@CO3 The question is what is the metabolic link between socioeconomic status and longevity? I suppose happiness/lower stress is the obvious factor but I suspect there are other psychological and physiological effects of power

@flexthorton Another option would be for you to consider physicians that are listed with Orthomolecular.org that treat endocrine issues. See here: http://orthomolecular.org/resources/pract.shtml

@Orindere The only ones I’ve ever used and think are trustworthy are Idealabs Tocovit and HealthNatura Whole E. I’d love more options or suggestions if anyone has.

@arkos I’m in a similar position. I’m super sluggish in the morning too. Usually pretty congested and eyes get puffy. I think it’s cause my metabolism gets so low over night. But it cranks back up to 98.6. Especially with bits of t3. I’m taking a small amount of cynoplus hoping to get my morning temp up. But at least cortisol isn’t cranking so high in the morning to make the temps high. But also maybe my circadian rhythm is flipped cause usually the evening is when I really feel energized

@linx Have you ever tried combination T3/T4 therapy? Over what timeline have you worked up to 87.5mcg T3 daily?

@Ray-Peat-Fanboy High iodine intake, without sufficient micronutrient support, increases the risk of Hashimoto's, especially in women. Selenium seems to plays a crucial role in protecting the thyroid from further tissue damage caused by excess iodine intake.

@evan-hinkle There is a study I will try to find later that assessed medications dissolved in Vit E and their accumulation in the brain after traumatic brain injury, IIRC. Vit E significantly improved accumulation in the brain, Vit E itself accumulates in the brain and the liver(other places too, but these two are the most accumulating). This makes sense due to the sensitivity of each organ to lipid peroxidation, cell membrane disruption, etc.

@CO3 I found the issue. Once in a while I eat mushrooms but I cook them only for half an hour and it requires at least 2 hours of boiling. The endotoxin and bloating that this created increased the intensity of nightmares. Now I stopped them and I don't have them anymore. Maybe also the high amount of copper does something I don't know. I was eating 500,g a day.

@John-Smith lol

@deliciousowl yes its opiod. I think even that is too much I never go above 12 mg a day and I only use it three times a week. serotonin is generally androgen inhibitory and I dont think the opiod agonism outweighs the pro sero- inhibitors effects on T at that dose

My biggest success is treating it before symptoms appear. Slam yourself with Vit D and C every time you get little to no sleep.

@speed A little bit of flowers of sulphur will not harm you and likely get rid of a fungal infection, and you can use a little bit on the skin as well to help reduce acne. Although your problems do not sound like they're fungal in nature. White tongue is mostly related to reverse peristalsis, endotoxin, and liver health. I don't wanna just give you a list with things to buy but a waterpik to remove filth from in between the teeth, particularly the molars, might help to reduce the white tongue. Those flossing bows can do the job too but it's a bit harsher on the gums. Scraping everyday, gargling baking soda in warm water will help too. oil pulling once a week with coconut oil isn't a bad idea. Then mastic gum is a really good addition to help make your mouth hygiene better, and it has beneficial effects on the gut as well. This is not medical advice but the antibiotics is a route i would inspect as well. It requires a lot of care not to overdo them. to balance the microbiome and i always take it with (weekly small amount of) sulphur so as to avoid strengthening fungus by getting rid of their natural competition. I've had all of these symptoms you described and sometimes they pop up again, but you can change all of it. Shift the diet towards more solid foods is another suggestion i'd give. Godspeed

@DarthGomas said in Coffee weird effects: If I start using it regularly, it drastically reduces my energy, makes me very irritable, and gives me a sensation as if my body is burning (in a bad way). Coffee blocks thiamine. "As thiamine is an essential micronutrient for humans its needs are supplied from diet rich in thiamine, such as yeast, pork, legume and cereal grains. Enzyme called thiaminase I (EC2.5.1.2), present in raw fish, shellfish, tea and coffee, decreases thiamine absorption." also this one: https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2019.00207/full "Heavy consumption of tannin-containing or food rich in caffeine, theobromine, and theophylline (such as those present in coffee, chocolate, and tea, respectively) can inactivate thiamine, thereby compromising the thiamine status (7, 14, 15)." and this one: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753639/ "Plant-derived anti-thiamine factors, heat-stable compounds known as polyhydroxyphenols, which include caffeic acid, phenols, flavonoids, and tannins, are present in certain plants and destroy thiamine by an oxidative process that transforms it to non-absorbable thiamine disulfide [17,63,66,87,88,89,90]. Plants containing polyhydroxyphenols include coffee, tea, and some fruits and vegetables, such as blueberries and red cabbage [17]. " The experts can't seem to agree on exactly what in the coffee messes with thiamine (thiaminase I? caffeine? polyhydroxyphenols??) but they know it's something. I had a terrible reaction to a few sips of coffee when I was thiamine deficient and it nearly made me collapse onto the floor. I don't try to drink it anymore.

@PrinceMyshkin Thank you for your reply, yes I had that starch suspicion and will definitely try to make some more changes. Didn’t know about the zinc supplementation but will look into that.

Interesting! Tryptophan can be very inflammatory, and if you are hypothyroid low protein can alleviate certain symptoms. As has been mentioned above, the balance of amino acids is key. In From PMS to Menopause Ray writes: "In the case of amino acids, balance is everything"

Did you notice any negative effects on your muscle growth with this dose? When people say that aspirin affects gains, I don't think that prostaglandins are the problem in this case; perhaps it's the fact that aspirin increases AMPK and AMPK reduces muscle protein synthesis.

You do realise iso- tretinoin does an almost complete opposite job of retinoic acid and most of its other metabolites?