Posts made by izkrov

I think haidut once mentioned 3g of vitamin b3 and 3g of b6 fixed glaucoma.

I remember reading awhile ago that injecting Hyaluronic Acid (HA) into a scar made it fade then come back, but injecting HA + CO2 made it go away. (https://pubmed.ncbi.nlm.nih.gov/37723352/). I think there's something about the combination that might be good even if you're not exactly dealing with scars. I'd look into carboxytherapy (it's a subcutaneous injection, but I think CO2 absorbs well enough through the skin even without that. there's little gels for a face mask you can get like from here

Otherwise I read that Vitamin A is needed in excreting calcium in the calcium cycle, so a topical vitamin A and D combo in coconut oil wouldn't hurt to try if you think calcification is involved.

Lutein also preferentially accumulates in the human brain across multiple life stages.

Preferentially accumulating in the brain as you age doesn't sound very good.

I actually remember reading older people were less sensitive to blue light/screens to kids, so lutein having a role in blue light filtering makes sense to me. I just don't know how stable lutein is given the double bonds though.

I've got some mild bacne and I'll be trying hibiclens, supposedly should have results in a week. Foid told me about it. Could be worth a try.

Most AGEs happen because of PUFA.
https://www.jbc.org/article/S0021-9258(17)31047-5/fulltext

@wester130
https://pubmed.ncbi.nlm.nih.gov/830547/

However, when E3 is present continuously and RnE3 is elevated and maintained, E3 is a potent estrogen without antagonistic properties.

In an estrogen dominant state like in menopause (which is what they're advertising it for), it doesn't seem useful. Even context aside, I can't think of a use in which someone would prefer that over progesterone.

lidocaine demethylates DNA, so things like re-occurring rashes and ingrown nails get their "memory cleansed" and stop. I imagine the same applies to genetic mutations. Most things that increase the metabolism have that same mechanism. Progesterone probably too, I'd just take some of that and then hopefully you'll epigenetically adapt.

I remember reading somewhere minoxidil increased scalp PGE2, so it makes sense aspirin stops that

@NNight I don't really understand what MR gene expression is. Could you explain?

Low salt raises aldosterone and I think prolactin too. Aldosterone helps you retain sodium by disposing potassium and magnesium, I don't think you want that.

I remember Ray mentioning the better the reflexes of an organism, the more intelligent you are generally.
I also remember this one video of some zoomers robbing an asian guy, with one of them jumping over the counter top to steal things. The asian guy automatically just got a knife and started stabbing him, then dragged him outside. Someone asked the asian guy on a Q&A how he remained calm and quick during that situation and he said something akin to "This sounds a bit weird but the muscle memory of team fighting in League of Legends allowed me to know what I'm doing and not panic".
Now not necessarily League, but any game that's fun that requires fast acting would be good.

@yerrag Don't need your "you have much to learn young padawan" redditism. Seems odd of you to accuse me not having read what he's written if you didn't recall him talking about the rate of living theory.

What if the food cannot be converted to energy as easily because there is a bottleneck

Progesterone and B vitamins fixes that bottleneck.

@yerrag A very reasonable takeaway if you were to read Ray's ideas talking against the Rate of Living Theory, would be to meet the demands of your metabolism.
But no, even in abundance progesterone shouldn't stress the system. When your metabolism increases and you get hungry, you should probably eat.

@bee12 Yeah I think your iron's fine, I wouldn't worry about it. The only time Ray considered iron supplementation as an idea is if your iron saturation is less than 5%, and you seem fine in that regard. I think the issue is hypothyroidism and a general lack of B vitamins (or whatever's missing from your diet. maybe b1 and b7).

It's all reversible. Low pregnenolone creation from cholesterol is associated with wrinkles and fatigue, and your inefficient liver from lack of thyroid creates circulating estrogen and excess cortisol (which probably adds onto the fatigue). I've read glucocorticoids thin the skin, so that makes sense yours is thinning. Ehlers Danlos symptoms are a cause from estrogen and lack of vitamin K, and probably high PTH (from lack of vitamin D and calcium).

Not sure what you CAN eat but if you go on a diet of 2Ls of low fat milk, 1L of OJ, and an egg or two a day with some salt and you'll be generally okay for the time being for nutrients.

Progesterone directly suppresses cortisol and opposes estrogen. I'd definitely get progest-e. The rest is just restoring thyroid function, so this means no polyunsaturated fat intake, eating more foods with cholesterol, and if you're not into supplementing thyroid then vitamins B1 (high dose)/B3/B7 midday and the aspirin in the evening should be a game changer.

