The First Orally Active Low Molecular Weight Agonists for the LH Receptor

[engineer]

LH (Luteinizing Hormone) is the hormone that binds to the LH receptors in the gonads and triggers the production of sex hormones. This study (from 2002!) showcases the first class of LHR agonist, thienopyr(im)idines, otherwise nonexistent until this study because LH is a large molecule, and so its receptor normally responds to such large molecules only. Note that this is DIFFERENT from GNrH agonists because the agonism of GNrH in the pituitary gland leads to desensitization and thus a lowering of LH, not increase.

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/1439-7633(20021004)3:10<1023::AID-CBIC1023>3.0.CO;2-9

Personally, I'm shocked this didn't get more attention. This seems like a supplement with huge potential but there are only a handful of studies on it and its derivatives:

https://link.springer.com/article/10.1134/S1990519X17010035

https://link.springer.com/article/10.1134/S0022093019050090

https://link.springer.com/article/10.1134/S0022093019010046

I couldn't find anything regarding toxicity.