Microgram doses of Melanotan II may increase the androgenic effects of testosterone
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https://eurekamag.com/research/041/765/041765107.php
25mcg of Alpha MSH was given to these mice.
When co-adminstered with testosterone, alpha MSH drastically increased testosterone's andorgenicty.
Prostate was 35% heavier
Seminal glands were 25% heavier25mcg doses of a MSH were used.
For a 200 gram rat, that is 125mcg per kg
HED is 20mcg per kg
80kg male the HED is 1.6mgNow it is important to recognise that Melanotan II has a binding affinity for the melanocortin receptors of up to 155x that of alpha MSH
The receptors present on these organs are mostly MC5R receptors.
Melanotan II has a binding affinity for the melanocortin receptors 5 that is 155x that of alpha MSH.So to simulate the effects of alpha MSH 155x less melanotan II is needed.
For an 80kg man 10.3mcg of melanotan II is needed daily to greatly increase andronegic effects of testosterone
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A alfredoolivas referenced this topic
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Isn't melanotan II not Peaty? As a consequence of being a MC3/4 agonist it increases NO, and Peat was not a big fan of NO. I would love to try it out but the NO issue is impossible to ignore unless the levels are too low to matter metabolically.
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@engineer It also can cause "sympton free cushing syndrome", where a user developed cortisol levels over detectable levels (>1,750 nmol/L) too. But he exhibited no symptoms, which makes me think that it is anti-glucocorticoird too.
Some more horror stories too. But plenty of people use it, and love it.
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@engineer Pt 141 is now a trialed prescription drug and sold as a peptide on the grey market, and binds to MCR4 with comparable affinities. Is probably safer
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@alfredoolivas the purpose of PT-141 is specifically to increase NO similarly to the PDE5 inhibitors like sildenafil/tadalafil, and it seems to be great at doing that. The benefit of melanotan II would be the added tanning which would be good if that's what you're looking for with the androgenicity/GR antagonism as a bonus. I personally have no need for that extra NO but in small quantities I think it wouldn't be a problem unless there's evidence otherwise.
For the "symptom free cushing" thing it appears that if there are truly no symptoms, then the actual cause could be a faulty test where it's getting triggered by something else or had some manufacturing defect. Actually, the fact that the result was off the charts with no symptoms and that this was one case drastically increases the probability of a testing error.
I am so curious about MT II's tanning and androgenicity that I'm thinking of grabbing some vials and trying something like 50ug/d. Anybody else thinking the same?
