Crohn's Disease Drugs
-
How Peaty are typical Crohn's drugs such as Humira, Rinvoq, Remicade? Is there one that's preferable?
What are some alternatives to consider from a Bioenergetic lense?
-
@yeehawyinzer said in Crohn's Disease Drugs:
What are some alternatives to consider from a Bioenergetic lense?
Crohn's disease or irritable colon (IBS): how to soothe and get out of it?
Crohn’s is related to the pathology of elimination and not to autoimmunity. Crohn's disease has a mechanism similar to that of colitis, with high levels of inflammatory cytokines, but not correlated with HLA failure (genetic reaction).
Jean Seignalet (deceased in 2002, immunologist) has treated several Crohn’s: The results are 62 frank success, with complete or almost complete remission, 9 more nuanced results and one single true failure.
In this article, we’ll see that exclusion diets were effective to improve leaky gut (intestinal permeability), what kinds of food are beneficial and which substances to optimize homeostasis.
See original post (in French):
https://mirzoune-ciboulette.forumactif.org/t2023-maladie-de-crohn-ou-colon-irritable-ibs-comment-apaiser-et-sen-sortir#29501
Irritable colon syndrome is a functional gastrointestinal system disease. Thus, unlike Crohn's disease, no change in the structural level is present, it is rather the function of the digestive system that is altered.
Jean Seignalet (immunologist) talked about colitis, also called spasmodic colopathy, irritable colon (IBS) or functional colopathy. With an IBS we often meet an abdominal bloating, transit disorders: constipation, diarrhea or alternation of both. The colopath is often tired, sometimes even anxious or depressed, prey to various discomforts (…).
In this type of colopathy Nanda and Coll. (1989) found that exclusion diets were effective in 47 % of patients, and that many subjects were able to identify dangerous foods. With a decline of one year, the benefit is maintained. I quote Jean Seignalet, in L’Alimentation ou la 3ème Médecine – &28 : Pathologie d’élimination – - 5th edition book:
“Certainly foods have a major responsibility in colitis, but not by an allergy or intolerance mechanism. The disease is not due to the assault of the colic mucosa by a poorly tolerated food. Raws and fruits are only triggers of crises. They are only dangerous because the colic wall is the seat of permanent inflammation. It is therefore we must find the root cause of the inflammation in order to treat it. Only an etiological treatment can be able to cure a colitis.”Inflammation of the colon wall (inner lining)
Some patients have often been offered a treatment oriented towards psychopathy – it happens in the head at first time – by modulating the diet with a few common sense prescriptions (eating homemade, Mediterranean style), as soon as the inflammation of the intestinal walls will allow it ...
Inflammation – not an autoimmune reaction – is due to the assault of the mucosa by one or more poorly tolerated food, not by an allergy or intolerance mechanism. The disease is not of psychic origin, either. The fatigue and signs of anxiety are only the consequence of a mined ground. The motility is altered and the sensitivity of the colon is exacerbated. Otherwise expressed, these are symptoms of the colitis we have there.
For Jean Seignalet, this is the most likely observation, confirmed by the following analyzes: this inflammation is demonstrated by the excessive presence in the colic wall of various varieties of leukocytes, in particular mastocytes, macrophages and T lymphocytes (Fioramonti et al. 2001) (Barbara et al. 2002).
Similarity with Crohn: intestines hypermeability (leaky gut)
The attack on the mucosa of the intestines through modern diet and certain dangerous bacteria it promotes, the leaky gut with passage of bacterial and food macromolecules, this causes a permanent blood infiltrate. Drugs should not be given to slow down digestive transit, but on the contrary let this flow expurgate the body of its waste.
It is therefore logical to propose an original type diet, by promoting raw products and not cooked products, unlike certain conventional medical practices, as soon as a lull of inflammation of the intestinal walls will allow it. The patient will have to adapt in a 1st step and select what is most easily passed. It is a question here of adopting a coordinated approach: to calm the exacerbated sensitivity, then orient the type of food at the 1st stage of the remission to then gradually increase the tolerance of the intestinal walls.
X
Intestinal permeability (leaky gut)
In Crohn's disease there is a mechanism similar to that of colitis, but more complex. The Crohn’s evolves frequently by successive thrusts, separated by sometimes complete, often incomplete remissions.
Before speaking in more details of Crohn's disease, I need to highlight a common point between Crohn and IBS: leaky gut.
