For me salt drives my thirst.

Inhibition of gut-derived serotonin synthesis: a potential bone anabolic treatment Abstract Osteoporosis is a low bone mass disease most often caused by an increase in bone resorption not compensated by a similar hike in bone formation1. Since gut–derived serotonin (GDS) inhibits bone formation2, we asked whether hampering its biosynthesis could treat osteoporosis through an anabolic mechanism. To that end we synthesized and used LP533401, a small molecule inhibitor of Tph1, the initial enzyme in GDS biosynthesis. Oral administration once daily for up to 6 weeks of this small molecule prevents the development of and fully rescues, in a dose–dependent manner, osteoporosis in ovariectomized rodents because of an isolated increase in bone formation. These results provide a proof of principle that inhibiting GDS biosynthesis could become a novel anabolic treatment for osteoporosis. Or for the non-pharmaceutical approach: Peatbot: To lower gut serotonin, you can consider the following strategies based on the provided context: Avoid Foods Containing Fermentable Fibers and Starches: These include grains, beans, and other seeds that resist quick digestion and can promote intestinal irritation, leading to increased serotonin production. Consume Fibrous Foods with Antibacterial Properties: Foods such as bamboo shoots and raw carrots contain antibacterial chemicals that help reduce endotoxin and serotonin levels in the gut. Use Activated Charcoal: Activated charcoal can absorb many toxins, including bacterial endotoxin, which is likely to reduce serotonin absorption from the intestine. However, it should be used intermittently as it can also bind or destroy vitamins. Consider Theanine Supplementation: Theanine, an amino acid found in tea, has been reported to decrease the amount of serotonin in the brain by decreasing its synthesis and increasing its degradation. Supplement with Progesterone, Thyroid, and Niacinamide: These substances can help reduce serotonin formation and/or accelerate its elimination. Niacinamide, in particular, seems to increase serotonin uptake. Address Hypothyroidism: Since hypothyroidism is a common cause of increased serotonin, supplementing thyroid hormone until symptoms are resolved can help normalize serotonin levels. By implementing these strategies, you may be able to lower gut serotonin and mitigate its associated effects.

Though this study used supplementing it still jibes with what we've heard previously, that unsaturated fats don't provide the same satiety as most of the saturated ones. If your food isn't making you "feel full" then you might simply eat more of it. On another related note, who else here has read that a spoonful of beef tallow 10 or 20 minutes before a meal would result in quicker satiety and eating less? Interesting study btw, will pass it on, thank you for linking.

@questforhealth2 oh wait you mentioned that i wasnt paying attention

@Hando-Jin yeah it was just the flu bro. /s

@LiftWaffe88 Your favorite painter would have presided over the same purported degeneration in the populace which is why i find your comment really funny against the backdrop of your banner and forum persona.

@thyroidchor27 I don't see a problem with a little olive oil, but if you want to tip the scales to the "peaty side", macadamia is probably a better option due to the Oleic:Linoleic ratio.

@oliveoil I hit every RDA on 95% of days. It's not that difficult with a diet largely based around milk. A diet composed mostly of milk, eggs, beef, orange juice, and certain nutrient dense leafy vegetables like spinach makes it very easy. Espresso is also an incredibly good source of B3, B7, and magnesium, all of which are somewhat difficult to get enough of (B3 is easy with enough meat but difficult without). Track nutrient intake with cronometer.

Digging a bit deeper into refs 8 and 26 in my post above. (8) UV radiation suppresses experimental autoimmune encephalomyelitis independent of vitamin D production by Bryan R Becklund , Kyle S Severson, Souriya V Vang, Hector F DeLuca From the abstract: Our results indicate that continuous treatment with UVR dramatically suppresses clinical signs of [the experimental autoimmune encephalomyelitis] EAE. Interestingly, disease suppression occurs with only a modest, transient increase in serum 25(OH)D(3) levels. Further analysis demonstrated that the levels of 25(OH)D(3) obtained upon UVR treatment were insufficient to suppress EAE independent of UVR treatment. These results suggest that UVR is likely suppressing disease independent of vitamin D production, and that vitamin D supplementation alone may not replace the ability of sunlight to reduce MS susceptibility. (26) Suppression of experimental autoimmune encephalomyelitis by ultraviolet light is not mediated by isomerization of urocanic acid by Amy A. Irving, Steven J. Marling, Lori A. Plum, and Hector F. DeLuca From the Discussion: It is clear that ultraviolet B exposure efficiently prevents EAE, though we find no evidence to support [urocanic acid] UCA isomerization as the mediator of this suppression. This is not the first study to discount UCA as a mediator of UV immunosuppression, or that UCA administration does not mimic the effects of UV exposure.

@basebolt For sure, that's the chart I was looking at.

@AlphaCog Hmm, quite interesting, thanks for sharing.

@Mulloch94 said in levated TSH is an independent risk factor for Major Depressive Disorder and Metabolic Syndrome.: Good to know, thank you! A propos Newly released review this May. What's interesting here is many doctors won't consider someone for thyroid therapy unless their TSH is >5.0 mIU/L. So you're pretty much on your own if you're so called "subclinically" hypothyroid. [image: 1717858548461-98453e8e-057c-43b9-9fe7-59d867fc5948-image.png]

@haidut i think it's more likely that they have a healthy metabolism and that that leads to high testosterone and low risk for diabetes.