Dandruff or scalp irritation? Try BLOO.

  1. Home
  2. Bioenergetics Discussion

Subcategories

  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

    693 Topics
    5k Posts
    MauritioM
    @CrumblingCookie Hesperedin/ Hesperitin are interesting substances. IIRC @cs3000 posted some good studies on them on the RPF. And not only is it anti-fungal, but in accordance with the topic of this thread, it could help with fungal issues via alleviating cholestasis / helping with bile flow. It is an FXR agonist: "HP prevented bile acid toxicity in HepaRG cells, and this effect was blocked by FXR silencing. HP appears to activate FXR to prevent cholestatic liver injury." And a Cholagogue: "...HP promoted bile acid excretion into feces..." https://pubmed.ncbi.nlm.nih.gov/32841642/ Also seems to be anti-estrogenic and activates 5HT1a https://pubmed.ncbi.nlm.nih.gov/23238426/ https://pubmed.ncbi.nlm.nih.gov/22996046/

  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

    62 Topics
    703 Posts
    CiceroC
    I noticed the reprint of Nutrition for Women says "100 short articles by Ray Peat, PHD," where the old one said "92...". What did they add to it? Also, note that From PMS to Menopause is for sale on Peat's website but not Amazon, and Peat's website doesn't have Generative Energy. Weird. I wonder if Katherine gets more of the money if you order from Peat's site. I'd imagine so.

  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

    1k Topics
    11k Posts
    MauritioM
    I think it has to do with bile flow issues /cholestasis. IIRC a progesterone metabolite is implicated in pregnancy induced cholestasis. "Significantly less hepatic bile partitioned into the gallbladder in progesterone-treated than in control animals." https://pmc.ncbi.nlm.nih.gov/articles/PMC1191632/ Ive had similar issues in the past when taking pregnenolone and progesterone. Id try some things that help with cholestasis like TUDCA, gentian or cascara.

  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

    401 Topics
    4k Posts
    J
    @GRay I would not worry about this. You can always take glycine/gelatin/lysine/BCAAs with it if you're really concerned it could contain or be converted to arginine.

  • Recipes, food, meal prep, brands. Discuss them all here.

    238 Topics
    2k Posts
    F
    Fresh berries and sliced bananas are always good upgrade. You can also do warm cinnamon apples, stewed cherries or a little vanilla Greek yogurt with fruit.

  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

    95 Topics
    1k Posts
    C
    I thought aspirin and/or baking soda w water is good for afterwards? Gummy bears or fruit before and during lifting, no?
Log in to post
Load new posts
  • lobotomizeL

    how do you survive 30c

    12
    0 Votes
    12 Posts
    51 Views
    lobotomizeL
    @user1 not eating tons of refined sugar???? Welp had i not been chugging refined sugar i wouldnt have been on this forum aye
  • I

    Epitestosterone, premature balding, and "male PCOS"

    45
    0 Votes
    45 Posts
    5k Views
    J
    @Mauritio Another piece of this puzzle I'm putting together is that 17a-HSD seems to be mainly concentrated in the testes with very little peripheral activity relative to 17b. And it seems to be stimulated by gonadotropins. So supplemental androstenedione and DHEA are pretty unlikely to form meaningful amounts of epiTest. Frustratingly, it does look like supplementing epiTest directly is probably the only real way to accomplish our goals. Another roadblock is that 17a steroids have a steric hindrance which prevents cleavage of most esters. This means that the steroid ester floats around with the ester still attached, and the unchanged steroid ester can have a meaningfully different pharmacological profile than a base steroid. For example, 17a-hydroxyprogesterone acetate doesn't convert to 17ahp base very much, and this changes its receptor binding. (Positively in this case) For a 17a androgen, the uncleaved ester would probably make it unable to bind to the androgen receptor at all. So while it could potentially form estered 17a neurosteroids with long half lives (which could certainly be interesting) it probably will not be useful in the same way that natural EpiTest would. It's quite a condundrum. That all being the case, it's pretty clear IMO that doing a group buy or convincing said source that there's a market for this molecule is probably our best bet.
  • gg12G

