@pittybitty Mixed tocopherols, the cleanest supplement you can find, 400 IU as needed, is what I'm doing.

@Milk-Destroyer 1. Yep, 25 capsules and you're right, might've been an issue with the supplement. Although i noticed some positive results like whiter teeth which makes me think it might not be the supplement.

Yes, Cypro was interesting for me too. I think it helped my poops but made me moody and tired to the point where it wasn't really worth it.

You're right, I've stopped everything except thyroid. Interestingly, 50mg Niacinamide makes the diarrhoea from milk less severe. It's still diarrhea so still pretty shit lol

Appreciate your help 🙂

All three posters above in this thread raise some very good points.

The problem I have with a term like "dopamine fasting" is that the proponents - although well-meaning - make it sound like dopamine release is the villain. It doesn't ask the question why people, increasingly in my observation, feel the need to consume what is called supernormal stimuli in order to increase their dopamine levels. The current dopamine fasting trend sounds like high dopamine releases are the problem itself and not just a symptom.

OP mentions the anecdote with the kid that gave up computer games after abstaining for 30 days. I know people like that from real life, so it's not just anecdotes. But what happens if you abstain for 30 days and your problems are still the same after those 30 days - whether the problem is hormonal or psychological? Wouldn't you just continue doing the same stuff as before? My guess would be that the kid lost the desire for computer games, because he spent time with friends, maybe playing some sports, spent more time outside, and realized that this is actually better than counter strike.

I remember in one episode of the GE podcast Danny asked Dr. Peat about porn addicts, and Peat said something like "I think they just need a girlfriend". While that may have been a partial joke and is not as easy as it sounds, I think there's also some truth to it. If you have the experience that "the real thing" is better, more fullfilling and less shallow than pixels on a screen, that might abolish your desire for the fake alternative.

I have tried meditation in the past and it helps me to just deal with life and become calmer. I have never looked into any connection to thyroid function, so I don't have any input here. The only thing I know is that experienced meditators have more gray matter in the prefrontal cortex and a better connectivity between certain brain areas.

@orgon wow cool
thanks for the info

@newyear2025
Stop doing coffee with collagen between meals. Do it with meals or don’t do it. Or add milk and sugar.

Protein and caffeine on empty stomach… 😐

@heyman It's probably the single safest approach after just cutting it off clean, which is very difficult to do if not trained, especially on one's self.

I would drop all supplements and eat only what i crave while trying to include orange juice, dairy and eggs, and see how that goes. rice with butter for when i crave starch.
The vast majority of supplements cause problems. Have you tried bag breathing?

Thyroid and microbiote
Does the thyroid impact the microbiome? (Conversation with Google IA)
Yes, the thyroid gland and the gut microbiome have a reciprocal relationship, meaning they influence each other. Thyroid hormones can affect the composition and function of the gut microbiome, and conversely, the gut microbiome can impact thyroid hormone synthesis and metabolism.
How Thyroid Impacts Gut Microbiota?
Altered Gut Microbiota Composition:
Studies have shown that thyroid disorders, such as hypothyroidism and hyperthyroidism, are associated with changes in the types and amounts of bacteria in the gut. For example, some studies have found a decrease in beneficial bacteria like Bifidobacteria and Lactobacilli in hyperthyroidism, while others have observed increased levels of certain bacteria like Veillonella and Paraprevotella in hypothyroidism.
Immune System Modulation:
Thyroid hormones can influence the immune system, and the gut microbiota plays a crucial role in shaping the immune system. Alterations in the gut microbiome due to thyroid issues can lead to immune dysregulation, which can potentially contribute to or exacerbate autoimmune thyroid diseases. (As our diet has several components that modulate the immune system this might explain why our diet contributes to a more stable thyroid function, when bringing appropriate useful nutrients like Se, I or Fe).
DOI: 10.4236/fns.2012.33059
Thyroid diseases can exacerbate disturbances in the microbiota. Inducing immune-inflammatory responses, altering iodothyronine metabolism, and affecting thyroid-associated micronutrient absorption are potential pathways through which the microbiota and metabolites are involved in thyroid homeostasis. Nevertheless, the causal relationships between gut microbiota and thyroid diseases, how gut microbiota modulates thyroid autoimmunity, and the specific mechanisms by which a particular bacterium or core flora triggers thyroid diseases, are still poorly understood.
Source: Front. Endocrinol., August 2022
The relationships between the gut microbiota and its metabolites with thyroid diseases.
How Gut Microbiota Impacts Thyroid (through the thyroid hormone synthesis)

The gut microbiota can influence the availability of essential nutrients, like iodine, selenium, zinc, and iron, which are crucial for thyroid hormone synthesis.

