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  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

    729 Topics
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    LunaticRedL
    @thebiooracle said: He wrote that it tends to locally activate thyroid secretion "by a variety of mechanisms, increasing cyclic AMP and decreasing serotonin in thyroid cells, for example, and also by lowering the systemic stress mediators." Interesting, thyroid mostly expresses PDE8, same form mostly present in leydig cells, inhibition of which significantly raises testicular steroidogenesis.
  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

    62 Topics
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    C
    Cancer Treatments – from Research to Application MCS Foundations for Life, In memory of my dear wife Mihaela Catalina Stanciu https://www.cancertreatmentsresearch.com/ https://jeffreydachmd.com/cancer-articles/
  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

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    J
    There's something fishy about Hans. He claims he's been doing all these self-experiments where he takes a mega dose of something for 2 weeks and does before and after blood tests, and frequently other tests like stool tests. If it were all true, he'd be practically living at a clinic! He says doctors are useless and that he pays for all his own private tests. But then makes a post about having a chat with his doctor, and discussing various results with him. He never posts his labs, as others have pointed out. He could just be making it all up, for all we know. What he does do, constantly, is try to make money off his claims. So I'm a bit dubious.
  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

    419 Topics
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    alfredoolivasA
    @Meursault this is an easy finesse stay safe nigga
  • Recipes, food, meal prep, brands. Discuss them all here.

    243 Topics
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    thebiooracleT
    @SilvertipConch Peat did describe how he made his milk powder pancakes in one email: "I just mix them according to the consistency that I want, a thick batter for puffy pancakes, with just milk powder and egg and a little salt, or a thinner batter, with a little liquid milk added, for crepes; fried in butter." Ghee would do fine for the butter out there. In another one he said "With any powdered milk it’s important to find out whether an anti-caking agent was used in making it." Might be worth checking the label on that big bag.
  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

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    alfredoolivasA
    @wester130 I just do the medium high seat biking due to convinience. Should be higher tbh.
  • Nuclear Peating

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    engineerE
    Looks like I'm going viral on Twitter! https://x.com/slurptyronene/status/2053326045168783577
  • will I Shrek myself eating 100g raw pumpkin seed daily?

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    engineerE
    @sunsunsun well, avocados are a different thing. With pufas you have the mechanistic biochemistry for why they're bad and that doesn't seem to be wrong.
  • Homemade SolBan

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    engineerE
    @Cicero I'm almost ready to make my own SolBan too and have everything except distilled water. Are you using a magnetic stir plate? It seems like it's the way to get the salicylic acid to dissolve completely but I haven't tried it yet.
  • Cancer (AML)

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    @thibaud I found a post in the old forum where someone submitted their email exchange with Ray Peat. Hope it helps: Post in thread 'Ray Peat Email Advice Depository' https://lowtoxinforum.com/threads/ray-peat-email-advice-depository.1035/post-119453 I don't eat liver as it makes me very nauseas but I could try brewers yeast if it is useful for something? I haven't tried B1 or pantothetic acid. Would this be in addition to brewers yeast? I don't currently use aspirin but am trying to source a pure form in the UK. Would you be able to provide approximate doses for all of the above please and let me know what they assist with? Ray Peat said: Vitamin B1 helps to oxidize glucose, so if you try 50 or 100 mg with a meal you should watch for possible hypoglycemia from the insulin. Pantothenic acid is safe in doses of 100 or 200 mg, and helps to limit hypoglycemia. Brewers' yeast has other nutrients that help with repairing the pancreas, but can cause gas, so it's best to start by pouring hot water over an ounce or two of it, and using just the liquid.
  • Mitochonic acid

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  • How to prevent and reverse skull expansion? (Hair loss)

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    LetTheRedeemedL
    @risingfire brought the final boss variable compounder
  • Stopping Antibiotic Course

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    M
    @Meeka I stopped taking it early and felt better within a couple of days. I was prescribed it again after that and only made it through one dose. I won’t be taking that antibiotic again.
  • This topic is deleted!

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  • Jordan Peterson dying from akathisia.

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    alfredoolivasA
    [image: 1776786468717-a4097f4b-73f2-4c4b-a340-db6378d8681d-image.png] JP is doing everything to not go back to this.
  • opinion on whey protein?

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    sunsunsunS
    @Milk-Destroyer not really, just as a convenience to add to oatmeal if i dont have eggs for some reason. there’s no point when i can just drink 1L of milk for a protein drink giving 36g protein.
  • Hypothyoidism and overschdeuling yourself?

