Dandruff or scalp irritation? Try BLOO.
yeah swishing with a little water is a good shout, i do that every time i drink juice or eat a fruit to sort the leftover sugar & acid @highseabasch
if not this riboflavin / iron / copper deficiency can play into it sometimes
holding some coconut oil in mouth for a while and boosting folate intake for a few days might speed up healing
@yerrag maybe played a role, and also directly as cinnamon has some nasty effects
it can drop cholesterol (also needed for myelin in the brain) + crash T3 levels
https://diabetesjournals.org/care/article/26/12/3215/21858/Cinnamon-Improves-Glucose-and-Lipids-of-People
1g 3g 6g all reduce cholesterol , These decreases in serum cholesterol level ranging from 13 to 26% were maintained even after not consuming additional cinnamon for 20 days
maybe partly due to a buildup of benzoate over weeks which has toxicity at a certain level and takes a while to leave system
https://pubmed.ncbi.nlm.nih.gov/26374392/
** LOWERS T3 ACTION IN HEART AT 4G WATER EXTRACT 25 DAYS (lower trA mrna and protein levels) and LOWERED SERUM T3
(heart toxic)
https://www.sciencedirect.com/science/article/pii/S1756464618305139 4g of cinnamon powder crashed t3 the same as extract
Interestingly, the treatment with cinnamon, in both preparations, further reduced serum T3 of hypothyroid animals to undetectable levels
Combined administration of lauric acid and glucose improved cancer-derived cardiac atrophy in a mouse cachexia model
There's an antimicrobial peptide in saliva that inhibits viruses / covid (LL37) - but nicotinamide/niacinamide is needed for the full effect https://pmc.ncbi.nlm.nih.gov/articles/PMC10663372/
@AlphaCog most b5 production might be produced in the gut instead of from food, aligning with those studies (which would make rda irrelevant)
i think the impact here is on need to help myelin repair so brain can function well
its a nice finding theres an intervention study showing effects on mammals in alzheimers model, https://link.springer.com/article/10.1007/s13311-019-00754-z#Sec12 the amyloid-β idea is apparently based on fraud, but shows b5 lowering the excess aggression & restoring neuroinflammation to controls
Vitamin B5 (d-pantothenic acid) localizes in myelinated structures of the rat brain: Potential role for cerebral vitamin B5 stores in local myelin homeostasis
https://pubmed.ncbi.nlm.nih.gov/31759626/
Also on substack https://cs3001.substack.com/p/arthritis-and-the-effects-of-thyroid
https://raypeat.com/articles/articles/tissue-destruction.shtml
A very healthy 71 year-old man was under his house repairing the foundation, when a support slipped and let the house fall far enough to break some facial bones. During his recovery, he developed arthritis in his hands. It is fairly common for arthritis to appear shortly after an accident, a shock, or surgery, and Han Selye's famous work with rats shows that when stress exhausts the adrenal glands (so they are unable to produce normal amounts of cortisone and related steroid hormones), arthritis and other "degenerative" diseases are likely to develop.
But when this man went to his doctor to "get something for his arthritis," he was annoyed that the doctor insisted on giving him a complete physical exam, and wouldn't give him a shot of cortisone. The examination showed low thyroid function, and the doctor prescribed a supplement of thyroid extract, explaining that arthritis is one of the many symptoms of hypothyroidism. The patient agreed to take the thyroid, but for several days he grumbled about the doctor 'fixing something that wasn't wrong' with him, and ignoring his arthritis. But in less than two weeks, the arthritis had entirely disappeared. He lived to be 89, without a recurrence of arthritis. (He died iatrogenically, while in good health.)
Hypothyroidism presenting as destructive arthropathy of the fingers
She was initially believed to have rheumatoid arthritis but non-steroidal anti-inflammatory drugs were of no help
The patient was subsequently found to have hypothyroidism and erosive osteoarthritis of the fingers. Joint swelling, pain and stiffness responded dramatically to thyroid hormone substitution. The PIP joint spaces reappeared on the radiographs within 9 months.
