Dandruff or scalp irritation? Try BLOO.
https://raypeatforum.com/community/threads/why-is-this-serotonin-receptor-type-bad.25497/
"there is a difference between plasma and platelet serotonin, and it's my understanding the 5HT2B is plasma, which is the very bad serotonin" by user alywest
and then
"1,4-naphthoquinones stimulate serotonin uptake in platelets in a manner similar to other SSRE such as tianeptine and in opposition to SSRI drugs like Prozac (fluoxetine)." by user haidut
So it seems like a good effect
No luck yet with chemically synthesizing the NAD prodrugs. Additionally, I've heard absorbtion is not great above 500 dalton molecular weight, which NAD itself is about 660.
There is a chance that vitamin E will enhance plain NAD by the way Ray Peat has spoken of. Additionally, an endogenous conjugate of the two has been found. It is called tocopheryl nicotinate. Perhaps tocopheryl NAD will be formed somehow.
For making progress on the DIY iontophoretic application of NAD, I need to explore the ways of protecting against heavy metal impurities. Much of these ions are positively charged and will enter the body alongside the NAD. If anyone has suggestions, I'd like to hear.
Soon I will be testing a theory about high dose inosine + caffeine + uridine + adenine + niacin being able to have the same effect as the NAD IVs (the compound is made up of B3 + adenosine so it makes logical sense to try this). In the past I got a decent result of my near lifelong absence of an appetite suddenly returning but then intense lower back pain and vomitting prevented me from continuing. This time I'm adding baking soda, vitamin E, salt supplementing, and magnesium.
This is mostly to update on the progress.
This post has some nice info
https://chrismasterjohnphd.substack.com/p/this-is-what-causes-b6-toxicity
high estrogen, inflammation, high protein intake, and sulfur dysregulation are mentioned as increasing the need for b6
He states neuropathy can happen with pyridoxine and P5P. That it may get worse for weeks after stopping but usually will resolve.
Anyone have access to the full version and can share his thoughts on the mechanism of toxicity?
@Energia said in Rapid Deterioration?:
The most recent labs have been relatively normal. Cortisol levels have actually lowered over the past few years and at this point are probably within the range of normal or borderline high ( probably not enough to be causing issues this substantially). Looking at family history more closely is what lead me to consider ehlers danlos, more specifically the vascular type possibly. Autoimmune type issues seem to have taken over ever since cortisol started to lower. Although inflammatory tests such as CRP, ESR are normal, antibody tests negative, so autoimmunity is probably out of the picture. In fact, ferritin levels were low also surprisingly, so inflammation seems unlikely. Estrogen total was normal, on the somewhat lower end of the scale actually. Both regular and ionized calcium normal. TSH was around 3.0 but then dropped to about 1.4 within like a month (still had symptoms). The most common trend seems to be high protein and albumin results Cortisol shredding through protein? Also, low lymphocytes occasionally. Anyone have any other ideas? Thanks again.
Dr. Gupta AI (created by Martin Shkreli) says "High protein levels can be caused by various factors including dehydration, infections, inflammation, or liver or kidney disease."
Have you tested GFR? Also lactate would be a good test in general.
Joint and skin weakness, try gelatin.
Stress issues, try inosine and salt supplementation. Test inosine for at least a month to gauge effect.
Underweight and low appetite, try cyproheptadine. Low dose, taken three times per day for best effect.
Indigestion / GERD, try ACV capsules with each meal. Among other effects, this may kill any H. Pylori.
metabolomics testing: iollo.com (you will only get useful info about the biomarkers that are in their reports though, not all of them)(Y Combinator funded company)
DNA testing: whole genome at sequencing.com (recommended by Chris Masterjohn PhD) can show Ehlers Danlos.
@babou said in Low dose DHT experiment log:
Mg conversion of 10% gel: 0.10 mL liquid = 100 mg liquid, 10% DHT = 1mg active dht per 0.01 mL (Abt 1 drop)
my understanding is that there are 20 drops in a mL. This means there are 5 mg of DHT per drop. Could be more depending on the viscosity of the gel
It found a significant and prolonged increase in creatine phosphokinase after exercise. A significantly greater serum myoglobin during exercise. No difference in DOMS. This could potentially increase the stressfulness of exercise to the body, but potentially one could exercise more lightly and less frequency and get the same benefits. Along the lines of what you're saying.
Something that looks interesting is the glasses from Kubota Pharmaceuticals. They use micro LEDs to project a myopically defocused image into the eyes.
It isn't clear if actually reversal can occur or if it is just for stopping the progression. The info that first came out often mentioned reversal.
Here is some info
"Innovative, first-in-class myopia control devices seeking to reduce the progression of myopia by projecting myopically-defocused virtual images generated using micro-LEDS on the peripheral visual field to actively stimulate the retina
➢ Passive stimulation using myopic defocus is already in use in an FDA-approved contact lens
➢ Projecting a myopically defocused image on the peripheral retina generates a growth signal that moves the retina inwards, inhibiting myopia progression, while a hyperopically defocused image causes the reverse effect"
This suggests reversal is possible. Also in one of their patents reversal is mentioned.
