Niacinamide may treat post-orgasmic illness syndrome (POIS)
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Over the last several years I have received hundreds of emails from males in regards to POIS. The number of publications about POIS in the scientific literature, as well as articles in the popular press have been steadily rising. While some medications such as finasteride and SSRI are known to cause POIS symptoms, the fact that the reports/rates of POIS have been steadily increasing suggest something else is also at play in this condition. Some people report relief after thyroid or testosterone therapy, suggesting the conditions is energetic in origin. The case study below is perhaps the most direct evidence that POIS is energetic in origin, considering its successful and sustained resolution with niacinamide therapy, at a daily dose of 500mg, taken for 5 months.
https://pubmed.ncbi.nlm.nih.gov/38952608/
“…Post-orgasmic illness syndrome (POIS) is a rare condition characterized by debilitating symptoms following ejaculation. We present a case of a 25-year-old male with flu-like symptoms post-ejaculation since age 17. Despite minimal relief from conventional treatments, a comprehensive evaluation led to the diagnosis of POIS and successful management with niacinamide therapy. The presentation of flu-like symptoms following ejaculation in this case raises several questions regarding the underlying pathophysiology. While the exact cause of his symptoms remains elusive, the resolution achieved with niacinamide therapy underscores the importance of considering alternative treatment modalities in complex cases. The role of varicocele in symptom manifestation, if any, also warrants consideration, as varicocele has been associated with male infertility and testicular dysfunction.”
“…Following the comprehensive evaluation, the patient was initiated on niacinamide therapy (500 mg per day, taken orally in the form of a tablet) for five months. Niacinamide, a form of vitamin B3, is known for its role in cellular energy production and overall metabolic function. Its mechanism of action in alleviating the post-ejaculation symptoms in this case remains an area of interest and warrants further exploration.”
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@haidut
Interesting. I looked for success markers along the stated timeframe of 6 months in the study's full text but the authors did not disclose any details.
Would be great to contact them and ask if anybody here would be so forthcoming?
As in: How was the success measured and did those measures improve gradually or was it switch-like at about 6 months or earlier?Has anybody looked into this 2021 study from Hungary below?
Post Orgasmic Illness Syndrome (POIS) and Delayed Onset Muscle Soreness (DOMS): Do They Have Anything in Common?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392034/They argue for a complex system of energy depletion, mitochondria dysfunction and also a polyamine depletion (by expulsion) for the crucial spermidine levels in neurons in combination with odd stress signalling patterns. There could be a unique case for spermidine supplementation.
And the participation of a long-term manifestation of changes in the endocannabinoid and opioid system.
And much more.
For some odd reason there even seems to be succesful, positive interaction between hCG injections and spermidine and POIS?By the authors' establishing ties of a common multifactorial pathogenesis between POIS and delayed onset muscle soreness I wonder whether either of these two are 'special' manifestations of a general CFS, mitochondrial, energy, neuronal, autonomic dysfunction.