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  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

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    LucHL
    @AlphaZance said: Stoichiometric Limitation: One molecule of Vitamin E quenches one peroxyl radical before needing to be recycled by Vitamin C or Glutathione. It protects the surrounding bis-allylic motifs as long as active Vitamin E levels are maintained. Hi, Thanks for the post. I've been searching for additonal info, trying to connect the dots. (8 pages docx for an article on my forum). Here is a no-conventional aspect: There is a bidirectional save effect between AA and tocos. Translation of an excerpt: Bidirectional recycling: Once Vitamin E is regenerated (recycled by ascorbic acid), its membrane anchoring allows it to act as a shield; this not only exerts a sparing effect on the nearby ascorbic acid but also enables a bidirectional exchange. The precise mechanism of this reciprocal support remains a complex biochemical challenge, yet the outcome is clear: the two molecules protect and sustain each other amidst the oxidative storm.
  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

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    C
    Cancer Treatments – from Research to Application MCS Foundations for Life, In memory of my dear wife Mihaela Catalina Stanciu https://www.cancertreatmentsresearch.com/ https://jeffreydachmd.com/cancer-articles/
  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

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    BearWithMeB
    I was experimenting with various solid foods recently (I was eating mostly liquid or blended food until now) and it made me realize that I'm not digesting my food at all. My stool is indistinguishable from the food I eat. My stool is a lump of bits of food with absolutely no change in size, shape, texture or color, and very little change in smell (sorry for TMI). What goes in leaves my body almost unchanged, undigested.
  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

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    T
    How do I take thyroid anyone have a guide on dosing and such? also what form of thyroid to take and im looking to take thyroid to increase my metabolic rate as much as possible through various methods and i want to start taking t3, i will take it with b1 current supplements and drug stack testosterone anastrozole thiamine vitamin d3 and k2 glycine magnesium glycinate
  • Recipes, food, meal prep, brands. Discuss them all here.

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    JenniferJ
    @Mossy, I can understand liking the ease of digital format, and referencing authors that have influenced you, sure. I will read almost anything that crosses my path because I’m an information junkie so I gladly welcome recommendations. My religious history may be a bit different. My parents weren’t practicing Catholics, just my extended family, which included a nun and priest. I was sent to parochial school to get a better education than public schools were providing at the time—teachers in our district were holding back capable students, just to get funding for a Readiness Program. My class had daily bible study, attended church every Wednesday, and I also attended church functions with a baptist friend because her faith was important to her so I’m familiar with Christianity, but it’s not a faith I ever adopted. It was separate from my own. Oh, yeah, Kalona. I don’t know how pricy it is now, but I was getting a case of their yogurt weekly, just after my spine collapsed and I was recovering from veganism. I also got a weekly case of Maple Hill yogurt, and an East Coast brand that’s similar to Alexandre Family Farm called Family Farmstead. I averaged 4 liters of dairy daily during that time, and it worked wonders at building back my bone density. But yep, I essentially make my own Greek yogurt by straining regular versions. Interesting. I haven’t looked into whether or not a plant’s defense chemicals are broken down by juicing, but their (supposed) beneficial compounds are degraded by heat, oxygen and light so I don’t see why not, especially with centrifugal juicers where more heat and oxidation are produced, less so with slow juicers like the two-stage hydraulic press juicers Norwalk and Pure juicer. I juiced using a 2-ton hydraulic juice press made by the Amish because at the time, raw fruit juice and coconut were the only plant sources that didn’t trigger a reaction, but then I started reacting to the juice, too. It was so bad that my hands looked like they had been burned just from handling the fruit, and my mouth blistered and bled as soon as it came in contact with the juice. I read that heating the juice for a certain amount of time would degrade the protein triggering the reaction, but it didn’t help. Regarding mushrooms and vitamin D, do you consume mushrooms regularly? If so, have you seen vitamin D mushrooms like the brand below at your local supermarket? I used to get them prior to supplementing thyroid when I had a low vitamin D level and was sensitive to supplements.    https://www.montereymushrooms.com/products/vitamin-d-mushrooms Gotcha. I thought maybe traditions had been passed down so you might have had some Italian influence, but I understand not looking the part. LOL I get mistaken for Latin American (by Latin Americans) and British (I’ve been told quite often that I resemble two British Hollywood actresses from the 1940s). Thank you so much for sharing all that info on olive oil. I learned 15 or so years ago that many of the olive oils on the market are adulterated and had a short list of oils that were guaranteed pure. California Olive Ranch was my family’s staple oil up until my doctor put me on the ancestral diet dominant in animal fat, and I also used to order incredible raw olives from goodfaithfarm.com. You mentioned the banana bread—is it still treating you okay?
  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

    96 Topics
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    T
    @alfredoolivas i eat under 3g of PUFA daily, ive been avoiding PUFA for long time so i think my fat is pretty much saturated fats atp. idk what is EFA ill look into it. im not doing low protein just 0.7-0.9g/lb protein. i will try out this stack that im going to do and report back here about my results but just looking for some additional info on what im doing or what else to do. Also what do u suggest i restrict my calories to?
  • opinion on whey protein?

