Possible Prevention of Alzheimer’s Disease by Aldehyde Dehydrogenase

[DavidPS]

Japan is experiencing an increased incidence of Alzheimer's disease. Tetsumori Yamashima has written a book on a possible cause of Alzheimer's. In his eyes, cooking oil appears to be a major concern. The oil may be 'cooked' in the ships cargo area on the way to Japan. Similarly, PUFAs may be cooked on trucks and railcars as they are transported to local grocery stores.

Here is an article that Yamashima published:
Possible Prevention of Alzheimer’s Disease by Aldehyde Dehydrogenase: A Perspective Review

In an earlier paper authored by Yamashima, he shows that cooking times at 200C increased the amount of hydroxynonenal (HNE) in oils.

a: HNE generation (ppm) in five representative five cooking oils at 30 and 60 min during 200ºC heating. Extra virgin olive oil generates abundant HNE during heating, because it contains ~10% of linoleic acid. Intriguingly, the product from Australia contained a small amount of HNE prior to heating, because of warm temperature within the ship’s container en route to Japan. Popular can ola oil and rice oil containing abundant linoleic acid generate a large amount of HNE,and both soybean and sunflower oils are similar (data not shown here). In contrast, transfat-free canola oil generates very little, and coconut oil comprising of saturated fatty acids generates negligible HNE.