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  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

    729 Topics
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    LunaticRedL
    PDE4 is mainly expressed in skeletal muscles. Chronic activation of mTORC1 by exercise and aging upregulates catabolic factors, limiting muscular development. PDE4 inhibitors counteract this and can be used as anabolic agents. Relevant research: The phosphodiesterase-4 inhibitor roflumilast reverts proteolysis in skeletal muscle cells of patients with COPD cachexia https://pubmed.ncbi.nlm.nih.gov/29648516/ Impaired cAMP–PKA–CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia https://www.nature.com/articles/s42255-025-01397-5#Sec10 Phosphodiesterase 4 inhibition restrains muscle proteolysis in diabetic rats by activating PKA and EPAC/Akt effectors and inhibiting FoxO factors. https://www.repositorio.ufop.br/items/1bd5a6b9-2627-467f-8ca8-ffac2170b4fa

  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

    62 Topics
    703 Posts
    C
    Cancer Treatments – from Research to Application MCS Foundations for Life, In memory of my dear wife Mihaela Catalina Stanciu https://www.cancertreatmentsresearch.com/ https://jeffreydachmd.com/cancer-articles/

  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

    1k Topics
    11k Posts
    J
    There's something fishy about Hans. He claims he's been doing all these self-experiments where he takes a mega dose of something for 2 weeks and does before and after blood tests, and frequently other tests like stool tests. If it were all true, he'd be practically living at a clinic! He says doctors are useless and that he pays for all his own private tests. But then makes a post about having a chat with his doctor, and discussing various results with him. He never posts his labs, as others have pointed out. He could just be making it all up, for all we know. What he does do, constantly, is try to make money off his claims. So I'm a bit dubious.

  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

    419 Topics
    4k Posts
    alfredoolivasA
    @Meursault this is an easy finesse stay safe nigga

  • Recipes, food, meal prep, brands. Discuss them all here.

    243 Topics
    2k Posts
    S
    @Jennifer Raisins are a classic, but I usually carry dates as a nice trail snack, I can get them for a good price at the nearby grocery stores. As for everything else you've mentioned thanks for the ideas! I'm usually short on time since I tend to find out I'm going out into the backcountry maybe a few days before I head to the Trailhead, but at this point I think I should invest in learning how to dehydrate some stuff instead of buying whatever I can find at a store for sure.

  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

    96 Topics
    1k Posts
    alfredoolivasA
    @wester130 I just do the medium high seat biking due to convinience. Should be higher tbh.
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  • the MOUSET

    my recent subhuman bloodwork for recurring nausea/anxiety

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    ?
    @the-MOUSE https://bioenergetic.forum/topic/1630/soil-health-and-its-relations-to-plant-animal-and-consequently-human-health/10 Have a look at the second post for ideas about gut health too. Not exactly the same type of approach but can still work.
  • cs3000C

    This topic is deleted!

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  • ILikeToGetPeatOnI

    Bioenergetic Guide to Pregnancy?

    pregnenolone progesterone postpartum
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    JulofEnochJ
    @Sippy They were full of excipients if I recall correctly. So many things are these days. Do you know of any resources for interpreting the results and deciding how to correct imbalances? Regarding interpretation, I am no expert myself so I've relied on others knowledgeable to help me. I cannot vouch for everything this guy says but his videos on HTMA have been useful for me. If you want a real expert with a focus on mineral balancing, fertility, etc. then Andra is someone who you should consider speaking with. Her Twitter is a good resource for free knowledge. Andra is no stranger to Peat and the Bioenergetic community.
  • wolfyW

    How do I get rid of ring worm?

