Thoughts. Dopamines effects on mitochondria

[user73636]

Dopamine directly affects mitochondria, particularly in neurons, by inhibiting complex I of the electron transport chain, reducing membrane potential, and causing swelling. Excessive dopamine oxidation leads to mitochondrial dysfunction, decreased ATP production, and increased oxidative stress, which are relevant to neurodegenerative diseases like Parkinson's.

Key Impacts of Dopamine on Mitochondria:

Complex I Inhibition: Dopamine

specifically inhibits mitochondrial complex I, reducing the efficiency of energy production.

Oxidative Stress: The oxidation of dopamine produces reactive oxygen species (ROS), causing mitochondrial

National Institutes of Health (NIH) | (....

https://pubmed.ncbi.nlm.nih.gov

L-DOPA causes mitochondrial dysfunction in vitro

by S Giannopoulos 2019 Cited by 23 - L-DOPA causes mitochondrial dysfunction in vitro:

https://www.nature.com

Impairment of neuronal mitochondrial function by I-DOPA ...

by P Hörmann 2021 Cited by 25 - Further mechanistic analysis indicated that I-DOPA reprogrammed mitochondrial metabolism
PLOS
https://journals.plos.org
Dopamine Inhibits Mitochondrial Motility in Hippocampal Neurons

by S Chen 2008 Cited by 99 - In the present study, we found that dopamine exerts a net inhibitory effect on mitochondrial movement

Thoughts on all this?