@yerrag said in Vitamin D deficiency may drive myopia, supplementing may prevent/treat it: I hope though, that the evolution if the field of bioenergetics would see us sharing more success stories. Success is not as much the taking of individual substances as magic bullets. It is more a process of seeing each substance as a role player than a star that leads one to the championship and winning it. It is a team effort, and there is a process to it. I totally agree.

Thanks for sharing Georgi! Awesome study!

I work with vaccines in healthcare. The below conclusion of a study used to have some interest. Now you hear nothing about it anymore. I'm still very suspicious. The US childhood immunization schedule requires 26 vaccine doses for infants aged less than 1 year, the most in the world, yet 33 nations have better IMRs. Using linear regression, the immunization schedules of these 34 nations were examined and a correlation coefficient of 0.70 (p < 0.0001) was found between IMRs and the number of vaccine doses routinely given to infants. When nations were grouped into five different vaccine dose ranges (12–14, 15–17, 18–20, 21–23, and 24–26), 98.3% of the total variance in IMR was explained by the unweighted linear regression model. These findings demonstrate a counter-intuitive relationship: nations that require more vaccine doses tend to have higher infant mortality rates. Efforts to reduce the relatively high US IMR have been elusive. Finding ways to lower preterm birth rates should be a high priority. However, preventing premature births is just a partial solution to reduce infant deaths. A closer inspection of correlations between vaccine doses, biochemical or synergistic toxicity, and IMRs, is essential. All nations—rich and poor, advanced and developing—have an obligation to determine whether their immunization schedules are achieving their desired goals.

@Norwegian-Mugabe said in PUFA can cause male infertility by inhibiting oxidative metabolism (OXPHOS): People will let other men impregnate their wife before fixing their diets. Wow, where did this come from? I had to reread the original post twice. Nope, this comment is a complete nonsequitur.

So, would a supplement like Magnesium Lactate be a cause for concern?

@albion Copied from Georgi's thread at the old forum. Aspirin-induced long-term tumor remission in hepatocellular carcinoma with adenomatous polyposis coli stop-gain mutation: A case report - PubMed

@Emilia your best bet is to convince tardchan that Peat is a subversive antistasi and a quick low-profile subversion of his enemies (actual wins are the ones that go unnoticed) is to hackerchan the rationalwiki using all tactics possible (I condemn such actions). This will be the most realistic practical way to yield results. Or, spend 2 years getting into their inner circle, and slowly counter edit in inconspicuous ways that actually undermines their credibility further. Ply some toxic femininity here for best results.

@b1 said in Effect of Aspirin on Male Hormones, Testicular and Epididymal Histology In Mice: @GreekDemiGod So take iron supplements or consume more iron to counteract this? I personally wouldn't. Iron supplements are dangerous, and it can be a potent oxidizer. Almost as bad as PUFA. Unless you've got cancer, there's never really a reason to take more than 1,000mg a day. Even less in most cases will work. 500mg is enough to lower stress and free fatty acids.

@evan-hinkle said in Doxycycline has antidepressant effects by lowering nitric oxide in mice: @Mulloch94 thanks for posting this. I’m curious as to whether or not the benefit came from blocking or eliminating the endotoxin the mice were injected with, or if doxy itself lowered the iNOS that was upregulated due to the endotoxin? Haidut had an old post talking about endotoxin being a typical cause of back pain. I’ve had unexplained back pain for a few years now that hits every morning but goes away as the day progresses. I assume it’s endotoxin related as I’ve had endotoxin issues in the past. I have used doxy, but never at the dose suggested here, (HED would be about 4mg/kg I believe). May give this a shot. Thanks! No problem! I'm sure there's some synergy between lowering the endotoxin and blocking nitric oxide. But if I had to guess, at least according to this study, the main mechanism is behind the nitric oxide suppressing effects. Because when they administered sodium nitroprusside the antidepressant action of doxy was inhibited.

Grant’s conclusion is weird. Goes from rice -> fortified sourdough + honey. Calories increased from the paltry ~1600 he ate previously. States he hasn’t exercised much either. 8 months later gets dry itchy scalp. Switches to German non-fortified buns + honey, recovers fully in 5 months. Conclusion is… blame niacin? What about everything else in fortified flour? Why not switch back the working diet and supplement nicotinic acid to isolate affect? Also, isn’t niacin in fortified foods really niacinamide? What?

