La Farmacia del Niño ships to the US. In my experience it takes about one month for items to arrive.
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Latest posts made by banquos-ghost
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RE: Sources for Cynoplus in the U.S
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RE: Thyroid Therapy for Chronic Digestive Issues
@GreekDemiGod The plan is to retest thyroid levels (fT3, fT4, TSH) every couple months. I'll continue to post those results here.
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RE: Thyroid Therapy for Chronic Digestive Issues
Update #4 on thyroid therapy:
- Protocol at 25 mcgs T3 / 50 mcgs T4, taking T3/T4 in morning and evening, only T3 during the day.
- Sleep has improved tremendously. For the first time in well over a decade, I can sleep soundly through the night, for 6-8 hours, without waking to urinate. As a result, I'm not as fatigued as I was before treatment.
- BBT is consistently at or above 97.8 degrees Fahrenheit, unless experiencing an hypothermic adrenaline spike from digestive issues
- PR is at 70-80 BPM and stable, unless (again) experiencing adrenaline issues.
- Lightheadedness and fainting are gone. I can now stand up without reaching for the wall to stabilize myself.
- Mood has improved dramatically. Ambition and drive has been mostly restored, which were all but gone before treatment.
- Appetite is much higher. On most days I can eat enough to satiate it without exacerbating digestive issues.
- Gyno was transient. Maybe once a week I'll notice slight nipple tenderness. At this frequency, it's not concerning.
- I'm pleased with the bloodwork results I pasted earlier.
As you may gather from the above, thyroid therapy has been a success; in almost all areas it could directly improve my health, it has. However, I think it has taken me about as far as it can. No changes have been observed in my digestive health. All digestive symptoms I dealt with at the start—severe bloating, indigestion, oral thrush, stool biofilm, cognitive impairment—still persist. I think that thyroid can only do much on its own to resolve chronic intestinal overgrowths, or whatever it is I'm dealing with.
That is not to say that I'll discontinue treatment; in fact, I see no reason at all to discontinue, as I've not experienced any real side effects. Instead, I'll likely continue at this dosage for the foreseeable future. I hope that being euthyroidic will improve my immune system resilience as I begin another self-treatment protocol for these digestive issues. I'm very satisfied with this experience over the last three months, and grateful for the insights you all have provided.
I'll update the forum either in this thread or another with the progress I make on resolving my other issues.
@GreekDemiGod Per my above comments, I feel that thyroid treatment has taken me as far as it can. Despite the low fT4, I feel mostly euthyroidic at this dosage and frequency.
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Fluconazole Treatment
Does anyone have experience with fluconazole (a.k.a. Diflucan)? Anecdotes here and on RPF are limited.
I think that fluconazole, taken at a moderate dosage and concurrently with natural, Peaty antifungals, would be a very potent treatment for intestinal fungal overgrowth.
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RE: Thyroid Therapy for Chronic Digestive Issues
Update #3 on thyroid therapy:
I'm staying at 25 mcg T3 and 50 mcg T4 for now, as work and family activities are too overwhelming this week to worry about adjusting the dosage and monitoring my response.
In Update #4, I'll provide a more comprehensive overview of my experience so far. For this one, I only wanted to share recent endocrine bloodwork results after about 6 weeks of T3/T4 combination therapy (all previous bloodwork data are in this thread):
- TSH: 0.456 uIU/mL (Ref: 0.450-4.500)
- T4, Free: 0.98 ng/dL (Ref: 0.82-1.77)
- T3, Free: 4 pg/mL (Ref: 2-4.4)
- Cholesterol, Total: 197 mg/dL (Ref: 100-199)
- HDL Cholesterol: 55 mg/dL (Ref: >39)
- LDL Chol Calc : 133 mg/dL (Ref: 0-99)
- Dihydrotestosterone: 51 ng/dL (Ref: 30-85)
- DHT, Free: 3.21 pg/mL (Ref: 2.30-11.60)
- FSH: 1.2 mIU/mL (Ref: 1.5-12.4)
- Testosterone: 748 ng/dL (Ref: 264-916)
- Free Testosterone (Direct): 221 ng/mL (Ref: 109-353)
- DHEA-Sulfate, Prolactin, Estradiol, and LH were all in range
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RE: Thyroid Therapy for Chronic Digestive Issues
@bubble Last year I tried very high dose thiamine HCl (3g+/day) to no effect. On this forum and Twitter I've read many success stories, but it proved ineffective for my condition.
