@questforhealth From this perspective yes. I personally prefer raw milk, but have not had noticeable issues with ultra pasteurized homogenized milk. However, if drinking lower quality milk, it can’t hurt to get a little extra folate, either from supplements or food.

@Appa Well said. Very much lines up with my experience and I couldn't help but notice the similarities with SSRI's on mood, behavior, sleep, appetite. It turns you into a zombie. Cypro made me sleep, hungry, and foggy. Never liked it. Now I have these unwanted side effects long term... that I'm thinking of correcting with a serotonin agonist. Any recommendations for an agonist?

Trace Element Speciation in Food ↳ [54] Iron and Zinc Compounds in the Muscle Meats of Beef, Lamb, Pork and Chicken "Figure 1 shows that the soluble zinc in all meats is distributed between five main components. The first zinc peak corresponds to the exclusion volume of the column (molecular weight approximately 130 000) and therefore represents high molecular weight zinc. The zinc in this peak is possibly associated with a-macroglobulin which has a molecular weight of 820 000 and is known to account for one-third of all plasma zinc.[30] Zinc peak II eluted in the same volume as the reference protein, transferrin, at a molecular weight of 76 000. Transferrin is known to bind a small amount of plasma zinc.[30] The third zinc peak is very large and eluted at a molecular weight of approximately 65 000. Some, if not all, of the zinc in this peak is probably bound to albumin (molecular weight 67 000). Albumin is one of the sarcoplasmic proteins of meat[31] and is the predominant form of zinc in plasma.[30] Zinc peak IV is also large and eluted at a molecular weight of approximately 35 000. This peak probably consists of the zinc metallo-enzyme carbonic anhydrase which has the same molecular weight, is a major soluble form of zinc in liver,[32] and accounts for nearly all the zinc found in erythrocytes.[30] The fifth zinc peak eluted in a volume corresponding to low molecular weight compounds (< 12 000). The fractions from zinc peak Vb reacted with ninhydrin which suggests that this peak consists of zinc bound to amino acids.[19] Fractions from peak Va showed no reaction with ninhydrin and therefore probably consist of zinc bound to small peptides." [image: 1710812258296-5a53761c-680e-43b4-8835-c7df9d5d7917-image.png]

@questforhealth the problem seems to be that you’ll never approach 1mg of vitamin K2 from most foods. The most concentrated source is natto and even though it does have about 600mcg per the most common serving size, most people here won’t touch it because it’s a soybean food containing significant PUFA; also the form is MK-7 not MK-4, which is viewed as a disadvantage by most

@Kvothe said in Vitamin A increases T3 by more than 60% in humans!: Some dude posted this study on RPF. In rats, an equivalent dose was enough increases TSH and suppress T3. I personally experienced that anything over an extra 5.000IU can be suppressive for a mildy hypothyroid person. https://link.springer.com/content/pdf/10.1007/s00394-022-02945-5.pdf [image: 1710202886357-0db5dde3-7db7-4cfb-8447-a8fe77b96aba-grafik.png] Well that dude (sinatra) probably has the study from this thread here (https://bioenergetic.forum/post/12395) where I posted it a few days before him, it's interesting that he did not post the main study of this very thread or any of the other pro-vitamin A things I posted. The HED of about 30k IU per day is still realtively high. And i agree that this can make you hypo, which peat has said for decades. On the other hand the study, which this thread is about (human study, not rat) shows clear benefits in a similar dosage.

Thanks for sharing. Activation of the PXR/SXR is an interesting thing in and of itself. It increases phase 1,2 and 3 detoxification in the liver and increases CYP3A4. Other ligands are for example: progesterone, 5aDHP or bile acids. The authors of this study hypothesize that the liver-regenerating capabilites of Vitamin K2 were reliant on PXR-activation. All the nucelar "X" receptors are really interesting, the FXR probably beeing my favorite. PXR/SXR also upregulates a protein that takes up and excretes prostaglandins. So vitamin K leads to less PUFA/prostaglandin metabolites and damage.

@Master Too bad but thanks anyway Master.

How's your thyroid, what's your waking up temp? It's probably not good since your sleep is bad.

@GreekDemiGod Are you trolling?

@Mauritio said in Vitamin A quotes from Ray's favorite physiology book: @Peatly said in Vitamin A quotes from Ray's favorite physiology book: @Mauritio There are huge variations in results for vitamin A studies. I think Dr Peat’s recommendation, which is to be cautious if hypothyroid, seems reasonable. I would like to see that Iranian study replicated elsewhere – especially in regions where Billy Goat is blocking the sun. Yes, I agree. What does it have to do with the sun/ Vitamin D? I was under the impression that being exposed to sunlight, for extended periods, increases your vitamin A requirements. I was thinking that if the sun is being blocked this might lower need? Dr Peat talking about light exposure and vitamin A This is the dentist Dr Peat mentions in that clip Emanuel Cheraskin, M.D., D.M.D., late Professor of Oral Medicine at the University of Birmingham, AL. The "ideal" daily vitamin A intake Relationship of vitamin A and oral leukoplakia

@banquos-ghost I originally started taking NDT by the Life Giving Store, around four years ago. When I first started taking it, it worked for me but stopped working about a year after I started it (my TSH went up to 3.0 and I still had all of my hypo symptoms). What ended up working the best for me and what I take now is Cynomel (I break up one pill into four pieces and take it throughout the day with meals). Then starting around 6:00 PM, I take one drop of Tyromix. I take one drop of that every 1.5 hours until I go to bed. So, I end up taking 5 drops total of Tyromix (orally) and spread out. That amount of Tyromix is what helps me sleep throughout the entire night without waking up, and that is the marker that I use to decide the dosage of the Tyromix.

https://pubmed.ncbi.nlm.nih.gov/27565891/#affiliation-4 Agmatine is very peaty? I think Dr Peat mentioned agmatine somewhere? I'm currently dealing with rabid insomnia. I pray this helps.

@Amazoniac said in Vitamin C in the prevention of cellular respiration (CcO) inhibition by sulfide: 200 mg ascorbic acid per day Practical application: that's roughly the amount in 500ml of orange juice, less if it's fresh.