to antagonize or agonize serotonin? conflicting POVs
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someone help me out. why is antagonizing receptors a good thing if it ends up increasing serotonin overtime?
E.g. cypro blocks serotonin which causes it to increase in the brain.
SSRI's do the same thing. blocking its uptake by the receptor.
also it appears the Peaty substance "Emodin" is a natural serotonin AGONIST. As we all know this stuff is great for the gut, overall wellbeing, and according to this effective against alzheimers, TnF, inflamation in the brain.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450432/
what gives Peaters?
to antagonize or agonize serotonin?
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I've done both for several years, and partial agonism is far superior to antagonism.
In the long term, partial agonism makes you more creative, benevolent, empathetic, authentic, loving, with an ease of feeling this connection with others while remaining open-minded and keeping an emotional distance without being cut off from your emotions, which helps on a social level and doing things in service to yourself and others, you begin to act no longer in a purely individualistic way but through a form of collective consciousness while really feeling the impact of your presence in this life.
Antagonism turns you into a sleeping and eating machine, with a feeling of isolation and disinterest in reaching out to others.
Most of the time, the so-called "rebound" that some people like Lokzo experience with cyproheptadine is just the result of homeostasis, where the body after antagonism will try to resensitize the receptors and increase serotonin again to compensate.
But then, most people, like the last one I mentioned, will remain in total denial due to their belief system concerning serotonergic agonists, most of which are psychedelics, which creates resistance even to trying them or taking them, even for therapeutic purposes.
In the end, whether it is agonism or antagonism, the objective is almost the same which is the regulation of serotonergic 5HT-2a receptors, and the ideal cycle being 4 to 5 days ON, with a break of 2 or 3 days.
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@Appa Well said. Very much lines up with my experience and I couldn't help but notice the similarities with SSRI's on mood, behavior, sleep, appetite.
It turns you into a zombie. Cypro made me sleep, hungry, and foggy. Never liked it.
Now I have these unwanted side effects long term... that I'm thinking of correcting with a serotonin agonist.
Any recommendations for an agonist?
