regulation of alternative ROS-producing enzymes (NOX, XO, COX, LOX, CYP2, etc.). I suppose that here we're mainly talking about excess PUFA loaded in adipocytes (AA cascade). When we stress or have a diet (fat loss). If we remain under 10 g PUFA/day, preferably 5-6 g, it would be OK. Edit: fine, the picture on ROS effects. (downloaded) ROS concentration & deleterious effects on cells. The next question is: What about when corn / soy food (from real food) is eaten, with LPS by-side load. Otherwise, it remains a theory. 1° In presence of ALA (thiol antioxidant) or a lipoprotection (A D3 K2 + vit E). 2° The same with aspirin or WWB.

@lobotomize said in less salt = more social bell curve?: Coincidentally, when I'm sick, I'm also extremely social Hi, Not the same when you feel tired. Energy is derived towards temperature. Why aggressive when you lack Na? Na is required for osmolarity and balance. Brain function is impaired. This imbalance disrupts cognitive control, leading to irritability, confusion, and reduced impulse control. You may possibly feel as if your were threatened too (survival instinct) if you've already lived such a deficiency.

@Mossy yea some call me the messi of bootyko breathing

This one's a doozy. https://www.reddit.com/r/nattyorjuice/comments/zzkr29/diagnosed_with_cardiac_heart_failure_at_31_natty/ Title: diagnosed with cardiac heart failure at 31... Natty or not? "Toxic habits: Very light tobacco smoker mixing tobacco with hashish ~4 times per day for decades. I do like fatty foods but generally well under control. I consume coke and mdma once a year but never was the most intense with these and usually not on cycle." There's your problem. Tobacco and PUFAs! "PED background: Jumped to the dark side ~2 years ago, started low (300mg test e per week + 40mg anavar a day for the last 8 weeks - 16 weeks total) and biggest cycle was 500mg test e/ 400mg primo + up to 60 mg anavar ed for the last few weeks + 40mg tbol ed. Never had to use any AI. I cruised at the most at 250mg test e & 100mg primo but typically only 200mg test e/ week." No AI = estrogen. Next!

@Mossy, I bet your potato soup is delicious! The bacon is a splurge I only get periodically, but I found ways to stretch it. The fat from 1 lb of it is enough to roast 4 lb of potatoes or kabocha squash, for example, then I just chop up the bacon, add it to the (seasoned) roasted veggies, add cheese, top it with some sour cream, and my dad gets at least 6 meals out of it. I get the woodland over conventional for purely ethical reasons. I’m a bad Peater—I’m not concerned about PUFA in whole foods, especially when the food is as nutritious as animal proteins.