Topics created by basebolt

@basebolt

Perhaps it would be worth looking into eye drops with NAD+? You would try dissolving raw NAD+ powder into a super saturated yet eye safe solution, and putting a few drops in each eye.

Benefits would be felt in the brain the quickest, due to law of locality.

How was your bromantane experience? Have you tried kratom? Its not meant for long term use but its an antagonist at 5 ht2a and 2c iirc and agonises presynaptic 5 ht1a , also has some action at MOR (which we dont want but can be helpful short term esp. if pain issues) and at NMDA (antagonist). Its also an instant fix for anhedonia.

I am not sure it is that easy with NAC. Anecdotes are often incredible.

It is a (weakish) biofilm buster, scavenges aldehydes, interacts with heavy metals (iirc positively) along with what you already mentioned increasing glutathion. There is alot more to it and i think its magic as with most things lies in the right application at the right time.

Most chronic ill people i speculate have a bad persistent infection going on where NAC has its place.

In that sense it would help the energetic situation as its helping dealing with toxins and pathogens. As for a more general statement in healthy people i could see it being a net negative?

Even more so what one should consider doing to offset negative outcomes that could come with longterm use (ive been taking it for half a year now)

@jamezb46 said in Need To Figure Out Niacin and NAC Curing Me:

Can you link to any studies showing that 500-600mg Niacinamide daily caused any insulin resistance?

I'm not going to make this search for 3 reasons:

Need time and much energy. The excerpts from the study given by Amazoniac have already given 2 sources on excess B3. You could have been first trying to reach them. Note that the excess B3 must be understood on the long term, not in cure. The studies are not all clear (different conclusions).

B3 supplement has an impact on lipogenesis. The time period impact is said to be only for 2 hours. I don't feel it so (I took Kg / Lb weight when taking niacinamide 100 mg).
Niacin and niacinamide are said to affect lipolysis differently. In theory.

Examples of studies:
*) From “Long-term Treatment With Nicotinamide Induces Glucose Intolerance and Skeletal Muscle Lipotoxicity” p4
https://raypeatforum.com/community/threads/long-term-treatment-with-nicotinamide-induces-glucose-intolerance-and-skeletal-muscle-lipotoxicity.15393/post-211103
=> It is shown that nicotinamide and oxythiamine inhibit inclusion of C from glucose into free fatty acids, antivitamin intensifies lipolysis in the fatty tissue of the diseased animals."
*) Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277745/
NB: Possible adverse effect when taking B3 longer than 1 month.

Study Link (given by Amazoniac): https://doi.org/10.1038/hr.2011.133
https://www.nature.com/articles/hr2011133
35. Li D, Sun WP, Zhou YM, Liu QG, Zhou SS, Luo N, Bian FN, Zhao ZG, Guo M . Chronic niacin overload may be involved in the increased prevalence of obesity in US children. World J Gastroenterol 2010; 16: 2378–2387.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20480523
Conclusion: The appetite-stimulating effect of nicotinamide appears to involve oxidative stress. Excess niacin consumption may be a major factor in the increased obesity prevalence in US children.
=> A 3-h blood glucose was significantly lower after co-administration of glucose and 300 mg nicotinamide. The obesity prevalence among American children increased with the increasing per capita niacin consumption, the increasing grain contribution to niacin due to niacin-fortification, and the increasing niacin-fortified ready-to-eat cereal consumption, with a 10-year lag. The regression analyses showed that the obesity prevalence in the US children of all age groups was determined by niacin consumption.
60. Zhou SS, Li D, Sun WP, Guo M, Lun YZ, Zhou YM, Xiao FC, Jing LX, Sun SX, Zhang LB, Luo N, Bian FN, Zou W, Dong LB, Zhao ZG, Li SF, Gong XJ, Yu ZG, Sun CB, Zheng CL, Jiang DJ, Li ZN . Nicotinamide overload may play a role in the development of type 2 diabetes. World J Gastroenterol 2009; 15: 5674–5684.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19960564
Conclusion: These findings suggest that nicotinamide overload, which induced an increase in plasma N(1)-methylnicotinamide, associated with oxidative stress and insulin resistance, plays a role in type 2 diabetes.
=> Results: Diabetic subjects had significantly higher plasma N(1)-methylnicotinamide levels 5 h after a 100-mg nicotinamide load than the non-diabetic subjects.
Decrease in NAD/NADH ratio and increase in H(2)O(2) generation were also observed in human erythrocytes after exposure to N(1)-methylnicotinamide in vitro.
Note (LucH): increase in H(2)O(2) = Hydrogen peroxide => ROS = oxidative stress.