Inflammation and "Leaky Gut"
Dysbiosis (an imbalance in the gut microbiome) can disrupt the gut barrier, potentially leading to increased inflammation and "leaky gut," which can further impact thyroid health and potentially contribute to autoimmune thyroid conditions.
Summary
In essence, the thyroid and the gut microbiome are intricately linked, and disruptions in one can affect the other, highlighting the importance of a healthy gut for overall thyroid health and vice versa.

@16characterstwas @EagleTwoRomeo

Hope those help.
Again, I wouldn’t take more than 4 or 5 mcg per hr, since that’s around the amount the body normally produces per hour (If I really wanted to take more i would take 4 or 5 mcg/hr several times a day rather than all at once)
Above all It’s important to go by how one feels. If i got jittery I’d stop and then when restarting make sure i took it less frequently, ie a lower total amount per day.

Now brand has a nice vit e with gamma.

You wrote you were visiting your in-laws. Is it possible you had a different brand of orange juice than usual and had an allergic reaction to something in that brand?

Did you have anything else high in histamine since then (aged cheese, dark chocolate, fermented foods, red wine, ...) and experienced the same flush of the skin?

If you still have problems breathing, baking soda could also help. One teaspoon of baking soda in some water.

@Turk
what's the best glycine?

Youtube Video

Youtube Video

Youtube Video

bump bump

@SanguisEtAqua Yes, it is probably metabolic. Check your body temp when you are lacking imagination. It's probably at or below 37°C.

Childlike play, which includes creativity, requires high body temp.

@RayPeatFan said in Vit E and Vit K:

Where is the study that claims HD Vit K could contribute to Vit E deficiency?

No deficiency but possibly preventing from assimilation. No clear proof.
Most studies establish the fact that we should avoid HD vit E (> 300 UI) when taking vitamin K, especially K1. It makes sense (conversion to MK4 more complicated). But that's not this aspect I mentioned. I'm talking about HD MK4 supplement with 400 UI vitamin E.

So, studies establishing why or at least mention the advice we shouldn’t take Vit E at the same time as HD K2.

Mechanisms according to MG Traber (deduction)
https://academic.oup.com/nutritionreviews/article-abstract/66/11/624/1868525?redirectedFrom=fulltext
Vitamins E and K appear to share the same metabolic pathways because both undergo side chain ω- hydroxylation and b-oxidation to produce their respective metabolites.

Possible mechanisms for the vitamin E and K interaction
*) Vitamins E and K share the same metabolic pathways
*) Vitamin E competes for the enzyme (yet undiscovered) that truncates the K1 side chain to form menadione;
*) Vitamin E increases xenobiotic pathways that increase the metabolism and excretion of all vitamin K forms from the liver;
*) Vitamin E competes with K1 for the cytochrome P450 (CYP) that ω-hydroxylates the tail, thereby preventing the b-oxidation of the tail to form menadione. The latter mechanism is hypothetically less likely because, as discussed by Thijssen et al. (11), there is likely to be steric hindrance preventing the complete removal of the K1 side chain via b-oxidation for menadione formation. All of these mechanisms would decrease the production and/or availability of MK-4. The hypothesis that vitamin E interferes with the conversion of K1 to MK-4 is supported by the observations that MK-4 concentrations in extrahepatic tissue are lower in rats fed a high vitamin E diet.

@lobotomize-me

If there is a consensus, it is Vitamin A is needed by the body. If there is too much of what is good, it will be bad. Vitamin A is no exception.

Why you are here and there is a here is because many of the members here that used to be in the other forum could not stand the authoritarian insistence of its admin that vitamin A is toxic.

I personally feel eating liver for retinol, or vitamin A, does wonders that eating the precursor of vit A, beta-carotene (as popularly found in carrots) could not do for me.

For eating beef liver once a week for 5 years, my myopia was gone and my driver's license did not require me to wear glasses anymore.