When I was 29, my spine collapsed (12 vertebral fractures, 8 of which compressed) due to a thyroid disorder that went undiagnosed and I increased my bone density, going from a DEXA score of -6.7 to -3.6 (for reference, -3.5 is osteoporosis) within a year on a Weston A. Price inspired diet supplemented daily with fermented cod liver oil and high vitamin butter oil. Now that I have my thyroid under control and I’m weight restored—I went from my normal weight of 99 lb/45 kg to 67 lb/30 kg within a few months after my thyroid crashed—my body is no longer wasting nutrients so I no longer require high amounts of the fat solubles, however, I attribute climbing mountains again, in part, to a diet abundant in them. I was an active climber prior to the injury and not only had to learn how to walk again, I had to build back my spine so that I was no longer at risk of paralysis if I were to fracture again, and I couldn’t have done that without the dense nutrition.

Interesting. Throwing in some K2/other decalcifying agents may help as well.

@LucH, thank you for the post and reference to your site. Luckily, I read in French :).
Didn't know this concentration-dependent action of LPB protein. Will have to study more.

Hi @jet9, if you consume starch and like hearty dinners, here are some ideas…

Quiche with a hash brown crust:

https://www.spoonforkbacon.com/bacon-cheddar-and-chive-quiche-with-a-hash-brown-crust/

Hasselback potatoes au gratin:

https://www.sumptuousspoonfuls.com/hasselback-potatoes-au-gratin/

Seafood chowder (I use extra crab in place of the salmon):

https://www.allrecipes.com/recipe/228991/moms-nova-scotia-seafood-chowder/

Kalua pork (I make roasted murasaki sweet potatoes or seasoned and buttered jasmine rice as a side):

https://playswellwithbutter.com/kalua-pork-recipe/

Poutine (I use tallow for frying and gelatin in place of the flour for the gravy):

https://www.seasonsandsuppers.ca/authentic-canadian-poutine-recipe/

Tourtière (I make a hash brown crust in place of the pastry crust):

https://growagoodlife.com/tourtiere/

Caribbean brown oxtail stew (I use baby potatoes in place of the kidney beans):

https://caribbeanpot.com/recipes/classic-caribbean-brown-stew-oxtail/

And here are some low starch options…

Spaghetti squash fritters (I use cheddar cheese in place of the almond flour):

https://healthyrecipesblogs.com/spaghetti-squash-fritters/

Honey garlic butter scallops (can use coconut aminos in place of soy sauce):

https://therecipecritic.com/scallops-recipe/#wprm-recipe-container-52729

Cantonese omelette (I use mung bean sprouts, coconut oil for frying and tapioca starch in place of the corn starch):

https://grantourismotravels.com/egg-foo-young-recipe/#wprm-recipe-container-65979

Foods high in inulin include:
.

067914cc-9a07-423a-9ef9-2d4bf895548d-image.png
The Importance of Prebiotics in Functional Foods and Clinical Practice (2011)

@Budht All I can say is that my friend @Mulloch94 (@jjames94X on twitter) bought this product from this seller and said it was legit.

Youtube Video

I haven't listen to the video. No need with your explanation.
Question to ChatGPT (In summary)
Is consuming 50 g fructose from whole food (thus mainly with fiber for 3/4), concomitantly with 50g glucose, fractioned into 3 meals and one snack – no corn syrup added – going to set a problem with uric acid if your kidneys function normally. No overload?

Fructose and Uric Acid Production:
Fructose metabolism does indeed lead to the generation of uric acid, primarily through its conversion to fructose-1-phosphate by the enzyme fructokinase. This process consumes ATP, and the depletion of ATP can increase the purine degradation pathway, producing uric acid as a byproduct. In excessive amounts, this can potentially lead to high uric acid levels, which can be problematic, especially in conditions like gout or kidney stone formation.

