why are you eating a not-varied diet in the first place

@Thyrotic Hey, did you survive?

As a counterpoint, I think I've crashed my estrogen with both androsterone and 11kDHT in the past but never noticed anything with my joints because I was taking boron at the same time.

Talk with AI (Claude) How efficient is the intake of a MK4 supplement, (with enough fat, hereby 25 g fat with some MUFAs), when taking 1 mg (1 000 mcg) K2 MK4? Question of vehicle only? No intermediate change into menadione, I suppose, since there is no digest process. Need a confirmation, whenever there is a target amount limited to 2-3 mg K2 supplement. Note: 2 takes of 1 mg MK4 at breakfast and midday meal, with 1 000 UI D3 (both at the same time, AKA 2 x 1 000 UI D3). Brain target. AI says (Claude): Summary: A moderate amount of D3 and K2 are co-absorbed in the same chylomicron pathway; so simultaneous intake is fine. Brain target and dose adequacy: 2 mg/day total is a reasonable range for a brain-focused protocol. Step 1 — Chylomicrons (intestinal phase, 0–4h postprandial) Step 2 — Chylomicron remnants → liver (4–6h) Step 3 — VLDL → IDL → LDL (hepatic re-export, hours to days) A possible route for extra-hepatic tissue supply is that part of the K-vitamins are re-packed into LDL, which forms a major transport system from the liver to peripheral tissues. ScienceDirect This is the key insight for your brain target — the liver processes the chylomicron-delivered MK4 and re-exports it via VLDL, which is then progressively remodeled into IDL and LDL for peripheral tissue delivery. Agarose gel electrophoresis of lipoprotein fractions after K2 supplementation revealed distinct chylomicron bands and variations in VLDL and HDL mobility, influenced by dietary lipids and VK2 supplementation. Wiley Online Library

COX-2 is overexpressed in advanced stages of tumors. Aspirin starts inhibiting COX-2 meaningfully after dosages of about 500mg (better would be >1g). Aspirin vindicated as an anti cancer drug. "Most solid tumors express the cyclooxygenase-2 (COX-2) protein, a target of NSAIDs. COX-2 overexpression in tumorsis considered a predictor of more advanced stage disease and of worse prognosis in a number of studies investigating solid malignancies. Therefore, NSAIDs are evaluated as anti-cancer drugs." Artificially overexpressing COX-2 makes mice more prone to developing tumors and knocking it out makes them less likely to develop tumors. "Both COX-1 and COX-2 are involved in tumor vascularization. COX inhibitors can directly affect angiogenesis [47]. " "Thus, COX-2 may be the cause of progression of estrogen-dependent breast cancer either directly by stimulating tumor cell proliferation, or indirectly by upregulating aromatase activity [60]. " "Part of the rationale for combining NSAIDs with chemotherapy involves circumvention of chemotherapy resistance mechanisms." https://pubmed.ncbi.nlm.nih.gov/16945549/ COX-2 inhibition makes chemotherapy (5-fluorouracil) more effective in vitro. https://pubmed.ncbi.nlm.nih.gov/21163769/

@alfredoolivas yeah im aware. Me and my son use this account. We are not on here though mainly the raypeat forum. And the reason i give him t3 is because his ATP production is bad.

skin surface way is capacitive coupling https://pubmed.ncbi.nlm.nih.gov/8200888/ this showed effect i dont have the info on their approach rn. non fusing fractures for 11+ months 6/10 fused vs 0 The non-union healed in six of the ten patients who had been managed actively but in none of the patients who had been managed with the placebo unit. https://www.semanticscholar.org/paper/Capacitively-coupled-electrical-stimulation-results-Abeed-Naseer/bc78f0db97ce86d9fc64d5487b91cee839744c8d 11 of non unions unified by 15 weeks applied through steel plates on the skin - healed if the plates were within 8cm of each other The only significant factor determining the success of healing was the distance between the plates; a distance of eighty millimeters or less resulted in healing in all cases https://pubmed.ncbi.nlm.nih.gov/8458140/ partial limb regeneration https://pmc.ncbi.nlm.nih.gov/articles/PMC4683620/ https://pmc.ncbi.nlm.nih.gov/articles/PMC3495370/

