Vitamin A deficiency impairs gonadal steroid synthesis

[jamsey]

Got banned before I could post this
https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC1165941&blobtype=pdf

“Earlier nutritional work had shown that vitamin A deficiency affects the reproductive processes of both male and female rats (Moore, 1957). Later sustained work by Grangaud and his colleagues (Grangaud et al., 1969) with whole living animals and with isolated enzyme systems from adrenals has produced extensive evidence showing that normal synthesis of steroid hormones in male and female rats is dependent on the Vitamin A nutritional status of the animals…..We have further investigated the effect of vitamin A deficiency on steroidogenesis in rat tissues and report here that even at the mild stage of the deficiency the activity of yet another enzyme, the cholesterol side-chain cleavage enzyme (cholesterolC(20)-C(22)desmolase), is significantly decreased in the ovaries and testes this becoming more pronounced with the progress of the deficiency”

Results:
Wasn’t sure how to add pictures, so I’ll summarize. Compared to the control group, the mild deficiency group had:

• ~50% of the cholesterol side-chain cleavage activity
  -35% testes weight

acute deficiency group had:

• ~29% of the cholesterol side-chain cleavage activity
  -32% testes weight

Mild deficiency group after 30 days of retinyl acetate supplementation had:

• ~105% of the cholesterol side-chain cleavage activity
  -60% testes weight

Just to clarify, cholesterol side-chain cleavage enzyme converts cholesterol to pregnenolone

[Kvirion]

@jamsey Interesting one, thank you!

[Verdad]

Thanks for sharing. Do you think you would have been banned if you had posted this? Im nervous now to even post anything on the ray peat forum that is pro-vitamin A

[jamsey]

@Verdad
Probably not immediately as he tries to disguise the fact that he bans dissenters. It will just make you an auto ban if you complain about the forum or any of his questionable choices.

[sphenoid]

The vitamin A movement could be a possible pop control psyop

[Mauritio]

Great points. You can get too much Vitamin A, but you can certainly get too little.

To clarify what you said: if your Vitamin A is low, you will get a pregnenolone deficiency, since the side chain cleaveage enzyme converts cholesterol to pregnenolone. Pregnenolone was peats one supplement he would take on a lonely island with him for a reason and he often repeated how you need T3 and Vitamin A to turn cholesterol into hormones and bile acids.

[saturnuscv]

So this means that Charlie will not reproduce. Good.

[jamsey]

@Mauritio
Yep, I had repeatedly read Ray or others mentioning retinol as necessary for steroid synthesis, but I could never find the mechanism until recently.

[Mauritio]

https://pubmed.ncbi.nlm.nih.gov/26303142/

[S.Holmes]

@sphenoid said in Vitamin A deficiency impairs gonadal steroid synthesis:

The vitamin A movement could be a possible pop control psyop

Disturbing! I'm not too concerned about the fertility of older people who go low A, but the young people and children who have to eat what their low A moms prepare. I sure hope this is reversible.