Fractionation of Meals
Dividing your intake into 3 meals and 1 snack will likely reduce any immediate metabolic spikes in blood sugar and uric acid production compared to consuming all 100g of sugar at once. This makes the load on the liver (and kidneys) less intense at any given time. However, the total daily load still matters, and the 50g of fructose consumed across these meals might still lead to some degree of ATP depletion if you’re regularly consuming fructose in this range.

LucH asked
I suppose that if you eat some dairies with fruits (calcium and fructose), it won't set a problem.
ChatGPT answered:
Yes, consuming dairies with fruits, especially with calcium-rich foods like yogurt or cheese, might help mitigate. Calcium binds to oxalates and could potentially reduce the uric acid burden. The mechanism isn’t fully understood (…).
Note’s editor: Eating one slice of cheese like Gouda could do the job, as well as cottage cheese or Greek yaourt but moderate then the protein amount.

Fibrous Fruits, Dairy, and Fructose
In summary, consuming dairy products with fruit is unlikely to cause problems with uric acid levels and could actually help reduce some of the potential issues, thanks to the buffering effects of calcium and protein from dairy. It’s a well-balanced combination, especially if you’re not consuming large amounts of fructose or dairy, and if you have no preexisting conditions like gout or kidney problems. Keep the total intake in check, and your body should be able to handle it without issue.

I eat a quite Peaty diet - milk, various carbs (both starches and simple carbs), meat, coffee etc.

Sometimes intaking more carbs or protein or minerals etc.

No one can work with et cetera.

What could be the cause/-s and treatments?

10.1016/j.bbr.2020.113049

@Maximalus said in Le sex vs semen retention:

Also keep in mind that many of the nofap/semen retention enthusiasts possibly have some form of POIS (post orgasmic illness syndrome) which reduces once they abstain

So they associate the return to a healthy POIS-free state as "benefits" when those without POIS feel that way all the time

A lot of POISers found that anti-inflammatories/anti-histamines help, some think it's a form of mast cell activation syndrome in some cases

But there are many clusters with their own causes and treatments

I wonder how many nofappers/semen retainers have some form of POIS not being aware not everyone has it

Semen emission affect everyone, aint necessary negative, can be positive

@CrumblingCookie said in Cancer & cell proliferation in the breast and prostate:

There are also research hints to idiodide/iodine dissolving the agglutination of granulatomous tissues

Thanks for posting.
I’ve used Luc’s pendulum trying to understand “idiodide/iodine dissolving the agglutination of granulatomous tissues”.
Granulotomous tissues: small clusters or clumps of immune cells that form in response to infections or damaged tissue, as a way for the body to isolate the threat.
=> Iodine, often in the form of potassium iodide or Lugol's iodine, is used to treat certain granulomatous diseases because it concentrates in infected granulomas and can inhibit their further formation. The treatment works by altering the host's immune response, increasing granulocyte chemotaxis, and improving phagocytosis of pathogens.
=> Potassium iodide (IK) has shown success in treating various granulomatous lesions, including those caused by fungal and tuberculous infections. The efficacy of iodine treatment is thought to be mediated by changes in the host's immune response, rather than direct killing of the organism.
Iodide supplementation can increase the movement (chemotaxis) of granulocytes to inflamed areas, improving their ability to engulf (phagocytosis) bacteria.
=> So It makes it easier for the immune system to reach the target.
ScienceDirect Topics – mechanism of action of potassium iodide

