Posts made by basebolt

Hey Nate, I saw haidut mention thyroid, folate, and vitamin E as offering protection against plastic chemicals. (RPF link)

Then there is the concern of microplastic particulates. For this I bet aspirin and adamantane/Diamant would be good

@Mauritio said in Danny Roddy on "avoid liquid thyroid":

@basebolt that's interesting! I also only give it a couple of shakes.
Does that apply to tyromix only or tyronene as well?

Hmm.. it seems they are talking about tyromax (NDT). Probably less shaking is required for tyromix and tyronene.

The tablet should be dissolved or crushed before taking. Gericare brand I've heard is good because the only additive is corn starch. Ray Peat never took more than 500 mg in one go. He recommended the crystals over the powder and to refrigderate some and freeze the rest for longterm storage. Take 1 mg vitamin k2 per 325 mg aspirin, don't use k1. Lastly, take alongside gelatin and a bit of baking soda. (protects stomach)

On RPF, some spoke of the need to shake liquid thyroid very well

xeliex said: and by shake it, I mean shake it 40 times or more. I asked Georgi to ship it to me in a clear bottle one time to see how much shaking it takes to mix well. It takes a lot of shaking. Don't slack on them shakes.

Yes! Thank you for sharing this. My dad takes TyroMax, too, and no matter how many times I’ve explained to him that he needs to shake the heck out of the bottle, he only shakes it a few times and then tells me that he always has a thick layer of thyroid leftover when the bottle is finished, and that thyroid doesn’t work. I’ve been contemplating filling gelatin capsules with it so that he’s getting his full dose, but I just told him what you shared here and he shook his head okay so I think he may actually shake it more. lol Again, thank you!

1. become a doctor. they are in demand
2. become an unlicensed doctor
3. become an unlicensed psychologist/psychiatrist
4. sell shipping pallets on eBay. drive around to local businesses and ask if you can have their discarded pallets for free. sell for profit.
5. find people in the countryside to live with. do chores around the property in exchange for room and board.

1-3 are peaty because you are doing meaningful work and are clearly interested in the field
4 is adventerous and slightly manual labor and outdoors
5 is peaty because it is relaxing and have free time and more meaningful social connection

Thanks guys

The bad smell indicates undigested protein

What I know about t3 is the general advice is to go slow at first, take it with meals for slowing absorption and ensuring adequate fuel, and that it can take weeks to months before benefits.

I've heard that to find your dosage you should stay at a certain level for a week or so before increasing.

btw,
Ray has said hypothyroid people can wean off after 6 months I think. 6 months of being at a dose high enough to have good temp and pulse I assume. There is also something called Wilson's T3 Protocol where you slowly increase dose to around 150 mcg then back down (all over like several weeks). This is to deplete rt3. Sometimes several cycles are needed before your baseline is fixed which is the protocol's goal. You can read about it on RPF and other sites.

You mention psychosis, aggression, derealization, and memory loss. These are all associated strongly with depression. What I would recommend is get some basic blood work. Rule out thyroid issues, systemic inflammation, hormonal problems, low iron/ferritin, b12 deficiency. And look at liver enzymes and the other basics to see where they're at.

I'm not an expert and going by memory here, but a minimalist way of going about this would be something like
AST, ALT, hsCRP, ESR, CBC, CMP, lactic acid, TSH, total testosterone, prolactin, homocysteine, iron panel including ferritin.
Free testosterone maybe.

Marek Diagnostics, Link2Labs, Life Extension are some places to order from. Biotin can interfere with test results so be careful with that.

Take the PQ-9, patient questionnaire #9. See where you stand.

Rule out sleep apnea by recording yourself sleep and or using a continuous oxygen monitor.

Many Peaty things will tend to boost mood in coincidence with improved metabolism.

Feeling consistently much better. Still have chronic depression, however there is a sense of peace and calm now. It is more bearable.

The basic Peat advice is good and there are some specific things too that are potentially helping.

Methylene Blue
From a high quality source. Haidut mentioned 10 mg / day being useful for depression and that is what I use.

Cyproheptadine
Low dosage, and thrice per day because that makes it more effective. Sometimes my first dose will be metergoline instead.

Folinic acid
The other B9 forms, folic and methylfolate, are toxic at high doses. This isn't necessarily Peaty and could have negative effects. It apparently may have Peaty epigenetic effects. 20 mg / day from a dropper bottle.

Salt supplementing

AlloP from idealabs
High doses and low doses. Sometimes intranasally and in the eyes.

Many of these I cycle off of for a little bit. Will be trying Peaty euphoriants/antidepressants like LDN and selegiline (cautiously) soon. Also I see a psychologist infrequently.

Molasses has traditionally been viewed as healthy, but Ray was against its use. He said it promotes inflammation and cancer.

Sorry if this has already been mentioned.

Some people use low-dose naltrexone for cancer. It seems like a low risk adjunctive. Ray Peat was not against its use.

It would be nice to have more data on this subject.

dopamine from sunlight exposure has an antimyopia effect.

I'm going to use tyrosine and phenylalanine on my eyes as an experiment, along with several hours of bright light exposure. sodium bicarbonate too. I'll try to maintain this for a while.

If anyone has adamantane/diamant (or another dopaminergic), consider using it in your eyes for a few months and report the results.

a k2 supplement may help

"A few years ago I increased K2 intake (although not that radically) and noticed my face, particularly jawbone, looked wider." (RPF post)

other posters have mentioned this too, and also skin glowing effects. some say the effect on the jaw is ugly though

what is the viscosity like? What is the color? (pull the top off and look inside)

idk. selenium and thiamine are good at protecting from heavy metals. it is possible to overdo it with these, so be aware. thiamine needs sufficient magnesium. studies show vitamin C protecting against heavy metal exposure. so simply have some fruit everyday. avoid meat that someone hunted with lead ammunition. use copper ammunition instead.

milk is considered to be relatively pure of heavy metals, if I remember correctly.

@Crypt-Keeper he said his liver enzymes have been elevated for years I think

serotonin promotes blood coagulation, so cyproheptadine being anti-serotonin may have a blood thinning effect.

"Cyproheptadine can also cause bleeding issues, so I would not use it together with aspirin. Anything that inhibits serotonin will reduce platelet aggregation." (haidut)

"Something to consider.

http://www.ncbi.nlm.nih.gov/pubmed/24466319
'...Collectively, our data indicate that the antidepressant 5-HT2A antagonists, cyproheptadine and pizotifen do exert antiplatelet and thromboprotective effects, but similar to clopidogrel and EMD 281014, their use may interfere with normal hemostasis.'

I have seen other studies as well stating that cyproheptadine is known to prolong bleeding time in rodents so it was not considered optimal for some animal models such as hemorrhaging shock." (haidut)

maybe try a k2 supplement with it

"I think the main thing that causes that age-related interrupted sleep is that things like decreased thyroid function slow your digestive processes and as your blood sugar falls in darkness and when you're sleeping, the falling blood sugar lets you experience a toxic reaction to the whatever is in your intestine and the irritation, inflammation, and absorption of endotoxin and surges of serotonin from the intestine, those get into the bloodstream, finish off your stored glycogen and wake you up with a stress reaction. And so trying to have the calmest, cleanest intestine possible at bedtime..."

"Having a carrot salad or a good bowl of cooked mushrooms or some slightly antiseptic fiber like that in the early afternoon and then having a fairly low protein, high carbohydrate supper right before bed like ice cream or a chicken broth that's very salty. A combination of salt and sugar right at bedtime helps to relax the intestine for a longer period."

• Ray Peat