@haidut said in Niacinamide improves bone health and reduces fat synthesis: Two of the features of aging thought to be unavoidable are brittle bones and increased visceral fat, both of which (alone or in combination) are a major contributing factor for the increased mortality seen with aging. As it turns out, both these features are apparently driven by decline in metabolism/OXPHOS, which is driven primarily by a relative NAD+ deficiency (i.e. low NAD+/NADH ratio), and supplementation with NAD+ precursors such as niacinamide may be able to stop/reverse them. https://www.xiahepublishing.com/2835-6357/FIM-2023-00046 https://www.eurekalert.org/news-releases/1054674 “…Recent studies indicate that oxidative phosphorylation plays a critical role in osteogenesis, the process by which new bone is formed. During osteogenic induction, cells shift their energy metabolism from glycolysis to mitochondrial oxidative phosphorylation, increasing respiratory enzymes, mitochondrial DNA copy number, oxygen consumption, and intracellular ATP content​. Bone morphogenetic protein 2 (BMP2) has been shown to trigger metabolic adaptations in mesenchymal stem cells (MSCs), characterized by successive activation of glycolysis and oxidative phosphorylation​. NAD+ levels and the NAD+/NADH ratio are crucial for mitochondrial function, linking cellular metabolism to transcriptional events and signaling pathways. Nicotinamide mononucleotide (NMN), a key NAD+ intermediate, promotes osteogenesis and reduces adipogenesis in MSCs, protecting bone from aging and damage.” Via: http://haidut.me/?p=2604 Niacinamide and Weight Loss: Niacinamide Has Striking Antiobesity Effects https://www.onedaymd.com/2022/07/low-dose-niacinamide-has-striking.html

@Ecstatic_Hamster

I think this lines up generally with PUFAs/increased serotonin/increased cortisol being associated with ASD (autism spectrum disorder) symptoms. Very nice that you keep collecting these studies! Not specifically related to PUFA, but more to the endotoxin part, I have noticed that a lot of people I know with ASD have somewhat of a "pot belly". The evidence here is of course anecdotal, but I was wondering if this could be bloatedness associated precisely with endotoxin? The correlation with increased bacterial activity in the gut seems likely via the serotonin/cortisol connection in people with ASD, and I guess increased bacterial activity could lead to bloating. It would also line up with what you have mentioned for long distance runners in this connection, the "subclinical Cushing's disease", if I'm not mistaken. Could you kindly comment if you consider this makes sense? Much appreciated!

For anyone researching the related topics of myopathy, muscle weakness/endurance, NAD and lactate, be sure to check out the RP forum for more info. There you'll find info on how Thiamine and especially Niacinamide can be helpful.

Good post https://raypeatforum.com/community/threads/war-is-coming-in-2024-be-prepared.52436/post-999500

@haidut This is a different angle on Vitamin C I had never thought about. As the molecule is very close to glucose, vitamin C could take on the properties of glucose and be used by the body for energy as needed by our immune system to counter pathogens. On this alone, I have a newfound respect for vitamin C that goes beyond its usual association to being an antioxidant. I have been monitoring my oxygen saturation every night for 3 years already, and I follow with interest the nightly spO2 charts (at 4 second intervals), and see the effects of phagocytosis by neutrophils and macrophages using respiratory burst, which consume plenty of oxygen that lead to sharp temporary drops in spO2. Even eosinophils consume large amounts of oxygen to produce ROS that spewed at larger pathogens. Energy is needed for these white blood cells to protect us from pathogenic insults, and it is plausible that vitamin C does as much as glucose does to provide an emergency boost to strengthen our immune system. [Don't know how to attach an image here. Unless it is in the form of a url]

@haidut I think that adopting just another Peaty routine to my nutritional lifestyle has helped me. This routine is in eating well cooked leafy greens. The vitamin K, as well as calcium and magnesium, has helped me. I had been eating leafy greens for quite some time now, and when I had bronchitis, I put myself in a year long downward cycle that involved heart failure. From being at the ICU, I thought my recovery would be difficult, if not impossible. But I am now back to having healthy lungs and a healthy heart, like I was before. It speaks to having a lifestyle that prepares one to bounce back from a heart failure easily. Having all the nutrients we need met, and by eating whole foods, is the simplest way to be resilient. Vitamin K is just one nutrient though. We need them all, and I for one, like to keep things simple. And for me, the simplest lifestyle is to have all our nutritional needs met by food, clean air, and sunshine. I used to rely on supplementation when I lived in the US, but before I came back to the Philippines, I vowed to stop all supplementation and make food my medicine. Except for vitamin E and C and some B vitamins, I have no deficiency to worry about and my body has been more resilient. Vitamin K from leafy greens is adequate. I don't have a reason to want K2 supplementation. But if I ever go back to live in the US, I may have to rely on more supplementation given that I don't trust the food ecosystem there to be able to supply nutrients adequately. It is very much a wasteland of industrial food.

@haidut I have to get a lot of sun exposure at or around mid-day sun to get the most vitamin D produced by the skin and eyes. I started this right before my cat my ankle and since I never had a bite wound on the skin on top of an ankle bone, I didn't know until know how to heal from such a wound. It's been 3 months since that bite and it's only now thst the wound is closing. I think the myelin sheath may have been damaged when my body was exposed to a week of taking orally cinnamon bark oil. This left me ataxic and I walk like drunk and have drop foot. Megadosing thiamine is somewhat effective, but something is still lacking to fully heal. I think vitamin D may be all that's needed to effect the healing on a damaged myelin sheath. When my ankle wound heals, I will resume a daily midday sun exposure of about an hour in my koi pond, where I am exposed to the sun. It may take a while, but I hope that vitamin D is the missing ingredient in my recovery from ataxia.

@haidut Empathy is a tricky process, especially in our culture that negates it. It requires good health, and ample biological energy. If the organism is faced with a detrimental situation in which most of the energy is required to keep itself alive, less energy can be used for the perception of other minds. In Mind and Tissue Ray talks about forming a "dominant" for other people as a brain process for acquiring impressions of other people`s internal life. It is probably one of the most energy-requiring process in the cerebral cortex, and something like endotoxin should be able to switch it off almost immediately. “You know, the hardest thing in the world for a person may be to free himself of his double, his automatic tendency to see himself, his faults, his shortcomings, his secret deviance in everyone he meets; but even more difficult is to liberate himself from the constant company of his double! And only from the moment when the double is overcome is the road open to free communication with another! "It is then for the first time that mind, heart, and word are revealed, making it possible truly to hear what it is that makes the person one has encountered tick….An open heart and open and intelligent hearing detect and understand in the other that which the individual had been unaware of in himself, and which merely dully exhausted and tormented him from some undiscovered part of his insides!" (Ukhtomksky)