It's not about the empiricism, it's his methodological philosophy. In that, I believe he was being clear that the uniqueness of an individual must be taken into account instead of relying on aggregate research with questionable controls.

Try some starch with saturated fat. Bread and butter. Rice and beef. The combination of the two create high internal temperature.

Suppressing SCD1 is key, which is achieved through the aforementioned synergy.