"The dopamine system of healthy, highly creative people is similar to that found in people with schizophrenia"
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low D2 receptor density (not to be mistaken with D3) is correlated to creativity
low protein high carb diet decreases D2 receptor density
antipsychotic medicine increases D2 density and lowers dopamine, so one can argue that high baseline dopamine reduces D2 density
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More evidence for the schizo <-> autism spectrum.
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@pittybitty are you implying autism is the opposite of schizophrenia?
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@sunsunsun Indeed. If you imagine for a second our thoughts as interconnected factoids and connections between the factoids. Schizophrenic have very lateral thinking, they make connections between very distant, unrelated factoids. Autists on the other hand have very narrow thinking, they don't see connections between unrelated things at all. That allows them to hyperfixate on just one thing covering a lot of ground but only in one direction. That's the two extremes, a true schizophrenic might be too eager to make connections that aren't actually there, that's what can make them delusional while a true autist is unable to make the connections in the first place even when they are there, not understanding implied context.
Then there is shizo-adjacent and autism-adjacent people who have strong lateral or linear thinking capabilities but don't have the same shortcomings of a true autist or a true shizo.
And finally In the middle you have normies.
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The voice inside your head is not your own, its external.
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@pittybitty oscillating between the two as required at will is probably the best and then living in the middle for balance and health otherwise
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@lobotomize-me said in "The dopamine system of healthy, highly creative people is similar to that found in people with schizophrenia":
low D2 receptor density (not to be mistaken with D3) is correlated to creativity
low protein high carb diet decreases D2 receptor density
Interesting finding! Thanks for sharing!
BTW, a lower degree of signal filtering is technically referred to as Reduced Latent Inhibition (RLI) and Reduced Inattentional Blindness (RIB).
I've asked ChatGPT about their roles:
Dimension Reduced Latent Inhibition (RLI) Reduced Inattentional Blindness (RIB) Filtering Type Stimulus pre-processing filter—selective tuning at the perceptual/cognitive threshold Attentional spotlight filter—selective tuning within focused attention Default Role Prevents distraction by familiar/unimportant inputs Prevents distraction from peripheral/unexpected events Neural Basis Linked to dopaminergic modulation, especially in mesolimbic pathways (e.g. nucleus accumbens, prefrontal cortex) Linked to fronto-parietal attentional networks, including dorsal and ventral attentional systems Associated Traits Creativity, schizophrenia, high openness to experience, ADHD, genius-madness continuum Hypervigilance, mindfulness, elite perceptual-cognitive performance (e.g. pilots, special forces) Cognitive Mode Associative, divergent—binds unrelated stimuli, sees patterns and novel links Alert, convergent—detects anomalies within or outside the focus of attention Potential Downside Overstimulation, chaotic associations, psychosis risk Sensory overload, hypervigilance, burnout, possibly anxiety States That Induce It Psychedelics (esp. LSD, psilocybin), manic states, creative flow Mindfulness training, certain psychedelics (e.g. ayahuasca), trauma hyperarousal, combat readiness Function in Evolution Exploratory, useful in novel problem-solving or innovation Survival-enhancing in threat detection or awareness of predators/anomalies -
@lobotomize-me said in "The dopamine system of healthy, highly creative people is similar to that found in people with schizophrenia":
antipsychotic medicine increases D2 density and lowers dopamine, so one can argue that high baseline dopamine reduces D2 density
BTW, I had some doubts about the statement above, so I've asked gpt to refine it...
"Antipsychotics block D2 receptors, which can lead the brain to upregulate D2 density over time. This suggests that the brain responds to dopamine levels dynamically: when dopamine signaling is low (due to receptor blockade), D2 density may increase; when dopamine signaling is chronically high, the brain may compensate by reducing D2 receptor density. Thus, baseline dopamine levels may influence D2 receptor availability through feedback mechanisms."
