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  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

    729 Topics
    5k Posts
    LunaticRedL
    PDE4 is mainly expressed in skeletal muscles. Chronic activation of mTORC1 by exercise and aging upregulates catabolic factors, limiting muscular development. PDE4 inhibitors counteract this and can be used as anabolic agents. Relevant research: The phosphodiesterase-4 inhibitor roflumilast reverts proteolysis in skeletal muscle cells of patients with COPD cachexia https://pubmed.ncbi.nlm.nih.gov/29648516/ Impaired cAMP–PKA–CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia https://www.nature.com/articles/s42255-025-01397-5#Sec10 Phosphodiesterase 4 inhibition restrains muscle proteolysis in diabetic rats by activating PKA and EPAC/Akt effectors and inhibiting FoxO factors. https://www.repositorio.ufop.br/items/1bd5a6b9-2627-467f-8ca8-ffac2170b4fa

  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

    62 Topics
    703 Posts
    C
    Cancer Treatments – from Research to Application MCS Foundations for Life, In memory of my dear wife Mihaela Catalina Stanciu https://www.cancertreatmentsresearch.com/ https://jeffreydachmd.com/cancer-articles/

  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

    1k Topics
    11k Posts
    J
    There's something fishy about Hans. He claims he's been doing all these self-experiments where he takes a mega dose of something for 2 weeks and does before and after blood tests, and frequently other tests like stool tests. If it were all true, he'd be practically living at a clinic! He says doctors are useless and that he pays for all his own private tests. But then makes a post about having a chat with his doctor, and discussing various results with him. He never posts his labs, as others have pointed out. He could just be making it all up, for all we know. What he does do, constantly, is try to make money off his claims. So I'm a bit dubious.

  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

    419 Topics
    4k Posts
    alfredoolivasA
    @Meursault this is an easy finesse stay safe nigga

  • Recipes, food, meal prep, brands. Discuss them all here.

    243 Topics
    2k Posts
    S
    @Jennifer Raisins are a classic, but I usually carry dates as a nice trail snack, I can get them for a good price at the nearby grocery stores. As for everything else you've mentioned thanks for the ideas! I'm usually short on time since I tend to find out I'm going out into the backcountry maybe a few days before I head to the Trailhead, but at this point I think I should invest in learning how to dehydrate some stuff instead of buying whatever I can find at a store for sure.

  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

    96 Topics
    1k Posts
    alfredoolivasA
    @wester130 I just do the medium high seat biking due to convinience. Should be higher tbh.
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  • L

    This topic is deleted!

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  • raytreatsR

    Dry mouth - need advice

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    CO3C
    @raytreats Awesome! I think more broadly it was stress hormones causing this, hence the spike when you drank espressos without milk or sugar. But this can have been caused by the deficiency! So not to say that isn't a perfect solution. Try to avoid additives in your supplements. Glad you solved it.
  • B

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  • OrpingtonCloseO

    if Estrogen is so bad, why does it direct fat towards feminine areas

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    D
    Estrogen, in sufficient quantities, just puts the breaks on testosterone production (through negative feedback loop). That's what causes feminising effects. Its not the estrogen itself that feminises. Transexuals often use anti-androgen compounds (like spironolactone) for the feminising effects. I don't think increasing estrogen to very high levels even has the capacity to fully feminise a male if his androgen are still high enough. Many men have very high estrogen but still look like men.
  • B

    best way to take progesterone?

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    Milk DestroyerM
    Progest-E
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    This topic is deleted!

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  • Ray Van WinkleR

    its time to gather dandelion greens

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    ?
    @Ray-Van-Winkle holy shit cheapest vegan diet ever
  • SugarS

    How do you define richness from a bioenergetic point of view?

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    onliestO
    @Norwegian-Mugabe said in How do you define richness from a bioenergetic point of view?: @Ray-Van-Winkle Only a few select people like myself are suited for luxury. This is incredibly real. Low frequency people given money will still live in filth and squalor, and waste their fortune on trivial distractions. The goal is to live a charmed life. The life you save could be your own.
  • PartyEverday88P

    Coffee absorbed through ballsack

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    M
    That's interesting, but wouldn't it make more sense to use pure topical caffeine on the scrotum for this effect? Seems like it would, because unlike coffee, the caffeine would not have to be digested first. It's basically following the same principle of using topical t4/t3 mixtures, and NOT topical desiccated thyroid.
  • CO3C

    Curing Parkinson's disease with B1

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    CO3C
    @basednigga2006 said in Curing Parkinson's disease with B1: Can you not get the enough doses of b1 by eating healthy.....? Theoretically, maybe. But we live in a real world. So in our current world: not even remotely. Stress depletes all kinds of vitamins and minerals, and our food is more devoid of them than it has ever been in the history of mankind... Starches contain no vitamin B1. Sugar, which is what starches are converted to, requires a lot of it. The advent of white rice (where the thiamine-rich husk is discarded) caused up to 90% of the Japanese military to become B1 deficient!!! [image: main-qimg-4af9ab3816e4e317228dce55b499552d-lq]
  • hwisdomH

    High fructose corn syrup ultra giga peaty?!?!?!

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  • CO3C

    Simplifying Bioenergetics for others

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    DonkeyDudeD
    @CO3 Where I live the topic is somewhat well known; for example, TV nutrition experts often promote a rule of thumb that the more liquid a dietary fat is in room temperature, the healthier it is. Confidently stating the opposite at least gets some attention, and if someone is unable to understand the solid fat/liquid oil distinction I'm not sure it's possible to simplify it even more.
  • B

    T3 pooling from low cortisol?

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    R
    @BroJonas there has to be some truth because Ray suggested if you had cortisol issues to take t3 with pregnenolone. I'm not sure how prevelant it is or how much it related to low or high cortisol.
  • raytreatsR

    Aspirin recommendations?

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    DavidPSD
    Ray Peat email exchanges - Aspirin
  • I

    Does mead acid form prostaglandins?

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    I
    @TexugoDoMel Great response, thank you!
  • T

    Aspirin for uncoupling?

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    T
    @dan-dominic Thanks, dan-dominic, for posting that from him. I was mistaken in thinking he'd been banned years ago. I hope VoS considers putting in an appearance here at some point. If anyone has personal contact with VoS, please ask if he's still using his Co2 regulator/canula setup and/or if there are any other links where some of us who enjoyed following his experiments at RFP might read up on what he's been up to in terms of up-regulating metabolism since he left.
  • rayjeetR

    Accidentally cured my lactose intolerance using high-dose antibiotics

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    rayjeetR
    @skywxlker My digestion for milk has deteriorated a lot but is still a lot better to what it was before this round of antibiotics. Despite eating carrots and mushrooms regularly, I have not been able to keep my gut "cleansed". I felt clean and euphoric on eating/drinking food after the antibiotics. I dont know if I should do that again or what.
  • CO3C

    Frequency of the micro-nutrient dense foods (Liver, Oysters)

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    C
    @CO3 I just eat oysters when I crave them, which is usually about once a week and they always taste good, but if i just force myself to eat them when my body doesn’t want them they taste disgusting and i can barely swallow them without throwing up
  • P

    why does the cheap store milk make me feel warm and depressed?

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    CreusetC
    @peatyourmeat Probably because coffee is anti-opioid: https://pubmed.ncbi.nlm.nih.gov/15088081/ Travis on the previous RPF used to talk about this kind of things.