Question to AI:
Could a wart be seen as an extended middle to lodge HPV virus (Human Papillomavirus)?
=> Yes, a wart can be seen as a way for the Human Papillomavirus (HPV) to lodge and spread, as the wart itself is a visible manifestation of an HPV infection. The virus infects the cells of the skin or mucous membranes and causes them to grow, forming the wart which acts as a site for further viral activity and transmission to other individuals.
NB: There are over 100 types of HPV identified.
I’ve been using several specific essential oils (EO) but the only effect seen is an over-reaction. The beast / creature gets lightly thicker. I know it takes several weeks…
I could have used Lugol 12% iodine concentration (1 oz solution bottle) to attack the virus. Apply directly on the wart 2x/d. Mind the surrounding skin (irritation).
However, Lugol's solution does not have a keratolytic effect (keratin-dissolving effect). Instead, salicylic acid is used as a keratolytic agent. It takes several weeks before seeing a result. Or use "cryotherapy" with silver nitrate to see a quicker effect.
1 drop Lugol 12% (1 drop = approx. 0.05 ml) is potassium iodide and it contains 9 mg iodine. 9 000 mcg! Compare with the RDA 150 mcg 😉
Note: Tincture of iodine has been used for more than 150 years for disinfecting wounds.
Iodine was a well-known agent used by the US army during WW1 (and povidone-iodine during WW2) to treat wounds. And sulfanilamide as well. Iodine was commonly carried in medic's belts and aid stations during WW1, and similar antiseptic applications continued through WW2 by corpsmen.
doi: 10.1111/j.1742-481X.2007.00405.x

How effective is iodine as virucidal? (And by microbes, viruses, fungi and parasites)

DOI: 10.1530/ERC-17-0515 Role of iodine metabolism in physiology and cancer. Endocr. Relat. Cancer. 2018
New research supports the exciting idea that I- participates as a protective antioxidant and can be oxidized to hypoiodite, a potent oxidant involved in the host defense against microorganisms. This was possibly the original role of I- in biological systems, before the appearance of TH in evolution. I- per se participates in its own regulation, and new evidence indicates that it may be antineoplastic, anti-proliferative and cytotoxic in human cancer. Alterations in the expression of I- transporters are associated with tumor development in a cancer-type-dependent manner. SARS-Cov-2
doi: 10.1371/journal.pone.0254341
The in vitro virucidal activity of intranasal Povidone-Iodine (PVP-I) has been demonstrated recently to reduce SARS-CoV-2 viral titers.
EID (200 μg iodine/ml) after exposure for 60 and 90 seconds was compared to controls. In both cases, the viral titer was reduced by 99%.
EID = Essential Iodine Drops. Influenza viruses
Iodine, particularly in the form of povidone-iodine, is effective against influenza viruses by disrupting their structure and blocking their ability to attach to and enter host cells.
How it works
• Disrupts viral structure:
Iodine makes structural changes to the viral coat by attacking key viral proteins
• Blocks attachment:
Iodine interferes with the hemagglutinin protein, preventing the virus from attaching to receptors on human cells.
• Inhibits viral release:
It also inhibits neuraminidase, a viral enzyme essential for releasing new virus particles from infected cells.

@alfredoolivas

We’re going on a cruise, so I’m more limited while on the ship. I rarely eat fried food because it gives me the shits anyway. I’m going to try to eat as much fruit as possible, maybe hard boiled eggs so they’re not cooked in vegetable oil. I can bring a bunch of gelatin packets at least. I just know it will overall be a lot more PUFA than I usually get. My only source now is from the natural amount that’s in meat, milk, eggs, and solid fats.

@CrumblingCookie said:

Maybe it's time to up your scope before any more dabbling and to get an abdominal MRI to look for structural constrictions or masses and also your plasma levels of Ca, PTH, CT and a GI hormones panel at a specialized clinic.

As for GI hormones my initial thought would be to check for elevated somatostatin (constipation, lack of motility, steatorrhea; pancreatic and reciprocal gastric dysfunction). In the US they typically run a complete GI hormones panel which includes SST but it's more selective and specialized in other places. Weirdly, the symptomatic treatment for SSTomas is the SST-analogon octreotide, due to a high affinity to SST autoreceptors. You'd be a 1 in 40 millions /year case with that. Anatomically, surgical removal of such neuroendocrine tumors are far from elegant. Clearly it's better to not have one. I'd work my way forward by exluding possible causes step by step. Not sure what your state of insurance and medical services provision is like where you are (Eastern Europe). At this point I would try to (also) get a contrast-enhanced full abdominal MRI without further deferral.

https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-024-02013-6? In a pig-derived L. reuteri study, rats gavaged with that strain had higher body weight and fat pad weights vs controls.

