Short-term effects of replacing milk with cola beverages on insulin-like growth factor-I (IGF-1)
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Hoppe, C., Kristensen, M., Boiesen, M., Kudsk, J., Fleischer Michaelsen, K., & Mølgaard, C. (2009). Short-term effects of replacing milk with cola beverages on insulin-like growth factor-I and insulin–glucose metabolism: a 10 d interventional study in young men. British Journal of Nutrition, 102(07), 1047. doi:10.1017/s0007114509338829
Introduction
Both IGF-I and insulin might be related to certain cancer forms and other non-communicable diseases with high levels of circulating IGF-I associated to higher risk of some cancers, and low levels of circulating IGF-I associated with higher risk of CVD, type 2 diabetes, osteoporosis and cognitive decline.
Several observational studies have reported positive association between milk intake and circulating IGF-I in adults.
In the Western world, the trend in food consumption is presently moving towards a reduced milk intake coinciding with an increased consumption of soft drinks, of which the most popular are cola beverages.
Methods
In the two experimental periods, subjects were randomised to consume a strictly controlled diet and either 2.5 litres of Coca Cola or semiskimmed milk per day
Subjects were given the same diet in the two intervention periods in addition to the 2.5 litres of cola or milk, and all foods and drinks were provided and served by the department.
Results
Concentrations of IGF-I, IGFBP-3 and molar ratio of IGF-I:IGFBP-3 increased slightly after the intervention with milk, and decreased after the intervention with cola compared with baseline levels, but non-significantly.
The concentrations of fasting insulin and glucose as well as insulin resistance and b-cell function were decreased after both interventions, with only the decreased fasting glucose concentration after cola intervention being significant resulting in a tendency towards decreased insulin resistance compared with baseline.
The effect of treatment (milk v. cola) was significant only for IGF-I. No significant differences in changes between the two intervention periods were observed in serum concentrations of IGFBP-3, IGF-I:IGFBP-3, insulin, glucose, insulin resistance or b-cell function
Parameter and treatment Baseline After 10d IGF-I (ng/ml) Milk 287.9 304.8 Cola 295.0 270.4 IGFBP-3 (ng/ml) Milk 3257 3348 Cola 3290 3168 IGF-I:IFGBP-3 Milk 0.317 0.335 Cola 0.324 0.306 Insulin (pmol/l) Milk 26.58 22.71 Cola 30.12 24.34 Insulin resistance Milk 0.92 0.78 Cola 1.10 0.81 -
Interesting
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@DrRobertLustig
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@Milk The difference is like 10% ...