1981 the joint spaces at the middle are closed
Next year after restoring thyroid, space between the joints
From the beginning of November 1981, the patient was treated with 1-thyroxine in gradually increasing doses to 100 ug/d. Thyroxine replacement was followed within 3 months by the disappearance of the symptoms of hypothyroidism.
In March 1982, the swelling of the joints had disappeared and the grip strength had increased to 140mmHg. During the following months, the patient remained well, without stiffness or pain except on maximum flexion of the fingers. She remains well at follow-up examination 2 years later.
Radiographs of the hands in July 1982 showed that the soft tissue swelling had disappeared and there was marked subchondral sclerosis with well defined articular margins. The articular spaces had become visible. No progression of the erosions could be seen; osteophytes were prominent around the PIP joints of both index fingers and the right middle (Figure 2). MCP, DIP and wrist joints remained normal.
She still had leftover osteophytes / calcium deposits, if thats a problem famotadine or cimetidine might be able to clear this
https://journals.sagepub.com/doi/pdf/10.1177/2309499017717193
Calcific periarthritis or calcific tendinitis occurs most frequently in the shoulder and rarely in the elbow. Cimetidine was previously reported to be effective for chronic calcific periarthritis of the shoulder. Here, we present five patients with chronic calcific periarthritis of the elbow treated by administration of cimetidine; there were six affected elbows in these five patients. Although all patients had been treated with nonsteroidal anti-inflammatory drugs for at least 3 months, their symptoms were not relieved.
All patients took oral administration of cimetidine 400 mg daily. The pain was completely relieved in an average of 1.8 months after the administration of cimetidine, and the calcification of the elbow disappeared in an average of 5.1 months. During the follow-up period, there were no symptoms suggesting a recurrence. Although the detailed mechanism of action of cimetidine on periarticular calcifications remains to be understood, cimetidine appears to be a potential therapeutic agent for chronic calcific periarthritis
^ also famotidine is a carbonic anhydrase inhibitor (CA is biomarker for vascular calcification), carbon dioxide helps clear calcium.
so co2 baths for the hands might help too but idk how deep it gets
IGF-1 plays a key role in cartilage repair but IGF-1 binding protein often elevated in osteoarthritis which diminishes its repair effects. Thyroid can raise igf-1, maybe it gets around this effect somehow e.g thyroid hormone increases igf receptor density in some areas https://pubmed.ncbi.nlm.nih.gov/2152872/
adding some orange juice daily for the hesperedin which can help restore igf-1 levels in older age might be a plus
Thyroid + Famotadine should be effective for osteoarthritis restoration
Selye's work with the diseases of stress, and the anti-stress hormones of the adrenal cortex, helped many scientists to think more clearly about the interaction of the organism with its environment, but it has led others to focus too narrowly on hormones of the adrenal cortex (such as cortisol and cortisone), and to forget the older knowledge about natural resistance. There are probably only a few physicians now practicing who would remember to check for hypothyroidism in an arthritis patient, or in other stress-related conditions. Hypothyroidism is a common cause of adrenal insufficiency, but it also has some direct effects on joint tissues. In chronic hypothyroidism (myxedema and cretinism), knees and elbows are often bent abnormally.
Stress-induced cortisone deficiency is thought to be a factor in a great variety of unpleasant conditions, from allergies to ulcerative colitis, and in many forms of arthritis. The stress which can cause a cortisone deficiency is even more likely to disturb formation of progesterone and thyroid hormone, so the fact that cortisone can relieve symptoms does not mean that it has corrected the problem.Besides many people whose arthritis improved with only thyroid supplementation, I have seen 30 people use one or more of these other natural hormones for various types of arthritis, usually with a topical application. Often the pain is relieved within a few minutes. I know of several other people who used progesterone topically for inflamed tendons, damaged cartilage, or other inflammations. Only one of these, a woman with rheumatoid arthritis in many joints, had no significant improvement. An hour after she had applied it to her hands and feet, she enthusiastically reported that her ankle had stopped hurting, but after this she said she had no noticeable improvement.