@DavidPS
A good strategy when investigating foods is to explore their profile from a traditional medicine perspective. This gives an insight into the items more subtle properties which are equally as important as it's physical properties. Often it tells you things which a "conventional" analysis (eg a scientific study on Nutmeg's influence on digestive transit time) wouldn't, or which a "conventional" way of thinking would overlook.

Personally I find the traditional Chinese medicine (TCM) take on foods easy to understand, more so than the Indian Ayurvedic one. TCM is orientated for medicinal intentions but the info is applicable for general day-to-day use.

Here's the TCM profile for Nutmeg:

TCM category: Herbs that stabilize and bind
TCM nature: Warm
TCM taste: Pungent
Meridian affinity: Large intestine, Spleen, Stomach
Dosage: 3 - 9 grams [for medicinal purposes]
Key Actions: Warms the Spleen and Stomach, circulates Qi. Protects the Intestines and stops diarrhea.
Medicinal Uses: Diarrhea / Abdominal pain / Vomiting / Loss of appetite / Abdominal bloating

Here's the TCM profile for coffee:

TCM nature: Warm
TCM taste: Bitter, Pungent/Acrid
Meridian affinity: Liver, Spleen, Heart
Key Actions: Regulates the flow of Qi, Opens the Heart, Clears toxins, Cleanses the Gallbladder, Warms and Moves Blood
Medicinal Uses: Regulates menses, relieves headaches, lifts the spirit, energizes, promotes mental clarity, improves circulation, prevents gallstones, regulates constipation, boosts metabolism, promotes urination, eliminates toxins

For some contrast, here's the TCM profile for milk:

TCM nature: Slightly cold
TCM taste: Sweet
Meridian affinity: Heart, Lung, Stomach
Key Actions: Tonify deficiency, Tonify the Lung and Stomach, Promote the secretion of body fluid, Moisten the Intestines, Tonify Blood and remove Toxicity.
Medicinal Uses: Weakness, physical strain, constipation, diabetes, regurgitation, dysphagia.
Dosage and Administrations: Boil it beforehand
Cautions: It is contraindicated in case of deficiency cold in Spleen and Stomach.

As you can see, TCM offers a rich context for interpreting herbs/spices/foods. The point of TCM is restoring and maintaining balance. In this context, nutmeg's warming nature would be balanced by mixing with something cooling like milk or cheese. This also applies to the body condition, if the body is in a cold condition then adding nutmeg will warm things up. This isn't referring to temperature!

There are some subtleties which might cause someone accustomed to the typical Western modality to do a "double take". Eg on a super hot day drinking warm peppermint tea is more effective than ice cold water.

IMHO the Ray Peat approach would greatly benefit from incorporating TCM principles. TCM would be the icing on the cake so to speak. I wonder if Ray ever peeked into the world of TCM, no doubt he would have found it fascinating and worthwhile. I bet you it would have influenced his recommendations, for example...

only drink warm liquids (especially milk)...explains why OG Chinese prefer warm OJ/water add warming spices to dairy (milk/cheese) combine sugar/honey/maple syrup with things to mitigate "dampness" (dampness not good) combine heavy meals with warming spices/herbs which aid digestion combine coffee with an item that mitigates dryness, eg dairy adds moisture (in excess = damp) and notably...avoid cold ice cream (!). The issue there is that ice cream is composed of cooling/cold/damp ingredients, and the item itself is frozen - double whammy. At the very least, Ray would have said to add warming/hot spices like ginger which seems most suitable. Powdered ginger, candied ginger etc.

In a tropical sunny environment, items with a cooling/cold nature can be better tolerated, whilst in a cold environment items with a hot/warming nature are preferable. Again, this isn't referring to temperature.

cheers_boys