    Under eating causes SIBO - Eating more fixes it

    4
    0 Votes
    4 Posts
    136 Views
    C
    @Jennifer Good point. I generally like meat for protein but yeah, you're right about seafood or dairy also being good sources. I must have had similar effects from vitamin and nutrient deficiencies because I had signs of hypothyroidism (overweight, thinning hair, low energy, slow digestion, etc) for several years. Also a lot of sugar cravings while eating crappy food. I think red meat and reducing pufa helped me initially. Now I worry more about getting variety and not skipping things like gelatin, greens, etc., and have been much better in the last 4 years. Maybe you know why - but it's hard to find high protein sources that are also low in fat. Beans and seafood, for example, are always touted as good protein sources. Chicken breast I suppose is low fat. Low or nonfat dairy is good as well. My issue is that I'm never satiated with low fat protein sources. It will lead to me adding butter, olive oil, or something else with fat, naturally. It really is the predicament for trying to consume less fat daily and still get protein needs. But, this is why I question the supposed protein requirements. Sugar IIRC doesn't have any recommended daily requirement, which is really interesting. I've never felt worse eating more fruit, but I wonder if eating more fruit can reduce the craving for protein??
  • MossyM

    Diclofenac gel to regrow hair on bald head and beard

    221
    0 Votes
    221 Posts
    32k Views
    W
    @evan.hinkle yes i agree it isn't conclusive, all theory
  • sunsunsunS

    Landfills

    5
    0 Votes
    5 Posts
    137 Views
    sunsunsunS
    @Atman cool thanks i also agree my original post is more a critique of bad local city council development practices, like doing stuff that makes built environment worse for another generation because economic will to tear down something just built even when it is bad is low
  • L

    Peptides straight from vendor - Analyzed bulk (Reta 30mg vials/motsC 40mg/GHK CU 100mg/SS31 50mg/BPC 20mg n so on

    18
    0 Votes
    18 Posts
    277 Views
    sunsunsunS
    @CrumblingCookie megadosing ghkcu is literally proven suboptimal by the studies , and ghk base and ghkcu are interchangeable. the former will just pick up cu in serum. thats all.
  • sunsunsunS

    Thriving, getting better

    9
    4 Votes
    9 Posts
    1k Views
    sunsunsunS
    @Milk-Destroyer I steam potatoes for 75minutes and then peel them with a knife. russet potato peels especially seem suboptimal. the French are correct in their method of potato preparation. Then instead of adding butter I just eat with 87/13 ground beef and use the fat from that mixed in the potatoes. with ketchup and finely diced raw red onion.
  • W

    Per capita - Autistic people are the most violent group in society

    32
    2 Votes
    32 Posts
    1k Views
    ThinPickingT
    @DKJoeAgain said: If not all of this is still just speculation right? Easier to say lots of odd people end up in prison. Which part. @wester130 said: some form of neurodivergent condition @DKJoeAgain said: Have they identified a single biological marker for autism It's a behavioral exam but the autonomic component may have markers.
  • S

    high iron

    5
    0 Votes
    5 Posts
    188 Views
    LucHL
    @VehmicJuryman said: Not sure if that's healthy or safe though Fine if you know ho to manage to recover platelet function: 10-12 days pause for a plateau.
  • W

    Quinones and Conspiracy

    2
    0 Votes
    2 Posts
    120 Views
    ThinPickingT
    Did this vertical vid, studio mic, 'One-time payment' enjoyer have something to say about gojira at the olympics. I hope not.
  • H

    Pure Cellulose Source? Not MCC...

    1
    0 Votes
    1 Posts
    34 Views
    No one has replied
  • sunsunsunS

    North America urban areas might be too ugly for optimal health

    9
    1 Votes
    9 Posts
    260 Views
    sunsunsunS
    @Milk-Destroyer xD
  • C

