Dihydromyricetin in the management of diabetes and its complications: a narrative review Managing diabetes mellitus (DM) and its long-term complications remains a major global health challenge. Dihydromyricetin (DHM), a natural flavonoid abundant in Ampelopsis grossedentata and Hovenia dulcis, has attracted increasing attention for its multi-target anti-diabetic properties. Growing evidence indicates that DHM improves glucose metabolism, alleviates oxidative stress and inflammation, regulates autophagy and cell death, and exerts beneficial effects in DM and a range of related complications, including diabetic nephropathy, cardiomyopathy, cognitive impairment, and wound healing impairment, and other related complications. Overall, this review provides an overview of preclinical research on DHM in DM and its main complications, emphasizing its therapeutic benefits and underlying molecular mechanisms.

@Mauritio was it the pheromones or the thermogenic part that made you consider 11 keto T?

@engineer it really depends on what you ordered and what solvent you selected. Not all have options but some do. Which product are you referring to? Georgi will randomly swap out ingredients and or solvents on occasion. Not too often but enough times where I pay close attention to what he is selling “in stock” as an example I order his magnoil which is always a specific form of magnesium in dmso oil. But one time I got the product and I had to squeeze so hard my eyeballs were going to pop out of my head to get one drop. After a week of tripling my grip strength I looked it up and he was out of the normal for of magnesium and put the fill mag in a deferent solvent. I threw the dumb one away and waited for dmso to show up on the website. I’ve seen varying bottle types over the years too.

@John-Smithra I dealt with this while stuck living in a moldy house for two years. Along with the loud explosion noise I was also experiencing hypnic jerks where I would lurch forward involuntarily, or an arm or leg would whip into the air, as I attempted to drift off into sleep; this would violently jolt me awake. Sometimes they were accompanied by a flash of light in my vision. I would regularly go through 40-50 of those in a row or more, forced to stay awake for hours before my body became so exhausted that it was able to push over the threshold into sleep, for a short while at least. Needless to say it was torturous; once I got out of that house, my life and health got so much better.

Eat potato instead

silicon chelates aluminum *edit posted that b4 reading your whole post

@user73636 Quoting Wikipedia: https://en.wikipedia.org/wiki/Diisopropylamine_dichloroacetate#:~:text=DADA is formed by combining diisopropylamine with dichloroacetic acid. It is chemically related to pangamic acid (formerly known as "vitamin B15")%2C which may convert to DADA and diisopropylamine in the body.[4] Pangamic acid = ester of D-gluconic acid (the sugar-acid part) N,N-dimethylglycine (DMG) (the amino-acid part) Pangamic acid, stomach acid quickly breaks the ester bond and you get free DMG + free gluconic acid.

I believe a stack of B5 + carnitine + OAA/malate High carb low fat Eating leaner meat cuts Lower bcaa intake And focusing on odd chain fats (produce less acetyl coa) would be a great way to lower the acetyl coa/coa ratio further increasing the activity of pyruvate dehydrogenase Also eat foods rich in nad precursors as the nad/nadh ratio is also important for pdh/pdk ratio malate and OAA can not only help pull acetyl-CoA into the TCA cycle (Krebs cycle) to make energy, which frees up CoA. They also help turn NADH back into usable NAD+. (TCA Cycle Pull) OAA mixes with acetyl-CoA to start the cycle, releasing free CoA each turn . Malate turns into OAA inside mitochondria, keeping OAA stocked so the cycle keeps running smoothly.

@happyhanneke said in Sudden dental issues/lack of saliva: @Jennifer I took some time to think about this. Thanks very much for the information. I am inclined to think it has nothing to do with hormone levels. The problematic part of menopause is years behind me and in those years I did have an increased amount of plaque. But I actually feel very good now. No more excess plaque. I used to have ulcerative colitis but that seems to have disappeared too with my menopause issues. I haven't had a flare up for years. But my nails are also brittle and break off easily. Therefore, I am going to the doctor to have a blood test done. If you have suggestions on what to specifically have tested I would like to know. I will ask her for sure to do thyroid panels. In the meantime I am slowly coming off cynomel. It didn't seem to do that much for me other than helping with my heart palpitations. I just want to see if I improve and if not I can always start again. You’re welcome. I’m glad you’re feeling good. Brittle nails, and any other connective tissue weakness, would relate back to thyroid/parathyroid gland function, as they are the main glands involved in calcium metabolism. The fact that you had heart palpitations, i.e., symptoms of adrenaline, would also indicate an underactive thyroid as the adrenals/adrenaline compensate for the thyroid when it’s not producing enough thyroid hormone. Personally, I don’t think blood tests are the most accurate diagnostic for thyroid function. Better are temps, including temps of extremities (feet, hands, nose and ears), taken first thing in the morning just after waking up, before eating, and 20–30 minutes after eating, pulse rate, achilles tendon reflex test and evaporation rate—total fluids consumed and eliminated via urine in a 24 hr period.

