@Vapid-Bobcat said in Why is the epidemiological literature overwhelmingly in favor of PUFAs?:
In pretty much every retrospective, cohort study or RCT I happen to take a look at, higher PUFA consumption, especially linoleic acid, almost always leads to better outcomes than lower PUFA consumption.
@Vapid-Bobcat I suspect that there are ulterior motives. But then, I've become pretty cynical.
Sometimes animal research performed for the preservation of an industry (and making $) provides better designed studies and interesting results that can be extrapolated to humans in general ways.
Thiamine Deficiency M74 Developed in Salmon (Salmo salar) Stocks in Two Baltic Sea Areas after the Hatching of Large Year-Classes of Two Clupeid Species—Detected by Fatty Acid Signature Analysis
"Fatty fish that feed on fatty marine prey fish are prone to suffer from thiamine deficiency [1,13] because the requirement for thiamine increases with the increase in the diet’s energy content [14] and because thiamine is depleted as a consequence of lipid peroxidation [14,15,16]."
"In fish with a high tissue concentration of n−3 PUFAs, thiamine can be depleted during the pre-spawning fast so that the eggs do not provide enough thiamine for the yolk-sac fry (free embryos or eleutheroembryos [23]) to develop. Thiamine deficiency, therefore, primarily affects yolk-sac fry [8,24,25], which must survive on yolk nutrients from hatching to the alevin stage, i.e., the stage when the hatched fry start external feeding [23]. As THIAM is a reserve form of thiamine, its concentration of the different thiamine components in eggs varies most, depending on the female’s thiamine status [8]. The thiamine deficiency of the offspring of fish can, therefore, be predicted from the THIAM concentration of the eggs [8,26]. At worst, thiamine deficiency can be seen as weakness and loss of equilibrium in brood fish before spawning, and they may die before spawning [8,27,28,29]."
also:
Changes in thiamine concentrations, fatty acid composition, and some other lipid-related biochemical indices in Baltic Sea Atlantic salmon (Salmo salar) during the spawning run and pre-spawning fasting
also:
Fatty acid signatures connect thiamine deficiency with the diet of the Atlantic salmon (Salmo salar) feeding in the Baltic Sea
"Thiamine is an essential micronutrient, which has a central role in energy metabolism (Lonsdale 2006) and also a linkage to fatty acid (FA) metabolism. Moreover, thiamine serves as an antioxidant (Lukienko et al. 2000; Gibson and Zhang 2002). Fish need to obtain thiamine from their diet (Niimi et al. 1997), and the requirement for it depends on the energy density of the food (Woodward 1994). As the net energy value of lipids is more than double that of proteins (Kriketos et al. 2000), the need for thiamine largely depends on the lipid content of prey fish."
-end pastes-
I think that each of these studies confirm Ray Peat's work regarding fats. The added wrinkle is the connection to thiamine deficiency. Thiamine deficiency is implicated in many of today's chronic diseases, including coronary heart disease, diabetes, and the dementias.
