Farmaciadelnino is out of stock. What are some other sources?

Thanks!

When I get it, sure it’s freaky and uncomfortable, but I’ve never seen any shadow figures. Maybe because I don’t believe in demons or Christianity so my imagination doesn’t take me there.

Get an ultrasonic tooth scalar from Amazon. That’s the main thing that’s nice at the dentist is the deep cleaning they do with those around the gumline, and you can it yourself! And it’s great for getting rid of stains after drinking lots of grape and pomegranate juice.

He’s pretty dang lean and sun baked

@natureman My juice of choice is usually pineapple, not the best quality, and I’ll mix it with some grape, pomegranate, or cranberry. I’ve been putting some calcium carbonate in it in the morning just to add more calcium.

I do milk powder pancakes with syrup or marmalade and eggs and dates, pineapple, or banana for breakfast. Lately been making sourdough French toast but it’s not the best

Sometimes Fruit smoothies with pure pea protein

Lunch and dinner it’s usually some kind of mix of meat/seafood, milk, cheese, maybe a bit of cooked veggie, carrot, and fruit like dates, raisins, banana, juice. Sometimes I’ll have it with rice or potatoes.

Really nothing too naughty that I think would suppress thyroid. But I think the starches do mess with my digestion. And on the off occasion we eat out like chipotle that usually sets me off too.

I’ve gotten up to about a grain and a half of cynoplus split between breakfast and dinner and sometimes dose an extra 5mg of t3 at lunch.

My morning temp is still 97 - 97.3 and feel pretty hypo in the morning, like lack of circulation in face, puffy eyes, congestion.

After breakfast my temp goes up over a degree and I always hit 98.6 by afternoon and I generally feel good after some meals. I notice meals initially make me cold while digesting like all my circulation goes towards digestion not warming my extremities.

I’m wondering if I should go for the 2 grain mark that Broda and Peat saw was generally needed for patients to get out of hypo. Or should I address something else first like fine tuning diet and eating more. My digestion has always been very sensitive (prone to the runs) and the balance of eating enough while keeping good gut health has always been a challenge since our food quality is so bad.

Also what would be a good approach to taking 2 grains of cynoplus a day to avoid taking too much t3 at a time?

Thanks

@bio3nergetic Dude thank you so much. Without Peat and this community there would be darkness. Literally how would we figure this out on our own

@haidut ?

@bio3nergetic I appreciate that.

The study showing the inhibition of PDH seems to use P4. Is that not real progesterone?

“ By what mechanism is PDK4 gene expression induced in late pregnancy? To investigate this question, isolated neonatal rat ventricular myocytes (NRVMs) were treated with various pregnancy hormones. While neither estrogen nor prolactin altered expression, progesterone increased PDK4 expression more than 8-fold (Figure 4D). Progesterone is induced during pregnancy, both in mice and humans12. To test if the progesterone receptor is required for this effect, we used a receptor partial agonist/antagonist, mifepristone (RU486) to pre-treat NRVMs for one hour prior to progesterone incubation. Mifepristone treatment alone led to a modest increase in PDK4 expression due to its partial agonist activity. The induction of PDK4 by progesterone, however, was fully blocked in the presence of mifepristone, indicating that the induction is progesterone receptor-mediated (Figure 4E). “

Just googling certain things like “progesterone effect on PDH, or progesterone effect on insulin” gives me conflicting research from what I’ve learned from Peat.

How do we make sense of this within the bio energetic framework?

https://pubmed.ncbi.nlm.nih.gov/28928113/

“Rather, we find that the pregnancy hormone progesterone induces PDK4 (pyruvate dehydrogenase kinase 4) in cardiomyocytes and that elevated PDK4 levels in late pregnancy lead to inhibition of PDH (pyruvate dehydrogenase) and pyruvate flux into the tricarboxylic acid cycle. Blocking PDK4 reverses the metabolic changes seen in hearts in late pregnancy.”

https://journals.physiology.org/doi/full/10.1152/ajpendo.00649.2009#:~:text=To clarify the involvement of,suppressing insulin-induced Cbl phosphorylation.

“To clarify the involvement of progesterone in the pathophysiology of insulin resistance during pregnancy, we examined the molecular mechanism by which progesterone affects insulin's metabolic signaling, leading to glucose uptake in 3T3-L1 adipocytes. Here, we show that progesterone causes insulin resistance by multiple mechanisms. Progesterone suppressed the PI 3-kinase pathway by promoting IRS-1 degradation and suppressed the subsequent phosphorylation of Akt. In addition, progesterone inhibited GLUT4 translocation and glucose uptake in a step distal to Akt phosphorylation. Furthermore, progesterone inhibited TC10 activation by suppressing insulin-induced Cbl phosphorylation.”

Any ideas y’all?