My wife has been having this issue for about 6 months. Once or twice a month she will have a very bad “allergy” like symptoms develop. Itchy hot face, puffy face, stuffy nose, congestion, headache, body aches and chills. The first time it happened it was after a night of drinking wine so I figured it might be histamine. It happened a few weeks ago after a night of eating shrimp. And then this morning it happened again but no particularly high histamine foods were eaten. She noticed that it seems to happen right before (a day or two) her menstrual cycle. But there are a few times it happened a week or so before.
I have been giving her 2-4mg of cyproheptadine before bed when it happens and it will be cleared up by the next day. But it’s hasn’t solved the issue long term. It will eventually return.
Does anyone have any idea the cause or what to look for here? Is it histamine? Estrogen? Serotonin? The proximity to her menstrual cycle makes me think it’s hormonal.
Any help would be appreciated. Every doctor we have consulted is no help (shocker I know). They just suggest hepatoxic allergy meds.