Zonulin, a marker of intestinal permeability
Zonulin is a protein that regulates the permeability of the intestinal wall by acting on the tight junctions between the cells. (1) Its role is to allow the passage of certain molecules necessary for the body, but to block undesirable substances such as bacteria or toxins. However, zonulin can be disturbed by genetic, environmental or food factors, which leads to an increase in intestinal permeability and stimulation of the immune system.Among the foods that can increase zonulin production and therefore promote intestinal hyperpermeability, we find in particular (2):
• Casein (milk protein)
• Gliadin (gluten)
• Potatoes, especially young potatoes, or potatoes in shirts.
• Peppers
• Tomatoes
• Lectins (proteins present in legumes, cereals, shell fruits, etc.)
It is therefore advisable to avoid or limit these foods if one suffers from excessive intestinal permeability. There are also zeolite-based food supplements that can help restore the balance of the intestinal wall and eliminate harmful substances.
Beneficial foods and substances- The butyrate
The butyrate, a short chain fatty acid, has beneficial effects on the health of the colon, strengthening the intestinal barrier, modulating the immune system and preventing inflammation. The indicated dosage of butyric acid is on average 300 to 600 mg / day in a 3-month cure. Butyrate is found in appropriate quantities (> 3 mg / 100 gr) in the butter / ghee. See julienvenesson.fr later to deepen "sensitivity" to gluten, endocrine disruptors and associated pathologies, such as neurodegenerative diseases (MS, depression, autism, hyperactivity, etc.). + an overview of nutraceutics.
Practical question
In the event of inflamed intestinal walls (IBD), apart from the curcumin and lemon balm (Melissa officinalis), what could calm the irritation of the intestinal walls to make it possible to ingest mixed sweet fibers (shaker) with cooked foods? And not a classic NSAID, which will not extend the taking, if necessary.
- Zeolite
Zeolite is a natural mineral that has detoxifying and anti-inflammatory properties. It can help strengthen the intestinal wall and reduce intestinal hyperpermeability, which is linked to many chronic diseases (3). - Homeopathy
There are several homeopathic remedies that can relieve abdominal pain, diarrhea, bloody stools or spasms related to MICI. Note that we are not trying to stop the transit but to modulate it because it is necessary to let out the circulating toxins. For example, in case of cramps with spasms, Colocynthis 4 hp (if the pain improves by being folded in half or with a hot water bottle) or Dioscorea villosa 5 hp (if the pain is improving while hiding back, improved pain in extension and walking, or leaning back).
Sources et Références
- Zonuline – définition & rôle
fr.wikipedia.org - Aliments favorisant la production de zonuline
santedigestion.com
labo-barla.eu
carolinenaturopathe.ca - La zéolithe
https://www.biogena.com/fr-FR/savoir/zeolithe.html
To be continued on next page
- The butyrate
-
Crohn disease
The main clinical signs are abdominal pain, prolonged diarrhea, the emission of bloody mucus, a possible palpable mass in the right iliac pit, moderate fever, asthenia and weight loss. Biologically, there is an accelerated ESR, increased CRP (reactive Protein-C), light anemia, leukocytosis with polynucleosis and hypo-albuminemia.
Note: Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are two markers in the blood that measure levels of inflammation.
For JS, Crohn's disease has a mechanism similar to that of colitis. The severity of the Crohn’s would be due to a difference in the waste to be eliminated, perhaps a stronger quantity, often a more complex structure. The activation of several varieties of leukocytes and the secretion of multiple pro-inflammatory cytokines cause the release and activation of matrix metaloproteinases which degrade tissues, which can generate fistulas, cracks, large abscesses and fibrous strenosis (Shanahan 2002).
The proportion of various cells and cytokines in the infiltrate suggests a much more inflammatory than immune response (Mac Dermott et al. 1993), which is corroborated by the absence of association between Crohn and HLA and the ineffectiveness of the Ciclosporin which reduces the immune response in vain (Sandborn 1995). Crohn’s is related to the pathology of elimination and not to autoimmunity. Crohn’s is for Seignalet a giant colitis, a multifactorial pathology (bacteria and food).
In Crohn's disease, certain foods have awakened certain symptoms (diarrhea, pain), even a simple exclusion diet would have put these symptoms under the nod: it is interesting to note that cereals, milk and some cooked products appear frequently challenging for patients. And JS cites case studies carried out on his patients.
The results
The hypotoxic diet has been implemented in 99 cases of Crohn’s, but he will only retain the 72 patients for whom the decline is more than one year. The results are 62 frank success, with complete or almost complete remission, 9 more nuanced results and one single true failure. JS comment
Nutritional change can remove ulcers, micro-abscess and inflammatory granulomas; in short, the inflammatory process characteristic of the Crohn’s. But it can do nothing against certain definitive lesions, such as cracks, fistulas, macro-abscess and fibrous stenosis.