Here's a concrete example of where the information came from and how I used AI, in relation to microglia and inflammation. I don't master everything https://mirzoune-ciboulette.forumactif.org/t2174-neuropathologie-comment-attenuer-la-fibrose-en-cas-d-algodystrophie-et-de-fibromyalgie#30632 Excerpt Neuropathology & how to mitigate fibrosis in complex regional pain syndrome (CRPS) and fibromyalgia. Key ideas • Improve nerve conduction and limit hyperalgesia. • Limit fibrosis (dermal sclerosis) by modulating TGF-β1 stimulation. • Combined approach to fibrogenesis, the extracellular matrix (ECM), and inflammation. • Tactics to counteract fibrosis & optimize conduction – Practical aspects. Antifibrotic action of curcumin & dexamethasone. Anti-excitotoxic action of magnesium bisglycinate Neurotropic mechanism of action of thiamine (B1), pyridoxine (B6), and vitamin B12 in cases of heightened neurosensitivity and as modulators of inflammation PEA to stabilize mast cells and limit microglial activation. By stabilizing mast cells, PEA reduces the sensitization of peripheral and central nerves.

No proof with iodine on warf but ... I don't need a study to confirm the efficacity on every virus when it helps the immune system How effective is iodine as virucidal? (And by microbes, viruses, fungi and parasites) DOI: 10.1530/ERC-17-0515 Role of iodine metabolism in physiology and cancer. Endocr. Relat. Cancer. 2018 New research supports the exciting idea that I- participates as a protective antioxidant and can be oxidized to hypoiodite, a potent oxidant involved in the host defense against microorganisms. This was possibly the original role of I- in biological systems, before the appearance of TH in evolution. I- per se participates in its own regulation, and new evidence indicates that it may be antineoplastic, anti-proliferative and cytotoxic in human cancer. Alterations in the expression of I- transporters are associated with tumor development in a cancer-type-dependent manner. SARS-Cov-2 doi: 10.1371/journal.pone.0254341 The in vitro virucidal activity of intranasal Povidone-Iodine (PVP-I) has been demonstrated recently to reduce SARS-CoV-2 viral titers. EID (200 μg iodine/ml) after exposure for 60 and 90 seconds was compared to controls. In both cases, the viral titer was reduced by 99%. EID = Essential Iodine Drops. Influenza viruses Iodine, particularly in the form of povidone-iodine, is effective against influenza viruses by disrupting their structure and blocking their ability to attach to and enter host cells. How it works • Disrupts viral structure: Iodine makes structural changes to the viral coat by attacking key viral proteins • Blocks attachment: Iodine interferes with the hemagglutinin protein, preventing the virus from attaching to receptors on human cells. • Inhibits viral release: It also inhibits neuraminidase, a viral enzyme essential for releasing new virus particles from infected cells.

I think the most powerful tool for both SIBO and SIFO is MSM sulfur. This podcast by Dr Janel explains how well it has worked for antibiotic resistant sibo. Its cheap, safe and works. https://gijanel.com/gi-janel-one-video/

Get your eggs in! Spinach also is rich in lutein. Interestingly, cooking it doesn't degrade the lutein content. And having calcium with the spinach is two-fold beneficial: block oxalate absorption enhance lutein absorption by 30 to 40%

@Ecstatic_Hamster said in Does low TSH correlate with longevity and health: What do you think about this and why? I think that a low TSH is associated with health, especially when it occurs naturally without pharmaceuticals or exogenous hormones. I do not think that a low TSH is associated with longevity; but I think that a high TSH is associated with increased mortality (a shorter duration in lifespan). So there is an incentive to keep TSH low or at least on the low side of the normal range. As to the 'why", I have not read the literature but I have a general analogy. First, there has been an explosion in the number of people with Type II diabetes and the term adult onset diabetes is no longer appropiate since children also develop Type II diabetes. The general cause for this explosion is our modern lifestyle (with many non-ancestral components) which has over stimulated our hormonal insulin secretion. And for the analogy, lifestyle promotes high ISH (insulin secreting hormone). It takes years of high ISH before diabetes is diagnosed. [image: 1771780870851-e3378664-92f2-4d65-a6f7-8b80cc3897c1-image.png] I am wondering if high TSH will eventually result in thyroid problems, that is thyroid resistance and the lucrative medical manangement thereof. There are hotlinked references about thyroid resistance at the end of this article. Thyroid hormone resistance and its management (2016)

@CrumblingCookie nice

i am now re thinking this idea after finding another patent using losartan for hair US20160081901A1 - "Compositions and methods for hair growth"