Blood Bio-markers in Centarians and Non-Cent in Swedish 35 year follow-up Cohort
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My first post here. I am migrating from the RPF. Onwards.
Interesting study I found while cruising around the Yandex.ru (translated into English). This is something I rarely do, but... proved to be fruitful. Check it out. There were over 44,000 participants starting in 1985. I believe it is the largest study of it's kind."In total, 1224 participants (84.6% females) lived to their 100th birthday. Higher levels of total cholesterol and iron and lower levels of glucose, creatinine, uric acid, aspartate aminotransferase, gamma-glutamyl transferase, alkaline phosphatase, lactate dehydrogenase, and total iron-binding capacity were associated with reaching 100 years." from the intro...
and from the final 'discussion' section:
"As such, clinically defined normal ranges might not always reflect the optimum for the oldest old. For example, we found that a higher total cholesterol level was associated with a higher chance of becoming centenarian, which stands in contrast to clinical guidelines regarding cholesterol levels [29] but is in line with previous studies showing that high cholesterol is generally favorable for mortality in very old age [30]"https://link.springer.com/article/10.1007/s11357-023-00936-w#change-history
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Older people have less tolerance to endotoxin. Cholesterol binds to endotoxin to neutralize its effects. Higher cholesterol in older people would increase tolerance and defense against endotoxin.
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IIRC, Okinawan centenarians have a higher cholesterol level than most Okinawans and Japanese. This is likely due to their higher intakes of eggs, dairy, and pork; consumption of animal products actually increases over the life of Okinawan centenarians, IIRC.
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@JulofEnoch
Yeah you right about that! So is Ray Peat!
[[https://www.oki-islandguide.com/cuisine/pork-culture[link text](link url)](link url)](link url)The Okinawan diet has been heavily promoted as 97% Plant based which is entirely FALSE. Heavy on the Pork, pork fat, AND of course the sweet potatoes.
And they ain't low-fat traditionally. Heavy on the lard (pork fat) spiced with a little sesame oil.
[https://nourishingtraditions.com/true-blue-zones-okinawa/](link url)Anyhow, interesting that his study was so long, and fantastic that over 1000 folks made it to 100 years. Life is not a 100 metre dash, it is an endurance race.
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