Any benefits of baking soda over Acetozalamide
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What are you trying to do? Acetozalamide is a carbonic anhydrase inhibitor; so is thiamine.
The importance of thiamine (vitamin B1) in humans" Carbonic anhydrase isoenzyme inhibitors (e.g. acetazolamide) are used to prevent pulmonary edema, altitude sickness, and increase oxygen levels. Thiamine also acts as an inhibitor of the isoenzyme of carbonic anhydrase. "
also:
New Developments in High-Dose Thiamine: The Legacy of Antonio Costantini
"The inhibition of carbonic anhydrase isoenzymes by high-dose thiamine and the resulting production of carbon dioxide could lead to reductions in fatigue and other symptomatic improvement through one or more of four potential pathways: (a) by reducing intracranial hypertension and/or ventral brainstem compression; (b) by increasing blood flow to the brain; (c) by facilitating aerobic cellular respiration and lactate clearance through the Bohr effect; or (d) by dampening the pro-inflammatory Th-17 pathway, again through the Bohr effect, potentially mediated by reductions in hypoxia-inducible factor 1."Are you trying to resolve lactic acidosis with the baking soda? In order to have good oxidative metabolism, thiamine is needed because it acts as a co-factor for several enzymes in the process. In a thiamine deficiency, the final bi-product from the Krebs cycle is lactic acid; when thiamine is available, the final product is carbon dioxide.
Or are you working on something else entirely?