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    sunsunsunS
    @Milk-Destroyer not really, just as a convenience to add to oatmeal if i dont have eggs for some reason. there’s no point when i can just drink 1L of milk for a protein drink giving 36g protein.
  • Hypothyoidism and overschdeuling yourself?

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    JenniferJ
    What risingfire said. With thyroid energy, I feel like I have all the time in the world, like I did when I was a child—it’s as if time moves slower when my thyroid is functioning optimally—and I feel an excitement to do things, but it’s accompanied by this sense of calm or peace, while adrenaline energy feels like there isn’t enough time in the day to get everything I want done, like time is flying by, and there’s usually this background feeling of anxiety, a fear of my own mortality, really. With both energy sources, I have moments of euphoria, which made distinguishing between the two and adjusting my diet and thyroid dose accordingly quite challenging in the beginning so going by my temps (including temps of extremities—cold feet, hands, nose and/or ears are a telltale sign that adrenaline is compensating for thyroid and cutting off circulation to them to keep the core and vital organs warm), pulse rate and slightly more involved but very helpful is evaporation rate, i.e., average total fluids consumed and eliminated via sweat vs urine in a 24 hr period.
  • Oral va Topical.

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    W
    @alfredoolivas yeah im aware. Me and my son use this account. We are not on here though mainly the raypeat forum. And the reason i give him t3 is because his ATP production is bad.
  • does glycine increase need for caffeine intake?

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    alfredoolivasA
    @LucH Why is your AI so fucking chill?
  • the last piece of the peaty puzzle ? simplified with ai

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    B
    This picture of VDR knockout mice being "lean" and "obesity resistant" is taking some of the trees for the forest and claiming it's the whole forest. If you are insulin resistant, generally force-feeding a lot of carbohydrate substrate without any other measures is probably not a good idea. Are carbohydrates bad? No. Vitamin D has been skewed, I am sure intentionally, as a general calcified public is also "paradoxically" calcium deficient, or more aptly on a very low calcium:phosphate ratio, focusing on inflammatory, active D (1,25) paints the perfect, evil picture of vitamin D overall and is frankly wrong. Hydroxylases tightly regulate local conversions to 1,25 from 25. What interrupts this regulation? Calcium deficiency, estrogens, PUFA. In other words pre-inflammatory state. Knockout mice, barring all other factors of health - which is usually the game here in these worthless studies - will not experience this inflammatory, dysregulated system. And looking only at this narrowly through a lens, you derive your conclusion you are looking for: manipulating the meaning and function of things. In reality, in the real world, the better method in avoiding these inflammatory responses is, you guessed it, sufficient calcium, low PUFA, in turn keeping estrogen in check, and being careful of other inflammatory things. Much like the knockout mice scenario, removing some apparatus to prove something is bad, when that something itself is hijacked and fed into a detrimental cycle is a sleight of hand, not proof. Vitamin D is not the problem, and VDR knockout doesn't prove it is, only in that if 25 is converted via inflammation. Lipopolysaccharide derived MKP-1, inhibition by inactive D already shows vitamin D is an anti-inflammatory, but not 1,25. And 1,25 is one of the resident experts of inflammation, when conditions of health are not met. Get tho9se conditions met and D does what it does that is good for us. By the way, progesterone and methylene blue also help Also, "constant milk intake" is an absurd, hyperbolic suggestion. I am certain nobody here has an IV of milk coursing through their veins 24-7. You have some milk throughout the day, then we all fast whether we know or not: it's called sleep.
  • Something to know about i.p vs oral dosing animal studies

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    B
    Probably because the cells utilize more sugar as a concerted effort to recover from infection. If we picture a U curve, with the state of infection being one extreme side, more sugar would perhaps satiate the need to recover from infection with the surplus leveling out for glycogen formation.
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    cs3000C
    Acute first aid treatment after brain injury Case Report: Buccal administration of hydrogen-producing blend after a mild traumatic brain injury in a professional athlete https://pubmed.ncbi.nlm.nih.gov/32595937/
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    U
    @cs3000 any update on your electrical symptoms from sunlight and vitamin D?
  • WARNING Alkaline environments hyper-accelerate the Maillard

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    LucHL
    @lobotomize said in WARNING Alkaline environments hyper-accelerate the Maillard: aspirin also does the blocky thing Yes, very useful but we have to manage the impact on platelet renewal, whatever the dose is. 10-12 days to recover a functional system. I can give a link if interested.
  • strong histamine reaction after startingh levothyroxine...