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    K
    @wolfy Just a few drops of liquid iodine on to the affected area.
  • Hando-JinH

    Taurine extends life up to 12%

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    P
    @DavidPS It doesn’t have to be either or. You are right CoQ10 could have been studied and it was Coenzyme Q10 as Treatment for Long Term COVID-19 High-dose coenzyme Q10 therapy versus placebo in patients with post COVID-19 condition: a randomized, phase 2, crossover trial Clearly taurine helps in a way that q10 does not Functional Role of Taurine in Aging and Cardiovascular Health: An Updated Overview From the article "The beneficial effects of taurine on Ca2+ and sodium (Na+) handling [89,90,99,100,101,102,103], myocardial energetics [104,105], and cellular signaling pathways (including glucose transport, 3-phosphoinositide-dependent protein kinase-1, AKT, sirtuin 1 (SIRT1), FOXO3, p38, NFkappaB, and others) [106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121] are thought to underlie its major cardioprotective effects. Other mechanisms include the promotion of natriuresis and diuresis, most likely via an osmoregulatory activity in the kidney, a regulation of vasopressin release, and a modulation of the atrial natriuretic factor secretion [122,123,124,125]. In addition, taurine has been shown to attenuate the actions of angiotensin II on its downstream signaling pathways, on Ca2+ transport, and on protein synthesis [113]." I came across this - so leaving it here too Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System
  • HeightOptimizedH

    Caffeine is BAD for GROWING TALLER

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    HeightOptimizedH
    @izkrov ? That is not associated with what I’m talking about. That study is not even associated with what im talking about either I agree with you that the difference isn’t huge. Although based upon the 2 responses you have sent me you did not read all the articles fully, then understood what they were talking about. The writing clearly states bone growth pauses because of caffiene.
  • TopicalsOnBallsT

    Topical Solutions on scalp for hair regrowth

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    ChudC
    @TopicalsOnBalls said in Topical Solutions on scalp for hair regrowth: interesting, you’re not concerned of the downstream effects of minoxidil? im making sure to apply minoxidil away from the times i dermastamp, i wait 24 hours, the systemic aborbtion is very low from what ive read. i am a little concerned about downstream effects, i think haidut posted on RPF how some people are getting PFS from topical minox which is pretty scary. https://www.askapatient.com/viewrating.asp?drug=20834&name=ROGAINE+EXTRA+STRENGTH+(FOR+MEN) ive been on it for a few weeks now and my erections are fine and no sides so far. its by far the most effective pharmaceutical for hairloss and doesnt seem to mess with DHT so im taking the chance. @TopicalsOnBalls said in Topical Solutions on scalp for hair regrowth: Unique way to use coke, I’ve read about others getting glucose to the scalp by using a honey mask honey is too sticky and gets tangled in my hair. i filled a spray bottle with some coke and just spray it on my scalp and massage it in whenever i can remember, its just a convenient way to get some sugar on there. "Ray Peat: I've been thinking that with a concentrated glucose solution, you could probably activate hair growth just by keeping your scalp moistened with glucose."
  • HeightOptimizedH

    Mean foot length increased by nearly a half size after 3 hours of walking on a treadmill.

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    JulofEnochJ
    Study link Important to note that this is not a structural change. The post-exertion swelling of the feet is due to increased blood flow. If one were to walk for many hours, for many months, then you'd develop structural changes. Walking on a treadmill for three hours sounds like it sucks.
  • HeightOptimizedH

    DHT and its role in promoting GROWTH in HEIGHT

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  • wolfyW

    Is there a way to change my curly hair into straight

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    wolfyW
    @pittybitty I don't like curly hair, it doesn't suit my face and frizzes up really easily. It's more difficult to maintain. And people make fun of me for it.
  • the MOUSET

    do you need to get sterile small intestine first before going on raypeat?

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    M
    SIBO can always cause unforeseen issues, but "transitioning" should be smooth. A good healthy diet wouldn't be that much different from a so called "normie diet." The biggest differences are what you're not eating. Processed foods for the most part. But more importantly seed oils, thickeners like guar gum, gellan gum, bean gum, arabic gum, xanthan gum, carrageenan, added phosphates like dicalcium phosphate, sodium phosphate, trisodium phosphate, phosphoric acid, etc. For many people citric acid will be a no go as well, also iron fortification. Vitamin fortification may cause issues with some people who are sensitive. Some people can tolerate whole milk but not low-fat milk (which is fortified). That's literally 95% of the work right there. Anything else is minuscule at best. And would more or less be "fine tuning" to your specific tolerances. Like, for example, some people don't respond to starch well, or grains. Some people can't handle dairy. Some do better with starch than fruit, etc.
  • M

    haidut

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    CO3C
    @mag-me yes. use google
  • P

    Where do people get their Vitamin B1 from without supplement?

