Microgram doses of Melanotan II may increase the androgenic effects of testosterone

[alfredoolivas]

https://eurekamag.com/research/041/765/041765107.php

25mcg of Alpha MSH was given to these mice.
When co-adminstered with testosterone, alpha MSH drastically increased testosterone's andorgenicty.

Prostate was 35% heavier
Seminal glands were 25% heavier

25mcg doses of a MSH were used.
For a 200 gram rat, that is 125mcg per kg
HED is 20mcg per kg
80kg male the HED is 1.6mg

Now it is important to recognise that Melanotan II has a binding affinity for the melanocortin receptors of up to 155x that of alpha MSH

The receptors present on these organs are mostly MC5R receptors.
Melanotan II has a binding affinity for the melanocortin receptors 5 that is 155x that of alpha MSH.

So to simulate the effects of alpha MSH 155x less melanotan II is needed.

For an 80kg man 10.3mcg of melanotan II is needed daily to greatly increase andronegic effects of testosterone