@pittybitty said in How do I reign in my overreactive immune system?: when I get over the hypothyroidism hump then my immune system is no longer suppressed and I get the illness symptoms. Whenever I get better I get worse. Hi, I 'd proceed by elimination. See first why you're overreactive: Histamine reaction, lack of sulfur and methyl (if deficient in some nutrients or excess other ones). Enough Zinc (Zn10-15 mg) and copper (Cu 1.5 mg) for SOD enzymes. No milk / cheese when eating meat (Zn) or nuts (Cu). Afterwards, we'll see for the thyroid requirements. Mind excess B6.

[image: 1772905356270-0ac86b03-3ad3-48df-a48c-dc07cd844381-image-resized.png] Does this sound like a customer or a business?

@sunsunsun said in switched to brown rice, cut back granulated sugar, increased vegetable (even raw) intake: Italian regular semolina pasta I eat semolina pasta occasionally, semolina flour is less processed and particles are too big to get easily mixed with chemicals. And I think semolina maintain some vitamins and minerals unlike refined flour so there is no need to fortify it. Just it is not a fast food and takes longer time to cook so it is not a convinience food for most fast living americans. For an italian peasant no problem, he can contemplate boiling pasta all day long

https://www.youtube.com/watch?v=WIF4_Sm-rgQ

@user73636 Di Bella method is very successful in many difficult cancers It usues somatostatin and melatonin. http://www.metododibella.org/it/Archivio-Newsletter.html https://www.metododibellaevidenzescientifiche.com/2022/05/03/mdb001-di-bella-et-al-2018/ Il sinergismo di somatostatina, melatonina, retinoidi, vitamin E, D3, C, inibitori prolattinici ed estrogenici, microdosi metronomiche di ciclofosfamide, ha incrementato sopravvivenza, risposte obiettive, performance status, in 297 casi di carcinomi del seno – The Synergism of Somatostatin, Melatonin, Vitamins Prolactin and Estrogen Inhibitors Increased Survival, Objective Response and Performance Status In 297 Cases of Breast Cancer

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@sunsunsun facts

@user73636 1 cup of chocolate chips has 15.691g of stearic acid. I think this fusion is just the result of fixing a deficiency. there are lots of foods with decent amounts of stearic acid in them.

@Luke dang rip. I bet they had that anti-socmed epiphany/mid-life-crisis to finally do something good with their life hahahaha

Wonderful! Thank you for sharing, @Ecstatic_Hamster. That’s how I make curds, except I haven’t tried boiling the milk in the microwave. I’ll do that from now on. Seems easier. I don’t drink the whey, either. I give it to my plants. I find it increases their Brix.

Mulberry I recently got introduced to mulberries by the great saint Hildegard von Bingen. She had an astounding knowledge on plants and medicine. Mulberry is one of the things she recommended for improving liver health. And indeed, there is a bunch of studies showing benefits on the liver, corroborating what she said already 800 years ago. On top of that mulberries taste really good, I could see them pair well with yogurt and honey. [image: 1772815177825-1000027188.webp] Liver: It ameliorates NAFLD, Increasing ATP, endogenous antioxidants, michondrial complex I + II. While lowering triglycerides, liver weight, FFAs and SCD1. https://pubmed.ncbi.nlm.nih.gov/30643537/ Mulberry extract lowers liver damage induced by the fungal toxin AflatoxinB1. It increases antioxidants, phase 2 liver detox enzymes and SCFAs in the gut. https://pubmed.ncbi.nlm.nih.gov/41046554/ It inubits liver inflamamtion in diabetes model. Lowers TLR4. Seems therapeutic for diabetes too. https://pubmed.ncbi.nlm.nih.gov/35845591/ Mulberry leaves extract ameliorates alcohol-induced liver damages through reduction of acetaldehyde toxicity and inhibition of apoptosis caused by oxidative stress signals https://pubmed.ncbi.nlm.nih.gov/33390773/ Mulberry leave polysaccharides increase the enzyme that converts cholesterol into bile acids and cholic acid in particular. https://pubmed.ncbi.nlm.nih.gov/39490871/ Hormonal: It strongly increases StAR in diabetic mice, to values even above the control group. [image: 1772814519576-1000027187.jpg] https://pubmed.ncbi.nlm.nih.gov/24644381/ Metabolism/Weight loss It lowers weight on a HFD by over 5%. Decreases leaky gut and intestinal endotoxin. https://pubmed.ncbi.nlm.nih.gov/41645603/ Mulberry leave polysaccharides increase liver AMPK and bile acids. https://pubmed.ncbi.nlm.nih.gov/33994909/

Hass avocado vs le Fuerte Hass avocado has a black or brown grainy skin The Fuerte avocado has a smooth, green skin, with yellow flesh. A much bigger fruit too. (See the picture). The total amount fat could be quite different. How much (proportion)? Why the difference matter The Fat Breakdown Hass avocados have a lower water content. The "Hass Advantage": Because it’s proportionally about 25-30% higher in fat than the Fuerte, it mashes better. On average, here is how the two compare in terms of fat proportion: Feature - Hass Avocado - Fuerte Avocado Total Fat Content ~18–22% / ~12–15% Texture Rich, creamy, and buttery. / Lighter, thinner, and "cleaner" Water Content / Low / High Flavor Profile - Nutty and intense - Mild and slightly grassy

Yes, these might interest you: Oxidation of hydrogen sulfide by Quinones: How polyphenols initiate their Cytoprotective effects ‘Antioxidant’ berries, anthocyanins, resveratrol and rosmarinic acid oxidize hydrogen sulfide to polysulfides and thiosulfate: A novel mechanism underlying their biological actions Alteration of the Gut Microbiome in Inflammatory Bowel Disease

@ThinPicking things are good. Launching a new product and developing v2 of Healthkeeper. Thanks for asking.

