Sorry if this has already been mentioned.
Some people use low-dose naltrexone for cancer. It seems like a low risk adjunctive. Ray Peat was not against its use.
Dandruff or scalp irritation? Try BLOO.
Sorry if this has already been mentioned.
Some people use low-dose naltrexone for cancer. It seems like a low risk adjunctive. Ray Peat was not against its use.
It would be nice to have more data on this subject.
dopamine from sunlight exposure has an antimyopia effect.
I'm going to use tyrosine and phenylalanine on my eyes as an experiment, along with several hours of bright light exposure. sodium bicarbonate too. I'll try to maintain this for a while.
If anyone has adamantane/diamant (or another dopaminergic), consider using it in your eyes for a few months and report the results.
a k2 supplement may help
"A few years ago I increased K2 intake (although not that radically) and noticed my face, particularly jawbone, looked wider." (RPF post)
other posters have mentioned this too, and also skin glowing effects. some say the effect on the jaw is ugly though
what is the viscosity like? What is the color? (pull the top off and look inside)
idk. selenium and thiamine are good at protecting from heavy metals. it is possible to overdo it with these, so be aware. thiamine needs sufficient magnesium. studies show vitamin C protecting against heavy metal exposure. so simply have some fruit everyday. avoid meat that someone hunted with lead ammunition. use copper ammunition instead.
milk is considered to be relatively pure of heavy metals, if I remember correctly.
@Crypt-Keeper he said his liver enzymes have been elevated for years I think
serotonin promotes blood coagulation, so cyproheptadine being anti-serotonin may have a blood thinning effect.
"Cyproheptadine can also cause bleeding issues, so I would not use it together with aspirin. Anything that inhibits serotonin will reduce platelet aggregation." (haidut)
"Something to consider.
http://www.ncbi.nlm.nih.gov/pubmed/24466319
'...Collectively, our data indicate that the antidepressant 5-HT2A antagonists, cyproheptadine and pizotifen do exert antiplatelet and thromboprotective effects, but similar to clopidogrel and EMD 281014, their use may interfere with normal hemostasis.'
I have seen other studies as well stating that cyproheptadine is known to prolong bleeding time in rodents so it was not considered optimal for some animal models such as hemorrhaging shock." (haidut)
maybe try a k2 supplement with it
"I think the main thing that causes that age-related interrupted sleep is that things like decreased thyroid function slow your digestive processes and as your blood sugar falls in darkness and when you're sleeping, the falling blood sugar lets you experience a toxic reaction to the whatever is in your intestine and the irritation, inflammation, and absorption of endotoxin and surges of serotonin from the intestine, those get into the bloodstream, finish off your stored glycogen and wake you up with a stress reaction. And so trying to have the calmest, cleanest intestine possible at bedtime..."
"Having a carrot salad or a good bowl of cooked mushrooms or some slightly antiseptic fiber like that in the early afternoon and then having a fairly low protein, high carbohydrate supper right before bed like ice cream or a chicken broth that's very salty. A combination of salt and sugar right at bedtime helps to relax the intestine for a longer period."
https://raypeatforum.com/community/threads/why-is-this-serotonin-receptor-type-bad.25497/
"there is a difference between plasma and platelet serotonin, and it's my understanding the 5HT2B is plasma, which is the very bad serotonin" by user alywest
and then
"1,4-naphthoquinones stimulate serotonin uptake in platelets in a manner similar to other SSRE such as tianeptine and in opposition to SSRI drugs like Prozac (fluoxetine)." by user haidut
So it seems like a good effect
No luck yet with chemically synthesizing the NAD prodrugs. Additionally, I've heard absorbtion is not great above 500 dalton molecular weight, which NAD itself is about 660.
There is a chance that vitamin E will enhance plain NAD by the way Ray Peat has spoken of. Additionally, an endogenous conjugate of the two has been found. It is called tocopheryl nicotinate. Perhaps tocopheryl NAD will be formed somehow.
For making progress on the DIY iontophoretic application of NAD, I need to explore the ways of protecting against heavy metal impurities. Much of these ions are positively charged and will enter the body alongside the NAD. If anyone has suggestions, I'd like to hear.
Soon I will be testing a theory about high dose inosine + caffeine + uridine + adenine + niacin being able to have the same effect as the NAD IVs (the compound is made up of B3 + adenosine so it makes logical sense to try this). In the past I got a decent result of my near lifelong absence of an appetite suddenly returning but then intense lower back pain and vomitting prevented me from continuing. This time I'm adding baking soda, vitamin E, salt supplementing, and magnesium.
This is mostly to update on the progress.