Resistant starch increase endotoxin?
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I actually noticed a study showing a positive effect in diabetic women.
https://pubmed.ncbi.nlm.nih.gov/26655398/
However, this one shows a negative effect for rural Malawi children.
https://pubmed.ncbi.nlm.nih.gov/26334878/
How do we know it's the resistant starch per se that would be causing issues? Maybe the issues seen are caused by lectins etc.
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Peatbot.com: Yes, resistant starch can contribute to the increase of endotoxin. Resistant starches are not easily digested by human enzymes and therefore reach the lower intestine, where they are fermented by bacteria. This fermentation process can lead to the production of endotoxin, as well as other compounds like lactic acid, which can have overlapping and additive inflammation-producing effects. The presence of endotoxin is associated with increased serotonin release and synthesis, which can further contribute to inflammation and other symptoms.
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In Dr. Peat's own words:
“…Oh, the starch? There have been a series going back about a hundred years of studies showing that if you put in especially raw starch, you can purify the starch, corn starch, potato starch, each has a characteristic granule size ranging from five microns in diameter to a hundred microns in diameter. And if you give a good feeding, maybe a stomach tube to put a lot of starch in at once and then sample the animals, bloodstream, its liver fluids, its cerebrospinal fluids, the urine, all of the body fluids,”
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Endotoxins sources when eating starch?
Short answer:
LPS toxins don’t come from starch from itself but are the result of died gram-negative bacteria (killed by the milieu or arrived at the end of their life).
Developed theory
Endotoxins, specifically lipopolysaccharides (LPS) from Gram-negative bacteria, can be a concern when eating starch, but the primary source is not the starch itself. While some LPS may be present in food, including those containing starch, the major source of endotoxins in the body is from the bacteria that naturally inhabit the gut. Starch, especially resistant starch, can influence the gut microbiome and potentially impact the amount of LPS produced and absorbed.
Endotoxins from Gut Bacteria
Gram-negative bacteria, which are a normal part of the gut flora, have LPS in their outer membrane. When these bacteria die or their cell walls are disrupted, they release LPS into the gut. Some LPS can be absorbed into the bloodstream from the gut, potentially contributing to inflammation. (…)In essence, while starch itself isn't a direct source of endotoxins, its impact on the gut microbiome can influence the amount of endotoxins produced and absorbed, with resistant starch potentially playing a beneficial role in mitigating the effects of LPS if, and only if, there is no stagnation of the feces (optimal transit, with a functional MMC), the liver isn’t overburdened (neutralization of side-effects), the way-out is free …
Note: The kind of stuff used in the 2 studies is deprived of fiber. An isolated “nutrient”.
Potatoes induce a higher insulin reaction than sugar cane. When I eat 2 medium potatoes, I mix them with butter, one egg and pieces of broccoli or some frozen spinach. (+ a calcium source to neutralize the very high source of oxalates from spinach: 660 mg for 100 gr spinach).
The capacity of the body is 50 mg oxalate/d. 150 - 200 mg if not every day.