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    P
    Histamine is a stress signal Iirc it also turns on NO You are under metabolic stress You need to energize cell function I am simplifying this a lot…. 1- blood sugar. 2- endotoxin. Start there If you raise your metabolic rate Naturally- not with exogenous t4 But sugar Sugar supplies your liver and thyroid essential metabolic support It’s a pillar of Peats teachings Addendum: not glucose supplements
  • Still Haven’t Found a Perfect Food, Does It Even Exist?

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    sunsunsunS
    @Gardner i ate four pita wraps last night after already eating a peaty meal of greek yogurt and cooked fruit , i noticed zero downside to the wheat flour meal vs the peaty dairy + fruit meal all of this is possible due to mogging timeline once u begin to mog it doesnt matter , i suspect even some pufa deep fried food is ok, but it grosses me out to think of eating deep fried pufa oil tbh so i havent tried
  • Why am i smarter when sick/histamine?

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    daposeD
    @lobotomize I was being sarcastic but, so, what I meant was, you are smarter meaning the brain is in like an excited lots of blood glucose from the cortisol adrenal realize. I’m not saying that’s a good thing or healthy but it does happen.
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    lobotomizeL
    @bio3nergetic you are right apologise i wrote that in a hurry
  • Vit D3 in Milk is Fish Oil

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    LukeL
    There's something fishy about this story.
  • thyroxine and severe histamine reaction?

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    BiochemNordicB
    Thyroxine is T4 - it is best to use both T4 and T3 in the right ratio. I have written a book about thyroid replacement therapy - it also presents Dr. Ray Peat's protocol for using T4+ T3. The title of the book is: "How to Use Thyroid Medication." It is helpful for anyone who wants to use thyroid medication correctly. You can get it on Amazon. I spent more than three years researching for this book in hopes of helping people who are confused about thyroid medication - I hope it will help. You are also welcome to contact me via my website: https://biochemnordic.com/ [image: 1773483570697-how-to-use-thyroid-medication-ray-peat-resized.png]
  • Crushed NO. Was Ray Peat wrong here?

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    lobotomizeL
    @engineer https://bioenergetic.forum/topic/9249/nnos-a-useless-harmful-byproduct
  • nNos a useless harmful byproduct

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  • Ray Peat Inspired Books

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  • Milk is goyslop

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    LetTheRedeemedL
    @cookielemons Only 2 minerals are used in bone mineralization: calcium or phosphorus. As metabolism decreases, bone mineralization via phosphorus increases. For a brief correlation: older people have a higher phosphorus to calcium ratio in the bones than young people (who have higher calcium in the bones), and older people also have more bone fractures than young people. For the amount of phosphorus naturally occuring in the diet, it's actually pretty hard to balance it on a 1:1 parity with calcium, which is a way more important balance than with magnesium. High dietary calcium does not cause a problem, you urinate out excess. PTH causes all kinds of problems with calcium metabolism, tho. PTH raises when dietary calcium is low, and this forces calcium rich tissues to dump calcium into the blood, and for calcium uptake everywhere. It's an emergency response and redistribution by the body because of how vital calcium is for metabolism and the heart. If dietary calcium is not present, supplemental vitamin D can place higher demand on calcium, which will raise PTH to get it, and this cause the afformentioned problems. This is not Peat's crazy ideas he just made up. I can't remember the Japanese researcher, but he got a nobel prize for his research on calcium metabolism. Peat referenced his work. Peat is on the ball with calcium metabolism. While it's totally possible to be so low in magnesium, and metabolism be so retarded, you could possibly cause problems, it's possible you just weren't eating magnesium rich foods. Kidney stones are actually created by elevated PTH -- this is paradoxically caused by low dietary calcium. Toying with mineral balances is mostly what it sounds like: playing wackamole -- because minerals can never be regulated effectively until thyroid is addequate. the body doesn't feel the presence of a high calcium food and go "oh no, need more magnesium." Storage, utilization, and/or discarding of nutrients, is a constant automatic process. Either the metabolism is functioning to do this, or it's retarded. hand-selecting the nutrients to attempt to bypass this has little basis in reality as far as I understand it. Sodium and calcium are the only minerals you really have to conciously consume in accute weigh-able amounts, the rest come from a nutrient dense diet. They function like a chemical, directly impacting physiological processes. Sodium turns off aldosterone, a vasoconstricting hormone. Calcium lowers PTH, a calcium leaching hormone. Both of these are stress hormones. Between coffee, milk, OJ, oysters, and liver, you should hit your other mineral intakes decently well.