In case you're not familiar with saddle chairs, they're elevated stools with a better seat, not intended for full relaxation. Yet, they can improve hip positioning, spinal alignment, and reduce leg compression. Sitting pressure distribution for different chair types How to use your saddle chair ⠀ Salli Story Saddle chairs have been on the market for years and are popular with professionals who need to sit actively for long periods (such as dentists, tattoo artists, aestheticists). Some models include a modest backrest, but it's meant for stretching on occasion rather than constant support. So, if you perceive discomfort with your chair or want sitting variety, give these a try. Some companies offer satisfaction guarantees. Desks with adjustable height carry the LITEK seal (Licensed to Exist by Kvothe), but you can improvise and slip a block under each leg to reach the desired height and match the stool.

Compounds that inhibit lactate overproduction are usually beneficial, but relying on oxaloacetate for this is not ideal. Pyruvate carboxylase is required for glutamine-independent growth of tumor cells (PC synthesizes oxaloacetate) In case of oxaloacetate supplementation, delivery is the first challenge because most of the dose is metabolized in the liver after absorption. For esterified forms, the fraction that reaches target cells is likely overestimated, especially when tissue circulation is poor. Malate dehydrogenase (MDH) interconverts malate and oxaloacetate, and this enzyme is also part of the malate-aspartate shuttle (MAS) that you mention. [image: 1772751634940-d34ce921-acea-4633-9653-639c96f9838f-image.png] ⠀(10.1101/cshperspect.a040543) The figure shows some potential concerns: Cytosolic NAD reoxidation by MDH can promote glycolysis, but without reliably improving mitochondrial metabolism for further oxidation. Increased demand for NAD+ relative to ATP drives aerobic glycolysis Extra oxaloacetate (OAA) may not convert into malate as expected. Aspartate is another component of the shuttle and is a reaction away from oxaloacetate (GOT/AST is bidirectional). [image: 1772751647814-4f7a93ec-7e75-4c6a-a1ad-ae54d314276c-image.png] ⠀(10.1016/j.ymgmr.2023.100967) An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells Oxaloacetate enters mitochondria hydrogenated as malate. Recovering oxaloacetate on the mitochondrial side depends on sufficient NAD⁺ (also shown on the figure), which may be scarce and prioritized for other reactions, such as that of KGDHc. Recovery of oxaloacetate from malate in mitochondria doesn't guarantee its reaction with acetyl-CoA. It may instead support glutamate metabolism by accepting its amino group, yielding ketoglutarate for KGDHc (↻) or IDH (↺). One route doesn't exclude the other, as a fraction of ketoglutarate can undergo oxidative decarboxylation (releasing CO₂) and the other reductive carboxylation (incorporating CO₂), Supporting glutamate metabolism in forward function: Oxaloacetate + glutamate ←{GOT}→ Aspartate + Ketoglutarate Ketoglutarate –{KGDHc}→ Succinyl-CoA ←{STK}→ ATP + Succinate A portion of oxaloacetate-derived malate can also be converted to fumarate in reverse TCA cycle operation. Oxaloacetate → Malate → Fumarate → Succinate [image: 1772751671369-3224a3ed-9ba4-4586-bbab-57e75c344b76-image.png] ⠀(10.3389/fendo.2012.00022) This way, oxaloacetate helps to generate ketoglutarate to support mitochondrial fermentation and non-respiratory ATP synthesis with minimal oxidation. In addition, fumarate may be used as a substitute to deficient oxygen, accepting electrons from the respiratory chain sourced from ketoglutarate itself, dihydro-orotate, etc. (Oxaloacetate +) Glutamate → Ketoglutarate → Succinate ← Fumarate ← Oxaloacetate Succinate accumulation becomes comparable to lactate. Both metabolites are exported as fermentation end-products together with an extra H⁺, contributing to extracellular acidification. [image: 1772751690253-15d16b6b-0813-45e0-8bb1-7fecd96f1d33-image.png] ⠀(10.1080/17590914.2024.2422268) "Succinate-stabilized HIF-1a" reinforces PDHc inhibition, giving another reason not to assume that extra oxaloacetate and CoA release will serve PDHc, because they may just as well promote fatty acid oxidation. If oxaloacetate condenses with acetyl-CoA, that doesn't commit it oxidation either; oxaloacetate can serve as a carrier to export excess acetyl groups to support lipid synthesis. As for pyruvate and its multiple metabolic fates, even discounting lactate and oxaloacetate in this context, we can't assume that pyruvate routing to the chronically inhibited PDHc will prevail over supporting an upregulated pathway, such as in metabolizing abundant glutamate via GPT/ALT, which remains expressed outside the liver. Pyruvate + H⁺ + CoA + NAD⁺ –{PDHc}→ Acetyl-CoA + CO₂ + NADH + H⁺ Pyruvate + ⇈Glutamate ←{GPT}→ Alanine + Ketoglutarate This is another potential route that would supply ketoglutarate without depending on glutamate oxidation, sparing oxidative capacity to keep KGDHc running.

@gg12 high in silicon to get moggy. lots of oxalates so good call on milk

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