    Eating a lot of chocolate made it way HARDER TO FOCUS

    copper chocolate adhd dopamine serotonin
    2
    0 Votes
    2 Posts
    131 Views
    LucHL
    @CarbCarbCarbs said: I think it’s because of the higher amounts of copper. I don't think so. HD dark chocolate impact What are the negative impact of HD black chocolate: Side effects on cardia muscle and focus. Impact of High Level theobromine? Answer (Talk with AI - Google) The cardia muscle (the smooth muscle fibers surrounding the lower esophageal sphincter, or LES) and high-level (HL) theobromine changes the health dynamics entirely. [1] https%3A%2F%2Fwww.researchgate.net%2Fpublication%2F7901663_The_lower_esophageal_sphincter&ved=0CAEQ1fkOahcKEwiwj4HA9OqUAxUAAAAAHQAAAAAQKw&opi=89978449 When dark chocolate impairs your focus or causes a "wrong" energetic state, high levels of theobromine can trigger a cognitive crash and prolonged brain overstimulation. Concurrently, it causes a direct physical relaxation of the cardia muscle, promoting severe gastrointestinal reflux. [1, 2, 3] Cardia Muscle Dysregulation The cardia is the muscular anatomical zone where the esophagus meets the stomach. Dark chocolate negatively impacts it through two distinct mechanisms: [1]  Sphincter Relaxation: High-dose cocoa stimulates the release of nitric oxide and triggers a direct relaxation response in the smooth cardia muscle fibers. [1]  Acid Backflow: Once this muscular gateway loses its tone, the lower esophageal sphincter cannot close properly. This permits highly acidic stomach contents to escape upward into the esophagus, causing chemical irritation, chronic heartburn, and acid reflux. [1, 2] High-Level (HL) Theobromine: The Cognitive & Energy Disruption Theobromine acts primarily by blocking adenosine receptors (the chemical that signals sleepiness to your brain). While it is structurally similar to caffeine, its half-life is exceptionally long (7 to 12 hours). If your focus or energetic baseline is already misaligned (e.g., you are experiencing fatigue, ADHD-like executive dysfunction, or over-exhaustion), high levels of theobromine can exacerbate these issues: [1, 2, 3, 4, 5] PS: Never give a piece of chocolate to a cat, nor to a small dog because it may kill them. Toxic. They haven’t got the right enzyme to get rid of residual molecules. Explanation Chocolate contains methylxanthines—specifically theobromine and caffeine. While human enzymes break these compounds down +/ easily, cats and dogs (especially smaller breeds) metabolize them much slower, allowing toxins to build up in their systems. [1, 2]
  • gg12G

    Healing isnt possible for me

    4
    0 Votes
    4 Posts
    196 Views
    lobotomizeL
    @gg12 99% of people dont tolerate it. They simply never connect the dots of them being retarded feeling tired and gassey to the food they eat. Drink lac free low fat for a bit add glucose and then normal sugar to it
  • cs3000C

    #11 Malate / malic acid

    malate malic acid mitochondria complex inflammation
    19
    1
    3 Votes
    19 Posts
    2k Views
    alfredoolivasA
    Bananas have high Malic, zero citric acid
  • gg12G

    / skin Hair products ???

    6
    1 Votes
    6 Posts
    272 Views
    sunsunsunS
    @gg12 charlies company has soap on sale rn and ngl their soap is fiya
  • gg12G

    Does any of this shit matter?

    29
    -1 Votes
    29 Posts
    1k Views
    ThinPickingT
    @ZackVegas said: Weird thing to say. Western Medicine will use dangerous and deadly "therapies" at the drop of a hat. From Chemo and Radiation to Ventilators during "Covid" (which had a higher lethality rate than Suicide by Firearm), to dangerous drugs like SSRIs, Finasteride, Statins and such. No doubt it was Dr. Peat's stubbornness about Western Medicine that enabled him to exceed the average US life expectancy by over a decade, and outliving the average lifespan of all the "Blue Zones" for males as well. My guess is that avoiding doctors and Western Medicine probably added at least 20 years to his life. Indeed. Odd. In that context, what is a (claude-based) chatbot with a "Peat perspective" if it isn't a form of "stubbornness about Western medicine". And wasn't it established he was "done in" by a nocturnal cerebrovascular event. Is hammy calling the prior conditions "COVID", because I thought there was "smoke from a forest fire". Are they interchangeable.
  • W

    Camphosal Alternative - Would this work?

    2
    1
    0 Votes
    2 Posts
    114 Views
    F
    @wester130 I wouldn’t treat that as real Camphosal substitute. CamphoSal is camphoric acid plus phenyl salicylate, while that bottle is camphor tree resin extract so its not the same compound or formulation.
  • BirkB

    Is Cialis/Tadalafil Harmful?

    14
    0 Votes
    14 Posts
    1k Views
    W
    @ZackVegas ever considered black ginger?
  • CiceroC

    Homemade SolBan - Summer 2026

    10
    0 Votes
    10 Posts
    379 Views
    engineerE
    Would it be a good idea to add minoxidil to the mixture for extra hair growth? If you are making it homemade, the main issue with minoxidil (needing to use it constantly or lose the benefits) ceases to exist because the cost gets pushed so low. Edit: According to Grok, it looks like minoxodil wouldn't work because of the salicylic acid, which breaks down the sulfotransferase enzymes that minoxidil depends on to function.