@cs3000 said in After diet, exercise and sleep, using a sauna may be of the best things for health:
HSP60 (majority found in mitochondria)
, Warning for using hsp60 inhibitors in cancer, over-expression of hsp60 (outside of heat induced) can promote cancer growth, but its also vital for healthy cells, removing HSP60 = mitochondria dysfunction + heart failure https://www.nature.com/articles/s41418-019-0374-x
effects of body heating on heart failure
https://bioenergetic.forum/post/25082
Waon therapy improves the prognosis of patients with chronic heart failure
https://www.journal-of-cardiology.com/article/S0914-5087(08)00328-6/fulltext
https://www.researchgate.net/publication/8162176_Effects_of_Repeated_Sauna_Treatment_on_Ventricular_Arrhythmias_in_Patients_With_Chronic_Heart_Failure
2 weeks, big differences in dodgy beats
@oliveoil
depends how long i guess as the infrared off your body warming up is still gonna bounce back to your nuts from the foil in a loop, or if 1 sided could measure how hot the air gets there. like jakeandpace said ice or cool bag is probably enough if needed
it mainly affects sperm by the looks of it as more sensitive, but by this leydig cells can become damaged too if done for 30 minutes every day without a break submerged in 42 degrees https://www.academia.edu/120946685/Amelioration_of_heat_stress_induced_damage_to_testes_and_sperm_quality
sperm isnt killed directly by this level of heat it creates signalling / ROS changes so theres a delay and they undergo apoptosis. so the vitamin C + hesperedin from having some OJ before should help
@BearWithMe Sounds like sjogrens, i would try GABA if can get it, for a few weeks. idk the sweat part isnt mentioned as much but its an autoimmune condition, so if its that maybe could damage sweat glands too
https://bioenergetic.forum/topic/3239/gaba-administration-ameliorates-sjogrens-syndrome-in-two-different-mouse-models/2?_=1729514797980
@greekdemigod looks like sperm cells are especially vulnerable , successful implantation apparently went down by half from just 1x a week for 30 minutes at 39 degrees, and might negatively affect offspring https://www.rbmojournal.com/article/S1472-6483(20)30073-0/abstract
20 minutes at 40 degrees water immersion too https://www.sciencedirect.com/science/article/abs/pii/S0093691X20305343
and in humans it would take 2-3 months at least to restore to normal after stopping because of regen time ,
human study, using extreme heat sauna 2x a week, impaired sperm, but didn't find negative effect on hormone production, motility back to normal by a few months after stopping but full count at 6 months
https://emilkirkegaard.dk/en/wp-content/uploads/Seminal-and-molecular-evidence-that-sauna-exposure-affects-human-spermatogenesis-.pdf
@Jakeandpace nice add with the icing idea, or just a bag of cold water to avoid other extreme (or if its hot enough i guess it doesnt matter)
I found it takes about 10 minutes to elevate body temp well and lasts a bit after stopping
In type 2 diabetes, insulin resistance and increased glucose levels cause mitochondrial dysfunction and decreased expression of HSP60 in the brain, which promotes brain hyperglycemia, resulting in high ROS levels and contributing to mitochondrial dysfunction [94]. This highlights the importance of HSP60 expression in type 2 diabetes for maintaining mitochondrial proteostasis.
Notably, the interaction between HSP60 and toll-like receptors (TLRs) supports the hypothesis that HSP60 could be involved in disease progression. However, the dysregulation of HSP60 in mouse hypothalamic cell lines and brain samples from T2DM patients further supports its role in the pathophysiology of T2DM [95,96].
