Just got an email
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legimitately checked the date to make sure it wasn't april 1st
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I got excited until I saw that it was estriol rather than estradiol.
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"Estriol, however, has been shown to protect against estrogenic cancers, decreases the risk of fibrocystic changes in the breasts, and can even help women with estrogen-related weight changes to drop the extra pounds."
in the presence of estradiol, it is antiestrogenic
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@wester130
https://pubmed.ncbi.nlm.nih.gov/830547/However, when E3 is present continuously and RnE3 is elevated and maintained, E3 is a potent estrogen without antagonistic properties.
In an estrogen dominant state like in menopause (which is what they're advertising it for), it doesn't seem useful. Even context aside, I can't think of a use in which someone would prefer that over progesterone.
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"It seems that an "empty/unbound androgen receptor" is the worst thing as far as glucocorticoid signalling - and that even androgen antagonists interacting with the androgen receptor can reduce that glucocorticoid signalling."
https://raypeatforum.com/community/threads/panquinone-liquid-triquinoyl-quinone-mix-for-lab-r-d.11566/page-8#post-292585
