Is Cialis/Tadalafil Harmful?
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based on my understanding
citrulline, minoxidil and cialis is bad
ginko biloba, black ginger and pomegranate and watermelon are good for you
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@wester130 watermelon has citrilluninee
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@wester130 citrulline boosts all NO (including the inflammatory kind) not just eNOS and nNOS
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I took cialis for a bit. It made me feel like crap: low mood, dizzy, back pain, low blood pressure, and a few times it gave me a hefty inflammatory response like the flu.
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i don't think it's good. But perhaps micro dosing has some benefit.
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I started taking 2.5mg recently. No noticeable side effects.
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I think tadalafil, when used daily in the lower doses (like 2.5 to 5mg) is fairly safe and beneficial. Most of the side effects of tadalifil come from people taking large doses, usually more "on demand" than daily. Tadalafil first came to market in 2004, meaning it has been out for more than 20 years, a number that Ray Peat suggested was a minimum for considering a drug.
There have actually been quite a number of positives reported from longer term use, both anecdotally, and from studies. Some studies have noted that tadalafil and sildenafil seem to be associated with longer lifespans than those who don't take the drugs. Doesn't seem like they increase aging, as one commenter above suggested. Tadalafil does not increase NO, and seems to lower estrogen and increase testosterone.
There was even this case study, which suggests that tadalafil helped to heal a chronic wound in about 2 months-
https://pmc.ncbi.nlm.nih.gov/articles/PMC7950937/Having said all that, I have been willing recently to personally experiment with tadalafil, in the lower daily doses, and have noted mostly positives, with no side effects to speak of. I wouldn't consider it "Peaty" necessarily, but I don't see any major objections that Dr. Peat would have had, based on what I now know about the drug. It seems similar, in some ways, to losartan. Both can lower BP, both can relax blood vessels, and both can help increase erections (due to improved blood flow), and both seem to have some anti inflammatory properties.
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@ZackVegas ever considered black ginger?
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@ZackVegas this is extraordinary
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Makes my sinuses congested which I assume means it is doing something bad systemically. Also weird vision side effects (Blue tint) probably not good. If you have ED take pregnenolone+DHEA, or just low dose topical DHEA. Will help.
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@jimmynelson what doses were used? low dose 2mg looks okay
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