Yes and the pro-metabolic things lowering them: progesterone, tetracyclines, selenium, methylene blue, ...
aye rays take seems fair enough based on these, but some benefits regardless of elevation
HSP60 (majority found in mitochondria)
, Warning for using hsp60 inhibitors in cancer, over-expression of hsp60 (outside of heat induced) can promote cancer growth, but its also vital for healthy cells, removing HSP60 = mitochondria dysfunction + heart failure https://www.nature.com/articles/s41418-019-0374-x
Recently, it has been reported that in burn sepsis situations, mitochondrial energy metabolism is restored in hepatocytes through upregulation and activation of SIRT4, an NAD+-dependent deacetylase, which subsequently reduces acetylation of HSP60 and facilitates the assembly of the HSP60–HSP10 complex. This reduced acetylation of HSP60–HSP10 restores the mitochondrial energy metabolism at complex II and complex III via glutamine-mediated SIRT4 activity (Table 2). Therefore, HSP60 may serve as a target of SIRT4 in hepatocytes, improving ATP production and protecting from burn-sepsis-dependent organ injury
HSP70 inhibits steroidogenesis? Where HSP60 is pro steroidogenesis? (or at least pro progesterone production)
https://pubmed.ncbi.nlm.nih.gov/7582246/
We have described two mitochondrial (mt) myopathy patients with reduced activities of various mt enzymes associated with significantly decreased amounts of heat shock protein 60 (hsp60). Experimental evidence suggested that the lack of hsp60 was the primary defect. Since hsp60 is essential for the proper folding of enzyme subunits in the mt matrix a partial deficiency of this protein can explain the observed defects of the mitochondria.
Here we report on morphological studies aimed at obtaining more insight into the relation between lack of hsp60 and pathological changes of the mitochondria. Under standard culture conditions mitochondria in the partially hsp60 deficient fibroblasts showed profound morphological aberrations. In contrast, the mitochondria in fibroblasts from a MELAS patient and a cytochrome c oxidase-deficient patient appeared normal.
Under stress conditions the integrity of the hsp60 deficient mitochondria declined even further: heat shock induced a temporary collapse of the electrochemical potential across the inner mt membrane, but did not affect the ultrastructure of the mitochondria; prolonged growth in confluent cultures resulted in decrease in mt number.
The altered mt morphology in the hsp60 deficient cells is probably indicative of the severely impaired mt metabolism whereas the decreased stress tolerance is likely to be a direct result of paucity of the heat shock protein. Both variables are potentially useful in the diagnosis and molecular characterization of mt disorders with systemic manifestation and multiple enzyme deficiency.
https://pubmed.ncbi.nlm.nih.gov/7986829/
In a recent paper (Agsteribbe et al. (1993) Biochem. Biophys. Res. Commun. 193, 146-154) we suggested deficiency of heat shock protein 60 (hsp60) as the possible cause of a systemic mitochondrial encephalomyopathy with multiple deficiency of mitochondrial enzymes. In this paper we present new data which strongly support this hypothesis. Hsp60 deficiency appeared to be not a common side effect of impaired mitochondrial metabolism as eight out of ten fibroblast cultures from patients with systemic mitochondrial myopathy contained normal quantities of the protein.
https://www.academia.edu/72683004/Role_of_HSP60_in_Steroidogenesis_and_Reproduction
incorporation of specifc proteins at the level of mitochondria becomes relevant because most proteins that constitute them are encoded in the nucleus and are synthetized in the cytoplasm with a pre-sequence or a signal peptide that allows their transportation into mitochondria. This process requires complex systems, like the TIM and theTOM, where HSP are required (Marom et al. 2011). For example, for the incorporation of the translocator of adenine nucleotides into the inner mitochondrial membrane, the presence of Hsp60 is indispensable (Mahlke et al. 1990)
overexpression of Hsp70 inhibits the synthesis of steroid hormones in luteal cells. It has been suggested that the action mechanism by which Hsp70 inhibits steroids’ synthesis is by interfering with cholesterol translocation to the mitochondrial cyto-
chrome P450scc (Khanna et al. 1994). Results revealed that the presence of Hsp70 in Leydig cells was constant, whereas Hsp60 was detected in both germinal and Leydig cells associated with an increase in the heat shock factor
1 and a diminution in the StAR protein, with the consequent diminution in testosterone production (Oka et al. 2017)
Authors proposed that the heat shock factor 1 regulates testicular steroidogenesis by stabilizing cholesterol transport through StAR. the heat shock increases eight to ten times the synthesis of progesterone with respect to control cells. Authors suggest that one of the effects could be the modifcation of cholesterol transport at the mitochondrial level (Khanna et al. 1994, 1995a, 1995b).
