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    Poor sleep health is associated with older brain age

    Literature Review
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    • DavidPSD
      DavidPS
      last edited by DavidPS

      More recent support from the UK Biobank.

      In a study of ~27,500 adults using MRI + machine learning, researchers found that people with poorer sleep had brains that looked older than their actual age. Poor sleepers had a “brain age gap” about 0.46 years higher than those with healthy sleep.

      They also found that systemic inflammation explained ~10% of that link — meaning inflammation is one of the ways bad sleep could speed up brain aging.

      So getting better sleep isn’t just about feeling rested. It might help slow down age-related changes in the brain too.

      Added value of this study

      In this large-scale prospective analysis of 27,500 individuals, we found that poor sleep health was related to older brain age, estimated using a machine learning model based on 1079 brain MRI phenotypes. Specifically, the gap between brain and chronological age grew by approximately 0.5 years for every 1-point decrease in healthy sleep score. These associations were more pronounced in males and participants who were below the age of 60 at baseline. Moreover, in mediation analysis, chronic inflammation (measured by a composite of C-reactive protein, white blood cell count, platelet count, and granulocyte-to-lymphocyte ratio) mediated >10% of the association between poor sleep and older brain age. Taken together, these findings provide strong evidence that poor sleep may contribute to accelerated brain ageing and point to inflammation as one of the likely underlying biological mechanisms.

      Poor sleep health is associated with older brain age: the role of systemic inflammation (2025)

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