From Dr. Peat:

“…So the reason for cooking meat or oysters or fish or whatever is to make sure that you've killed the parasites and microorganisms. There's no nutritional benefit at all from cooking them.

https://www.bioenergetic.life/clips/36a61?t=3773&c=80

@Uncover I think 2 weeks give or take but could take more.

@Serotoninskeptic ooops I can't read. I'm doing honey diet + using gelatin as primary protein source to get lean. Non-dietary just blast DNP

I'm not sure it's so (mis)calculated but still a reasonable illustration.

@alfredoolivas Thank you! I'll have to look into these things

The Insane Biology of: Humans

lol pushkin
runners.jpg

@haidut @Amazoniac @Mauritio Here's something unexpected in breast tumors,

EDIT: its in HER2-enriched breast cancer , so showing nuance between cancers here

using acetazolamide (most potent carbonic anhydrase inhibitor) surprisingly they said it caused tumors to grow. even though tumor pH lowered, and lactate lowered

https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-023-01644-1#Sec16

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so the beneficial Apoptosis effect you'd usually see happen in hypoxic cancered cells from the lower pH is hindered / prevented by another effect?
It didnt raise proliferation markers, didnt raise vessel growth,

The density of macrophages is high, T cells moderate, and B cells low; yet overall the abundance of these cell types is reduced by around half in breast cancer tissue from mice treated with acetazolamide compared to vehicle

so by the looks of it the lowered immune cell infiltration prevented the pro apoptosis effect

the extracellular carbonic anhydrases positively predict patient survival in HER2/ErbB2-enriched breast cancer

These observations suggest that carbonic anhydrases—likely via their ability to elevate tumor pHo (Figs. 6 and 8A)—provide an immune-stimulatory input that improves survival of patients with HER2-enriched breast cancer characterized by a weak immune response.

In contrast to HER2-enriched breast cancer, the association between extracellular carbonic anhydrase expression and patient survival in Basal-like breast cancer is seemingly unaffected by tumor inflammation

https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1268421/full Acidification of intracellular pH in MM tumor cells overcomes resistance to hypoxia-mediated apoptosis in vitro and in vivo

Hypoxia-mediated apoptosis of MM cells is correlated with acidic intracellular pHi (less than < 6.6) that is dependent on HIF activity. a carbonic anhydrase inhibitor (acetazolamide), and an NHE-1 inhibitor (amiloride) acidified the pHi and lead to cell death.
In contrast, treatment of cells with an alkalization agent, Na-lactate, rescued these cells by increasing the pHi (pH > 6.6). Finally, treatment of mice with acetazolamide decreased cell growth in the tumor nodules.

{{interestingly just 40 MICROgrams/kg i.p was used to slow tumor growth there)

So this approach should be effective in cancers not characterised by weak immune response , but for those that are, its detrimental to lower pH , (at least without added ph independent immune stimulus overcoming its inhibition , if possible)
(or maybe need to really drive the pH down lower to hit <6.6 ,
so no half measures there? but i think the 1st study already would have hit most of the CA IX inhibition/co2 raise with 40mg/kg i.p right?

here 40mg/kg orally inhibited lung tumor growth a little , and drastically lowered metastasis. so whether its a helpful or harmful effect does seem dependant on immune cell characteristics (otherwise if it worked at this dose here, it shouldnt have raised growth in the other) http://www.chinaphar.com/article/view/7735/8235

@wester130 said in Does anyone use the Thorne d and k (in one) drops?:

too early to tell

sometimes vitamin D can give tension in the body, I'm not sure I feel it with this

Ok, thanks. I've purchased some micellized D3 in the hopes it is the magic bullet for my vitamin D woes.

There are many production methods.
https://www.guanjiebio.com/news/how-many-plant-extracts-production-process-do-75963188.html

@war4512 @gg12 https://bioenergetic.forum/post/37610

This article appeared in my inbox. More support for apigenin protecting the liver.

Apigenin as an emerging hepatoprotective agent: current status and future perspectives (2024)

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@ThinPicking hell yeah

The big issue with this is something that I noticed when I was doing the warrior diet.

You really can’t metabolize more than around 25 or 30 g of protein at a time.

So your protein may be too low if you’re doing only one protein meal.

And you’re loading yourself with a lot of protein at one time, which increases ammonia levels and stresses your kidneys.

I now seem to tolerate milk much better, which is fantastic. Before I could feel it giving me brain fog, dandruff/ dermatitis, but recently I started drinking milk again: goat milk and non-homogenized cow's milk and I feel pretty good from it.

I also realized how much the quality of the thyroid product matters. Before I was using Levotiron for T4, now I use Novothyral (100mcg T4 and 20 mcg T3 per pill), and I started feeling better in days.

Novothyral is so far the best thyroid product I could get my hands on (in Europe).

@alfredoolivas it appears you are correct on that one! Finally, real progesterone.

@Kilgore Those kind of cravings are mad, consumes your whole mind 😂

The problem I have is because I'm always active, my bodies craving fuel constantly. Feels great when I'm having decent amount of carbs with moderate fats and protein but if I'm trying to lose weight I'm just constantly thinking about food at anything less than 3k calories.

But with carnivore I could easily drop to 2.5k or even a bit lower and the fats make me feel so full I barely even think about food, outside of occasionally craving fruit/rice.

I might just switch for a couple of weeks, I know it's not optimal but I'd rather do that for 2-3 weeks and get lean and get back to eating properly instead of trying to work a small calorie deficit for with carbs for a longer period.

Worth knowing...

and

peatbot: Peatbot: HCG, or human chorionic gonadotropin, is a hormone that is important for the health and intelligence of babies, particularly during pregnancy as it helps in strengthening the placenta. However, there are concerns about its use outside of pregnancy. It is suggested that HCG could promote the growth of hidden cancers, as some cancers produce HCG and it might have similar effects to pregnancy in accelerating cancer growth. Therefore, it is considered risky to use HCG for purposes such as weight loss until it can be shown that it does not promote cancer growth. Additionally, while HCG might help in treating some kinds of hypoglycemia, it should not be used or suppressed mindlessly.