@winters Thank you

@winters I do suspect lead poisoning. What kind of test did you do? Testing for heavy metals is tricky, as the metals seems to be very selective in where they accumulate, and might not be detectable in blood. Is hair test reliable?

@winters
I do have nutrient deficiencies. My body reacts to these nutrients in the same way it reacts to metabolic uncouplers, despite being deficient. I'm eating liver twice a month.

@winters
Thank you. I gave that a lot of thought, because yes, I do have many (all?) symptoms of hypothyroidism. But I suspect that hypothyroidism is not the root cause, rather it is a protective mechanism. Possibly to spare some nutrients via lowered metabolism?

When I try to stimulate / support thyroid, my teeth randomly crack, crumble and fall apart for no apparent reason. I have lost many healthy teeth. Supplementing T3/T4/NDT is the worst, but thiamine have the same effect to some degree.

@Aniciete
I can't digest eggs But you are absolutely right, supplements are not a way to go

@S-Holmes
Wow, that's incredible! I'm very happy for your husband. It must have been terrible, I can't imagine doing hard work in summer while being unable to sweat. Recently I have realized that orange juice is causing some digestive issues for me. I was just looking for different source of sugars, so your advice came at perfect time. The science behind glucose loading seems sound, so why not? Have replaced OJ with glucose solution last week and it feels pretty good so far. Thank you very much, S. Holmes!

@CrumblingCookie
Loading on supplemental choline did nothing, so ruling out / confirming Sjögren's will be the next course of action. Will do the tests you suggested. Thank you!

@yeyo12
Just have placed an order for choline supplement. Vitamin E made things much worse when I took it without choline, should I try again in combination with choline?

.........

@yeyo12 said in Can't sweat, cry, salivate and regulate body temperature:

could be due to low acetylcholine

This is tricky because there is apparently no test confirm or rule out low acetylcholine diagnosis, and the symptoms are very non-specific. That being said, I do have all the symptoms, including mild schizophrenia and extreme muscle weakness that worsens with exertion. I often had elevated ESR (and sometimes also ferritin) for no apparent reason since the earliest childhood. Also, I have experienced some improvements when supplementing choline.

Some of my relatives have the same symptoms I do. Maybe it would be worth to check for genetic errors predisposing to low acetylcholine?

@sneedful said in Can't sweat, cry, salivate and regulate body temperature:

@BearWithMe have you tried methylene blue?

Yes. It was 10 years ago so I don't remember the details, but I do remember that I stopped because it had some very unpleasant side effect and I did not perceived any benefit at the time. Maybe I wasn't using it long enough.

Another event that made my issues permanently worse was a short period of taking SSRIs. I thought about mild serotonin syndrome. Serotonin is apparently one of the most active aldosterone-stimulating substances

@yerrag said in Can't sweat, cry, salivate and regulate body temperature:

@BearWithMe

Seems like crying, sweating, and salivating involve the fascia and the lymphatic system and the extracellular fluids. I would want to look into decongesting or draining the lymphatic system.

Since I know of no way to evaluate or test the health of the lymphatic system, it is something like a black box to us. Perhaps a practitioner of TCM can help shed light on it as the way they classify organs involve organs like the triple burner, which involves the mysentery to which our medical system lacks in studying.

Thank you. I was never into TCM at all, but last week, I had a strange intuitive hunch that my issues might be related to some sort of energy imbalance, so I bought Unschuld's translation of Huang Di Nei Jing Su Wen. Yes, I would not trust modern TCM practitioner and especially not western TCM practitioner.

@ThinPicking said in Can't sweat, cry, salivate and regulate body temperature:

Can you describe in detail your food/fluid patterns over the last few months? By TOD.

Some kind of ORS substituting sodium chloride for sodium bicarb would probably straighten you out.

Preferably with some supervision and markers. Bloods, renal and pulmonary. Probably. I'm not a doctor.

Hi BearWithMe.

Hi ThinPicking! My fluid intake pattern is 200ml of warm/hot orange juice with 2g of salt every 2 hours. It contain plenty of glucose, sodium, potassium and chloride, so it is basically natural ORS. Have tried substituting salt for sodium bicarb but it caused milk alkali syndrome. I have been doing this consistently for over a year but I don't feel much better.

I'm eating mostly oatmeal and meats. My digestion is really screwed up, I'm not able to digest much else. Can you suggest some markers to keep an eye on, please?

I'm in constant state of mild heat stroke. My urine sometimes get so thick it is super painful to pass. The lack of saliva is wreaking havoc on my digestion and teeth.

I had a mild form of this since I was born, but it got significantly worse after a period of starvation due to illness. That was 20 years ago and it is getting progressively worse since then. I often have extreme thirst, but drinking more water doesn't help. Salt seems to make it worse.

What could be the reason for this? Am I deficient in some nutrient that is needed for fluid homeostasis? Is it hormonal? Any hint where should I focus my research would be greatly appreciated.