It has also been reported that heat of the summer produces stress in bovines increasing infertility. In this sense it has been reported that all HSP increase, particularly Hsp60 increases 2.6 times, and Hsp70 type 3 was the highest with a 4.9-times increase. Although levels of StAR and P450scc diminished, this did not affect the synthesis of progesterone,
overexpression of Hsp60 in Leydig cells induced by human chorionic
gonadotropin and the follicle stimulating hormone is associated with the increase
in testosterone secretion and regulation of steroidogenesis (Miller 2013; Issop et al. 2013).
using MA-10 cells subjected to heat stress, where Hsp70 levels increased between 6 and 20 times, depending on the treatment time, the inhibition of steroidogenesis was induced, without affecting the P450scc or 3β-HSD activities;
It was proposed that RoA deletion produced important changes in the cell’s cytoskeleton, causing accumulation of lipid droplets, and avoiding mitochondrial fusion/fssion processes, thereby impeding steroidogenesis by decreasing mitochondrial Hsp60.
In follicular cells of the ovary, the induction of protein StAR synthesis was accom-
panied by an increase of Hsp60. Transfection with the whole electron transport chain of P450scc, which is needed for cholesterol transformation into pregnenolone, increased signifcantly the expression of Hsp60 with the concomitant hormonal increase (Monreal-Flores et al. 2017)
the interpretation was that the mitochondrial Hsp60 of the human placenta is directly related with the transport of cholesterol. Furthermore, the presence of
maleimides did not modify the oxidative phosphorylation in these mitochondria,
confrming that inhibition of progesterone synthesis is related with blocking the
active cysteines of Hsp60
a reproducible model of non-steroidogenic cells
(HEK293) transformed into steroidogenic with the transfection of P450scc system,
and the protein 3β-HSD confrmed that overexpression of Hsp60 increased the transformation of cholesterol into progesterone (Monreal-Flores et al. 2017). Consistent with these data, in vitro assays demonstrated that the recombinant His10-Hsp60 protein favored progesterone synthesis in mitochondria isolated from JEG-3 cells, confrming its participation in steroidogenesis
Hsp60 could bind cholesterol similarly to what has been reported for
the StAR protein in MA10 cells
In general, it has been reported that HSP are the frst proteins to be produced in in vitro culture of embryos, and that they are immunodominant antigens of some pathogens like Chlamydia trachomatis.
Similar results were obtained in women with Chlamydia trachomatis infections, in which high levels of anti-Hsp60 were related with a diminution in in vitro fertilization.
It has been proposed that the presence of HSP, in particular of Hsp70, could avoid the cytotoxic effects produced by TNFα, which induces activation of phospholipase A2 with the subsequent activation of mediators that induce inflammation and mitochondrial formation of reactive oxygen species
It is interesting that in the human placenta, Hsp60 is associated with the
steroidogenic process by participating in the transport of cholesterol at the mito-
chondrial level where is transformed into progesterone by the P450scc chain
replied with more discussion on HSP at https://bioenergetic.forum/post/32387
@Mauritio @davidps
(replying to https://bioenergetic.forum/topic/2224/studies-showing-cancer-reversal-shrinking/2)
Hmm ty so ray was ok with heating for short times and if supported with carb intake before to prevent excess stress and boost gains from the metabolism increase,
if someones getting lightheaded / dizzy during & fatigued after this its a sign of pushing it excessively
but he also didnt like the heat shock proteins generally, basically saying cells are put in a limited protective state lowering capacity to produce energy. which fits with the anti metabolic things activating them mentions of estrogen nitric oxide, https://pubmed.ncbi.nlm.nih.gov/28903474/
" The HSP chaperone function can slow the degradation
of proteins under stress; if the HSPs were to be
named in the present, they could be called “energy deprivation stabilizing proteins." "Although the increased HSP can save the cells’
or organism’s life, it degrades oxidative energy production and metabolic efficiency. HSP are involved in the induction of dormancy or torpor in organisms ranging from the cellular slime mold Dictyostelium, to mammals"{i did notice this lasting torpor effect from hitting 39.1 degrees, sign i pushed it too much}
but thats odd seeing so many benefits of body heating,
So maybe the heat shock proteins are not generally beneficial but generally the ATP & co2 boosts from the sessions outweigh negative effects from the hsp?