@Ray-Peat-Fanboy no politics allowed in my Christian ray peat forum

@engineer nop sadly not

@user73636 sounded like a gimmick at first but its well studied theres a lot on it, decent amount from japan , another way to get it without a machine is buying some elemental magnesium metal sticks or ribbons (safer to avoid as fine powder tho unless stored right). can add a stick or ribbon chunk to water and it will make hydrogen bubbles (added a small amount of malic acid to speed up getting past the oxide surface and a bit more hydrogen , then rinsing after drinking. i added it without malic and it still bubbled) https://bioenergetic.forum/topic/9291/hydrogen-dissolved-in-drinking-water-or-via-gastric-acid i reckon 200ug hydrogen at once would be good. trying to figure out how much a 10cm 130mg ribbon would give. max water saturation you can get is 1mg - 1.5mg per L but it reacts slow and without a lot of acid it forms a black layer. i read some papers where they dipped it for a short time and it had effect still

Here's a very peaty explanation of CO2 by a german doctor in bamberg. Might be worth a shot for some. https://dr-kersten.com/kann-die-co2-inhalation-den-energiestoffwechsel-normalisieren

@peaty-runescape I had a period coming back after being in menopause for over a year. I am also careful. I feel moody too when I take it.

@LunaticRed I shave my arms and apply it there and the inside of thighs currently.

@bio3nergetic this is reasonable, but hear ye, hear ye, some dudes are deeply, keanly, eagerly, needy, of healing an exceedingly teeny weeny thingy, albeit a bigly hearted beefy meany Peeny, by any means necessary. speaking for a friend.

@TexugoDoMel I haven't used it for a week now because I didn't like my moles darkening. So, I still have 19 more vials left sitting around and I have no clue what to do with them. Looks like maybe PT141 would still have the pro metabolic effects without the darkening but the MCR affinities are a little different. Maybe if I want a tan I could experiment with gene therapy to change the natural skin color? I don't know what Ray Peat thought about gene modification though.

my eyesight goes from -4.0 glasses to perfect 20/20 can see eagles in the distance and individual branches of trees a mile away and license plate numbers and letters when the sun is out and I have good posture

@thezynmaster have experience with tbol from PPL, Tbol is like a milder form of dbol or anadrol. You need testosterone or else you will crash hormones after a few weeks / post cycle. Just run 250mg total test pinned twice a week with tbol and you will get strong as fuck if you lift right. Ive been buying from PPL since 2017 theyre good to go. Not a shill just a dude whos been doing steroids for a long time lol. For the past 6ish months ive been taking tiny doses of anadrol (from PPL) as well, Ive put on 85-100 lbs in all my lifts but also been very consistent and on 250-300mg cypionate a week. You will for sure have a boost in strength and endurance when lifting but the drugs are only as important as how you workout, what you eat, and how well you sleep. for reference from personal experience with the orals in terms of strength/side effects. Superdrol>Anadrol/Dbol>Tbol I have taken all and Tbol is was milder than Sdrol and the anadrol/dbol. I also was taking milk thistle or TUDCA daily to help with liver strain.

@gg12 image is fake proves chem trails and powershortages simultaniously?

@engineer interesting I'd like to see that study. Georgi cured cancer by giving mice high doses of biotin (HED ~200mg), other b vitamins and aspirin. And there's also a few long term studies on very high dose biotin for MS and i don't recall that they saw any increased level of severe side effects (like cancer).

@cs3000 I interesting ! Oleanolic acid sounds interesting, too. I took ursolic acid today for the first time. And it caused some hair loss but also a profound sense of relaxation that haven't felt in a while.