extremely real, my skull and bone all became thicker when i first started peating.

@CurmudgeonApple They use same metabolic pathways and when combined they synergistic effect. Metformin + Berberine combination is superior to using only one medication.

@77sahara an important one is by b. a. houssay, who showed that a high saturated fat diet prevented diabetes in rats and a high pufa diet caused it. "In 1947, B. A. Houssay found that a diet based on sugar as a source of energy was more protective against diabetes than a diet based on lard, while the most protective diet was based on coconut oil. Lard reflects the pigs' diet, and is usually extremely unsaturated, especially since it became standard to fatten them on soybeans and corn. Essentially, his study seems to show that unsaturated (pork) fat permits diabetes to develop, sugar is slightly protective, and coconut oil is very protective against the form of diabetes caused by a poison." piorry and bud cured diabetics using large amounts of sugar in the 1800s. "Budd described another patient, a young man who had become too weak to work and who was losing weight at an extreme rate. Budd's prescription included 8 ounces of white sugar and 4 ounces of honey every day, and again, instead of increasing the amount of glucose in the urine, the amount decreased quickly as the patient began eating almost as much sugar as was being lost initially, and then as the loss of sugar in the urine decreased, the patient gained weight and recovered his strength." the hyperglycemia in diabetes is the liver overproducing glucose , not a build up of unused sugar. diabetics die quicker without sugar. "Since the first doctor noticed, hundreds of years ago, that the urine of a diabetic patient tasted sweet, it has been common to call the condition the sugar disease, or sugar diabetes, and since nothing was known about physiological chemistry, it was commonly believed that eating too much sugar had to be the cause, since the ability of the body to convert the protein in tissues into sugar wasn’t discovered until 1848, by Claude Bernard (who realized that diabetics lost more sugar than they took in). Even though patients continued to pass sugar in their urine until they died, despite the elimination of sugar from their diet, medical policy required that they be restrained to keep them from eating sugar. That prescientific medical belief, that eating sugar causes diabetes, is still held by a very large number, probably the majority, of physicians." insulin allows you to use the glucose but it also blocks the free fatty acids “Diabetes is caused by excess FFA floating in the blood, which blocks sugar oxidation as per the Randle cycle. Niacinamide lowers excess lipolysis/FFA and thus allows the cell to oxidize sugar again. Insulin also lowers FFA and also stimulates the glucose oxidation. This is why it is a therapy for diabetes. Diabetics have high FFA and glucose in the blood but the former part is almost never mentioned by doctors unless somebody ends up in ketoacidosis (driven by excess FFA) and even then the narrative is somehow still shifted to blame the "evil" sugar, while hyperglycemia is just a sign of high FFA.” -haidut https://raypeat.com/articles/articles/sugar-issues.shtml https://raypeat.com/articles/articles/glycemia.shtml https://raypeat.com/articles/articles/glucose-sucrose-diabetes.shtml https://raypeat.com/articles/articles/diabetes.shtml

@donovan all the studies for HPA seem to be on incipient decay, not progressed decay with destroyed enamel and tooth structure, so there’s no clear research I’ve found on the structure being re-formed through the introduction of enamel-like components. Possible that scientists just assume it isn’t possible so they haven’t studied it, although it seems plausible that if you can restrengthen existing enamel with calcium and phosphorus those same minerals will reform the structure itself.

UCP1 activation is also one of the pathways thought of that methionine restriction causes lifespan extension: [image: 1706873358448-67f2904f-dd47-446a-9824-509da944a385-image-resized.png] https://pubmed.ncbi.nlm.nih.gov/34263088/

Very nice find, thanks.

@brad I am aware of the Products section- it seems to mostly be a "what do y'all recommend?" situation. I was thinking something more specific in regards to presenting products, tech specs, etc. for sellers to post. It's one thing to say "buy xyz", it's another to have a detailed writeup from a seller about their product and the evidence for it. Does that make sense? I understand that we don't want to become too commercialized or become a captive market for people. Appreciate you doing the work to get this forum up and running!

@cupofcoffee I would reckon this is also partially due to the effect of aspirin on things like IL-6 and reduction of IBA1 aka AIF1. Plasticity is the natural state of the brain, barring metabolic dysregulation. Worth noting that AIF-1 is normally only present in inflammatory situations and controls blood vessel formation; therefore, reduced expression would indicate reduced inflammation and indicate reduced risk of atherosclerosis, vessel thickening, stroke, etc. A Mild Dose of Aspirin Promotes Hippocampal Neurogenesis and Working Memory in Experimental Ageing Mice

@PUFADestroyerPPO taurine especially great for combat sports for the prehab / rehab effects on brain injuries. Protective effects of taurine in traumatic brain injury via mitochondria and cerebral blood flow Protective effects of taurine against inflammation, apoptosis, and oxidative stress in brain injury