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    JenniferJ
    What risingfire said. With thyroid energy, I feel like I have all the time in the world, like I did when I was a child—it’s as if time moves slower when my thyroid is functioning optimally—and I feel an excitement to do things, but it’s accompanied by this sense of calm or peace, while adrenaline energy feels like there isn’t enough time in the day to get everything I want done, like time is flying by, and there’s usually this background feeling of anxiety, a fear of my own mortality, really. With both energy sources, I have moments of euphoria, which made distinguishing between the two and adjusting my diet and thyroid dose accordingly quite challenging in the beginning so going by my temps (including temps of extremities—cold feet, hands, nose and/or ears are a telltale sign that adrenaline is compensating for thyroid and cutting off circulation to them to keep the core and vital organs warm), pulse rate and slightly more involved but very helpful is evaporation rate, i.e., average total fluids consumed and eliminated via sweat vs urine in a 24 hr period.
  • Oral va Topical.

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    W
    @alfredoolivas yeah im aware. Me and my son use this account. We are not on here though mainly the raypeat forum. And the reason i give him t3 is because his ATP production is bad.
  • does glycine increase need for caffeine intake?

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    alfredoolivasA
    @LucH Why is your AI so fucking chill?
  • the last piece of the peaty puzzle ? simplified with ai

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    B
    This picture of VDR knockout mice being "lean" and "obesity resistant" is taking some of the trees for the forest and claiming it's the whole forest. If you are insulin resistant, generally force-feeding a lot of carbohydrate substrate without any other measures is probably not a good idea. Are carbohydrates bad? No. Vitamin D has been skewed, I am sure intentionally, as a general calcified public is also "paradoxically" calcium deficient, or more aptly on a very low calcium:phosphate ratio, focusing on inflammatory, active D (1,25) paints the perfect, evil picture of vitamin D overall and is frankly wrong. Hydroxylases tightly regulate local conversions to 1,25 from 25. What interrupts this regulation? Calcium deficiency, estrogens, PUFA. In other words pre-inflammatory state. Knockout mice, barring all other factors of health - which is usually the game here in these worthless studies - will not experience this inflammatory, dysregulated system. And looking only at this narrowly through a lens, you derive your conclusion you are looking for: manipulating the meaning and function of things. In reality, in the real world, the better method in avoiding these inflammatory responses is, you guessed it, sufficient calcium, low PUFA, in turn keeping estrogen in check, and being careful of other inflammatory things. Much like the knockout mice scenario, removing some apparatus to prove something is bad, when that something itself is hijacked and fed into a detrimental cycle is a sleight of hand, not proof. Vitamin D is not the problem, and VDR knockout doesn't prove it is, only in that if 25 is converted via inflammation. Lipopolysaccharide derived MKP-1, inhibition by inactive D already shows vitamin D is an anti-inflammatory, but not 1,25. And 1,25 is one of the resident experts of inflammation, when conditions of health are not met. Get tho9se conditions met and D does what it does that is good for us. By the way, progesterone and methylene blue also help Also, "constant milk intake" is an absurd, hyperbolic suggestion. I am certain nobody here has an IV of milk coursing through their veins 24-7. You have some milk throughout the day, then we all fast whether we know or not: it's called sleep.
  • Something to know about i.p vs oral dosing animal studies

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    B
    Probably because the cells utilize more sugar as a concerted effort to recover from infection. If we picture a U curve, with the state of infection being one extreme side, more sugar would perhaps satiate the need to recover from infection with the surplus leveling out for glycogen formation.
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    cs3000C
    Acute first aid treatment after brain injury Case Report: Buccal administration of hydrogen-producing blend after a mild traumatic brain injury in a professional athlete https://pubmed.ncbi.nlm.nih.gov/32595937/
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    U
    @cs3000 any update on your electrical symptoms from sunlight and vitamin D?
  • WARNING Alkaline environments hyper-accelerate the Maillard

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    LucHL
    @lobotomize said in WARNING Alkaline environments hyper-accelerate the Maillard: aspirin also does the blocky thing Yes, very useful but we have to manage the impact on platelet renewal, whatever the dose is. 10-12 days to recover a functional system. I can give a link if interested.
  • strong histamine reaction after startingh levothyroxine...

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    P
    Histamine is a stress signal Iirc it also turns on NO You are under metabolic stress You need to energize cell function I am simplifying this a lot…. 1- blood sugar. 2- endotoxin. Start there If you raise your metabolic rate Naturally- not with exogenous t4 But sugar Sugar supplies your liver and thyroid essential metabolic support It’s a pillar of Peats teachings Addendum: not glucose supplements