here effects of heating mice + 2 degrees core temp on mitochondria complex activities in muscle , nice improvements regardless of stress hormones & hsp rising
https://journals.physiology.org/doi/full/10.1152/ajpregu.00525.2013?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org
(+1.5 degrees thru exercise vs 2.1 degrees through heating, probs sustained 20 mins)
^ this doesn't fit with rays take on these, also his mentions of loss of muscle mass in aging being related to hsp but there they gained muscle just by heating regardless
For fibrosis + heat shock protein part idk about effects of elevating over baseline but at least during muscle injury when HSP lowers below baseline, heating = faster recovery + with less scarring
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10717209/
so in that human study u posted they elevated very mildly +0.5 to +1 degree over 30 mins for a decent boost, and like u said heat stress proteins went back down quick (they only tested for a short time, but maybe the mild heat doesnt cause longer term changes like going higher)
Elevating core temp to 39 (through exercise but designed in a way to not cause muscle damage), weirdly the HSP got peak elevation by 2 days after and sustained similar levels for a week https://journals.physiology.org/doi/full/10.1152/japplphysiol.00046.2006?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org
@DavidPS Yeah looks great for heart arrythmias, mood/depression, diabetes, tumors, wounds etc. i got a portable sauna (pop up tent thing with a steamer).
exercise benefits outside of muscle traits are basically coming from it raising core temp by the looks of it. can get similar benefits in poor health (& some on muscle too) without the exercise by raising temp to 38 & sustaining for a bit with a bath / sauna
Gonna raise temp to 38 - 39 degrees for 20 minutes & 1-2 days between sessions. in the evening. with 40g sugar 30 mins before sessions to use during the metabolism boost. acute benefits last through the next day sometimes 48 hrs, heat shock protein is up for a while after
Sjogrens = autoimmune damage to glands that causes extreme dry mouth & eyes
GABA helps a lot preventatively and after the damage too in this model https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773584/
When assessed weeks later, GABA-treated mice had greater saliva and tear production, as well as quicker times to salvia flow, in both SS mouse models. {used preventatively or after symptoms}
Given that GABA-treatment preserved saliva and tear production which are the most salient symptoms of SS and is safe for consumption, it may provide a new approach to help ameliorate SS.
20mg / ml water female mice,
if they drank around 5ml water,
100mg per mouse per day , so ~4g per kg, so very high dose human equivalent 20g+ (probably not a great dose as lower can cause blood pressure changes dizziness). but here its spaced out in water
If someone has this considering the great outcomes might be worth trying a lower dose for a few weeks to see if its helpful. 500mg is active in the body going by other study areas & a couple grams has been used for lowering seizures in humans
Btw theres some fuckery going on with some popular supplements (idk if it was swanson or if it was the place i got it from), but one i got didnt dissolve in water (not gaba)
insight on what might be good timing for heat therapy
https://pubmed.ncbi.nlm.nih.gov/14023863/ (i've seen in other areas e.g decreasing repetitive behaviours, effects from 1 session can last into 24hrs - 48 hrs later)
When you heat cells they gain a temporary heat tolerance when recovering
I guess the main mechanisms with this are 1. heating cancer cells that have poor ability to dissipate heat so more easily damaged + 2. lowering pH to help induce apoptosis (lower pH so capsase can activate properly and self destruct the cell https://www.nature.com/articles/4400779 which happens optimally at 6.4 pH, and in a study i posted it showed glucose + heat took the tumor from 6.9 -> 6.5 and induced a slower rate of pH recovery) probably by increasing co2 with the carbs & stimulating metabolism. so for the first part
Resistant effect mostly lasts 2-3 days
day to day loses its effect
mostly back to normal with 1 day break but not fully,
the heat effect itself is not the only mechanism but going by that,
would be 1st day carb+heat session then waiting 2 days after , every 4th day
@cs3000 said in 2 studies showing cancer reversal / shrinking:
This reflects the stimulation of general metabolism and decrease of pH of tumour tissue, which contributes to the tumour growth inhibition
https://link.springer.com/chapter/10.1007/978-4-431-67035-3_48
After inducing hyperglycemia by glucose administration, nonheated tumor tissue pH decreased by 0.3 to 0.6, whereas pH of nonheated normal tissue fell by only 0.1 to 0.2, with a slower recovery to the previous level than the tumor tissue. On heating after glucose administration, tumor tissue pH fell from 6.9 to 6.5 immediately after heating with a delay of recovery time after heating. In normal tissue, tissue pH of 7.2 before heating fell to 6.9, rapidly recovering to a level higher than the baseline after the heat treatment. Hyperglycemia caused by glcose administration induced a selective decrease of tumor tissue pH, indicating the possibility of inducing selective heat sensitivity in tumors.
