@donovan all the studies for HPA seem to be on incipient decay, not progressed decay with destroyed enamel and tooth structure, so there’s no clear research I’ve found on the structure being re-formed through the introduction of enamel-like components. Possible that scientists just assume it isn’t possible so they haven’t studied it, although it seems plausible that if you can restrengthen existing enamel with calcium and phosphorus those same minerals will reform the structure itself.

UCP1 activation is also one of the pathways thought of that methionine restriction causes lifespan extension: [image: 1706873358448-67f2904f-dd47-446a-9824-509da944a385-image-resized.png] https://pubmed.ncbi.nlm.nih.gov/34263088/

Very nice find, thanks.

@brad I am aware of the Products section- it seems to mostly be a "what do y'all recommend?" situation. I was thinking something more specific in regards to presenting products, tech specs, etc. for sellers to post. It's one thing to say "buy xyz", it's another to have a detailed writeup from a seller about their product and the evidence for it. Does that make sense? I understand that we don't want to become too commercialized or become a captive market for people. Appreciate you doing the work to get this forum up and running!

@cupofcoffee I would reckon this is also partially due to the effect of aspirin on things like IL-6 and reduction of IBA1 aka AIF1. Plasticity is the natural state of the brain, barring metabolic dysregulation. Worth noting that AIF-1 is normally only present in inflammatory situations and controls blood vessel formation; therefore, reduced expression would indicate reduced inflammation and indicate reduced risk of atherosclerosis, vessel thickening, stroke, etc. A Mild Dose of Aspirin Promotes Hippocampal Neurogenesis and Working Memory in Experimental Ageing Mice

@PUFADestroyerPPO taurine especially great for combat sports for the prehab / rehab effects on brain injuries. Protective effects of taurine in traumatic brain injury via mitochondria and cerebral blood flow Protective effects of taurine against inflammation, apoptosis, and oxidative stress in brain injury