@JulofEnoch said in Topical T3 thyroid hormone greatly accelerates wound healing 4x (and non topical vs hypothyroid) [chronic diabetic ulcer]:

@cs3000
I am curious whether severe ulcers and deep wounds(in general) can be accelerated. Pressure sores and MRSA infections would also be of interest to me. If the thyroid application is accelerating healing, then I assume that there's immune-protective effects. I'd like to see a test of topical thyroid and its effect on MRSA recovery and wound healing.

should apply all over for a general effect, 1 of the studies showed taking i.p so not applied at wound site , also increased the chronic wound healing.
& id imagine would apply to severe ones should be the same mechanism needed to repair right

and this one "Thyroxine Accelerates Healing of Acetic Acid-Induced Gastric Ulcer" for some reason the t4 groups had bigger initial ulcers measured at day 3. but the t4 groups had faster healing, vs hypothyroid and vs controls. and using t4 which is less efficient than t3
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But there can probably be a problem in illness taken orally vs topically , t3 would have to actually bind nuclear receptor for effect probably & if t3 is shut down by deiodianse 3 enzyme being upregulated in illness might not get the effect. where on skin its easier to overwhelm the enzyme with high dose locally for local effect (high dose as in would be a high dose for the cells taking it in vs what they get systemically)