@yerrag I think the arts helped me to comprehend motifs, form and architecture and make abstract connections. I needed them though. I was a dyslexic child and received the weirdest report cards. Regina is a delightful child with many interests other than math. While her work is very creative, her homework does not reflect what was assigned. At all. Please monitor her work at home so we can resolve this matter. Hahaha. Oh well.

Great info, thank you very much.

@haidut said in Fish oil (omega-3) causes, not prevents cardiovascular disease (CVD): using fish oil on a regular basis might actually increase the risk for healthy people to go on and develop first-time heart disease and stroke.” Thank you for the highlighting and the source. One question still remains unanswered. Preamble I am aware that it is necessary to avoid taking omega-3 supplements because they are easily altered, even if protected (…) and then thus contribute to the alteration of the oxidized membranes, especially when the support of tocopherols is absent (clearly insufficient via food). I take 500 IU from a 2x/week mix (Gamma E Complex, Now Foods). I read that the intake of vitamin E can saturate fat acids with long chains. (I didn’t find the source back, and this requires confirmation). 20 mg Vit for 10 gr of AGPI are required. =>Ratio vitamin E / fatty acid in mg / g: 0.3/mono-; 2/di-; 3/tri-; 4/tetra-; 5/penta-; 6/hexaenoic fatty acid. (1-4) Deduction: 10 gr omega-6 (ALA) needs 2 mg x 10 = 20 mg vit E. Situation The person regularly consumes less than 10 gr of PUFA per day, including 1.5 gr of ALA. He / I aim at 6 gr LA and 0.5 to 1 gr of omega-3. He also takes 0.2 gr from Vit C per day, 100 mcg Se 2x/ week. 2x/ week 500 UI of Toco (5) This person suffers from recurrent latent inflammation (backpain). He was doing a rotating with salicine, curcumin and Celadrin, for more than 15 years, without really taking a break, except when he was doing a water fast. (Not fine for the CYP450 evacuation pathway). But since this person did a treatment with vitamin B6 (100 mg PLP) (B1 B2 B3 B6 + TMG, according to a protocol and with pause), the pain manifests itself very rarely. B6 is also anti-inflammatory and moderates the immune response. Question Knowing that it would be appropriate to avoid adding a layer to the problem – oxidation of PUFA’s –, knowing that the ratio and the amount AL / ALA is under control and at a moderate level (important), is it coherent / adequate to take half a tsp (2 gr) of oil rich in EPA, on a intermittent way, well protected from oxidation (important). Note that the protection time is only valid for 3 months, once the bottle is opened. After this period, I add an antioxidant (2 drops of Rosemary H.E.) (not vitamin E). And once ingested, protection disappears. It must be renewed. (5) I do this intermittently when I am between 6-10 gr of PUFA, without an adequate balance of omega-3 brought by food, only by food. I avoid oils, except olive oil and coconut. Omega-6 often comes from breakfast (Jordan oats + pecan nuts) 3x/week, and snack (wheat cake 2 x 24 gr or a Brownie 30 g). Note that there is an adequate SFA contribution at breakfast (Coco). Sources et Références : Efficacy of vitamin E in reducing oxidation of pufa If 10 gr PUFA (1.5 W3 LA and 8.5 gr W6 ALA): (1.5 x 3) + (8.5 x 2) = 18.5 mg Vit E Useful info: Mono-unsaturated fatty acid: Oleic acid. (Omega-9 = 9 Carbon atoms) 18:1 (9), n-9 Di-unsaturated fatty acid: Linoleic acid (LA / Omega-6). 18:2 (9,12), n-6 (2 doubles liaisons en n9 et n12 sur la chaine carbonée). Tri-unsaturated fatty acids: Linolenic acid (ALA) (Omega-3). 18:3 (9,12,15), n-3 (3 doubles liaisons en n9, n12 et n15) Tetra-unsaturated fatty acids: Arachidonic acid (AA). 20:4 (5,8,11,14), n-6 (4 doubles liaisons) Penta-unsaturated fatty acids: Eicosapentaenoic acid (EPA). 20:5 (5,8,11,14,17), n-3 (5 doubles liaisons) Hexa-unsaturated fatty acids: Cervonic acid (or docosahexaenoic acid). 