I think haidut once mentioned 3g of vitamin b3 and 3g of b6 fixed glaucoma.

I remember reading awhile ago that injecting Hyaluronic Acid (HA) into a scar made it fade then come back, but injecting HA + CO2 made it go away. (https://pubmed.ncbi.nlm.nih.gov/37723352/). I think there's something about the combination that might be good even if you're not exactly dealing with scars. I'd look into carboxytherapy (it's a subcutaneous injection, but I think CO2 absorbs well enough through the skin even without that. there's little gels for a face mask you can get like from here

Otherwise I read that Vitamin A is needed in excreting calcium in the calcium cycle, so a topical vitamin A and D combo in coconut oil wouldn't hurt to try if you think calcification is involved.

Lutein also preferentially accumulates in the human brain across multiple life stages.

Preferentially accumulating in the brain as you age doesn't sound very good.

I actually remember reading older people were less sensitive to blue light/screens to kids, so lutein having a role in blue light filtering makes sense to me. I just don't know how stable lutein is given the double bonds though.

I've got some mild bacne and I'll be trying hibiclens, supposedly should have results in a week. Foid told me about it. Could be worth a try.

Most AGEs happen because of PUFA.
https://www.jbc.org/article/S0021-9258(17)31047-5/fulltext

@wester130
https://pubmed.ncbi.nlm.nih.gov/830547/

However, when E3 is present continuously and RnE3 is elevated and maintained, E3 is a potent estrogen without antagonistic properties.

In an estrogen dominant state like in menopause (which is what they're advertising it for), it doesn't seem useful. Even context aside, I can't think of a use in which someone would prefer that over progesterone.

lidocaine demethylates DNA, so things like re-occurring rashes and ingrown nails get their "memory cleansed" and stop. I imagine the same applies to genetic mutations. Most things that increase the metabolism have that same mechanism. Progesterone probably too, I'd just take some of that and then hopefully you'll epigenetically adapt.

I remember reading somewhere minoxidil increased scalp PGE2, so it makes sense aspirin stops that

@NNight I don't really understand what MR gene expression is. Could you explain?

Low salt raises aldosterone and I think prolactin too. Aldosterone helps you retain sodium by disposing potassium and magnesium, I don't think you want that.