nmn lowers serotonin in a dose dependent manner
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Tryptophan → Kynurenine → NAD⁺ (serotonin trade-off)
~90–95% of dietary tryptophan runs through the kynurenine pathway; one branch yields quinolinic acid, the immediate precursor for de novo NAD⁺.
Evidence NMN boosts KP activity: In mouse macrophage models (in vivo/in vitro), NMN supplementation increased cellular kynurenine and activated kynurenine–AhR signaling—consistent with higher KP
When KP flux rises, less tryptophan is available for serotonin synthesis, so serotonin can fall while precursors for NAD⁺ rise.
TL;DR: NMN can, in inflammatory contexts, push more tryptophan down the kynurenine pathway (→ QA → NAD⁺), which can come at serotonin’s expense
so taking nmn can help one lose weight by allowing them to easily eat sugar without having to balance it out with other proteins out of fear that tryptophan will enter the brain whilst optimizing mitochondria increasing biogenesis and more
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