22:6 (4,7,10,13,16,19), n-3 Note: Cervonic acid depends on consumption of omega 3 essential fatty acids (e.g., ALA or EPA), but the conversion process is inefficient. From fish oils. Sources and references: To be reminded 1: “In declaring EPA and DHA to be safe, the FDA neglected to evaluate their antithyroid, immunosuppressive, lipid peroxidative (Song et al., 2000), light sensitizing, and antimitochondrial effects, their depression of glucose oxidation (Delarue et al., 2003), and their contribution to metastatic cancer (Klieveri, et al., 2000), lipofuscinosis and liver damage, among other problems.” From “The great fish oil experiment”. Ray Peat PhD. 2007 http://raypeat.com/articles/articles/fishoil.shtml *) To be reminded 2 Saturated Fat Protects Against Oxidation of Cholesterol Whereas Omega-6 Promotes It When cholesterol is bound to saturated fat, it is protected from oxidation, which lowers your risk for cardiovascular disease, and when it is bound to linoleic acid, the cholesterol is susceptible to oxidation, thereby raising your risk. The amount of linoleic acid contained in LDL can be seen as the true 'culprit' that initiates the process of oxidized LDL formation as it is the linoleic acid that is highly susceptible to oxidation. Dietary linoleic acid, especially when consumed from refined omega-6 vegetable oils, gets incorporated into all blood lipoproteins (such as LDL, VLDL and HDL) increasing the susceptibility of all lipoproteins to oxidize and hence increases cardiovascular risk." 16 Vitamin E function and requirements in relation to PUFA Daniel Raederstorff et al. Br J Nutr. 2015. doi: 10.1017/S000711451500272X =>## 20 mg Vit E for 10 gr PUFA *) The antioxidant function of vitamin E has been proven to be essential for preventing the oxidation of polyunsaturated fatty acids (PUFA) intake in men. PubMed 2000, E E Valk, G Hornstra – DOI: 10.1024/0300-9831.70.2.31 Vitamin E, Antioxidant and Nothing More Maret G. Traber and Jeffrey Atkinson. 2007 doi: 10.1016/j.freeradbiomed.2007.03.024 The differences in potency of α-tocopherol versus other tocols in vivo is due to hepatic discrimination favoring α-tocopherol, as well as the preferential metabolism of non-α-tocopherol forms. Excerpt: Of the four tocopherols and four tocotrienols (designated as α-, β-, γ-, and δ-) found in food, only α-tocopherol meets human vitamin E requirements [15]. Despite the fact that all of these vitamin Es have similar antioxidant functions (rate constants for H-atom donation within an order of magnitude (Table)), non-α-tocopherols are poorly recognized by the hepatic α-tocopherol transfer protein (α-TTP) [16]. Quantitative Consideration of the Effect of Polyunsaturated Fatty Acid Content of the Diet Upon the Requirements for Vitamin E https://doi.org/10.1093/ajcn/13.6.385 1963 Diets with E:PUFA ratios above 0.6 are predicted generally to protect against vitamin E deficiency, but diets with ratios lower than 0.6 are expected to have a depleting effect. Synergy effect with vitamin E “Vitamin C regenerates vitamin E and vitamin E protects β-carotene, helped in this by polyphenols. In the event of β-carotene supplementation (not advised: only 5-10 mg from food, note's editor), vitamin C regenerates vitamin E and β-carotene, and β-carotene seems to protect vitamin E without really explaining this phenomenon "(1) Savings effect Vitamin E is not just a vitamin. Vitamin C makes it possible to recycle oxidized vitamin E and thus prolong its lifespan. The same goes with glutathione which is thus saved for other more useful functions (detox). Glutathion is our antioxidant master. Vitamin E protects against the deleterious effects of polyunsaturated fatty acids when the latter are in excess. And it is quickly done! John Libbey Eurotext - Anti-oxydants d’origine alimentaire : diversité, modes d’action anti-oxydante, interactions. Auteur : Claude Louis Léger.