Niacin increase homocysteine, niacinamide protects against cerebral homocysteine toxicity
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@thyroidchor27 boom
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Niacinamide can raise homocysteine too. There are other valid criticisms of niacin vs niacinamide, but this isn’t one of them.
https://pubmed.ncbi.nlm.nih.gov/27567458/
“The level of 3-h plasma nicotinamide, N1-methylnicotinamide, homocysteine, the urinary excretion of N1-methyl-2-pyridone-5-carboxamide and pulse pressure (PP) in the NM group was 221%, 3972%, 61%, 1728% and 21.2% higher than that of the control group (P < 0.01, except homocysteine and PP P < 0.05), while the 3-h plasma betaine, normetanephrine and metanephrine level in the NM group was 24.4%, 9.4% and 11.7% lower (P < 0.05, except betaine P < 0.01), without significant difference in choline levels. Similar but less pronounced changes were observed in the NA group, with a lower level of 3-h plasma N1-methylnicotinamide (1.90 ± 0.20 μmol/l vs. 3.62 ± 0.27 μmol/l, P < 0.01) and homocysteine (12.85 ± 1.39 μmol/l vs. 18.08 ± 1.02 μmol/l, P < 0.05) but a higher level of betaine (27.44 ± 0.71 μmol/l vs. 23.52 ± 0.61 μmol/l, P < 0.05) than that of the NM group.”
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@jamsey yes I’m aware. Anything that reduces methyl groups can raise homocysteine. Would be interesting though if these were calibrated to the same dose. Since niacin also raises histamine which indirectly would reduce methylation even further. I see the study says niacin increases HC to a lower extent but people do use higher doses to get the same effects as a lower dose of NA
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P5P can help to reduce homocysteine.