All fillers inside the capsule are insoluble in DMSO, so they won’t penetrate the skin barrier.
I recently stopped using topical vitamin K; I’ve forgotten the reasoning behind the decision
When I applied it to my face, it burned. I persisted a couple of times, but I can’t say it was worth it no benefit or harm beyond the discomfort.
Haiduts Kuinone is generally formulated with a “secret” solvent he claims is as effective as DMSO but less irritating. I’ve never tried his products, so I can’t confirm its composition, and I don’t believe you need to layer DMSO onto Kuinone to improve absorption.