Then there is this study showing axial length shortening and myopia reversal using their tech.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279468/
"the estimated treatment effect improved by 6.051 microns (95% CI: 1.500 to 10.604 microns; p = 0.006) per month of treatment (Fig. 4); that is, with each month of treatment, the test eye becomes 6.051 microns shorter than that of the control eye."
"Using a repeated-measures regression model, the estimated treatment effect improved by 0.068 D (95% CI: 0.011 to 0.125; p = 0.011) per month of treatment."
The glasses are available for five thousand dollars, sold specifically for halting progression, so my concern is that maybe due to legal reasons they had to limit the tech to only halt progression not reverse.
https://www.sciencedaily.com/releases/2014/01/140127164559.htm
Has anyone seen this, which shows D2 supplementation in athletes resulted in poor outcomes, including lowering serum d3?
Something to consider is that they always seem to want to order CT scans. Both times I was in the hospital for sepsis I got head and chest CT scan. Chest X-ray too. X-ray is about 80 times less strong than CT, if I remember. They may do this for liability reasons.
Ray Peat's stance is to avoid these unless necessary.
I saw a post on RPF by haidut about niacinamide and inosine for protecting against radiation from scans. the advice was to take them before and after. and maybe for a few days afterward too. there are other things like maybe ginger and vitamin c and other that could protect too. so maybe get the scan with these in order to have more knowledge about the health problems you have
Something just doesn't taste right about it. I only have experience with one brand so far. It seems this is a common experience though.
Somewhere I read a little hack about adding a little self-squeezed fresh juice to reconstituted OJ in order to improve the flavor.
I want to share an alternative method that is easier. Add ginger extract to it, and that's all. An alcohol extract of ginger I made is what I've been using. The amount is quite a bit. There is not a strong ginger taste. Bonus is that ginger is health-promoting and getting large amounts like with this method may increase testosterone but also there is risk of lowering iron too much that occurs with all herbs.
Does anyone know if topical fatty acids increase serum fatty acids? That would make this a bad idea if true, right?
@Energia said in Any info on sepsis/bacteremia? Antibiotics used?:
Anyone familiar with how this is typically treated and what types of antibiotics are commonly used? How safe are these specific antibiotics (I know some antibiotics are more favored than others by this community)? Any tips for how to go about treating this?
I have had sepsis before. Two times requiring hospitalization. It isn't clear to me what you are experiencing. You mention neurological issues. Sepsis usually elevates your heart rate, how is yours? Sepsis can progress in to septic shock which means low blood pressure, low tissue perfusion, and potentially if this continues damage to liver (temporary hopefully) and necrosing of toes fingers limbs.
Check your blood pressure. Check liver enzymes maybe. And blood lactate test associated with the metabolic acidosis that occurs in sepsis. There are other tests too but im no expert.
Usually sepsis is not chronic.
My protocol that prevented me from having to go to the hospital when I got sepsis a third and fourth time:
ginger extract to prevent vomitting and allow supplementation
bag breathing
1 g of aspirin, the optimal amount theorized to stimulate the immune system, taken dissolved and alongside baking soda and gelatin for stomach protection
licorice extract as a glucocordicoid because that has positive results on sepsis
pregnenolone or progesterone
methylene blue at low to moderate dose maybe 10 mg because this inhibits nitric oxide which is elevated in sepsis
high dose thiamine because this was shown to yield positive results in sepsis, but could be taxing on your system if low in magnesium
inosine (not inositol) because studies showed positive results in sepsis. 1.5 grams per day is likely safe
multivitamin
beef liver
vitamin c because it was proven to have positive results
vitamin b3
(this is all from memory, so I have probably forgotten something)
many of these things synergize with each other, and that is critical for the success.
I also used an IV service where a mobile nurse came out and administered myer's cocktail, containing salt, vitamin C, zinc, magnesium, and others.
Salt supplementing will keep blood pressure up if thats an issue.
Let us pray that one day hospitals will adopt a more energetically-centered approach like this.
thiamine could be something to try if crypro isn't good. the rationale is that thiamine has a general anti-toxic effect and relationship with serotonin.
thiamine deficiency increases serotonin and thiamine excess, without magnesium, increases serotonin too. so modest physiological doses of 2mg-10mg with or without some magnesium. this would be dosing in line with ray peat's recommendation
you can try ginger root
I looked briefly at https://bioenergetic.life/?q=nausea
It mentions cryptoheptadine, scopolamine, and salt and sugar for nausea.
ingesting cocao powder has a protective effect against the sun
I think the vodka/alcohol in your formulation may have a negative effect.
Have you tried browsing bioenergetic.life to see info related to hair regrowth and atp? Maybe co2 therapy topically would be good. Massages. Low intensity red light (too high can harm).
Salt is significantly improving my quality of life. Every hour I take about a gram and a half. No negative effect on BP. The chloride can have an acidifying effect on the body so to bring more balance I sometimes take baking soda instead.
I'm two weeks into this.
NAC kills brain cells according to Peat.
inosine is good for atp, it is a component of cardenosine