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RE: Thyroid Therapy for Chronic Digestive Issues
Specificity in discussions like this is good! So far, I've changed my protocol every two weeks. I think this has given me ample time to adjust to the new ratio and dosage, and assess my body's response.
With your feedback in mind, the plan is to stick with gradually increasing the T4 dosage, pulling back if any protocol change suddenly leads to daily episodes of hyperthyroidism.
I'll continue to update this log with my progress.
Your advice is much appreciated!
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RE: Thyroid Therapy for Chronic Digestive Issues
I'd like to arrive at a long-term T3:T4 dosage of about 1:3, but started with T3 monotherapy to test my responsiveness to thyroid in general. After confirming that I can tolerate it, my plan was to gradually add in T4 over several weeks (1:0, 1:1, 1:2, 1:3), until I reach a more sustainable combo-therapy dosage. While I read Barnes and agree with much of what he said, I diverted from his advice on this question of starting with combo- versus monotherapy, but I think his advice and yours hold in the long term. Would you advise switching immediately to 1:3 ratio, and at what dosage is advisable? Again, at this dosage I've only experienced the occasional episode of mild hyperthyroidism.
As I mentioned in my #2 update, the gynecomastia is beginning to normalize. Over the years, my endocrine system has been very responsive to exogenous anything (5ARIs, progesterone, pregnenolone, etc.), so this estrogenic response to thyroid is not unexpected. It is not very concerning, but I thought I'd mention it for other men experiencing the same thing. As you recommend, I'll increase my intake of oysters and seafood to see if this improves, though it seems to improve by the day.
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RE: Thyroid Therapy for Chronic Digestive Issues
Update #2 on thyroid therapy:
- 5 days ago, I added T4 into the protocol, at 25mcgs nightly, increasing my total daily dose to 25mcgs T3/25mcgs T4
- BBT has markedly improved; hands and feets are consistently warm to the touch, so much so that my wife was startled at how hot my fingers were
- Digestive issues (extreme bloating, indigestion, BM irregularity, biofilm in stool) have not improved at all
- Cognitive impairment and depressive mood swings, which are likely the result of digestive issues, have also not improved
- Sleep quality has returned to pre-thyroid quality, which is about 6 hours of semi-restorative deep sleep, with the occasional interruption in the early morning
- PR have risen to euthyroidic levels (75+ BPM); no cardiac signs of hyperthyroidism
- I haven't passed out since starting thyroid; before, I'd weekly have one or two incidents of extreme lightheadedness and fainting
- Appetite has increased considerably; I can now comfortably consume 3000+ cals daily without feeling overfed (@JulofEnoch, thanks for your input)
- Oddly, I have noticed some nipple tenderness and hardness but no visible enlargement
- I've tried to cut out caffeine and nicotine to assess my response to thyroid without conflicting variables, though I still use dipping tobacco and drink coffee on occasion (mainly to stimulate BMs)
My thought here is that addressing chronic issues resulting from years of hypothyroidism will take time—likely several months—before I experience significant improvement.
Why the gynecomastia? I'm not sure. It could be that thyroid supplementation has elevated levels of testosterone, which is then aromatizing and causing estrogenic symptoms. The severity of those symptoms has gradually decreased over the last several days, but still persists. Libido, muscle hardness, confidence, sociability, and other androgenic signals have not changed. I've taken anti-androgens (5ARIs) in the past (pre-Peat), so I know what being in a weak, estrogenic state feels like.
Additionally, in my latest La Farmacia order, I also purchased 10 tablets of 100mg doxycycline. Over the last week, I took 50mg after breakfast and 50mg after dinner. Nothing to report here, and I'll likely stop this evening. Inflammation has not diminished; the only notable effect was worsening of oral thrush, as well as some esophageal pain after the first few doses.
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RE: Thyroid Log
@GreekDemiGod Why take 12.5 mcg in a single dose? I'd advise taking 2-3mcg every 2-4 hours, as your schedule permits, to mimic rhythmicity of endogenous secretion. Exogenous T3 in excess of physiological levels (e.g. the midday dose you took) will be neutralized by the liver and converted into rT3.