and more on selective action on tumors https://www.jstage.jst.go.jp/article/thermalmedicine1985/17/4/17_4_203/_pdf
Differrent effects on different tumors https://www.researchgate.net/publication/15612753_Apoptosis_in_tumors_and_normal_tissues_induced_by_whole_body_hyperthermia_in_rats
no effect on very aggressive type unless paired with something https://www.tandfonline.com/doi/pdf/10.3109/02656739709023548?needAccess=true&role=button
(those are without carbs boosting, so not getting full effect)
22 degrees ambient temp (blue) vs 30 degrees (red) = big difference in tumor growth.
but boosting core temp 1x a week 6 hours to an average of 39 degrees+ didnt have much effect (why a drastically less significant outcome to the other study? it isnt boosted with carbs before but im assuming they ate carbs during those 6 hours. and the other study also showed a decent inhibitory effect without carbs too. is 40 degrees being at the edge of harmful necessary e.g where atp starts to drop in heart ? is 6 hours too long vs 2-3 hours? maybe in the one with more profound effect most of them hit 39.5+ instead of 39? )
Or maybe once a week there wasnt enough to offset the negative effects of the cold temp being 22 degrees instead of preferred thermoneutral 26+ degrees in mice? did the other study use higher housing temp baseline? no, other one used 22-23 ambient temp too
@cs3000 Another good one easily accessible,
Simply heating up the body / raising core temp while giving some glucose before stopped breast cancer tumors from growing & even shrank them
https://www.jstage.jst.go.jp/article/thermalmedicine1985/16/4/16_4_229/_pdf/-char/en
Notably, the combined treatment with glucose and WBH suppressed the tumour growth almost completely for 7 days
Cool study, the glucose feeding with the body heating gave an improved effect and even shrank the tumor , (around 40 grams human equivalent glucose)
Just 1 use kept it from growing over a week and shrank it for 5 days, so doing it multiple times a week with a few days between might keep the shrinking effect going continually
Mammary tumour growth was strongly inhibited in both group WBH and group G+WBH though the degree of the inhibition was much more marked in group G+WBH, in which the growth was inhibited completely until 7 days after WBH compared to 2 days at most in group WBH.
they raised core temp to 39 - 41 degrees over 3 hours, but maintaining 40 degrees+ is where things can get dangerous with cell damage / death. 39 degrees - 39.5 degrees should be manageable and can hit using saunas / portable saunas / baths. (as doing this for hours with metabolism being stimulated i would top up some carb intake every 30 mins)
haidut mentioned in his study about changing cellular pH as a key, authors also mentioned:
This reflects the stimulation of general metabolism and decrease of pH of tumour tissue, which contributes to the tumour growth inhibition
@winters
not sure, but your white blood count & granulocytes are low
eating 2 small cans of pineapples a day (280g) can increase these a lot (and NK cells for early immunity) and reduce infection frequency
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258310/
and probably ensuring you eat enough protein
