Is Cialis/Tadalafil Harmful?
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Have seen a number of quotes from Ray and the community warning of the dangers of Nitric Oxide
AFAIK Tadalafil acts as a PDE-5 inhibitor and doesn't directly raise levels of Nitric Oxide in the body in the way beetroot or L-Arginine would
So my question would be, Boner pills peaty?
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they will speed up aging and cause oxidative damage
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@cupofcoffee hm faustian bargain worth it for big pump and penis
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@Birk extremely real, but try other pro-erection stuff first.
on RPF, haidut mentioned how aspirin can help erections and i concur
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@cupofcoffee are you sure? Citrulline and arginine and beetroot boost all NO including iNOS which is what RP was against, meanwhile tadalafil boosts only eNOS (and maybe nNOS?)
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based on my understanding
citrulline, minoxidil and cialis is bad
ginko biloba, black ginger and pomegranate and watermelon are good for you
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@wester130 watermelon has citrilluninee
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@wester130 citrulline boosts all NO (including the inflammatory kind) not just eNOS and nNOS
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I took cialis for a bit. It made me feel like crap: low mood, dizzy, back pain, low blood pressure, and a few times it gave me a hefty inflammatory response like the flu.
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i don't think it's good. But perhaps micro dosing has some benefit.
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I started taking 2.5mg recently. No noticeable side effects.
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I think tadalafil, when used daily in the lower doses (like 2.5 to 5mg) is fairly safe and beneficial. Most of the side effects of tadalifil come from people taking large doses, usually more "on demand" than daily. Tadalafil first came to market in 2004, meaning it has been out for more than 20 years, a number that Ray Peat suggested was a minimum for considering a drug.
There have actually been quite a number of positives reported from longer term use, both anecdotally, and from studies. Some studies have noted that tadalafil and sildenafil seem to be associated with longer lifespans than those who don't take the drugs. Doesn't seem like they increase aging, as one commenter above suggested. Tadalafil does not increase NO, and seems to lower estrogen and increase testosterone.
There was even this case study, which suggests that tadalafil helped to heal a chronic wound in about 2 months-
https://pmc.ncbi.nlm.nih.gov/articles/PMC7950937/Having said all that, I have been willing recently to personally experiment with tadalafil, in the lower daily doses, and have noted mostly positives, with no side effects to speak of. I wouldn't consider it "Peaty" necessarily, but I don't see any major objections that Dr. Peat would have had, based on what I now know about the drug. It seems similar, in some ways, to losartan. Both can lower BP, both can relax blood vessels, and both can help increase erections (due to improved blood flow), and both seem to have some anti inflammatory properties.
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@ZackVegas ever considered black ginger?
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