Study: coconut oil "has the potential to intensify the morphophysiological alterations that occur in the liver during aging" (accelerated signs of liver aging in gerbils)
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@Jennifer said in Study: coconut oil "has the potential to intensify the morphophysiological alterations that occur in the liver during aging" (accelerated signs of liver aging in gerbils):
@herenow said in Study: coconut oil "has the potential to intensify the morphophysiological alterations that occur in the liver during aging" (accelerated signs of liver aging in gerbils):
@Jennifer said in Study: coconut oil "has the potential to intensify the morphophysiological alterations that occur in the liver during aging" (accelerated signs of liver aging in gerbils):
I grew up on French, Cantonese and Polynesian cuisine and coconut was a staple....I even overcame gallbladder disease and liver “sludge,” as the ultrasound tech called it,
Is it possible that your French ancestry made you vulnerable to coconut products? Could butter or even olive oil be safer?
I have been using lots of coconut products off an on including the oil so it's something I think about from time to time. I'm not at all Polynesian.
Butter/dairy fat triggered my gallbladder attacks, but not coconut fat. Do you have any symptoms that are exacerbated by coconut or any liver tests that would cause you to be concerned?
No. I'm bullet-proof
climbing mountains in snow and flooded trails up to my waist, rapid river crossings, sub-zero temps with up to 60 mph winds that thrashed me against boulders like a ping pong ball, the issue was not my French ancestry
Why is a white French woman doing all that crap?
But seriously, thanks for keeping the low pufa community updated on your health. I appreciate that you're willing to be a guinea gerbil for a somewhat unusual pufa depleted diet while keeping everyone informed. Most seem to disappear
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It increases oxidative stress vs lowering it in lower amounts
(Study gives insight on where the harm tips over, 0.1g per mouse vs ~ a bit under 0.2g per mouse as lauric acid makes the difference,
by the time they measured with the lower bodyweight in the higher group it works out like 4g/kg vs 9g/kg bw mice amounts) https://cs3001.substack.com/p/a-bunch-of-quick-health-and-biology.
for a 60kg person >40g coconut oil a day is pushing it i think
(and probably better to split it am & pm)
30g in people beneficial (looks split) https://pubmed.ncbi.nlm.nih.gov/37409587/Another thing is caprylic acid has a big negative effect on bones at just 8g - 10g human equivalent. with capric acid having a smaller effect. coconut oil is ~10% caprylic + capric, people using MCT oil can hit that
LAA can be directly incorporated into mitochondria and undergo β-oxidation without a special transporter or carnitine shuttle [3, 9]. As a result, it may cause excessive OXPHOS in mitochondria and increase oxidative stress, thereby enhancing the myocardial catabolism pathway.
Immunohistochemical staining with an anti-8-OHdG antibody revealed no accumulation of oxidative stress in the myocardial tissues of the control and 2% groups.
administration of excessive LAA caused mitochondrial damage that produced myocardial damage by inducing catabolism of intracellular proteins by oxidative stress rather than inducing cardiomyocyte apoptosis.
This study revealed that administration of excessive LAA causes myocardial injury.
However, 2% LAA can be administered without inducing obvious myocardial damage. -
for a person 40g+ coconut oil a day is pushing it i think
See? I was right to be go into a panic.
I have keto tendencies and pufa phobias. 4 tablespoons of coconut butter is a light snack.
Damn
Thanks for posting @cs3000
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@herenow said in Study: coconut oil "has the potential to intensify the morphophysiological alterations that occur in the liver during aging" (accelerated signs of liver aging in gerbils):
No. I'm bullet-proof
Great! Then fear not the coconut.
Why is a white French woman doing all that crap?
But seriously, thanks for keeping the low pufa community updated on your health. I appreciate that you're willing to be a guinea gerbil for a somewhat unusual pufa depleted diet while keeping everyone informed. Most seem to disappear
Well, as a white woman, my choice of activity was either hiking or goat yoga, and subjecting goats to yoga is animal cruelty. In all seriousness, I did it for my brother, and now I climb for me.
And you’re welcome, but I do consume PUFA if I crave something higher in it so I may not be the best gerbil.
I know this is just my n = 1 but I ate a lot of Tropical Traditions' coconut concentrate (butter), after my spine collapsed from osteoporosis that was caused by the thyroid disease, and within a year I had increased my bone density significantly—almost a full reversal of the disease—proven by bone scans and other testing. My doctors had never seen such a severe case of bone loss, nor that level of remodeling before. This was even before I started supplementing thyroid. I did it with (natural) food alone.
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@Jennifer said in Study: coconut oil "has the potential to intensify the morphophysiological alterations that occur in the liver during aging" (accelerated signs of liver aging in gerbils):
my spine collapsed from osteoporosis
Reading stuff like this makes me self couscous complaining about how the coconut oil slowed my digestion a little.
I'll add that I was listening to some of Ray Peat's interviews from the last 6 or so years and he seemed to have stopped eating substantial amounts of coconut oil and stopped promoting it as far as I could tell. In one interview he developed concern over the mct fraction.
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@herenow said in Study: coconut oil "has the potential to intensify the morphophysiological alterations that occur in the liver during aging" (accelerated signs of liver aging in gerbils):
@Jennifer said in Study: coconut oil "has the potential to intensify the morphophysiological alterations that occur in the liver during aging" (accelerated signs of liver aging in gerbils):
my spine collapsed from osteoporosis
Reading stuff like this makes me self couscous complaining about how the coconut oil slowed my digestion a little.
I'll add that I was listening to some of Ray Peat's interviews from the last 6 or so years and he seemed to have stopped eating substantial amounts of coconut oil and stopped promoting it as far as I could tell. In one interview he developed concern over the mct fraction.
No need to feel self-conscious, herenow. My pain doesn’t invalidate your own concerns. Besides, so much good came from it. I’m not sure I would have realized what I’m made of or overcome a childhood trauma that was silently robbing me of my best life if it weren’t for my spine collapsing. But yeah, Ray warned that MCT oil is potentially irritating to the intestines and he also wasn’t a fan of unrefined coconut oil and coconut cream/milk.
