Serotonin question
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@alex155 Serotonin syndrome causes hyperthermia primarily through excessive muscle activity and rigidity, rather than through a change in the body's temperature set point.
As I said before foods with tytrophan are usually highly insulin stimulating causing a even greater need for the stress hormones you are living off of.
Serotonin-hibernation. https://pubmed.ncbi.nlm.nih.gov/3766776/
First link that came up when searching shows that researchers destroy seratonin receptors in a specific part of the brain hibernation is prevented -
@alex155 the guy you mentioned having seratonin depleted( which is not possible as it is a neurotransmitter the body/stomach bacteria can produce) had never mentioned anything about seratonin
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@lobotomize-me said in Serotonin question:
@alex155( which is not possible as it is a neurotransmitter the body/stomach bacteria can produce)
but isn't it possible to disrupt platelet function with things like aspirin, coffee, vit E, etc., which I've been doing for years, thereby disrupting serotonin transmission?
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@lobotomize-me said in Serotonin question:
@alex155 the guy you mentioned having seratonin depleted had never mentioned anything about seratonin
I'm just guessing
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@lobotomize-me said in Serotonin question:
As I said before foods with tytrophan are usually highly insulin stimulating causing a even greater need for the stress hormones you are living off of.
I feel stress hormones being released when I drink a cup of coffee (I feel cold and nervous) but products with tryptophan make me feel warm and calm, it's the exact opposite effect, so the first thing that came to my mind was serotonin
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for those who are afraid of tryptophan and serotonin, this study about B. subtilis will be interesting, what bacteria should be avoided, but I assure you that you won't even be able to take a shit without serotonin... and for now I will continue to experiment on myself
https://pmc.ncbi.nlm.nih.gov/articles/PMC10527075/
Mice treated with B. subtilis R0179 exhibited greater colonic tissue levels of Trp and the 5-HT breakdown product, 5-HIAA compared to vehicle-treated mice. Furthermore, B. subtilis treatment accelerated colonic motility in both healthy mice as well as in a mouse model of constipation. These effects were not observed with heat-inactivated R0179 or the live 1A2 strain that does not express tryptophan synthase. Lastly, we found that the prokinetic effects of B. subtilis R0179 were blocked by co-administration of a 5-HT4 receptor (5-HT4R) antagonist and were absent in 5-HT4R knockout mice.
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this is interesting:
https://pubmed.ncbi.nlm.nih.gov/18322094/
Serotonergic neurons project widely throughout the CNS and modulate many different brain functions. Particularly important, but controversial, are the contributions of serotonin (5-HT) neurons to respiratory and thermoregulatory control. To better define the roles of 5-HT neurons in breathing and thermoregulation, we took advantage of a unique conditional knock-out mouse in which Lmx1b is genetically deleted in Pet1-expressing cells (Lmx1b(f/f/p)), resulting in near-complete absence of central 5-HT neurons. Here, we show that the hypercapnic ventilatory response in adult Lmx1b(f/f/p) mice was decreased by 50% compared with wild-type mice, whereas baseline ventilation and the hypoxic ventilatory response were normal. In addition, Lmx1b(f/f/p) mice rapidly became hypothermic when exposed to an ambient temperature of 4 degrees C, decreasing core temperature to 30 degrees C within 120 min. This failure of thermoregulation was caused by impaired shivering and nonshivering thermogenesis, whereas thermosensory perception and heat conservation were normal. Finally, intracerebroventricular infusion of 5-HT stimulated baseline ventilation, and rescued the blunted hypercapnic ventilatory response. These data identify a previously unrecognized role of 5-HT neurons in the CO(2) chemoreflex, whereby they enhance the response of the rest of the respiratory network to CO(2). We conclude that the proper function of the 5-HT system is particularly important under conditions of environmental stress and contributes significantly to the hypercapnic ventilatory response and thermoregulatory cold defense.
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@alex155 maybe your glycogen stores are full but your body prefers liposyis for some reason and when you take coffee you still have a drop of stress hormones as your body starts to burn glucose as fuel. ( ray mentions many times that coffee acts as a thyroid mimetic)
theory 2 : you may be thiamine deficient and coffee and metabolism increasers make things worse as you thiamine gets depleted even more
theory 3 : you are high on acetylcholine
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@alex155 it seems like it
@alex155 said in Serotonin question:
Serotonergic neurons project widely throughout the CNS and modulate many different brain functions. Particularly important, but controversial, are the contributions of serotonin (5-HT) neurons to respiratory and thermoregulatory control. To better define the roles of 5-HT neurons in breathing and thermoregulation, we took advantage of a unique conditional knock-out mouse in which Lmx1b is genetically deleted in Pet1-expressing cells (Lmx1b(f/f/p)), resulting in near-complete absence of central 5-HT neurons. Here, we show that the hypercapnic ventilatory response in adult Lmx1b(f/f/p) mice was decreased by 50% compared with wild-type mice, whereas baseline ventilation and the hypoxic ventilatory response were normal. In addition, Lmx1b(f/f/p) mice rapidly became hypothermic when exposed to an ambient temperature of 4 degrees C, decreasing core temperature to 30 degrees C within 120 min. This failure of thermoregulation was caused by impaired shivering and nonshivering thermogenesis, whereas thermosensory perception and heat conservation were normal. Finally, intracerebroventricular infusion of 5-HT stimulated baseline ventilation, and rescued the blunted hypercapnic ventilatory response. These data identify a previously unrecognized role of 5-HT neurons in the CO(2) chemoreflex, whereby they enhance the response of the rest of the respiratory network to CO(2). We conclude that the proper function of the 5-HT system is particularly important under conditions of environmental stress and contributes significantly to the hypercapnic ventilatory response and thermoregulatory cold defense.
indeed it is fascinating (i didnt know this), but we as humans can rely on our on metabolism uncoupling and cell processes and brown fat to produce heat without us needed to shiver as much
here is why:
Organism Avg. Weight Avg. Surface Area Surface Area-to-Mass Ratio
Mouse
~20-30 g ~70-100 cm² ~3.5 cm²/g (very high)
Human 🧍
️ ~70 kg ~18,000 cm² ~0.26 cm²/g (low)we humans have a lot more cells inside us than cells outside us that absorb the low temperatures. slightly more than 10x then mice
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@alex155 said in Serotonin question:
for those who are afraid of tryptophan and serotonin, this study about B. subtilis will be interesting, what bacteria should be avoided, but I assure you that you won't even be able to take a shit without serotonin... and for now I will continue to experiment on myself
B.subtilis has shown to be capable of secreting polymyxin, difficidin, subtilin, and mycobacillin.
https://microchemlab.com/microorganisms/bacillus-subtilis/thus reducing overall unwanted bacteria.