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    ?
    Maybe look into gut bacteria and soil bacteria and how they are similar. I'm currently making a post about this but I'm still doing the reading. The bacteria in the gut can make B vits
  • HeightOptimizedH

    The formation of new growth plates is possible through hypoxia.

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    HeightOptimizedH
    @the-MOUSE definitely
  • HeightOptimizedH

    Simple ways to increase IGF-1.

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  • E

    Tips for naturally healing a dental pocket/cavity?

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    C
    raw carrots, maybe some antibiotics to cleanse it out then A D E K2 to max bone density+ lots of raw milk + aspirin + coffee with baking soda + Buteyko to boost hard tissue mineralization/calcification by upregulated minerals+oxidative metabolism induced higher CO2 production
  • F

    What B vitamin/s do you supplement? what dose, reason, and whats the effect.

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    R
    B1 at around 150mg a day cured me of all my digestive issues of "IBS", which I had struggled with for years, in a few days. Wasn't expecting it to do that at all, was taking it for something unrelated. I no longer need to take it daily and feel I need a "top up" of B1 every week or two. This was around 18 months ago and still have no issues.
  • secondkelpingS

    Didn't Ray bring up eating oat bran in the past?

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    hwisdomH
    Phytic acid in oats is anti cancer
  • T

    Thyroid, cholesterol, muscle growth

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    DonkeyDudeD
    @temple-of-salt said in Thyroid, cholesterol, muscle growth: particularly through consumption of brain - the organ meat with the highest concentration of cholesterol Vince Gironda's "12 to 36 raw eggs a day" protocol was based on a similar notion (along with a belief that cholesterol degrades with heat). According to him it was the closest one can get to a steroid cycle without actually using drugs. I'm not sure how much validity it has; I haven't experienced any effects from trying it, but I am hypothyroid and I haven't taken thyroid along with the eggs.
  • C

    Cenforce 200 Mg: Increase Intimacy Between two person

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    M
    The dosage is insane. Inhibiting the breakdown of second messengers like cAMP and cGMP can have vast benefits, including sexual benefits. But you generally should not need a dose so large. 1,500-2,000 milligrams of horny goat weed is good, quality varies. Something that's 20% Icariin or higher is best. Pharma cGMP facilitators are much much more potent. I can't remember the exact equivalence, but I'm pretty sure sildenafil is like 80x more potent than Icariin. So you wouldn't need that much, like 2.5-5mgs of tadalafil would work. But I generally fail to see how this will increase "emotional closeness." This will just improve erection quality. I think peptide research like PT-141 or Oxytocin is more up the alley you're looking for. I don't think any of these substances are "Peat approved" or even generically bioenergetic friendly, so do your research thoroughly and accordingly. I do have a more nuanced approach towards nitric oxide, and I think it's obviously useful in certain scenarios. But from a sexual standpoint it's only so useful before getting diminishing returns elsewhere (like dangerous hypotension). I see a lot of men striving to achieve that "teenage self" again. It's a valiant effort, but there's a reason few people ever succeed at this. Teenage sex drive isn't from nitric oxide or androgens. It's actually from an enhanced histaminergic tone with a lack of H3-H4 receptors. H2 (and to a slightly lesser extent H1)has a profoundly strong pro-libido effect, but in adults the autoreceptors (H3) and the H4 receptors prevent this from happening. The teenage brain still hasn't fully created all these networks yet. Dopaminergerc networks also form before serotonin. So a teenage brain is very high in pro-libido histamine receptors, dopamine receptors, and really low in anti-libido stuff like H3, H4, and serotonin.