So:

• Fix your diet (see above)
• Calcium (from milk), Vitamin D and Vitamin K for ehlers danlos symptoms.
• Progesterone to lower cortisol.
• Vitamin B1/B3/B7 and aspirin to make sure you're using sugar properly.

Hemoglobin depends on body temperature and if you have cold hands and feet (hypothyroidism) that's probably the underlying issue. Thyroid absorbs copper and copper is needed for integrating iron with blood (hemoglobin), so I'd look into sea food as well.

The blood tests aren't really useful markers, unfortunately.

I would also look into your PTH levels which can be lowered with generous vitamin D and calcium intake.

I can't know exactly what's going on but I can offer some musings.

• Progesterone does release estrogen from tissues, and estrogen lowers liver glycogen. I remember reading some girl's twitter awhile ago and she took 3 drops a day and felt awful, but later came back to it and tried 5 and felt a significant difference, much better. If you're feeling ballsy, could try a bit more than you usually take.
• I think Katharina Dalton mentioned if during progesterone treatment the blood sugar drops, that it takes about a week to recover from that, it's why she was keen on the 3 hour starch diet. I don't think she knew about thyroid though (or persorption of starches in the intestine for that matter).
• You do need an active thyroid to convert carotene to vitamin A. Having a carrot salad when you're running on stress hormones is probably not too good.
• Vitamin B3 (Niacinamide) and a little bit of thyroid before bed can promote glucose usage overnight. Milk and honey before bed could be helpful. Taurine also increases liver glycogen.

@FTMarinetti I don't think an area can be resistant to progesterone, especially when one of the main mechanisms of progesterone is to oppose estrogen. I was looking somewhere to see if Gilbert Ling made any mention of the difference in muscle contraction disallowing progesterone, but it doesn't make sense to me. All I found was the usual difference in exchanging sodium/potassium ions.

It may be concluded, then, that whatever the assumed proportional weight of the endometrium may be, the estrogen endometrium always contains more Na and less K than the progesterone endometrium.

It may be concluded, then, that progesterone muscles have a higher intracellular Na concentration and a lower intracellular K concentration than estrogen muscle.

There's seemingly less contractions in endometriosis as well, probably a cause of the estrogen. I imagine there's a greater generality about the resting, high energy state maintaining sodium which allows for more contractions that hasn't clicked in my head yet.

I've seen some women say progest-e wasn't enough. I think they should just take a megadose or do consistent topical application, but even then yeah just glucose metabolism over burning fat/ taking thyroid and eating well/aspirin truly ought to fix it.

And I think the concept of receptors is what a computer programmer would come up with in regards to how a breathing organism works. Just a convenient explanation attempting to describe something and it "just works" most of the time. But yeah breaking the cascade of effects that estrogen has (prostaglandins, inflammation, then aromatase making more estrogen) is crucial, on a systemic level.

@FTMarinetti I can't find that book online, but there's the idea that progestins "act on target progesterone receptors" and therefore progestins have the same mechanism as progesterone. This is absolutely not the case -- there is an enormous difference between progestin and progesterone. When progestins don't work, they just say that there's no receptors there or you're "resistant" to a hormone; it couldn't possibly be that progestin (synthetic progesterone) simply doesn't work like natural progesterone, or that the idea of receptors is faulty. I wouldn't be surprised if that textbook is following that exact logic.

Ray said that with endometriosis there's a loop of inflammation between estrogen, prostaglandins, and aromatase. No PUFA, aspirin, vitamin B3, thyroid and progest-e all would stop prostaglandins, inflammation, FFA release and support progesterone production to oppose estrogen. Things like OJ and milk eggs should be in the diet.

I remember reading someone's gf swearing by a vitamin E gelatin capsule vaginally before bed really helping too, which makes sense since it's anti-estrogenic. I'd try progest-e topically at the very least.

@GreekDemiGod T4 suppresses TSH, which is a good thing. I don't think TSH is in charge of T4 production. I think most people would agree a ratio of 3:1 or 4:1 for T4:T3 is fine (which is what I think is in Tyromax)

@DonkeyDude cortisol, adrenaline, prolactin, TSH are all stress mediators that are there for a reason. if you're trying to directly increase your metabolic rate without regard for what lowered it in the first place I'm not sure that's a good idea. I think you should lower the dosage to 4 drops and take pregnenolone to lower stress then just take it from there. no need to push for something that affects you adversely.